TY  - JOUR
AU  - Jauković, Zorica
AU  - Grujić, Svetlana
AU  - Bujagić Matić, Ivana
AU  - Petković, Anđelka
AU  - Laušević, Mila
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5189
AB  - In this work, the environmental distribution of steroid compounds and the level of sewage-derived contamination were assessed using sterol ratios in the confluence area of two major rivers in the Serbian capital, where raw sewage is discharged without any treatment. Special attention was paid to steroids partitioning between the dissolved and suspended phases of river and wastewater samples, since steroids tend to easily bind to particulate matter. The efficiency of sterol removal in two wastewater treatment plants in Serbia was also evaluated. Human/animal sterols coprostanol and cholesterol, and phytosterol β-sitosterol were the dominant compounds in all water samples. The sterol abundance pattern in river water was different from that in raw sewage, indicating a more pronounced biogenic input, as well as greater impact of wastewater discharges on the composition of the suspended phase. Severe contamination of the investigated area was determined, with the Danube being more contaminated than the Sava River due to different hydrodynamic conditions leading to significantly higher sterol levels in the suspended particulate matter. It was also shown that the greater part of human/animal sterols and phytosterols present in river water samples (83.0 ± 11.9 % and 87.1 ± 15.2 %) and wastewater samples (92.1 ± 6.8 % and 95.0 ± 5.7 %) was bound to suspended material compared to the dissolved phase, emphasizing the need to consider and analyze both water phases in the tracing of steroid-based environmental pollution in order to obtain a realistic picture of steroid contamination and their fate in the aquatic environment. A high removal rate (>98 %) of coprostanol and cholesterol during wastewater treatment was determined and only the coprostanol/(coprostanol + cholestanol) ratio was found to be sensitive enough to be affected by an improvement in the quality of treated wastewater.
PB  - Elsevier B.V.
T2  - Science of the Total Environment
T1  - Steroid-based tracing of sewage-sourced pollution of river water and wastewater treatment efficiency: Dissolved and suspended water phase distribution
SP  - 157510
VL  - 846
DO  - 10.1016/j.scitotenv.2022.157510
ER  - 

@article{
author = "Jauković, Zorica and Grujić, Svetlana and Bujagić Matić, Ivana and Petković, Anđelka and Laušević, Mila",
year = "2022",
abstract = "In this work, the environmental distribution of steroid compounds and the level of sewage-derived contamination were assessed using sterol ratios in the confluence area of two major rivers in the Serbian capital, where raw sewage is discharged without any treatment. Special attention was paid to steroids partitioning between the dissolved and suspended phases of river and wastewater samples, since steroids tend to easily bind to particulate matter. The efficiency of sterol removal in two wastewater treatment plants in Serbia was also evaluated. Human/animal sterols coprostanol and cholesterol, and phytosterol β-sitosterol were the dominant compounds in all water samples. The sterol abundance pattern in river water was different from that in raw sewage, indicating a more pronounced biogenic input, as well as greater impact of wastewater discharges on the composition of the suspended phase. Severe contamination of the investigated area was determined, with the Danube being more contaminated than the Sava River due to different hydrodynamic conditions leading to significantly higher sterol levels in the suspended particulate matter. It was also shown that the greater part of human/animal sterols and phytosterols present in river water samples (83.0 ± 11.9 % and 87.1 ± 15.2 %) and wastewater samples (92.1 ± 6.8 % and 95.0 ± 5.7 %) was bound to suspended material compared to the dissolved phase, emphasizing the need to consider and analyze both water phases in the tracing of steroid-based environmental pollution in order to obtain a realistic picture of steroid contamination and their fate in the aquatic environment. A high removal rate (>98 %) of coprostanol and cholesterol during wastewater treatment was determined and only the coprostanol/(coprostanol + cholestanol) ratio was found to be sensitive enough to be affected by an improvement in the quality of treated wastewater.",
publisher = "Elsevier B.V.",
journal = "Science of the Total Environment",
title = "Steroid-based tracing of sewage-sourced pollution of river water and wastewater treatment efficiency: Dissolved and suspended water phase distribution",
pages = "157510",
volume = "846",
doi = "10.1016/j.scitotenv.2022.157510"
}

Jauković, Z., Grujić, S., Bujagić Matić, I., Petković, A.,& Laušević, M.. (2022). Steroid-based tracing of sewage-sourced pollution of river water and wastewater treatment efficiency: Dissolved and suspended water phase distribution. in Science of the Total Environment
Elsevier B.V.., 846, 157510.
https://doi.org/10.1016/j.scitotenv.2022.157510

Jauković Z, Grujić S, Bujagić Matić I, Petković A, Laušević M. Steroid-based tracing of sewage-sourced pollution of river water and wastewater treatment efficiency: Dissolved and suspended water phase distribution. in Science of the Total Environment. 2022;846:157510.
doi:10.1016/j.scitotenv.2022.157510 .

Jauković, Zorica, Grujić, Svetlana, Bujagić Matić, Ivana, Petković, Anđelka, Laušević, Mila, "Steroid-based tracing of sewage-sourced pollution of river water and wastewater treatment efficiency: Dissolved and suspended water phase distribution" in Science of the Total Environment, 846 (2022):157510,
https://doi.org/10.1016/j.scitotenv.2022.157510 . .

TY  - CONF
AU  - Matić Bujagić, Ivana
AU  - Jauković, Zorica
AU  - Grujić, Svetlana
AU  - Gvozdić, Eleonora
AU  - Laušević, Mila
PY  - 2018
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5947
AB  - Komunalne otpadne vode i efluenti iz postrojenja za prečišćavanje otpadnih voda predstavljaju značajan izvor zagađujućih materija u vodenoj sredini. Studije su pokazale da se steroidna jedinjenja u postrojenjima za tretman ne uklanjaju u potpunosti, kao i da prisustvo steroida u vodi, čak i pri veoma niskim koncentracijama, može izazvati brojne neželjene efekte. U ovom radu analizirani su kompozitni uzorci otpadne vode, uzeti tokom pet dana sa dva ispusta komunalne vode u Novom Sadu. U uzorcima otpadne vode ispitivano je prisustvo 20 najčešće detektovanih steroidnih hormona i sterola optimizovanom metodom tečne hromatografije visokih performansi u sprezi sa tandem masenom spektrometrijom. Pored rastvornog oblika steroida, analizirana je i frakcija adsorbovana na suspendovanoj materiji.
PB  - Beograd : Srpsko hemijsko društvo
C3  - Knjiga izvoda / 8. simpozijum Hemija i zaštita životne sredine sa međunarodnim učešćem, Kruševac 30. maj - 1. jun 2018
T1  - Određivanje odabranih steroida u uzorcima komunalne otpadne vode
T1  - Determination of selected steroids in municipal wastewater samples
EP  - 170
SP  - 169
UR  - https://hdl.handle.net/21.15107/rcub_technorep_5947
ER  - 

@conference{
author = "Matić Bujagić, Ivana and Jauković, Zorica and Grujić, Svetlana and Gvozdić, Eleonora and Laušević, Mila",
year = "2018",
abstract = "Komunalne otpadne vode i efluenti iz postrojenja za prečišćavanje otpadnih voda predstavljaju značajan izvor zagađujućih materija u vodenoj sredini. Studije su pokazale da se steroidna jedinjenja u postrojenjima za tretman ne uklanjaju u potpunosti, kao i da prisustvo steroida u vodi, čak i pri veoma niskim koncentracijama, može izazvati brojne neželjene efekte. U ovom radu analizirani su kompozitni uzorci otpadne vode, uzeti tokom pet dana sa dva ispusta komunalne vode u Novom Sadu. U uzorcima otpadne vode ispitivano je prisustvo 20 najčešće detektovanih steroidnih hormona i sterola optimizovanom metodom tečne hromatografije visokih performansi u sprezi sa tandem masenom spektrometrijom. Pored rastvornog oblika steroida, analizirana je i frakcija adsorbovana na suspendovanoj materiji.",
publisher = "Beograd : Srpsko hemijsko društvo",
journal = "Knjiga izvoda / 8. simpozijum Hemija i zaštita životne sredine sa međunarodnim učešćem, Kruševac 30. maj - 1. jun 2018",
title = "Određivanje odabranih steroida u uzorcima komunalne otpadne vode, Determination of selected steroids in municipal wastewater samples",
pages = "170-169",
url = "https://hdl.handle.net/21.15107/rcub_technorep_5947"
}

Matić Bujagić, I., Jauković, Z., Grujić, S., Gvozdić, E.,& Laušević, M.. (2018). Određivanje odabranih steroida u uzorcima komunalne otpadne vode. in Knjiga izvoda / 8. simpozijum Hemija i zaštita životne sredine sa međunarodnim učešćem, Kruševac 30. maj - 1. jun 2018
Beograd : Srpsko hemijsko društvo., 169-170.
https://hdl.handle.net/21.15107/rcub_technorep_5947

Matić Bujagić I, Jauković Z, Grujić S, Gvozdić E, Laušević M. Određivanje odabranih steroida u uzorcima komunalne otpadne vode. in Knjiga izvoda / 8. simpozijum Hemija i zaštita životne sredine sa međunarodnim učešćem, Kruševac 30. maj - 1. jun 2018. 2018;:169-170.
https://hdl.handle.net/21.15107/rcub_technorep_5947 .

Matić Bujagić, Ivana, Jauković, Zorica, Grujić, Svetlana, Gvozdić, Eleonora, Laušević, Mila, "Određivanje odabranih steroida u uzorcima komunalne otpadne vode" in Knjiga izvoda / 8. simpozijum Hemija i zaštita životne sredine sa međunarodnim učešćem, Kruševac 30. maj - 1. jun 2018 (2018):169-170,
https://hdl.handle.net/21.15107/rcub_technorep_5947 .

TY  - JOUR
AU  - Jauković, Zorica D.
AU  - Grujić, Svetlana
AU  - Matić-Bujagić, Ivana
AU  - Laušević, Mila
PY  - 2017
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3630
AB  - The development and optimization of an analytical method for simultaneous extraction, determination and reliable confirmation of twenty steroids from different classes (human/animal and plant sterols, and natural and synthetic steroid hormones) in environmental water and wastewater at ng L-1 levels are described. Water samples were prepared using solid-phase extraction and extracts were analyzed by liquid chromatography-linear ion trap-tandem mass spectrometry. Improved instrumental method was developed for complete chromatographic separation of analytes with identical fragmentation reactions, based on the Use of a single C8 column and acetonitrile as organic solvent in the mobile phase. The optimized method provided high recoveries (70-114%) for both water matrices with the RSDs generally lower than 20%. Low limits of detection were achieved for both surface water (0.7-15.0 ng L-1) and wastewater (1.7-15.0 ng L-1). Method displayed good linearity in the tested concentration ranges. As a result of method application to real water samples, cholesterol was detected in all fifteen analyzed river water samples (in the concentration range 176-5162 ng L-1) and all seven wastewater samples (1092-4808 ng L-1). Also, coprostanol, stigmasterol, campesterol, beta-sitosterol and sitostanol were found in the investigated samples. Steroid hormones were not detected in any of the analyzed water samples.
PB  - Elsevier Science Bv, Amsterdam
T2  - Microchemical Journal
T1  - Determination of sterols and steroid hormones in surface water and wastewater using liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry
EP  - 47
SP  - 39
VL  - 135
DO  - 10.1016/j.microc.2017.07.011
ER  - 

@article{
author = "Jauković, Zorica D. and Grujić, Svetlana and Matić-Bujagić, Ivana and Laušević, Mila",
year = "2017",
abstract = "The development and optimization of an analytical method for simultaneous extraction, determination and reliable confirmation of twenty steroids from different classes (human/animal and plant sterols, and natural and synthetic steroid hormones) in environmental water and wastewater at ng L-1 levels are described. Water samples were prepared using solid-phase extraction and extracts were analyzed by liquid chromatography-linear ion trap-tandem mass spectrometry. Improved instrumental method was developed for complete chromatographic separation of analytes with identical fragmentation reactions, based on the Use of a single C8 column and acetonitrile as organic solvent in the mobile phase. The optimized method provided high recoveries (70-114%) for both water matrices with the RSDs generally lower than 20%. Low limits of detection were achieved for both surface water (0.7-15.0 ng L-1) and wastewater (1.7-15.0 ng L-1). Method displayed good linearity in the tested concentration ranges. As a result of method application to real water samples, cholesterol was detected in all fifteen analyzed river water samples (in the concentration range 176-5162 ng L-1) and all seven wastewater samples (1092-4808 ng L-1). Also, coprostanol, stigmasterol, campesterol, beta-sitosterol and sitostanol were found in the investigated samples. Steroid hormones were not detected in any of the analyzed water samples.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Microchemical Journal",
title = "Determination of sterols and steroid hormones in surface water and wastewater using liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry",
pages = "47-39",
volume = "135",
doi = "10.1016/j.microc.2017.07.011"
}

Jauković, Z. D., Grujić, S., Matić-Bujagić, I.,& Laušević, M.. (2017). Determination of sterols and steroid hormones in surface water and wastewater using liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry. in Microchemical Journal
Elsevier Science Bv, Amsterdam., 135, 39-47.
https://doi.org/10.1016/j.microc.2017.07.011

Jauković ZD, Grujić S, Matić-Bujagić I, Laušević M. Determination of sterols and steroid hormones in surface water and wastewater using liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry. in Microchemical Journal. 2017;135:39-47.
doi:10.1016/j.microc.2017.07.011 .

Jauković, Zorica D., Grujić, Svetlana, Matić-Bujagić, Ivana, Laušević, Mila, "Determination of sterols and steroid hormones in surface water and wastewater using liquid chromatography-atmospheric pressure chemical ionization-mass spectrometry" in Microchemical Journal, 135 (2017):39-47,
https://doi.org/10.1016/j.microc.2017.07.011 . .

TY  - JOUR
AU  - Matić-Bujagić, Ivana
AU  - Grujić, Svetlana
AU  - Jauković, Zorica D.
AU  - Laušević, Mila
PY  - 2016
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3285
AB  - In this work, source pollution tracing of the sediments of the Danube River and its tributaries in Serbia was performed using sterol ratios. Improved liquid chromatography-tandem mass spectrometry method, which enabled complete chromatographic separation of four analytes with identical fragmentation reactions (epicoprostanol, coprostanol, epicholestanol and cholestanol), was applied for the determination of steroid compounds (hormones, human/animal and plant sterols). A widespread occurrence of sterols was identified in all analyzed samples, whereas the only detected hormones were mestranol and 17 alpha-estradiol. A human-sourced sewage marker coprostanol was detected at the highest concentration (up to 1939 ng g(-1)). The ratios between the key sterol biomarkers, as well as the percentage of coprostanol relative to the total sterol amount, were applied with the aim of selecting the most reliable for distinction between human-sourced pollution and the sterols originated from the natural sources in river sediments. The coprostanol/(cholesterol + cholestanol) and coprostanol/epicoprostanol ratios do not distinguish between human and natural sources of sterols in the river sediments in Serbia. The most reliable sterol ratios for the sewage pollution assessment of river sediments in the studied area were found to be coprostanol/(coprostanol + cholestanol), coprostanol/cholesterol and epicoprostanol/coprostanol. For the majority of sediments, human-derived pollution was determined. Two sediment samples were identified as influenced by a combination of human and natural biogenic sources.
PB  - Elsevier Sci Ltd, Oxford
T2  - Environmental Pollution
T1  - Sterol ratios as a tool for sewage pollution assessment of river sediments in Serbia
EP  - 83
SP  - 76
VL  - 213
DO  - 10.1016/j.envpol.2015.12.036
ER  - 

@article{
author = "Matić-Bujagić, Ivana and Grujić, Svetlana and Jauković, Zorica D. and Laušević, Mila",
year = "2016",
abstract = "In this work, source pollution tracing of the sediments of the Danube River and its tributaries in Serbia was performed using sterol ratios. Improved liquid chromatography-tandem mass spectrometry method, which enabled complete chromatographic separation of four analytes with identical fragmentation reactions (epicoprostanol, coprostanol, epicholestanol and cholestanol), was applied for the determination of steroid compounds (hormones, human/animal and plant sterols). A widespread occurrence of sterols was identified in all analyzed samples, whereas the only detected hormones were mestranol and 17 alpha-estradiol. A human-sourced sewage marker coprostanol was detected at the highest concentration (up to 1939 ng g(-1)). The ratios between the key sterol biomarkers, as well as the percentage of coprostanol relative to the total sterol amount, were applied with the aim of selecting the most reliable for distinction between human-sourced pollution and the sterols originated from the natural sources in river sediments. The coprostanol/(cholesterol + cholestanol) and coprostanol/epicoprostanol ratios do not distinguish between human and natural sources of sterols in the river sediments in Serbia. The most reliable sterol ratios for the sewage pollution assessment of river sediments in the studied area were found to be coprostanol/(coprostanol + cholestanol), coprostanol/cholesterol and epicoprostanol/coprostanol. For the majority of sediments, human-derived pollution was determined. Two sediment samples were identified as influenced by a combination of human and natural biogenic sources.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Environmental Pollution",
title = "Sterol ratios as a tool for sewage pollution assessment of river sediments in Serbia",
pages = "83-76",
volume = "213",
doi = "10.1016/j.envpol.2015.12.036"
}

Matić-Bujagić, I., Grujić, S., Jauković, Z. D.,& Laušević, M.. (2016). Sterol ratios as a tool for sewage pollution assessment of river sediments in Serbia. in Environmental Pollution
Elsevier Sci Ltd, Oxford., 213, 76-83.
https://doi.org/10.1016/j.envpol.2015.12.036

Matić-Bujagić I, Grujić S, Jauković ZD, Laušević M. Sterol ratios as a tool for sewage pollution assessment of river sediments in Serbia. in Environmental Pollution. 2016;213:76-83.
doi:10.1016/j.envpol.2015.12.036 .

Matić-Bujagić, Ivana, Grujić, Svetlana, Jauković, Zorica D., Laušević, Mila, "Sterol ratios as a tool for sewage pollution assessment of river sediments in Serbia" in Environmental Pollution, 213 (2016):76-83,
https://doi.org/10.1016/j.envpol.2015.12.036 . .

TY  - CONF
AU  - Radišić, Marina
AU  - Jauković, Zorica
AU  - Kovačević, Srđan
AU  - Tolić, Ljiljana
AU  - Grujić, Svetlana
AU  - Dimkić, Milan
AU  - Laušević, Mila
PY  - 2015
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7255
AB  - Lekovi predstavljaju najznačajniju grupu novih zagađujućih supstanci koje se nalaze u prirodnim vodama [1]. Otpadne vode, poreklom iz domaćinstava, industrije i životinjskih farmi predstavljaju osnovne izvore zagađenja životne sredine. U prirodnim vodama, lekovi mogu biti prisutni u svojoj osnovnoj formi ili u formi metabolita. Koncentracije metabolita lekova koje su prisutne u životnoj sredini često su veće od koncentracija osnovnog leka. Metamizol je veoma popularan antipiretik i analgetik koji se koristi u mnogim zemljama preko 70 godina. Iako je, zbog sumnje da može da izazove agranulocitozu kod pacijenata, zabranjen u mnogim zemljama, u većini evropskih zemalja i dalje se koristi zbog svog analgetičkog dejstva. Posle apsorpcije metamizola u gastro-intestinalnom traktu, on potpuno hidrolizuje u 4-metil-aminoantipirin (4-MAA), koji u jetri metabolizuje u 4-aminoantipirin (4-AA), pa se dalje acetilizuje do 4-acetilaminoantipirina (4-AAA) i 4-formil-aminoantipirina (4-FAA) [2]. Krajnji metaboliti 4-AAA i 4-FAA su dosta stabilni u životnoj sredini i nađeni su u dosta visokim koncentracijama u otpadnim i prirodnim vodama [3]. U ovom radu je optimizovana, validirana i primenjena analitička metoda za određivanje metamizola i njegovih metabolita 4-AAA i 4-FAA u podzemnim i površinskim vodama.
PB  - Beograd : Srpsko hemijsko društvo = Serbian Chemical Society
C3  - Knjiga izvoda = Book of Abstracts / 7. simpozijum Hemija i zaštita životne sredine sa međunarodnim učešćem = 7th Symposium Chemistry and Environmental Protection with International Participation, Palić, Srbija, 09-12. jun 2015
T1  - Određivanje metabolita metamizola u površinskoj i podzemnoj vodi
T1  - Determination of metamizole metabolites in surface water and groundwater
EP  - 242
SP  - 241
UR  - https://hdl.handle.net/21.15107/rcub_technorep_7255
ER  - 

@conference{
author = "Radišić, Marina and Jauković, Zorica and Kovačević, Srđan and Tolić, Ljiljana and Grujić, Svetlana and Dimkić, Milan and Laušević, Mila",
year = "2015",
abstract = "Lekovi predstavljaju najznačajniju grupu novih zagađujućih supstanci koje se nalaze u prirodnim vodama [1]. Otpadne vode, poreklom iz domaćinstava, industrije i životinjskih farmi predstavljaju osnovne izvore zagađenja životne sredine. U prirodnim vodama, lekovi mogu biti prisutni u svojoj osnovnoj formi ili u formi metabolita. Koncentracije metabolita lekova koje su prisutne u životnoj sredini često su veće od koncentracija osnovnog leka. Metamizol je veoma popularan antipiretik i analgetik koji se koristi u mnogim zemljama preko 70 godina. Iako je, zbog sumnje da može da izazove agranulocitozu kod pacijenata, zabranjen u mnogim zemljama, u većini evropskih zemalja i dalje se koristi zbog svog analgetičkog dejstva. Posle apsorpcije metamizola u gastro-intestinalnom traktu, on potpuno hidrolizuje u 4-metil-aminoantipirin (4-MAA), koji u jetri metabolizuje u 4-aminoantipirin (4-AA), pa se dalje acetilizuje do 4-acetilaminoantipirina (4-AAA) i 4-formil-aminoantipirina (4-FAA) [2]. Krajnji metaboliti 4-AAA i 4-FAA su dosta stabilni u životnoj sredini i nađeni su u dosta visokim koncentracijama u otpadnim i prirodnim vodama [3]. U ovom radu je optimizovana, validirana i primenjena analitička metoda za određivanje metamizola i njegovih metabolita 4-AAA i 4-FAA u podzemnim i površinskim vodama.",
publisher = "Beograd : Srpsko hemijsko društvo = Serbian Chemical Society",
journal = "Knjiga izvoda = Book of Abstracts / 7. simpozijum Hemija i zaštita životne sredine sa međunarodnim učešćem = 7th Symposium Chemistry and Environmental Protection with International Participation, Palić, Srbija, 09-12. jun 2015",
title = "Određivanje metabolita metamizola u površinskoj i podzemnoj vodi, Determination of metamizole metabolites in surface water and groundwater",
pages = "242-241",
url = "https://hdl.handle.net/21.15107/rcub_technorep_7255"
}

Radišić, M., Jauković, Z., Kovačević, S., Tolić, L., Grujić, S., Dimkić, M.,& Laušević, M.. (2015). Određivanje metabolita metamizola u površinskoj i podzemnoj vodi. in Knjiga izvoda = Book of Abstracts / 7. simpozijum Hemija i zaštita životne sredine sa međunarodnim učešćem = 7th Symposium Chemistry and Environmental Protection with International Participation, Palić, Srbija, 09-12. jun 2015
Beograd : Srpsko hemijsko društvo = Serbian Chemical Society., 241-242.
https://hdl.handle.net/21.15107/rcub_technorep_7255

Radišić M, Jauković Z, Kovačević S, Tolić L, Grujić S, Dimkić M, Laušević M. Određivanje metabolita metamizola u površinskoj i podzemnoj vodi. in Knjiga izvoda = Book of Abstracts / 7. simpozijum Hemija i zaštita životne sredine sa međunarodnim učešćem = 7th Symposium Chemistry and Environmental Protection with International Participation, Palić, Srbija, 09-12. jun 2015. 2015;:241-242.
https://hdl.handle.net/21.15107/rcub_technorep_7255 .

Radišić, Marina, Jauković, Zorica, Kovačević, Srđan, Tolić, Ljiljana, Grujić, Svetlana, Dimkić, Milan, Laušević, Mila, "Određivanje metabolita metamizola u površinskoj i podzemnoj vodi" in Knjiga izvoda = Book of Abstracts / 7. simpozijum Hemija i zaštita životne sredine sa međunarodnim učešćem = 7th Symposium Chemistry and Environmental Protection with International Participation, Palić, Srbija, 09-12. jun 2015 (2015):241-242,
https://hdl.handle.net/21.15107/rcub_technorep_7255 .

TY  - JOUR
AU  - Matić, Ivana
AU  - Grujić, Svetlana
AU  - Jauković, Zorica D.
AU  - Laušević, Mila
PY  - 2014
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2751
AB  - In this paper, development and optimization of new LC-MS method for determination of twenty selected hormones, human/animal and plant sterols in river sediments were described. Sediment samples were prepared using ultrasonic extraction and clean up with silica gel/anhydrous sodium sulphate cartridge. Extracts were analyzed by liquid chromatography-linear ion trap-tandem mass spectrometry, with atmospheric pressure chemical ionization. The optimized extraction parameters were extraction solvent (methanol), weight of the sediment (2g) and time of ultrasonic extraction (3x 10 min). Successful chromatographic separation of hormones (estriol and estrone, 17 alpha- and 17 beta-estradiol) and four human/animal sterols (epicoprostanol, coprostanol, alpha-cholestanol and beta-cholestanol) that have identical fragmentation reactions was achieved. The developed and optimized method provided high recoveries (73-118%), low limits of detection (0.8-18 ng g(-1)) and quantification (2.5-60 ng g(-1)) with the RSDs generally lower than 20%. Applicability of the developed method was confirmed by analysis of six river sediment samples. A widespread occurrence of human/animal and plant sterols was found. The only detected hormone was mestranol in just one sediment sample.
PB  - Elsevier, Amsterdam
T2  - Journal of Chromatography A
T1  - Trace analysis of selected hormones and sterols in river sediments by liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry
EP  - 127
SP  - 117
VL  - 1364
DO  - 10.1016/j.chroma.2014.08.061
ER  - 

@article{
author = "Matić, Ivana and Grujić, Svetlana and Jauković, Zorica D. and Laušević, Mila",
year = "2014",
abstract = "In this paper, development and optimization of new LC-MS method for determination of twenty selected hormones, human/animal and plant sterols in river sediments were described. Sediment samples were prepared using ultrasonic extraction and clean up with silica gel/anhydrous sodium sulphate cartridge. Extracts were analyzed by liquid chromatography-linear ion trap-tandem mass spectrometry, with atmospheric pressure chemical ionization. The optimized extraction parameters were extraction solvent (methanol), weight of the sediment (2g) and time of ultrasonic extraction (3x 10 min). Successful chromatographic separation of hormones (estriol and estrone, 17 alpha- and 17 beta-estradiol) and four human/animal sterols (epicoprostanol, coprostanol, alpha-cholestanol and beta-cholestanol) that have identical fragmentation reactions was achieved. The developed and optimized method provided high recoveries (73-118%), low limits of detection (0.8-18 ng g(-1)) and quantification (2.5-60 ng g(-1)) with the RSDs generally lower than 20%. Applicability of the developed method was confirmed by analysis of six river sediment samples. A widespread occurrence of human/animal and plant sterols was found. The only detected hormone was mestranol in just one sediment sample.",
publisher = "Elsevier, Amsterdam",
journal = "Journal of Chromatography A",
title = "Trace analysis of selected hormones and sterols in river sediments by liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry",
pages = "127-117",
volume = "1364",
doi = "10.1016/j.chroma.2014.08.061"
}

Matić, I., Grujić, S., Jauković, Z. D.,& Laušević, M.. (2014). Trace analysis of selected hormones and sterols in river sediments by liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry. in Journal of Chromatography A
Elsevier, Amsterdam., 1364, 117-127.
https://doi.org/10.1016/j.chroma.2014.08.061

Matić I, Grujić S, Jauković ZD, Laušević M. Trace analysis of selected hormones and sterols in river sediments by liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry. in Journal of Chromatography A. 2014;1364:117-127.
doi:10.1016/j.chroma.2014.08.061 .

Matić, Ivana, Grujić, Svetlana, Jauković, Zorica D., Laušević, Mila, "Trace analysis of selected hormones and sterols in river sediments by liquid chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry" in Journal of Chromatography A, 1364 (2014):117-127,
https://doi.org/10.1016/j.chroma.2014.08.061 . .

TY  - JOUR
AU  - Jauković, Zorica D.
AU  - Grujić, Svetlana
AU  - Vasiljević, Tatjana
AU  - Petrović, Slobodan
AU  - Laušević, Mila
PY  - 2014
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2672
AB  - A sensitive method for determination of the eight most prescribed drugs used in combined cardiovascular therapy in Serbia was developed and optimized. The method was based on SPE followed by LC/ion trap-MS/MS with positive electrospray ionization. Parameters that affect the SPE were optimized, such as the eluent, sample pH, and sample volume. Good recoveries from groundwater (87.6-120.9%) as well as wastewater (84.5-106.6%) were achieved with this method, except in the case of atorvastatin (26.1 and 45.2%, respectively). The method was applied in the analysis of four river water samples collected in Serbia, as well as nine corresponding groundwater samples. Residues of the beta-blockers metoprolol and bisoprolol as well as the anticoagulant clopidogrel were detected for the first time in river water. Groundwater samples did not contain drug residues. Influents and effluents of two wastewater treatment plants showed the predominant presence of metoprolol and enalapril. The removal rate of metoprolol was generally low, whereas enalapril was eliminated with the highest efficiency. Atorvastatin was detected in influents and completely removed in the treatment.
PB  - Aoac Int, Gaithersburg
T2  - Journal of AOAC International
T1  - Cardiovascular Drugs in Environmental Waters and Wastewaters: Method Optimization and Real Sample Analysis
EP  - 1174
IS  - 4
SP  - 1167
VL  - 97
DO  - 10.5740/jaoacint.12-121
ER  - 

@article{
author = "Jauković, Zorica D. and Grujić, Svetlana and Vasiljević, Tatjana and Petrović, Slobodan and Laušević, Mila",
year = "2014",
abstract = "A sensitive method for determination of the eight most prescribed drugs used in combined cardiovascular therapy in Serbia was developed and optimized. The method was based on SPE followed by LC/ion trap-MS/MS with positive electrospray ionization. Parameters that affect the SPE were optimized, such as the eluent, sample pH, and sample volume. Good recoveries from groundwater (87.6-120.9%) as well as wastewater (84.5-106.6%) were achieved with this method, except in the case of atorvastatin (26.1 and 45.2%, respectively). The method was applied in the analysis of four river water samples collected in Serbia, as well as nine corresponding groundwater samples. Residues of the beta-blockers metoprolol and bisoprolol as well as the anticoagulant clopidogrel were detected for the first time in river water. Groundwater samples did not contain drug residues. Influents and effluents of two wastewater treatment plants showed the predominant presence of metoprolol and enalapril. The removal rate of metoprolol was generally low, whereas enalapril was eliminated with the highest efficiency. Atorvastatin was detected in influents and completely removed in the treatment.",
publisher = "Aoac Int, Gaithersburg",
journal = "Journal of AOAC International",
title = "Cardiovascular Drugs in Environmental Waters and Wastewaters: Method Optimization and Real Sample Analysis",
pages = "1174-1167",
number = "4",
volume = "97",
doi = "10.5740/jaoacint.12-121"
}

Jauković, Z. D., Grujić, S., Vasiljević, T., Petrović, S.,& Laušević, M.. (2014). Cardiovascular Drugs in Environmental Waters and Wastewaters: Method Optimization and Real Sample Analysis. in Journal of AOAC International
Aoac Int, Gaithersburg., 97(4), 1167-1174.
https://doi.org/10.5740/jaoacint.12-121

Jauković ZD, Grujić S, Vasiljević T, Petrović S, Laušević M. Cardiovascular Drugs in Environmental Waters and Wastewaters: Method Optimization and Real Sample Analysis. in Journal of AOAC International. 2014;97(4):1167-1174.
doi:10.5740/jaoacint.12-121 .

Jauković, Zorica D., Grujić, Svetlana, Vasiljević, Tatjana, Petrović, Slobodan, Laušević, Mila, "Cardiovascular Drugs in Environmental Waters and Wastewaters: Method Optimization and Real Sample Analysis" in Journal of AOAC International, 97, no. 4 (2014):1167-1174,
https://doi.org/10.5740/jaoacint.12-121 . .