TY  - JOUR
AU  - Marković, Maja
AU  - Seslija, Sanja, I
AU  - Ugrinović, Vukašin
AU  - Kunaver, Matjaz
AU  - Panić, Vesna
AU  - Pjanović, Rada
AU  - Spasojević, Pavle
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4802
AB  - pH- and magnetic-sensitive hybrid hydrogels based on poly(methacrylic acid) (PMAA), nanocellulose (NC), carboxymethyl cellulose (CMC) and magnetite particles (MN) were prepared as ibuprofen delivery system. NC was isolated from wood waste material and added to highly hydrophilic PMAA in order to improve the mechanical properties of PMAA and enable the encapsulation of poorly water-soluble ibuprofen. CMC was added in order to stabilize magnetite particles. The pH- and magnetic-sensitivity of the obtained hybrid hydrogels (originated from PMAA and MN, respectively) provided targeted delivery and controlled release of ibuprofen. Hybrid hydrogels were characterized by various technics: FTIR, SEM, XRD, VSM, the modified Faraday method, photon correlation spectroscopy and by using single compression tests. The swelling behavior of hybrid hydrogels and cumulative ibuprofen release were investigated depending on wt% of NC and MN in two media which were simulating pH environments in human stomach and intestines. The swelling degree of hybrid hydrogels and the percent of cumulative ibuprofen release decreased with the increase in wt% of NC. The same was found for increasing wt% of MN. Ibuprofen release kinetics was investigated with Korsmeyer-Peppas model. The obtained results showed that the prepared green dual responsive hybrid hydrogels were excellent candidates for the controlled release of ibuprofen, showing that the release kinetic can be easily tuned by changing only one hydrogel component.
T2  - Cellulose
T1  - Green pH- and magnetic-responsive hybrid hydrogels based on poly(methacrylic acid) and Eucalyptus wood nanocellulose for controlled release of ibuprofen
EP  - 11132
IS  - 17
SP  - 11109
VL  - 28
DO  - 10.1007/s10570-021-04222-w
ER  - 

@article{
author = "Marković, Maja and Seslija, Sanja, I and Ugrinović, Vukašin and Kunaver, Matjaz and Panić, Vesna and Pjanović, Rada and Spasojević, Pavle",
year = "2021",
abstract = "pH- and magnetic-sensitive hybrid hydrogels based on poly(methacrylic acid) (PMAA), nanocellulose (NC), carboxymethyl cellulose (CMC) and magnetite particles (MN) were prepared as ibuprofen delivery system. NC was isolated from wood waste material and added to highly hydrophilic PMAA in order to improve the mechanical properties of PMAA and enable the encapsulation of poorly water-soluble ibuprofen. CMC was added in order to stabilize magnetite particles. The pH- and magnetic-sensitivity of the obtained hybrid hydrogels (originated from PMAA and MN, respectively) provided targeted delivery and controlled release of ibuprofen. Hybrid hydrogels were characterized by various technics: FTIR, SEM, XRD, VSM, the modified Faraday method, photon correlation spectroscopy and by using single compression tests. The swelling behavior of hybrid hydrogels and cumulative ibuprofen release were investigated depending on wt% of NC and MN in two media which were simulating pH environments in human stomach and intestines. The swelling degree of hybrid hydrogels and the percent of cumulative ibuprofen release decreased with the increase in wt% of NC. The same was found for increasing wt% of MN. Ibuprofen release kinetics was investigated with Korsmeyer-Peppas model. The obtained results showed that the prepared green dual responsive hybrid hydrogels were excellent candidates for the controlled release of ibuprofen, showing that the release kinetic can be easily tuned by changing only one hydrogel component.",
journal = "Cellulose",
title = "Green pH- and magnetic-responsive hybrid hydrogels based on poly(methacrylic acid) and Eucalyptus wood nanocellulose for controlled release of ibuprofen",
pages = "11132-11109",
number = "17",
volume = "28",
doi = "10.1007/s10570-021-04222-w"
}

Marković, M., Seslija, S. I., Ugrinović, V., Kunaver, M., Panić, V., Pjanović, R.,& Spasojević, P.. (2021). Green pH- and magnetic-responsive hybrid hydrogels based on poly(methacrylic acid) and Eucalyptus wood nanocellulose for controlled release of ibuprofen. in Cellulose, 28(17), 11109-11132.
https://doi.org/10.1007/s10570-021-04222-w

Marković M, Seslija SI, Ugrinović V, Kunaver M, Panić V, Pjanović R, Spasojević P. Green pH- and magnetic-responsive hybrid hydrogels based on poly(methacrylic acid) and Eucalyptus wood nanocellulose for controlled release of ibuprofen. in Cellulose. 2021;28(17):11109-11132.
doi:10.1007/s10570-021-04222-w .

Marković, Maja, Seslija, Sanja, I, Ugrinović, Vukašin, Kunaver, Matjaz, Panić, Vesna, Pjanović, Rada, Spasojević, Pavle, "Green pH- and magnetic-responsive hybrid hydrogels based on poly(methacrylic acid) and Eucalyptus wood nanocellulose for controlled release of ibuprofen" in Cellulose, 28, no. 17 (2021):11109-11132,
https://doi.org/10.1007/s10570-021-04222-w . .

TY  - JOUR
AU  - Pepić, Dragana
AU  - Žagar, Ema
AU  - Žigon, Majda
AU  - Kržan, Andrej
AU  - Kunaver, Matjaz
AU  - Đonlagić, Jasna
PY  - 2008
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5576
AB  - A series of multiblock poly(ether-ester)s based on poly(butylene succinate) (PBS) as the hard segments and hydrophilic poly(ethylene oxide) (PEO) as the soft segments was synthesized with the aim of developing degradable polymers which could combine the mechanical properties of high performance elastomers with those of flexible plastics. The aliphatic poly(ether-ester)s were synthesized by the catalyzed two-step transesterification reaction of dimethyl succinate, 1,4-butanediol and α,ω-hydroxyl terminated poly(ethylene oxide) (PEO, over(M, -)n = 1000 g/mol) in bulk. The content of soft PEO segments in the polymer chains was varied from about 10 to 50 mass%. The effect of the introduction of the soft PEO segments on the structure, thermal and physical properties, as well as on the biodegradation properties was investigated. The composition and structure of these aliphatic segmented copolyesters were determined by 1H NMR spectroscopy. The molecular weights of the polyesters were verified by gel permeation chromatography (GPC), as well as by viscometry of dilute solutions and polymer melts. The thermal properties were investigated using differential scanning calorimetry (DSC). The degree of crystallinity was determined by means of DSC and wide-angle X-ray scattering. A depression of melting temperature and a reduction of crystallinity of the hard segments with increasing content of PEO segments were observed. Biodegradation of the synthesized copolyesters, estimated in enzymatic degradation tests in phosphate buffer solution with Candida rugosa lipase at 37 °C was compared with hydrolytic degradation in the buffer solution. The weight losses of the samples were in the range from 2 to 10 mass%. GPC analysis confirmed that there were significant changes in molecular weight of copolyesters with higher content of PEO segments, up to 40% of initial values. This leads to conclusion that degradation mechanism of the poly(ether-ester)s based on PEO segments occurs through bulk degradation in addition to surface erosion.
PB  - Elsevier Ltd
T2  - European Polymer Journal
T1  - Synthesis and characterization of biodegradable aliphatic copolyesters with poly(ethylene oxide) soft segments
EP  - 917
IS  - 3
SP  - 904
VL  - 44
DO  - 10.1016/j.eurpolymj.2007.11.035
ER  - 

@article{
author = "Pepić, Dragana and Žagar, Ema and Žigon, Majda and Kržan, Andrej and Kunaver, Matjaz and Đonlagić, Jasna",
year = "2008",
abstract = "A series of multiblock poly(ether-ester)s based on poly(butylene succinate) (PBS) as the hard segments and hydrophilic poly(ethylene oxide) (PEO) as the soft segments was synthesized with the aim of developing degradable polymers which could combine the mechanical properties of high performance elastomers with those of flexible plastics. The aliphatic poly(ether-ester)s were synthesized by the catalyzed two-step transesterification reaction of dimethyl succinate, 1,4-butanediol and α,ω-hydroxyl terminated poly(ethylene oxide) (PEO, over(M, -)n = 1000 g/mol) in bulk. The content of soft PEO segments in the polymer chains was varied from about 10 to 50 mass%. The effect of the introduction of the soft PEO segments on the structure, thermal and physical properties, as well as on the biodegradation properties was investigated. The composition and structure of these aliphatic segmented copolyesters were determined by 1H NMR spectroscopy. The molecular weights of the polyesters were verified by gel permeation chromatography (GPC), as well as by viscometry of dilute solutions and polymer melts. The thermal properties were investigated using differential scanning calorimetry (DSC). The degree of crystallinity was determined by means of DSC and wide-angle X-ray scattering. A depression of melting temperature and a reduction of crystallinity of the hard segments with increasing content of PEO segments were observed. Biodegradation of the synthesized copolyesters, estimated in enzymatic degradation tests in phosphate buffer solution with Candida rugosa lipase at 37 °C was compared with hydrolytic degradation in the buffer solution. The weight losses of the samples were in the range from 2 to 10 mass%. GPC analysis confirmed that there were significant changes in molecular weight of copolyesters with higher content of PEO segments, up to 40% of initial values. This leads to conclusion that degradation mechanism of the poly(ether-ester)s based on PEO segments occurs through bulk degradation in addition to surface erosion.",
publisher = "Elsevier Ltd",
journal = "European Polymer Journal",
title = "Synthesis and characterization of biodegradable aliphatic copolyesters with poly(ethylene oxide) soft segments",
pages = "917-904",
number = "3",
volume = "44",
doi = "10.1016/j.eurpolymj.2007.11.035"
}

Pepić, D., Žagar, E., Žigon, M., Kržan, A., Kunaver, M.,& Đonlagić, J.. (2008). Synthesis and characterization of biodegradable aliphatic copolyesters with poly(ethylene oxide) soft segments. in European Polymer Journal
Elsevier Ltd., 44(3), 904-917.
https://doi.org/10.1016/j.eurpolymj.2007.11.035

Pepić D, Žagar E, Žigon M, Kržan A, Kunaver M, Đonlagić J. Synthesis and characterization of biodegradable aliphatic copolyesters with poly(ethylene oxide) soft segments. in European Polymer Journal. 2008;44(3):904-917.
doi:10.1016/j.eurpolymj.2007.11.035 .

Pepić, Dragana, Žagar, Ema, Žigon, Majda, Kržan, Andrej, Kunaver, Matjaz, Đonlagić, Jasna, "Synthesis and characterization of biodegradable aliphatic copolyesters with poly(ethylene oxide) soft segments" in European Polymer Journal, 44, no. 3 (2008):904-917,
https://doi.org/10.1016/j.eurpolymj.2007.11.035 . .