TY  - JOUR
AU  - Enck, Paul
AU  - Aziz, Qasim
AU  - Barbara, Giovanni
AU  - Farmer, Adam D.
AU  - Fukudo, Shin
AU  - Mayer, Emeran A.
AU  - Niesler, Beate
AU  - Quigley, Eamonn M. M.
AU  - Rajilić-Stojanović, Mirjana
AU  - Schemann, Michael
AU  - Schwille-Kiuntke, Juliane
AU  - Simren, Magnus
AU  - Zipfel, Stephan
AU  - Spiller, Robin C.
PY  - 2016
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3234
AB  - Irritable bowel syndrome (IBS) is a functional gastrointestinal disease with a high population prevalence. The disorder can be debilitating in some patients, whereas others may have mild or moderate symptoms. The most important single risk factors are female sex, younger age and preceding gastrointestinal infections. Clinical symptoms of IBS include abdominal pain or discomfort, stool irregularities and bloating, as well as other somatic, visceral and psychiatric comorbidities. Currently, the diagnosis of IBS is based on symptoms and the exclusion of other organic diseases, and therapy includes drug treatment of the predominant symptoms, nutrition and psychotherapy. Although the underlying pathogenesis is far from understood, aetiological factors include increased epithelial hyperpermeability, dysbiosis, inflammation, visceral hypersensitivity, epigenetics and genetics, and altered brain-gut interactions. IBS considerably affects quality of life and imposes a profound burden on patients, physicians and the health-care system. The past decade has seen remarkable progress in our understanding of functional bowel disorders such as IBS that will be summarized in this Primer.
PB  - Nature Research, Berlin
T2  - Nature Reviews Disease Primers
T1  - Irritable bowel syndrome
VL  - 2
DO  - 10.1038/nrdp.2016.14
ER  - 

@article{
author = "Enck, Paul and Aziz, Qasim and Barbara, Giovanni and Farmer, Adam D. and Fukudo, Shin and Mayer, Emeran A. and Niesler, Beate and Quigley, Eamonn M. M. and Rajilić-Stojanović, Mirjana and Schemann, Michael and Schwille-Kiuntke, Juliane and Simren, Magnus and Zipfel, Stephan and Spiller, Robin C.",
year = "2016",
abstract = "Irritable bowel syndrome (IBS) is a functional gastrointestinal disease with a high population prevalence. The disorder can be debilitating in some patients, whereas others may have mild or moderate symptoms. The most important single risk factors are female sex, younger age and preceding gastrointestinal infections. Clinical symptoms of IBS include abdominal pain or discomfort, stool irregularities and bloating, as well as other somatic, visceral and psychiatric comorbidities. Currently, the diagnosis of IBS is based on symptoms and the exclusion of other organic diseases, and therapy includes drug treatment of the predominant symptoms, nutrition and psychotherapy. Although the underlying pathogenesis is far from understood, aetiological factors include increased epithelial hyperpermeability, dysbiosis, inflammation, visceral hypersensitivity, epigenetics and genetics, and altered brain-gut interactions. IBS considerably affects quality of life and imposes a profound burden on patients, physicians and the health-care system. The past decade has seen remarkable progress in our understanding of functional bowel disorders such as IBS that will be summarized in this Primer.",
publisher = "Nature Research, Berlin",
journal = "Nature Reviews Disease Primers",
title = "Irritable bowel syndrome",
volume = "2",
doi = "10.1038/nrdp.2016.14"
}

Enck, P., Aziz, Q., Barbara, G., Farmer, A. D., Fukudo, S., Mayer, E. A., Niesler, B., Quigley, E. M. M., Rajilić-Stojanović, M., Schemann, M., Schwille-Kiuntke, J., Simren, M., Zipfel, S.,& Spiller, R. C.. (2016). Irritable bowel syndrome. in Nature Reviews Disease Primers
Nature Research, Berlin., 2.
https://doi.org/10.1038/nrdp.2016.14

Enck P, Aziz Q, Barbara G, Farmer AD, Fukudo S, Mayer EA, Niesler B, Quigley EMM, Rajilić-Stojanović M, Schemann M, Schwille-Kiuntke J, Simren M, Zipfel S, Spiller RC. Irritable bowel syndrome. in Nature Reviews Disease Primers. 2016;2.
doi:10.1038/nrdp.2016.14 .

Enck, Paul, Aziz, Qasim, Barbara, Giovanni, Farmer, Adam D., Fukudo, Shin, Mayer, Emeran A., Niesler, Beate, Quigley, Eamonn M. M., Rajilić-Stojanović, Mirjana, Schemann, Michael, Schwille-Kiuntke, Juliane, Simren, Magnus, Zipfel, Stephan, Spiller, Robin C., "Irritable bowel syndrome" in Nature Reviews Disease Primers, 2 (2016),
https://doi.org/10.1038/nrdp.2016.14 . .