TY  - JOUR
AU  - Marković, Maja D.
AU  - Svetozarević, Milica M.
AU  - Panić, Vesna V.
AU  - Savić, Sanja I.
AU  - Mašulović, Aleksandra D.
AU  - Spasojević, Pavle M.
AU  - Pjanović, Rada V.
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5860
AB  - This study reports successful free radical synthesis of pH-sensitive hydrogels based on poly(methacrylic acid) (PMAA) by using new green initiation system based on vitamin C and hydrogen peroxide (VC/H2O2). The application of proposed initiation system provides many advantages, above all cost effective and eco-friendly synthesis which can be carried out under ambient conditions. The obtained PMAA hydrogels are analyzed by various technics: Differential Scanning Calorimetry, Fourier Transform Infrared spectroscopy, Scanning Electron Microscopy and by using single compression tests. In line with the intended application, PMAA hydrogels are further investigated in terms of their potential to be used for encapsulation and controlled release of active substances such as antioxidant phenolic compounds. To keep it green, the total phenolic compounds (TPC) were obtained from orange peels waste by applying ultrasonic-assisted extraction and deep eutectic solvent (DES) based on glycerol:urea:water. The TPC were successfully encapsulated into the PMAA hydrogels which were previously estimated to have the optimal mechanical and swelling properties with respect to the final application. The swelling behavior of the PMAA hydrogels and controlled release of the TPC were tested as a function of the various synthesis parameters in several media with different pH values. It was shown that TPC can be released in control manner in medium which simulates the environment in human intestines, finally resulting in enhanced bioavailability of TPC, reduced side effects and improved therapeutic effects.
PB  - Elsevier B.V.
T2  - Chemical Engineering Journal
T1  - Novel eco-friendly initiation system based on vitamin C for energy efficient synthesis of PMAA hydrogel used for delivery of phenolic compounds
SP  - 141580
VL  - 459
DO  - 10.1016/j.cej.2023.141580
ER  - 

@article{
author = "Marković, Maja D. and Svetozarević, Milica M. and Panić, Vesna V. and Savić, Sanja I. and Mašulović, Aleksandra D. and Spasojević, Pavle M. and Pjanović, Rada V.",
year = "2023",
abstract = "This study reports successful free radical synthesis of pH-sensitive hydrogels based on poly(methacrylic acid) (PMAA) by using new green initiation system based on vitamin C and hydrogen peroxide (VC/H2O2). The application of proposed initiation system provides many advantages, above all cost effective and eco-friendly synthesis which can be carried out under ambient conditions. The obtained PMAA hydrogels are analyzed by various technics: Differential Scanning Calorimetry, Fourier Transform Infrared spectroscopy, Scanning Electron Microscopy and by using single compression tests. In line with the intended application, PMAA hydrogels are further investigated in terms of their potential to be used for encapsulation and controlled release of active substances such as antioxidant phenolic compounds. To keep it green, the total phenolic compounds (TPC) were obtained from orange peels waste by applying ultrasonic-assisted extraction and deep eutectic solvent (DES) based on glycerol:urea:water. The TPC were successfully encapsulated into the PMAA hydrogels which were previously estimated to have the optimal mechanical and swelling properties with respect to the final application. The swelling behavior of the PMAA hydrogels and controlled release of the TPC were tested as a function of the various synthesis parameters in several media with different pH values. It was shown that TPC can be released in control manner in medium which simulates the environment in human intestines, finally resulting in enhanced bioavailability of TPC, reduced side effects and improved therapeutic effects.",
publisher = "Elsevier B.V.",
journal = "Chemical Engineering Journal",
title = "Novel eco-friendly initiation system based on vitamin C for energy efficient synthesis of PMAA hydrogel used for delivery of phenolic compounds",
pages = "141580",
volume = "459",
doi = "10.1016/j.cej.2023.141580"
}

Marković, M. D., Svetozarević, M. M., Panić, V. V., Savić, S. I., Mašulović, A. D., Spasojević, P. M.,& Pjanović, R. V.. (2023). Novel eco-friendly initiation system based on vitamin C for energy efficient synthesis of PMAA hydrogel used for delivery of phenolic compounds. in Chemical Engineering Journal
Elsevier B.V.., 459, 141580.
https://doi.org/10.1016/j.cej.2023.141580

Marković MD, Svetozarević MM, Panić VV, Savić SI, Mašulović AD, Spasojević PM, Pjanović RV. Novel eco-friendly initiation system based on vitamin C for energy efficient synthesis of PMAA hydrogel used for delivery of phenolic compounds. in Chemical Engineering Journal. 2023;459:141580.
doi:10.1016/j.cej.2023.141580 .

Marković, Maja D., Svetozarević, Milica M., Panić, Vesna V., Savić, Sanja I., Mašulović, Aleksandra D., Spasojević, Pavle M., Pjanović, Rada V., "Novel eco-friendly initiation system based on vitamin C for energy efficient synthesis of PMAA hydrogel used for delivery of phenolic compounds" in Chemical Engineering Journal, 459 (2023):141580,
https://doi.org/10.1016/j.cej.2023.141580 . .

TY  - JOUR
AU  - Panić, Vesna V.
AU  - Jovanović, Jelena D.
AU  - Popović, Ivanka G.
AU  - Savić, Sanja I.
AU  - Marković, Maja D.
AU  - Spasojević, Pavle M.
AU  - Adnađević, Borivoj K.
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5966
AB  - High concentrations of hydrophobic MFI zeolite (26.0–51.3 wt%) were successfully embedded in poly(methacrylic acid) (PMAA) network in simple, one-pot synthesis of PMAA-MFI composite hydrogels. The effects of zeolite concentration regarding pure PMAA xerogel, for all of the investigated properties (primary structural parameters, morphological properties, water swelling ability, thermal degradation mechanism and stability, and mechanical properties) were determined and discussed. The PMAA-MFI composite hydrogels had remarkably higher density than PMAA xerogel (1660/1420 kg m−3), higher crosslinking density (29/1.0 × 10−4), improved mechanics in the dry and swollen state (up to 4.9 times higher storage modulus) and lower swelling degree (42/420 g g−1), average molar mass between the network crosslinks (3.6/110 × 104 g mol−1), and distance between the macromolecular chains (64/710 nm). Despite high zeolite concentration, the composites kept porous hydrogel structure with uniformly dispersed zeolite particles. FTIR spectra disclosed the existence of functional groups of PMAA network and MFI zeolite that interacted mutually and led to increased crosslinking density. The effect of zeolite concentration on the thermal degradation mechanism was established. The composition-properties correlations were determined and described by the adequate linear or power law equations revealing the additive nature of the composites and the fractal structure of the networks. These correlations enable the achievement of desired properties by simple adjustment of the initial composition, i.e. zeolite concentration. Therefore, this work presents the base for further development of tailor-made PMAA-MFI composite hydrogels aimed for specific application.
PB  - Elsevier
T2  - Polymer
T1  - The study of composition-properties relationships for composite hydrogels based on poly(methacrylic acid) and high concentrations of MFI zeolite
SP  - 125750
VL  - 269
DO  - 10.1016/j.polymer.2023.125750
ER  - 

@article{
author = "Panić, Vesna V. and Jovanović, Jelena D. and Popović, Ivanka G. and Savić, Sanja I. and Marković, Maja D. and Spasojević, Pavle M. and Adnađević, Borivoj K.",
year = "2023",
abstract = "High concentrations of hydrophobic MFI zeolite (26.0–51.3 wt%) were successfully embedded in poly(methacrylic acid) (PMAA) network in simple, one-pot synthesis of PMAA-MFI composite hydrogels. The effects of zeolite concentration regarding pure PMAA xerogel, for all of the investigated properties (primary structural parameters, morphological properties, water swelling ability, thermal degradation mechanism and stability, and mechanical properties) were determined and discussed. The PMAA-MFI composite hydrogels had remarkably higher density than PMAA xerogel (1660/1420 kg m−3), higher crosslinking density (29/1.0 × 10−4), improved mechanics in the dry and swollen state (up to 4.9 times higher storage modulus) and lower swelling degree (42/420 g g−1), average molar mass between the network crosslinks (3.6/110 × 104 g mol−1), and distance between the macromolecular chains (64/710 nm). Despite high zeolite concentration, the composites kept porous hydrogel structure with uniformly dispersed zeolite particles. FTIR spectra disclosed the existence of functional groups of PMAA network and MFI zeolite that interacted mutually and led to increased crosslinking density. The effect of zeolite concentration on the thermal degradation mechanism was established. The composition-properties correlations were determined and described by the adequate linear or power law equations revealing the additive nature of the composites and the fractal structure of the networks. These correlations enable the achievement of desired properties by simple adjustment of the initial composition, i.e. zeolite concentration. Therefore, this work presents the base for further development of tailor-made PMAA-MFI composite hydrogels aimed for specific application.",
publisher = "Elsevier",
journal = "Polymer",
title = "The study of composition-properties relationships for composite hydrogels based on poly(methacrylic acid) and high concentrations of MFI zeolite",
pages = "125750",
volume = "269",
doi = "10.1016/j.polymer.2023.125750"
}

Panić, V. V., Jovanović, J. D., Popović, I. G., Savić, S. I., Marković, M. D., Spasojević, P. M.,& Adnađević, B. K.. (2023). The study of composition-properties relationships for composite hydrogels based on poly(methacrylic acid) and high concentrations of MFI zeolite. in Polymer
Elsevier., 269, 125750.
https://doi.org/10.1016/j.polymer.2023.125750

Panić VV, Jovanović JD, Popović IG, Savić SI, Marković MD, Spasojević PM, Adnađević BK. The study of composition-properties relationships for composite hydrogels based on poly(methacrylic acid) and high concentrations of MFI zeolite. in Polymer. 2023;269:125750.
doi:10.1016/j.polymer.2023.125750 .

Panić, Vesna V., Jovanović, Jelena D., Popović, Ivanka G., Savić, Sanja I., Marković, Maja D., Spasojević, Pavle M., Adnađević, Borivoj K., "The study of composition-properties relationships for composite hydrogels based on poly(methacrylic acid) and high concentrations of MFI zeolite" in Polymer, 269 (2023):125750,
https://doi.org/10.1016/j.polymer.2023.125750 . .

TY  - CONF
AU  - Pantić, Olga J.
AU  - Panić, Vesna V.
AU  - Marković, Maja D.
AU  - Spasojević, Pavle M.
AU  - Savić, Sanja I.
AU  - Kalagasidis Krušić, Melina T.
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6466
AB  - Novi trendovi u polimernoj industriji podstiču upotrebu sirovina dobijenih iz
bioobnovljivih izvora kao i prelazak na zelenu tehnologiju. Nezasićene poliestarske smole
su najzastupljenije termoreaktivne smole u proizvodnji polimernih kompozitnih materijala.
Otpadni materijali, kao što su ljuske preostale od upotrebe kokošijih jaja, nastaju u velikim
količinama, pri čemu ne predstavljaju opasan otpad zbog čega su korišćena kao punila za
proizvodnju polimernih kompozitnih materijala. Za sintezu matrice korišćene su itakonska
kiselina, ćilibarna kiselina, neopentil glikol, pri čemu je kao reaktivni rastvarač korišćen
dimetil itakonat. Karakterizacija dobijenih kompozitnih materijala se sastojala od
mehaničkog ispitivanja jednoosnim istezanjem kao i savijanjem u tri tačke, dok su
promene u hemijskoj strukturi ispitivane FTIR spektroskopijom, a stepen umreženja je
određivan analizom sadržaja gel faze.
AB  - Development of biobased thermoset polymers encourages the strategic use of biobased
resources and migrating to greener technologies. Unsaturated polyester resins have an
extensive array of properties which makes them the most used thermoset resins in the
production of polymer composite materials. Waste materials, such as eggshells left over
from the usage of chicken eggs, are abundant and non-hazardous materials which offer
many benefits in potential use as a filler in developing a biobased composite material.
Itaconic acid, succinic acid, and neopentyl glycol were employed in unsaturated polyester
synthesis, while dimethyl itaconate was used as a reactive diluent. Characterization of the
resulting composite materials included assessing mechanical properties (uniaxial tensile
test, three-point bending test), FTIR spectroscopy, and gel content analysis.
PB  - Serbian Chemical Society Karnegijeva 4/III, 11000 Beograd, Srbija
C3  - 59th Meeting of the Serbian Chemical Society
T1  - Kompozitni materijali na bazi otpadne ljuske jajeta i nezasićenih poliestarskih smola dobijenih iz bioobnovljivih izvora
T1  - Composite materials prepared from waste eggshells and biobased unsaturated polyester resin
EP  - 148
SP  - 148
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6466
ER  - 

@conference{
author = "Pantić, Olga J. and Panić, Vesna V. and Marković, Maja D. and Spasojević, Pavle M. and Savić, Sanja I. and Kalagasidis Krušić, Melina T.",
year = "2023",
abstract = "Novi trendovi u polimernoj industriji podstiču upotrebu sirovina dobijenih iz
bioobnovljivih izvora kao i prelazak na zelenu tehnologiju. Nezasićene poliestarske smole
su najzastupljenije termoreaktivne smole u proizvodnji polimernih kompozitnih materijala.
Otpadni materijali, kao što su ljuske preostale od upotrebe kokošijih jaja, nastaju u velikim
količinama, pri čemu ne predstavljaju opasan otpad zbog čega su korišćena kao punila za
proizvodnju polimernih kompozitnih materijala. Za sintezu matrice korišćene su itakonska
kiselina, ćilibarna kiselina, neopentil glikol, pri čemu je kao reaktivni rastvarač korišćen
dimetil itakonat. Karakterizacija dobijenih kompozitnih materijala se sastojala od
mehaničkog ispitivanja jednoosnim istezanjem kao i savijanjem u tri tačke, dok su
promene u hemijskoj strukturi ispitivane FTIR spektroskopijom, a stepen umreženja je
određivan analizom sadržaja gel faze., Development of biobased thermoset polymers encourages the strategic use of biobased
resources and migrating to greener technologies. Unsaturated polyester resins have an
extensive array of properties which makes them the most used thermoset resins in the
production of polymer composite materials. Waste materials, such as eggshells left over
from the usage of chicken eggs, are abundant and non-hazardous materials which offer
many benefits in potential use as a filler in developing a biobased composite material.
Itaconic acid, succinic acid, and neopentyl glycol were employed in unsaturated polyester
synthesis, while dimethyl itaconate was used as a reactive diluent. Characterization of the
resulting composite materials included assessing mechanical properties (uniaxial tensile
test, three-point bending test), FTIR spectroscopy, and gel content analysis.",
publisher = "Serbian Chemical Society Karnegijeva 4/III, 11000 Beograd, Srbija",
journal = "59th Meeting of the Serbian Chemical Society",
title = "Kompozitni materijali na bazi otpadne ljuske jajeta i nezasićenih poliestarskih smola dobijenih iz bioobnovljivih izvora, Composite materials prepared from waste eggshells and biobased unsaturated polyester resin",
pages = "148-148",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6466"
}

Pantić, O. J., Panić, V. V., Marković, M. D., Spasojević, P. M., Savić, S. I.,& Kalagasidis Krušić, M. T.. (2023). Kompozitni materijali na bazi otpadne ljuske jajeta i nezasićenih poliestarskih smola dobijenih iz bioobnovljivih izvora. in 59th Meeting of the Serbian Chemical Society
Serbian Chemical Society Karnegijeva 4/III, 11000 Beograd, Srbija., 148-148.
https://hdl.handle.net/21.15107/rcub_technorep_6466

Pantić OJ, Panić VV, Marković MD, Spasojević PM, Savić SI, Kalagasidis Krušić MT. Kompozitni materijali na bazi otpadne ljuske jajeta i nezasićenih poliestarskih smola dobijenih iz bioobnovljivih izvora. in 59th Meeting of the Serbian Chemical Society. 2023;:148-148.
https://hdl.handle.net/21.15107/rcub_technorep_6466 .

Pantić, Olga J., Panić, Vesna V., Marković, Maja D., Spasojević, Pavle M., Savić, Sanja I., Kalagasidis Krušić, Melina T., "Kompozitni materijali na bazi otpadne ljuske jajeta i nezasićenih poliestarskih smola dobijenih iz bioobnovljivih izvora" in 59th Meeting of the Serbian Chemical Society (2023):148-148,
https://hdl.handle.net/21.15107/rcub_technorep_6466 .

TY  - CONF
AU  - Marković, Maja D.
AU  - Pjanović, Rada V.
AU  - Spasojević, Pavle M.
AU  - Savić, Sanja I.
AU  - Panić, Vesna V.
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5643
AB  - Everyday demands for safer and more efficient therapy for many diseases, especially serious ones such as various types of cancer, put various challenges in front of modern science. One of them lies in the fact that numerous anticancer drugs are poorly-water soluble and therefore their encap-sulation and controlled release are quite demanding processes. In the present study, we deepened our research of carrier based on hydrophilic poly(methacrylic acid) modified with amphiphilic ca-sein, in which poorly water-soluble model drug caffeine was encapsulated (PMAC-Caf hydrogels). It was investigated how neutralization degree of methacrylic acid (MAA) and amount of encapsulated caffeine affected swelling behavior of the PMAC-Caf hydrogels and caffeine release. Easy, one pot, simultaneous synthesis of the carrier and the encapsulation of caffeine is presented, obtaining thereby as prepared PMAC-Caf drug delivery system that could respond to the specific demands of the tar-geted delivery of the poorly water-soluble drug - protecting it in the environment which simulated human stomach and releasing it in the environment which simulated human intestines. Changing the synthesis parameters (neutralization degree of MAA and/or amount of encapsulated caffeine) we achieved controlled release of caffeine, indicating that the number of the required doses of the drug in the treatment and its side effects could be reduced. Results showed that the PMAC-Caf drug deliv-ery systems have huge potential for controlled release of poorly water-soluble drugs.
PB  - Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS), Društvo za procesnu tehniku
C3  - Zbornik radova 35. Međunarodnog kongresa o procesnoj industriji
T1  - CONTROLLED RELEASE OF CAFFEINE FROM THREE DIMENSIONAL NETWORKS BASED ON POLY(METACRYLIC ACID) AND CASEIN - ANALYSIS OF THE EFFECT OF CAFFEINE CONCENTRATION ON RELEASE PROCESS
EP  - 24
IS  - 1
SP  - 19
VL  - 35
DO  - https://doi.org/10.24094/ptk.022.019
ER  - 

@conference{
author = "Marković, Maja D. and Pjanović, Rada V. and Spasojević, Pavle M. and Savić, Sanja I. and Panić, Vesna V.",
year = "2022",
abstract = "Everyday demands for safer and more efficient therapy for many diseases, especially serious ones such as various types of cancer, put various challenges in front of modern science. One of them lies in the fact that numerous anticancer drugs are poorly-water soluble and therefore their encap-sulation and controlled release are quite demanding processes. In the present study, we deepened our research of carrier based on hydrophilic poly(methacrylic acid) modified with amphiphilic ca-sein, in which poorly water-soluble model drug caffeine was encapsulated (PMAC-Caf hydrogels). It was investigated how neutralization degree of methacrylic acid (MAA) and amount of encapsulated caffeine affected swelling behavior of the PMAC-Caf hydrogels and caffeine release. Easy, one pot, simultaneous synthesis of the carrier and the encapsulation of caffeine is presented, obtaining thereby as prepared PMAC-Caf drug delivery system that could respond to the specific demands of the tar-geted delivery of the poorly water-soluble drug - protecting it in the environment which simulated human stomach and releasing it in the environment which simulated human intestines. Changing the synthesis parameters (neutralization degree of MAA and/or amount of encapsulated caffeine) we achieved controlled release of caffeine, indicating that the number of the required doses of the drug in the treatment and its side effects could be reduced. Results showed that the PMAC-Caf drug deliv-ery systems have huge potential for controlled release of poorly water-soluble drugs.",
publisher = "Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS), Društvo za procesnu tehniku",
journal = "Zbornik radova 35. Međunarodnog kongresa o procesnoj industriji",
title = "CONTROLLED RELEASE OF CAFFEINE FROM THREE DIMENSIONAL NETWORKS BASED ON POLY(METACRYLIC ACID) AND CASEIN - ANALYSIS OF THE EFFECT OF CAFFEINE CONCENTRATION ON RELEASE PROCESS",
pages = "24-19",
number = "1",
volume = "35",
doi = "https://doi.org/10.24094/ptk.022.019"
}

Marković, M. D., Pjanović, R. V., Spasojević, P. M., Savić, S. I.,& Panić, V. V.. (2022). CONTROLLED RELEASE OF CAFFEINE FROM THREE DIMENSIONAL NETWORKS BASED ON POLY(METACRYLIC ACID) AND CASEIN - ANALYSIS OF THE EFFECT OF CAFFEINE CONCENTRATION ON RELEASE PROCESS. in Zbornik radova 35. Međunarodnog kongresa o procesnoj industriji
Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS), Društvo za procesnu tehniku., 35(1), 19-24.
https://doi.org/https://doi.org/10.24094/ptk.022.019

Marković MD, Pjanović RV, Spasojević PM, Savić SI, Panić VV. CONTROLLED RELEASE OF CAFFEINE FROM THREE DIMENSIONAL NETWORKS BASED ON POLY(METACRYLIC ACID) AND CASEIN - ANALYSIS OF THE EFFECT OF CAFFEINE CONCENTRATION ON RELEASE PROCESS. in Zbornik radova 35. Međunarodnog kongresa o procesnoj industriji. 2022;35(1):19-24.
doi:https://doi.org/10.24094/ptk.022.019 .

Marković, Maja D., Pjanović, Rada V., Spasojević, Pavle M., Savić, Sanja I., Panić, Vesna V., "CONTROLLED RELEASE OF CAFFEINE FROM THREE DIMENSIONAL NETWORKS BASED ON POLY(METACRYLIC ACID) AND CASEIN - ANALYSIS OF THE EFFECT OF CAFFEINE CONCENTRATION ON RELEASE PROCESS" in Zbornik radova 35. Međunarodnog kongresa o procesnoj industriji, 35, no. 1 (2022):19-24,
https://doi.org/https://doi.org/10.24094/ptk.022.019 . .