TY  - JOUR
AU  - Kalušević, Ana
AU  - Lević, Steva
AU  - Čalija, Bojan
AU  - Milić, Jela R.
AU  - Pavlović, Vladimir
AU  - Bugarski, Branko
AU  - Nedović, Viktor
PY  - 2017
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3553
AB  - The goal of this study was to investigate the characteristics of grape skin extract (GSE) spray dried with different carriers: maltodextrin (MD), gum Arabic (GA) and skim milk powder (SMP). The grape skin extract was obtained from winery by-product of red grape variety Prokupac (Vitis vinifera L.). The morphology of the powders, their thermal, chemical and physical properties (water activity, bulk and tapped densities, solubility), as well as release studies in different pH conditions were analyzed. Total anthocyanin content and total phenolic content were determined by spectrophotometric methods. MD and GA-based microparticles were non-porous and spherical, while SMP-based ones were irregularly shaped. The process of spray drying Prokupac GSE using these three carriers produced powders with low water activity (0.24-0.28), good powder characteristics, high yields, and solubility higher than 90%. The obtained dissolution/release profiles indicated prolonged release of anthocyanins and phenolic compounds in different mediums, especially from GSE/GA microparticles. These results have shown that grape skin as the main by-product of wine production could be used as a source of natural colorants and bioactive compounds, and microencapsulation as a promising technique for the protection of these compounds, their stabilization in longer periods and prolonged release.
PB  - Springer India, New Delhi
T2  - Journal of Food Science and Technology-Mysore
T1  - Effects of different carrier materials on physicochemical properties of microencapsulated grape skin extract
EP  - 3420
IS  - 11
SP  - 3411
VL  - 54
DO  - 10.1007/s13197-017-2790-6
ER  - 

@article{
author = "Kalušević, Ana and Lević, Steva and Čalija, Bojan and Milić, Jela R. and Pavlović, Vladimir and Bugarski, Branko and Nedović, Viktor",
year = "2017",
abstract = "The goal of this study was to investigate the characteristics of grape skin extract (GSE) spray dried with different carriers: maltodextrin (MD), gum Arabic (GA) and skim milk powder (SMP). The grape skin extract was obtained from winery by-product of red grape variety Prokupac (Vitis vinifera L.). The morphology of the powders, their thermal, chemical and physical properties (water activity, bulk and tapped densities, solubility), as well as release studies in different pH conditions were analyzed. Total anthocyanin content and total phenolic content were determined by spectrophotometric methods. MD and GA-based microparticles were non-porous and spherical, while SMP-based ones were irregularly shaped. The process of spray drying Prokupac GSE using these three carriers produced powders with low water activity (0.24-0.28), good powder characteristics, high yields, and solubility higher than 90%. The obtained dissolution/release profiles indicated prolonged release of anthocyanins and phenolic compounds in different mediums, especially from GSE/GA microparticles. These results have shown that grape skin as the main by-product of wine production could be used as a source of natural colorants and bioactive compounds, and microencapsulation as a promising technique for the protection of these compounds, their stabilization in longer periods and prolonged release.",
publisher = "Springer India, New Delhi",
journal = "Journal of Food Science and Technology-Mysore",
title = "Effects of different carrier materials on physicochemical properties of microencapsulated grape skin extract",
pages = "3420-3411",
number = "11",
volume = "54",
doi = "10.1007/s13197-017-2790-6"
}

Kalušević, A., Lević, S., Čalija, B., Milić, J. R., Pavlović, V., Bugarski, B.,& Nedović, V.. (2017). Effects of different carrier materials on physicochemical properties of microencapsulated grape skin extract. in Journal of Food Science and Technology-Mysore
Springer India, New Delhi., 54(11), 3411-3420.
https://doi.org/10.1007/s13197-017-2790-6

Kalušević A, Lević S, Čalija B, Milić JR, Pavlović V, Bugarski B, Nedović V. Effects of different carrier materials on physicochemical properties of microencapsulated grape skin extract. in Journal of Food Science and Technology-Mysore. 2017;54(11):3411-3420.
doi:10.1007/s13197-017-2790-6 .

Kalušević, Ana, Lević, Steva, Čalija, Bojan, Milić, Jela R., Pavlović, Vladimir, Bugarski, Branko, Nedović, Viktor, "Effects of different carrier materials on physicochemical properties of microencapsulated grape skin extract" in Journal of Food Science and Technology-Mysore, 54, no. 11 (2017):3411-3420,
https://doi.org/10.1007/s13197-017-2790-6 . .

TY  - JOUR
AU  - Kalušević, Ana
AU  - Lević, Steva
AU  - Čalija, Bojan
AU  - Pantić, Milena
AU  - Belović, Miona
AU  - Pavlović, Vladimir
AU  - Bugarski, Branko
AU  - Milić, Jela R.
AU  - Žilić, Slađana
AU  - Nedović, Viktor
PY  - 2017
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3557
AB  - Black soybean coat is insufficiently valorised food production waste rich in anthocyanins. The goal of the study was to examine physicochemical properties of spray dried extract of black soybean coat in regard to carrier materials: maltodextrin, gum Arabic, and skimmed milk powder. Maltodextrin and gum Arabic-based microparticles were spherical and non-porous while skimmed milk powder-based were irregularly shaped. Low water activity of microparticles (0.31-0.33), good powders characteristics, high solubility (80.3-94.3%) and encapsulation yields (63.7-77.0%) were determined. All microparticles exhibited significant antioxidant capacity (243-386 mu molTE/g), good colour stability after three months of storage and antimicrobial activity. High content of total anthocyanins, with cyanidin-3-glucoside as predominant, were achieved. In vitro release of anthocyanins from microparticles was sustained, particularly from gum Arabic-based. These findings suggest that proposed simple eco-friendly extraction and microencapsulation procedures could serve as valuable tools for valorisation and conversion of black soybean coat into highly functional and stable food colourant.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Journal of Microencapsulation
T1  - Microencapsulation of anthocyanin-rich black soybean coat extract by spray drying using maltodextrin, gum Arabic and skimmed milk powder
EP  - 487
IS  - 5
SP  - 475
VL  - 34
DO  - 10.1080/02652048.2017.1354939
ER  - 

@article{
author = "Kalušević, Ana and Lević, Steva and Čalija, Bojan and Pantić, Milena and Belović, Miona and Pavlović, Vladimir and Bugarski, Branko and Milić, Jela R. and Žilić, Slađana and Nedović, Viktor",
year = "2017",
abstract = "Black soybean coat is insufficiently valorised food production waste rich in anthocyanins. The goal of the study was to examine physicochemical properties of spray dried extract of black soybean coat in regard to carrier materials: maltodextrin, gum Arabic, and skimmed milk powder. Maltodextrin and gum Arabic-based microparticles were spherical and non-porous while skimmed milk powder-based were irregularly shaped. Low water activity of microparticles (0.31-0.33), good powders characteristics, high solubility (80.3-94.3%) and encapsulation yields (63.7-77.0%) were determined. All microparticles exhibited significant antioxidant capacity (243-386 mu molTE/g), good colour stability after three months of storage and antimicrobial activity. High content of total anthocyanins, with cyanidin-3-glucoside as predominant, were achieved. In vitro release of anthocyanins from microparticles was sustained, particularly from gum Arabic-based. These findings suggest that proposed simple eco-friendly extraction and microencapsulation procedures could serve as valuable tools for valorisation and conversion of black soybean coat into highly functional and stable food colourant.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Journal of Microencapsulation",
title = "Microencapsulation of anthocyanin-rich black soybean coat extract by spray drying using maltodextrin, gum Arabic and skimmed milk powder",
pages = "487-475",
number = "5",
volume = "34",
doi = "10.1080/02652048.2017.1354939"
}

Kalušević, A., Lević, S., Čalija, B., Pantić, M., Belović, M., Pavlović, V., Bugarski, B., Milić, J. R., Žilić, S.,& Nedović, V.. (2017). Microencapsulation of anthocyanin-rich black soybean coat extract by spray drying using maltodextrin, gum Arabic and skimmed milk powder. in Journal of Microencapsulation
Taylor & Francis Ltd, Abingdon., 34(5), 475-487.
https://doi.org/10.1080/02652048.2017.1354939

Kalušević A, Lević S, Čalija B, Pantić M, Belović M, Pavlović V, Bugarski B, Milić JR, Žilić S, Nedović V. Microencapsulation of anthocyanin-rich black soybean coat extract by spray drying using maltodextrin, gum Arabic and skimmed milk powder. in Journal of Microencapsulation. 2017;34(5):475-487.
doi:10.1080/02652048.2017.1354939 .

Kalušević, Ana, Lević, Steva, Čalija, Bojan, Pantić, Milena, Belović, Miona, Pavlović, Vladimir, Bugarski, Branko, Milić, Jela R., Žilić, Slađana, Nedović, Viktor, "Microencapsulation of anthocyanin-rich black soybean coat extract by spray drying using maltodextrin, gum Arabic and skimmed milk powder" in Journal of Microencapsulation, 34, no. 5 (2017):475-487,
https://doi.org/10.1080/02652048.2017.1354939 . .

TY  - JOUR
AU  - Vidović, Bojana
AU  - Milašinović, Nikola
AU  - Vidović, Jana
AU  - Čalija, Bojan
AU  - Crevar-Sakač, Milkica
AU  - Vujić, Zorica
AU  - Milić, Jela R.
AU  - Đoržević, Brižita
AU  - Kalagasidis Krušić, Melina
AU  - Knežević-Jugović, Zorica
PY  - 2015
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3078
PB  - Karger, Basel
T2  - Annals of Nutrition and Metabolism
T1  - Preparation of alpha-lipoic acid/chitosan microparticle conjugate and its in vitro antioxidative activity
EP  - 485
SP  - 484
VL  - 67
UR  - https://hdl.handle.net/21.15107/rcub_technorep_3078
ER  - 

@article{
author = "Vidović, Bojana and Milašinović, Nikola and Vidović, Jana and Čalija, Bojan and Crevar-Sakač, Milkica and Vujić, Zorica and Milić, Jela R. and Đoržević, Brižita and Kalagasidis Krušić, Melina and Knežević-Jugović, Zorica",
year = "2015",
publisher = "Karger, Basel",
journal = "Annals of Nutrition and Metabolism",
title = "Preparation of alpha-lipoic acid/chitosan microparticle conjugate and its in vitro antioxidative activity",
pages = "485-484",
volume = "67",
url = "https://hdl.handle.net/21.15107/rcub_technorep_3078"
}

Vidović, B., Milašinović, N., Vidović, J., Čalija, B., Crevar-Sakač, M., Vujić, Z., Milić, J. R., Đoržević, B., Kalagasidis Krušić, M.,& Knežević-Jugović, Z.. (2015). Preparation of alpha-lipoic acid/chitosan microparticle conjugate and its in vitro antioxidative activity. in Annals of Nutrition and Metabolism
Karger, Basel., 67, 484-485.
https://hdl.handle.net/21.15107/rcub_technorep_3078

Vidović B, Milašinović N, Vidović J, Čalija B, Crevar-Sakač M, Vujić Z, Milić JR, Đoržević B, Kalagasidis Krušić M, Knežević-Jugović Z. Preparation of alpha-lipoic acid/chitosan microparticle conjugate and its in vitro antioxidative activity. in Annals of Nutrition and Metabolism. 2015;67:484-485.
https://hdl.handle.net/21.15107/rcub_technorep_3078 .

Vidović, Bojana, Milašinović, Nikola, Vidović, Jana, Čalija, Bojan, Crevar-Sakač, Milkica, Vujić, Zorica, Milić, Jela R., Đoržević, Brižita, Kalagasidis Krušić, Melina, Knežević-Jugović, Zorica, "Preparation of alpha-lipoic acid/chitosan microparticle conjugate and its in vitro antioxidative activity" in Annals of Nutrition and Metabolism, 67 (2015):484-485,
https://hdl.handle.net/21.15107/rcub_technorep_3078 .

TY  - JOUR
AU  - Korać, Radava
AU  - Krajišnik, Danina
AU  - Savić, Snežana
AU  - Pantelić, Ivana
AU  - Jovancić, Petar
AU  - Cekić, Nebojša
AU  - Milić, Jela
PY  - 2014
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5751
AB  - The fast inverted oil-in-water (o/w) emulsions named SWOP (SWitch Oil Phase) emulsions have been investigated with particular reference to physicochemical characteristics. Emulsions (oil-in-water (o/w) and water-in-oil (w/o)) are widely used in cosmetic and pharmaceutical formulations. Fast inverted o/w emulsions have been introduced as an alternative. The combination of appropriate w/o emulsifiers, anionic surfactants and polymeric stabilizers is essential for the formation of these emulsions. Samples of investigated, fast inverted o/w emulsion were prepared by hot-hot emulsification procedure using the combination of a w/o polymeric emulsifier (polyglyceryl-2 dipolyhydroxystearate) with a mild surfactant (sodium lauryl glucoside carboxylate (and) lauryl glucoside) in ratio 4:1.5 with addition of a stabilizing polymer (sodium polyacrylate). In the same manner, reference o/w and w/o emulsions were prepared. Investigated and reference emulsions were compared according to their physicochemical characteristics, structural characteristics, and their stability under the foreseen storage conditions and under the stress conditions employing the centrifugation test, pH, conductivity, rheological and contact angle measurements, microscopic observation, differential scanning calorimetry and thermogravimetric analysis. The samples of investigated and reference o/w emulsions were stable during three months storage at room temperature, while the samples of reference w/o emulsion showed phase separation. Only the samples of investigated emulsion remained stable in centrifugation test taken after the six freeze-thaw cycles. Oscillatory rheology indicated that the elastic modulus was dominant for both the investigated and the reference o/w emulsions due to the presence of gel structures, but the values of maximal apparent viscosity of the investigated emulsion which increased due to the temperature changes and the higher yield stress values that were obtained for the reference o/w emulsion indicated that the reference o/w emulsion had a stronger gel structure. Analysis of all the emulsions using polarization microscopy showed that the reference o/w emulsion had a more regular and a more rigid structure than the investigated emulsion. Obtained DSC and TGA results indicated that the SWOP emulsion showed a much faster evaporation of the water than the reference o/w emulsion which is in fine agreement with results from the contact angle measurements, i.e., the inversion point for the SWOP emulsion was attained in less than 15 min in comparison with the reference o/w emulsion. Generally, the fast inverted, SWOP emulsion showed better characteristics in comparison with the reference o/w and w/o emulsions making it suitable for the wide range of applications.
PB  - Elsevier Science BV, Amsterdam
T2  - Colloids and Surfaces A: Physicochemical and Engineering Aspects
T1  - A new class of emulsion systems - Fast inverted o/w emulsions: Formulation approach, physical stability and colloidal structure
EP  - 278
SP  - 267
VL  - 461
DO  - 10.1016/j.colsurfa.2014.08.005
ER  - 

@article{
author = "Korać, Radava and Krajišnik, Danina and Savić, Snežana and Pantelić, Ivana and Jovancić, Petar and Cekić, Nebojša and Milić, Jela",
year = "2014",
abstract = "The fast inverted oil-in-water (o/w) emulsions named SWOP (SWitch Oil Phase) emulsions have been investigated with particular reference to physicochemical characteristics. Emulsions (oil-in-water (o/w) and water-in-oil (w/o)) are widely used in cosmetic and pharmaceutical formulations. Fast inverted o/w emulsions have been introduced as an alternative. The combination of appropriate w/o emulsifiers, anionic surfactants and polymeric stabilizers is essential for the formation of these emulsions. Samples of investigated, fast inverted o/w emulsion were prepared by hot-hot emulsification procedure using the combination of a w/o polymeric emulsifier (polyglyceryl-2 dipolyhydroxystearate) with a mild surfactant (sodium lauryl glucoside carboxylate (and) lauryl glucoside) in ratio 4:1.5 with addition of a stabilizing polymer (sodium polyacrylate). In the same manner, reference o/w and w/o emulsions were prepared. Investigated and reference emulsions were compared according to their physicochemical characteristics, structural characteristics, and their stability under the foreseen storage conditions and under the stress conditions employing the centrifugation test, pH, conductivity, rheological and contact angle measurements, microscopic observation, differential scanning calorimetry and thermogravimetric analysis. The samples of investigated and reference o/w emulsions were stable during three months storage at room temperature, while the samples of reference w/o emulsion showed phase separation. Only the samples of investigated emulsion remained stable in centrifugation test taken after the six freeze-thaw cycles. Oscillatory rheology indicated that the elastic modulus was dominant for both the investigated and the reference o/w emulsions due to the presence of gel structures, but the values of maximal apparent viscosity of the investigated emulsion which increased due to the temperature changes and the higher yield stress values that were obtained for the reference o/w emulsion indicated that the reference o/w emulsion had a stronger gel structure. Analysis of all the emulsions using polarization microscopy showed that the reference o/w emulsion had a more regular and a more rigid structure than the investigated emulsion. Obtained DSC and TGA results indicated that the SWOP emulsion showed a much faster evaporation of the water than the reference o/w emulsion which is in fine agreement with results from the contact angle measurements, i.e., the inversion point for the SWOP emulsion was attained in less than 15 min in comparison with the reference o/w emulsion. Generally, the fast inverted, SWOP emulsion showed better characteristics in comparison with the reference o/w and w/o emulsions making it suitable for the wide range of applications.",
publisher = "Elsevier Science BV, Amsterdam",
journal = "Colloids and Surfaces A: Physicochemical and Engineering Aspects",
title = "A new class of emulsion systems - Fast inverted o/w emulsions: Formulation approach, physical stability and colloidal structure",
pages = "278-267",
volume = "461",
doi = "10.1016/j.colsurfa.2014.08.005"
}

Korać, R., Krajišnik, D., Savić, S., Pantelić, I., Jovancić, P., Cekić, N.,& Milić, J.. (2014). A new class of emulsion systems - Fast inverted o/w emulsions: Formulation approach, physical stability and colloidal structure. in Colloids and Surfaces A: Physicochemical and Engineering Aspects
Elsevier Science BV, Amsterdam., 461, 267-278.
https://doi.org/10.1016/j.colsurfa.2014.08.005

Korać R, Krajišnik D, Savić S, Pantelić I, Jovancić P, Cekić N, Milić J. A new class of emulsion systems - Fast inverted o/w emulsions: Formulation approach, physical stability and colloidal structure. in Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2014;461:267-278.
doi:10.1016/j.colsurfa.2014.08.005 .

Korać, Radava, Krajišnik, Danina, Savić, Snežana, Pantelić, Ivana, Jovancić, Petar, Cekić, Nebojša, Milić, Jela, "A new class of emulsion systems - Fast inverted o/w emulsions: Formulation approach, physical stability and colloidal structure" in Colloids and Surfaces A: Physicochemical and Engineering Aspects, 461 (2014):267-278,
https://doi.org/10.1016/j.colsurfa.2014.08.005 . .

TY  - JOUR
AU  - Ilić-Stojanović, Snežana
AU  - Nikolić, Ljubiša B.
AU  - Nikolić, Vesna D.
AU  - Milić, Jela R.
AU  - Stamenković, Jakov
AU  - Nikolić, Goran M.
AU  - Petrović, Slobodan
PY  - 2013
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2310
AB  - The method of the synthesis of poly(N-isopropylacrylamide-co-2-hydroxypropyl methacrylate) hydrogels obtained by radical polymerization is described. Their characterization was carried out by the determination of the quantity of residual monomers and by investigating their structure using FTIR. Three glass transitions were detected by DSC method. The porous surfaces of hydrogels with incorporated ibuprofen were shown in SEM micrographs. The swelling ratio of hydrogels decreased with the temperature increase and the swelling transport mechanism changed from non-Fickian to Fickian. Ibuprofen was incorporated in the hydrogel as a drug carrier and the released quantity depending on the temperature was monitored by HPLC. The hydrogel with the lower cross-linker content had the highest swelling degree (α = 34.72) at 10°C and released the largest amount of ibuprofen (64.21 mg/gxerogel) at 40C.
AB  - Prikazan je metod sinteze hidrogelova poli(N-izopropilakrilamid-ko-2-hidroksi-propilmetakrilata), p(NIPAM-ko-HPMet), sa 5 mol% monomera HPMet-a dobijenih radikalnom polimerizacijom. Karakterizacija sintetisanih hidrogelova je izvedena određivanjem količine rezidualnih monomera i izvršena je njihova strukturna analiza pomoću infracrvene spektroskopije (FTIR), diferencijalne skenirajuće kalorimetrije (DSC) i skenirajuće elektronske mikroskopije (SEM). FTIR spektri sintetisanih hidrogelova p(NIPAM-ko-HPMet)-a sa različitim sadržajem umreživača EGDM-a pokazuju uzajamnu sličnost u strukturi. Površinska struktura liofilizovanih hidrogelova je porozna i uočavaju se čestice uklopljenog ibuprofena. Termička svojstva kserogelova p(NIPAM-ko-HPMet)-a pokazuju tri staklasta prelaza sa endotermnim pikovima slabog intenziteta. Sadržaj rezidualnih monomera dovodi do zaključka da je konverzija monomera tokom sinteze gotovo kompletna. Kine-tika bubrenja hidrogelova pokazuje da se pri povećanju temperature od 20 na 40 °C mehanizam transporta tečnosti menja iz ne-Fikovog (proces bubrenja kontroliše difuzija tečnosti i relaksacija polimernih lanaca) u Fikov (kontrolisan samo difuzijom tečnosti). Mogućnost primene hidrogelova p(NIPAM-ko-HPMet)-a kao nosača lekova ispitivana je u zavisnosti od temperature. Ibuprofen, korišćen kao model lekovita supstanca, uklopljen je u hidrogel i količina oslobođene aktivne supstance određena je HPLC metodom. Utvrđeno je da uzorak hidrogela p(NIPAM-ko-HPMet)-a sa sadržajem umreživača od 1 mol% EGDM-a dostiže najveći stepen bubrenja (α = 34,72) na 10°C i otpušta najveću količinu ibuprofena na 40 °C (64,21 mg/gkserogel). Ispitana svojstva predstavljaju dobru osnovu za potencijalnu primenu hidrogelova kao nosača lekovitih supstanci sa modifikovanim oslobađanjem.
PB  - Association of Chemical Engineers of Serbia
T2  - Hemijska industrija
T1  - Synthesis and characterization of thermosensitive hydrogels and the investigation of modifiedrelease of ibuprofen
T1  - Sinteza i karakterizacija termoosetljivih hidrogelova i ispitivanje modifikovanog oslobađanja ibuprofena
EP  - 912
IS  - 6
SP  - 901
VL  - 67
DO  - 10.2298/HEMIND130119038I
ER  - 

@article{
author = "Ilić-Stojanović, Snežana and Nikolić, Ljubiša B. and Nikolić, Vesna D. and Milić, Jela R. and Stamenković, Jakov and Nikolić, Goran M. and Petrović, Slobodan",
year = "2013",
abstract = "The method of the synthesis of poly(N-isopropylacrylamide-co-2-hydroxypropyl methacrylate) hydrogels obtained by radical polymerization is described. Their characterization was carried out by the determination of the quantity of residual monomers and by investigating their structure using FTIR. Three glass transitions were detected by DSC method. The porous surfaces of hydrogels with incorporated ibuprofen were shown in SEM micrographs. The swelling ratio of hydrogels decreased with the temperature increase and the swelling transport mechanism changed from non-Fickian to Fickian. Ibuprofen was incorporated in the hydrogel as a drug carrier and the released quantity depending on the temperature was monitored by HPLC. The hydrogel with the lower cross-linker content had the highest swelling degree (α = 34.72) at 10°C and released the largest amount of ibuprofen (64.21 mg/gxerogel) at 40C., Prikazan je metod sinteze hidrogelova poli(N-izopropilakrilamid-ko-2-hidroksi-propilmetakrilata), p(NIPAM-ko-HPMet), sa 5 mol% monomera HPMet-a dobijenih radikalnom polimerizacijom. Karakterizacija sintetisanih hidrogelova je izvedena određivanjem količine rezidualnih monomera i izvršena je njihova strukturna analiza pomoću infracrvene spektroskopije (FTIR), diferencijalne skenirajuće kalorimetrije (DSC) i skenirajuće elektronske mikroskopije (SEM). FTIR spektri sintetisanih hidrogelova p(NIPAM-ko-HPMet)-a sa različitim sadržajem umreživača EGDM-a pokazuju uzajamnu sličnost u strukturi. Površinska struktura liofilizovanih hidrogelova je porozna i uočavaju se čestice uklopljenog ibuprofena. Termička svojstva kserogelova p(NIPAM-ko-HPMet)-a pokazuju tri staklasta prelaza sa endotermnim pikovima slabog intenziteta. Sadržaj rezidualnih monomera dovodi do zaključka da je konverzija monomera tokom sinteze gotovo kompletna. Kine-tika bubrenja hidrogelova pokazuje da se pri povećanju temperature od 20 na 40 °C mehanizam transporta tečnosti menja iz ne-Fikovog (proces bubrenja kontroliše difuzija tečnosti i relaksacija polimernih lanaca) u Fikov (kontrolisan samo difuzijom tečnosti). Mogućnost primene hidrogelova p(NIPAM-ko-HPMet)-a kao nosača lekova ispitivana je u zavisnosti od temperature. Ibuprofen, korišćen kao model lekovita supstanca, uklopljen je u hidrogel i količina oslobođene aktivne supstance određena je HPLC metodom. Utvrđeno je da uzorak hidrogela p(NIPAM-ko-HPMet)-a sa sadržajem umreživača od 1 mol% EGDM-a dostiže najveći stepen bubrenja (α = 34,72) na 10°C i otpušta najveću količinu ibuprofena na 40 °C (64,21 mg/gkserogel). Ispitana svojstva predstavljaju dobru osnovu za potencijalnu primenu hidrogelova kao nosača lekovitih supstanci sa modifikovanim oslobađanjem.",
publisher = "Association of Chemical Engineers of Serbia",
journal = "Hemijska industrija",
title = "Synthesis and characterization of thermosensitive hydrogels and the investigation of modifiedrelease of ibuprofen, Sinteza i karakterizacija termoosetljivih hidrogelova i ispitivanje modifikovanog oslobađanja ibuprofena",
pages = "912-901",
number = "6",
volume = "67",
doi = "10.2298/HEMIND130119038I"
}

Ilić-Stojanović, S., Nikolić, L. B., Nikolić, V. D., Milić, J. R., Stamenković, J., Nikolić, G. M.,& Petrović, S.. (2013). Synthesis and characterization of thermosensitive hydrogels and the investigation of modifiedrelease of ibuprofen. in Hemijska industrija
Association of Chemical Engineers of Serbia., 67(6), 901-912.
https://doi.org/10.2298/HEMIND130119038I

Ilić-Stojanović S, Nikolić LB, Nikolić VD, Milić JR, Stamenković J, Nikolić GM, Petrović S. Synthesis and characterization of thermosensitive hydrogels and the investigation of modifiedrelease of ibuprofen. in Hemijska industrija. 2013;67(6):901-912.
doi:10.2298/HEMIND130119038I .

Ilić-Stojanović, Snežana, Nikolić, Ljubiša B., Nikolić, Vesna D., Milić, Jela R., Stamenković, Jakov, Nikolić, Goran M., Petrović, Slobodan, "Synthesis and characterization of thermosensitive hydrogels and the investigation of modifiedrelease of ibuprofen" in Hemijska industrija, 67, no. 6 (2013):901-912,
https://doi.org/10.2298/HEMIND130119038I . .

TY  - JOUR
AU  - Ilić-Stojanović, Snežana
AU  - Nikolić, Ljubiša B.
AU  - Nikolić, Vesna D.
AU  - Milić, Jela R.
AU  - Petrović, Slobodan
AU  - Nikolić, Goran M.
AU  - Kapor, Agneš
PY  - 2012
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2044
AB  - Over the past years, many scientific research studies have been focused on thermo-sensitive hydrogels containing N-isopropylacrylamide (NIPAM) as a monomer. The NIPAM based hydrogels with 20 mol% 2-hydroxypropyl methacrylate (HPMet) were synthesized using ethylene glycol dimethacrylate as a cross-linker. The characterization of xerogel and phenacetin using Fourier transform infrared (FTIR) spectroscopy and Scanning electron microscopy (SEM)confirm the performed synthesis with satisfactory purity as well as loading of phenacetin into hydrogel. The swelling transport mechanism at simulated physiological conditions (pH 2.20 and 7.40 at 37 °C) is described by the time-independent kinetics. The potential application of synthesized hydrogels for the controlled release of phenacetin as a model drug was investigated at simulated physiological conditions by HPLC method. .
AB  - Brojna naučna istraživanja tokom poslednjih godina usmerena su na hidro- gelove koji sadrže N-izopropilakrilamid (NIPAM) kao monomer. Hidrogelovi na bazi NIPAM-a sa 20 mol% 2-hidroksipropilmetakrilata (HPMet), p(NIPAM-co-HPMet) sintetisani su korišćenjem različitih količina umreživača etilenglikoldimetakrilata (EGDM) i izvršena je njihova karakterizacija. FTIR spektar kserogela ukazuje na izvršenu sintezu iniciranjem pomoću radikala, a FTIR spektar fenacetina potvrđuje da je dobijen proizvod zadovoljavajuće čistoće. FTIR spektar kserogela sa fenacetinom ukazuju na izvršeno uklapanje fenacetina u unutrašnjost gela. SEM mikrografije nabubrelih i liofilizovanih uzoraka hidrogelova pokazuju da je njihova površina porozna, a uzorci sa uklopljenim fenacetinom pokazuju prisustvo fenacetina u porama hidrogela. Rezultati bubrenja pokazuju da termoosetljivi hidrogelovi NA 20 °C ispoljavaju anomaliju u mehanizmu difuzije, bubrenje ne prati Fickov zakon, već je proces bubrenja kontrolisan difuzijom vode i relaksacijom polimernih lanaca. Transportni mehanizam bubrenja na 40 °C može se svrstati u tip III, sa vremenski nezavisnom kinetikom. Slično ponašanje pri bubrenju ovi hidrogelovi pokazuju u simuliranim fiziološkim uslovima (pH 2,20 i 7,40 na 37 °C). Potencijalna primena dobijenih hidrogelova kao nosača lekova sa kontrolisanim oslobađanjem fenacetina, kao model leka, ispitivana je pomoću HPLC metode. Rezultati pokazuju da je u prvih 24 sata otpuštena veća količina fenacetina na 37 °C u rastvoru pH 7,40 (70-90%) u odnosu na količinu otpuštenog fenacetina u rastvoru pH 2,20 (50-65% od apsorbovane količine). Količina otpuštenog fenacetina srazmerno se smanjuje sa povećanjem gustine umreženja gelova. Proces otpuštanja lekovite supstance prati Fikov zakon difuzije za obe pH vrednosti. Dobijeni termoosetljivi hidrogelovi p(NIPAM-co-HPMet) pokazuju dobre mogućnosti za primenu kao 'inteligentni' nosači lekova (npr. fenacetina) sa kontrolisanom oslobađanjem.
PB  - Association of Chemical Engineers of Serbia
T2  - Hemijska industrija
T1  - Potential application of thermo-sensitive hydrogels for controlled release of phenacetin
T1  - Potencijalna primena termoosetljivih hidrogelova za kontrolisano otpuštanje fenacetina
EP  - 839
IS  - 6
SP  - 831
VL  - 66
DO  - 10.2298/HEMIND120222089I
ER  - 

@article{
author = "Ilić-Stojanović, Snežana and Nikolić, Ljubiša B. and Nikolić, Vesna D. and Milić, Jela R. and Petrović, Slobodan and Nikolić, Goran M. and Kapor, Agneš",
year = "2012",
abstract = "Over the past years, many scientific research studies have been focused on thermo-sensitive hydrogels containing N-isopropylacrylamide (NIPAM) as a monomer. The NIPAM based hydrogels with 20 mol% 2-hydroxypropyl methacrylate (HPMet) were synthesized using ethylene glycol dimethacrylate as a cross-linker. The characterization of xerogel and phenacetin using Fourier transform infrared (FTIR) spectroscopy and Scanning electron microscopy (SEM)confirm the performed synthesis with satisfactory purity as well as loading of phenacetin into hydrogel. The swelling transport mechanism at simulated physiological conditions (pH 2.20 and 7.40 at 37 °C) is described by the time-independent kinetics. The potential application of synthesized hydrogels for the controlled release of phenacetin as a model drug was investigated at simulated physiological conditions by HPLC method. ., Brojna naučna istraživanja tokom poslednjih godina usmerena su na hidro- gelove koji sadrže N-izopropilakrilamid (NIPAM) kao monomer. Hidrogelovi na bazi NIPAM-a sa 20 mol% 2-hidroksipropilmetakrilata (HPMet), p(NIPAM-co-HPMet) sintetisani su korišćenjem različitih količina umreživača etilenglikoldimetakrilata (EGDM) i izvršena je njihova karakterizacija. FTIR spektar kserogela ukazuje na izvršenu sintezu iniciranjem pomoću radikala, a FTIR spektar fenacetina potvrđuje da je dobijen proizvod zadovoljavajuće čistoće. FTIR spektar kserogela sa fenacetinom ukazuju na izvršeno uklapanje fenacetina u unutrašnjost gela. SEM mikrografije nabubrelih i liofilizovanih uzoraka hidrogelova pokazuju da je njihova površina porozna, a uzorci sa uklopljenim fenacetinom pokazuju prisustvo fenacetina u porama hidrogela. Rezultati bubrenja pokazuju da termoosetljivi hidrogelovi NA 20 °C ispoljavaju anomaliju u mehanizmu difuzije, bubrenje ne prati Fickov zakon, već je proces bubrenja kontrolisan difuzijom vode i relaksacijom polimernih lanaca. Transportni mehanizam bubrenja na 40 °C može se svrstati u tip III, sa vremenski nezavisnom kinetikom. Slično ponašanje pri bubrenju ovi hidrogelovi pokazuju u simuliranim fiziološkim uslovima (pH 2,20 i 7,40 na 37 °C). Potencijalna primena dobijenih hidrogelova kao nosača lekova sa kontrolisanim oslobađanjem fenacetina, kao model leka, ispitivana je pomoću HPLC metode. Rezultati pokazuju da je u prvih 24 sata otpuštena veća količina fenacetina na 37 °C u rastvoru pH 7,40 (70-90%) u odnosu na količinu otpuštenog fenacetina u rastvoru pH 2,20 (50-65% od apsorbovane količine). Količina otpuštenog fenacetina srazmerno se smanjuje sa povećanjem gustine umreženja gelova. Proces otpuštanja lekovite supstance prati Fikov zakon difuzije za obe pH vrednosti. Dobijeni termoosetljivi hidrogelovi p(NIPAM-co-HPMet) pokazuju dobre mogućnosti za primenu kao 'inteligentni' nosači lekova (npr. fenacetina) sa kontrolisanom oslobađanjem.",
publisher = "Association of Chemical Engineers of Serbia",
journal = "Hemijska industrija",
title = "Potential application of thermo-sensitive hydrogels for controlled release of phenacetin, Potencijalna primena termoosetljivih hidrogelova za kontrolisano otpuštanje fenacetina",
pages = "839-831",
number = "6",
volume = "66",
doi = "10.2298/HEMIND120222089I"
}

Ilić-Stojanović, S., Nikolić, L. B., Nikolić, V. D., Milić, J. R., Petrović, S., Nikolić, G. M.,& Kapor, A.. (2012). Potential application of thermo-sensitive hydrogels for controlled release of phenacetin. in Hemijska industrija
Association of Chemical Engineers of Serbia., 66(6), 831-839.
https://doi.org/10.2298/HEMIND120222089I

Ilić-Stojanović S, Nikolić LB, Nikolić VD, Milić JR, Petrović S, Nikolić GM, Kapor A. Potential application of thermo-sensitive hydrogels for controlled release of phenacetin. in Hemijska industrija. 2012;66(6):831-839.
doi:10.2298/HEMIND120222089I .

Ilić-Stojanović, Snežana, Nikolić, Ljubiša B., Nikolić, Vesna D., Milić, Jela R., Petrović, Slobodan, Nikolić, Goran M., Kapor, Agneš, "Potential application of thermo-sensitive hydrogels for controlled release of phenacetin" in Hemijska industrija, 66, no. 6 (2012):831-839,
https://doi.org/10.2298/HEMIND120222089I . .

TY  - JOUR
AU  - Aleksić, K.
AU  - Milić, Jela R.
AU  - Petrović, Slobodan
PY  - 2006
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/959
PB  - Pharmaceutical Association of Serbia, Belgrade, Serbia
T2  - Arhiv za farmaciju
T1  - Effect of particle size on dissolution rate in simvastatin tablets
T1  - Uticaj veličine čestica na oslobađanje simvastatina iz tableta
EP  - 493
IS  - 4
SP  - 492
VL  - 56
UR  - https://hdl.handle.net/21.15107/rcub_technorep_959
ER  - 

@article{
author = "Aleksić, K. and Milić, Jela R. and Petrović, Slobodan",
year = "2006",
publisher = "Pharmaceutical Association of Serbia, Belgrade, Serbia",
journal = "Arhiv za farmaciju",
title = "Effect of particle size on dissolution rate in simvastatin tablets, Uticaj veličine čestica na oslobađanje simvastatina iz tableta",
pages = "493-492",
number = "4",
volume = "56",
url = "https://hdl.handle.net/21.15107/rcub_technorep_959"
}

Aleksić, K., Milić, J. R.,& Petrović, S.. (2006). Effect of particle size on dissolution rate in simvastatin tablets. in Arhiv za farmaciju
Pharmaceutical Association of Serbia, Belgrade, Serbia., 56(4), 492-493.
https://hdl.handle.net/21.15107/rcub_technorep_959

Aleksić K, Milić JR, Petrović S. Effect of particle size on dissolution rate in simvastatin tablets. in Arhiv za farmaciju. 2006;56(4):492-493.
https://hdl.handle.net/21.15107/rcub_technorep_959 .

Aleksić, K., Milić, Jela R., Petrović, Slobodan, "Effect of particle size on dissolution rate in simvastatin tablets" in Arhiv za farmaciju, 56, no. 4 (2006):492-493,
https://hdl.handle.net/21.15107/rcub_technorep_959 .