TY  - JOUR
AU  - Enck, Paul
AU  - Aziz, Qasim
AU  - Barbara, Giovanni
AU  - Farmer, Adam D.
AU  - Fukudo, Shin
AU  - Mayer, Emeran A.
AU  - Niesler, Beate
AU  - Quigley, Eamonn M. M.
AU  - Rajilić-Stojanović, Mirjana
AU  - Schemann, Michael
AU  - Schwille-Kiuntke, Juliane
AU  - Simren, Magnus
AU  - Zipfel, Stephan
AU  - Spiller, Robin C.
PY  - 2016
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3234
AB  - Irritable bowel syndrome (IBS) is a functional gastrointestinal disease with a high population prevalence. The disorder can be debilitating in some patients, whereas others may have mild or moderate symptoms. The most important single risk factors are female sex, younger age and preceding gastrointestinal infections. Clinical symptoms of IBS include abdominal pain or discomfort, stool irregularities and bloating, as well as other somatic, visceral and psychiatric comorbidities. Currently, the diagnosis of IBS is based on symptoms and the exclusion of other organic diseases, and therapy includes drug treatment of the predominant symptoms, nutrition and psychotherapy. Although the underlying pathogenesis is far from understood, aetiological factors include increased epithelial hyperpermeability, dysbiosis, inflammation, visceral hypersensitivity, epigenetics and genetics, and altered brain-gut interactions. IBS considerably affects quality of life and imposes a profound burden on patients, physicians and the health-care system. The past decade has seen remarkable progress in our understanding of functional bowel disorders such as IBS that will be summarized in this Primer.
PB  - Nature Research, Berlin
T2  - Nature Reviews Disease Primers
T1  - Irritable bowel syndrome
VL  - 2
DO  - 10.1038/nrdp.2016.14
ER  - 

@article{
author = "Enck, Paul and Aziz, Qasim and Barbara, Giovanni and Farmer, Adam D. and Fukudo, Shin and Mayer, Emeran A. and Niesler, Beate and Quigley, Eamonn M. M. and Rajilić-Stojanović, Mirjana and Schemann, Michael and Schwille-Kiuntke, Juliane and Simren, Magnus and Zipfel, Stephan and Spiller, Robin C.",
year = "2016",
abstract = "Irritable bowel syndrome (IBS) is a functional gastrointestinal disease with a high population prevalence. The disorder can be debilitating in some patients, whereas others may have mild or moderate symptoms. The most important single risk factors are female sex, younger age and preceding gastrointestinal infections. Clinical symptoms of IBS include abdominal pain or discomfort, stool irregularities and bloating, as well as other somatic, visceral and psychiatric comorbidities. Currently, the diagnosis of IBS is based on symptoms and the exclusion of other organic diseases, and therapy includes drug treatment of the predominant symptoms, nutrition and psychotherapy. Although the underlying pathogenesis is far from understood, aetiological factors include increased epithelial hyperpermeability, dysbiosis, inflammation, visceral hypersensitivity, epigenetics and genetics, and altered brain-gut interactions. IBS considerably affects quality of life and imposes a profound burden on patients, physicians and the health-care system. The past decade has seen remarkable progress in our understanding of functional bowel disorders such as IBS that will be summarized in this Primer.",
publisher = "Nature Research, Berlin",
journal = "Nature Reviews Disease Primers",
title = "Irritable bowel syndrome",
volume = "2",
doi = "10.1038/nrdp.2016.14"
}

Enck, P., Aziz, Q., Barbara, G., Farmer, A. D., Fukudo, S., Mayer, E. A., Niesler, B., Quigley, E. M. M., Rajilić-Stojanović, M., Schemann, M., Schwille-Kiuntke, J., Simren, M., Zipfel, S.,& Spiller, R. C.. (2016). Irritable bowel syndrome. in Nature Reviews Disease Primers
Nature Research, Berlin., 2.
https://doi.org/10.1038/nrdp.2016.14

Enck P, Aziz Q, Barbara G, Farmer AD, Fukudo S, Mayer EA, Niesler B, Quigley EMM, Rajilić-Stojanović M, Schemann M, Schwille-Kiuntke J, Simren M, Zipfel S, Spiller RC. Irritable bowel syndrome. in Nature Reviews Disease Primers. 2016;2.
doi:10.1038/nrdp.2016.14 .

Enck, Paul, Aziz, Qasim, Barbara, Giovanni, Farmer, Adam D., Fukudo, Shin, Mayer, Emeran A., Niesler, Beate, Quigley, Eamonn M. M., Rajilić-Stojanović, Mirjana, Schemann, Michael, Schwille-Kiuntke, Juliane, Simren, Magnus, Zipfel, Stephan, Spiller, Robin C., "Irritable bowel syndrome" in Nature Reviews Disease Primers, 2 (2016),
https://doi.org/10.1038/nrdp.2016.14 . .

TY  - JOUR
AU  - Rajilić-Stojanović, Mirjana
AU  - Jonkers, Daisy M.
AU  - Salonen, Anne
AU  - Hanevik, Kurt
AU  - Raes, Jeroen
AU  - Jalanka, Jonna
AU  - de Vos, Willem M.
AU  - Manichanh, Chaysavanh
AU  - Golić, Nataša
AU  - Enck, Paul
AU  - Philippou, Elena
AU  - Iraqi, Fuad A.
AU  - Clarke, Gerard
AU  - Spiller, Robin C.
AU  - Penders, John
PY  - 2015
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2973
AB  - Irritable bowel syndrome (IBS) is a heterogeneous functional disorder with a multifactorial etiology that involves the interplay of both host and environmental factors. Among environmental factors relevant for IBS etiology, the diet stands out given that the majority of IBS patients report their symptoms to be triggered by meals or specifi c foods. The diet provides substrates for microbial fermentation, and, as the composition of the intestinal microbiota is disturbed in IBS patients, the link between diet, microbiota composition, and microbial fermentation products might have an essential role in IBS etiology. In this review, we summarize current evidence regarding the impact of diet and the intestinal microbiota on IBS symptoms, as well as the reported interactions between diet and the microbiota composition. On the basis of the existing data, we suggest pathways (mechanisms) by which diet components, via the microbial fermentation, could trigger IBS symptoms. Finally, this review provides recommendations for future studies that would enable elucidation of the role of diet and microbiota and how these factors may be (inter) related in the pathophysiology of IBS.
PB  - Lippincott Williams & Wilkins, Philadelphia
T2  - American Journal of Gastroenterology
T1  - Intestinal Microbiota And Diet in IBS: Causes, Consequences, or Epiphenomena?
EP  - 287
IS  - 2
SP  - 278
VL  - 110
DO  - 10.1038/ajg.2014.427
ER  - 

@article{
author = "Rajilić-Stojanović, Mirjana and Jonkers, Daisy M. and Salonen, Anne and Hanevik, Kurt and Raes, Jeroen and Jalanka, Jonna and de Vos, Willem M. and Manichanh, Chaysavanh and Golić, Nataša and Enck, Paul and Philippou, Elena and Iraqi, Fuad A. and Clarke, Gerard and Spiller, Robin C. and Penders, John",
year = "2015",
abstract = "Irritable bowel syndrome (IBS) is a heterogeneous functional disorder with a multifactorial etiology that involves the interplay of both host and environmental factors. Among environmental factors relevant for IBS etiology, the diet stands out given that the majority of IBS patients report their symptoms to be triggered by meals or specifi c foods. The diet provides substrates for microbial fermentation, and, as the composition of the intestinal microbiota is disturbed in IBS patients, the link between diet, microbiota composition, and microbial fermentation products might have an essential role in IBS etiology. In this review, we summarize current evidence regarding the impact of diet and the intestinal microbiota on IBS symptoms, as well as the reported interactions between diet and the microbiota composition. On the basis of the existing data, we suggest pathways (mechanisms) by which diet components, via the microbial fermentation, could trigger IBS symptoms. Finally, this review provides recommendations for future studies that would enable elucidation of the role of diet and microbiota and how these factors may be (inter) related in the pathophysiology of IBS.",
publisher = "Lippincott Williams & Wilkins, Philadelphia",
journal = "American Journal of Gastroenterology",
title = "Intestinal Microbiota And Diet in IBS: Causes, Consequences, or Epiphenomena?",
pages = "287-278",
number = "2",
volume = "110",
doi = "10.1038/ajg.2014.427"
}

Rajilić-Stojanović, M., Jonkers, D. M., Salonen, A., Hanevik, K., Raes, J., Jalanka, J., de Vos, W. M., Manichanh, C., Golić, N., Enck, P., Philippou, E., Iraqi, F. A., Clarke, G., Spiller, R. C.,& Penders, J.. (2015). Intestinal Microbiota And Diet in IBS: Causes, Consequences, or Epiphenomena?. in American Journal of Gastroenterology
Lippincott Williams & Wilkins, Philadelphia., 110(2), 278-287.
https://doi.org/10.1038/ajg.2014.427

Rajilić-Stojanović M, Jonkers DM, Salonen A, Hanevik K, Raes J, Jalanka J, de Vos WM, Manichanh C, Golić N, Enck P, Philippou E, Iraqi FA, Clarke G, Spiller RC, Penders J. Intestinal Microbiota And Diet in IBS: Causes, Consequences, or Epiphenomena?. in American Journal of Gastroenterology. 2015;110(2):278-287.
doi:10.1038/ajg.2014.427 .

Rajilić-Stojanović, Mirjana, Jonkers, Daisy M., Salonen, Anne, Hanevik, Kurt, Raes, Jeroen, Jalanka, Jonna, de Vos, Willem M., Manichanh, Chaysavanh, Golić, Nataša, Enck, Paul, Philippou, Elena, Iraqi, Fuad A., Clarke, Gerard, Spiller, Robin C., Penders, John, "Intestinal Microbiota And Diet in IBS: Causes, Consequences, or Epiphenomena?" in American Journal of Gastroenterology, 110, no. 2 (2015):278-287,
https://doi.org/10.1038/ajg.2014.427 . .