TY  - JOUR
AU  - Laban, Bojana B.
AU  - Lazarević-Pašti, Tamara
AU  - Veljović, Đorđe
AU  - Marković, Mirjana
AU  - Klekotka, Urszula
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6222
AB  - The silver and gold L-methionine capped nanoparticles (Ag and Au @LM NPs) were analyzed as prospective acetylcholinesterase (AChE) inhibitors to test their potential in the treatment of cognitive impairment in depression and Alzheimer's disease. The stability of NPs, and their ability to inhibit AChE were studied by UV-Vis and FTIR spectrophotometry. At the same time, TEM and SEM measurements, DLS, and zeta potential measurements were employed in the structural characterization of NPs. Nearly spherical, negatively charged Ag and Au @LM NPs, with 17 nm and 31 nm in diameter, respectively, showed moderate inhibitory potential toward AChE in the given frame of investigated concentrations. For both NPs IC50 is not reached. Furthermore, the adsorption of enzyme molecules on the surface of Ag and Au @LM NPs was demonstrated. Hence, our assumption is that inhibition of AChE is caused by blockage of the enzyme‘s active site due to the steric hindrance of NPs.
PB  - John Wiley and Sons Inc.
T2  - European Journal of Inorganic Chemistry
T1  - Methionine Capped Nanoparticles as Acetylcholinesterase Inhibitors
SP  - e202200754
DO  - 10.1002/ejic.202200754
ER  - 

@article{
author = "Laban, Bojana B. and Lazarević-Pašti, Tamara and Veljović, Đorđe and Marković, Mirjana and Klekotka, Urszula",
year = "2023",
abstract = "The silver and gold L-methionine capped nanoparticles (Ag and Au @LM NPs) were analyzed as prospective acetylcholinesterase (AChE) inhibitors to test their potential in the treatment of cognitive impairment in depression and Alzheimer's disease. The stability of NPs, and their ability to inhibit AChE were studied by UV-Vis and FTIR spectrophotometry. At the same time, TEM and SEM measurements, DLS, and zeta potential measurements were employed in the structural characterization of NPs. Nearly spherical, negatively charged Ag and Au @LM NPs, with 17 nm and 31 nm in diameter, respectively, showed moderate inhibitory potential toward AChE in the given frame of investigated concentrations. For both NPs IC50 is not reached. Furthermore, the adsorption of enzyme molecules on the surface of Ag and Au @LM NPs was demonstrated. Hence, our assumption is that inhibition of AChE is caused by blockage of the enzyme‘s active site due to the steric hindrance of NPs.",
publisher = "John Wiley and Sons Inc.",
journal = "European Journal of Inorganic Chemistry",
title = "Methionine Capped Nanoparticles as Acetylcholinesterase Inhibitors",
pages = "e202200754",
doi = "10.1002/ejic.202200754"
}

Laban, B. B., Lazarević-Pašti, T., Veljović, Đ., Marković, M.,& Klekotka, U.. (2023). Methionine Capped Nanoparticles as Acetylcholinesterase Inhibitors. in European Journal of Inorganic Chemistry
John Wiley and Sons Inc.., e202200754.
https://doi.org/10.1002/ejic.202200754

Laban BB, Lazarević-Pašti T, Veljović Đ, Marković M, Klekotka U. Methionine Capped Nanoparticles as Acetylcholinesterase Inhibitors. in European Journal of Inorganic Chemistry. 2023;:e202200754.
doi:10.1002/ejic.202200754 .

Laban, Bojana B., Lazarević-Pašti, Tamara, Veljović, Đorđe, Marković, Mirjana, Klekotka, Urszula, "Methionine Capped Nanoparticles as Acetylcholinesterase Inhibitors" in European Journal of Inorganic Chemistry (2023):e202200754,
https://doi.org/10.1002/ejic.202200754 . .