Kapor, Agneš

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The improved photostability of naproxen in the inclusion complex with 2-hydroxypropyl-β-cyclodextrin

Ilić-Stojanović, Snežana; Nikolić, Vesna D.; Nikolić, Ljubiša B.; Zdravković, Aleksandar S.; Kapor, Agneš; Popsavin, Mirjana; Petrović, Slobodan

(Association of Chemical Engineers of Serbia, 2015)

TY  - JOUR
AU  - Ilić-Stojanović, Snežana
AU  - Nikolić, Vesna D.
AU  - Nikolić, Ljubiša B.
AU  - Zdravković, Aleksandar S.
AU  - Kapor, Agneš
AU  - Popsavin, Mirjana
AU  - Petrović, Slobodan
PY  - 2015
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2891
AB  - The aim of this work was the preparation of the inclusion complex of naproxen with 2- hydroxypropyl-β-cyclodextrin (HP-β-CD) in order to improve the physical and chemical properties of naproxen. The molecular inclusion complexes of naproxen with HP-β-CD were prepared by using the co-precipitation method in the solid state with the molar ratio of 1:1. The structure of the obtained complex was characterized by using FTIR, 1H NMR, UV-Vis and XRD methods. The testing of naproxen photostability by the UV-Vis method indicated the degradation to aromatic ketone, 2-acetyl-6-methoxynaphthalene. FTIR analysis showed that the degradation has started 15 days after the exposure of naproxen to daylight while the inclusion complex of naproxen:2-hydroxypropyl-β-cyclodextrin was photostable for a period of 30 days.
AB  - Naproksen, (+)-(S)-2-(6-metoksinaftalen-2-il)propionska kiselina, je derivat 2-arilpropionske kiseline (profena) iz grupe nesteroidnih antiinflamatornih lekova koji u terapijskim dozama smanjuje biosintezu prostaglandina i snižava povišenu telesnu temperaturu. Ovaj slabo rastvoran i fotoosetljiv molekul se transformiše pod uticajem svetlosti dajući farmakološki neaktivne proizvode. Cilj ovog rada je priprema inkluzionog kompleksa naproksena sa 2-hidroksipropil-β-ciklodekstrinom (HP-β-CD) u cilju poboljšanja fizičko-hemijskih svojstava naproksena. Molekulski inkluzioni kompleks naproksena i HP-β-CD pripremljen je metodom koprecipitacije u čvrstom stanju u molskom odnosu 1:1. Za strukturnu karakterizaciju kompleksa, kompleksirajućeg agensa, odgovarajuće fizičke smeše i naproksena, korišćene su metode protonske nuklearne magnetne rezonance (1H-NMR), difrakcije rendgenskih zraka (XRD) i infracrvene spektrofotometrije sa Furijeovom transformacijom (FTIR). FTIR i UV-Vis metode korišćene su za analizu fotoosetljivih grupa naproksena u čistom i kompleksiranom obliku radi ispitivanja uticaja na fotostabilnost naproksena. Difraktogram inkluzionog kompleksa naproksen:2-hidroksipropil- β-ciklodekstrin ne sadrži pikove koji su karakteristični za difraktograme naproksena i HP-β-CD. Ovo ukazuje da je naproksen zaklonjen u šupljine domaćina prilikom molekularne inkapsulacije. Odsustvo karakterističnih pikova naproksena u FTIR spektru kompleksa ukazuje na formiranje supramolekularne strukture po tipu inkluzije. Hemijska pomeranja u 1H-NMR spektru nakon inkluzije naproksena u šupljine HP-β-CD, posebno H3, H6 i H9 protona i vodonika iz CH3 u HP-β-CD takođe ukazuju na formiranje molekulskog inkluzionog kompleksa. Ispitivanje fotostabilnosti naproksena, pomoću UV-Vis metode, ukazuje na degradaciju do aromatičnog ketona, 2-acetil-6-metoksinaftalena. FTIR analiza je pokazala da degradacija naproksena počinje nakon 15 dana izlaganja dnevnoj svetlosti i da je molekularnom inkapsulacijom on zaštićen od fotodegradacije za vremenski period od 30 dana.
PB  - Association of Chemical Engineers of Serbia
T2  - Hemijska industrija
T1  - The improved photostability of naproxen in the inclusion complex with 2-hydroxypropyl-β-cyclodextrin
T1  - Poboljšana fotostabilnost naproksena u inkluzionom kompleksu sa 2-hidroksipropil-β-ciklodekstrinom
EP  - 370
IS  - 4
SP  - 361
VL  - 69
DO  - 10.2298/HEMIND131128050I
ER  - 
@article{
author = "Ilić-Stojanović, Snežana and Nikolić, Vesna D. and Nikolić, Ljubiša B. and Zdravković, Aleksandar S. and Kapor, Agneš and Popsavin, Mirjana and Petrović, Slobodan",
year = "2015",
abstract = "The aim of this work was the preparation of the inclusion complex of naproxen with 2- hydroxypropyl-β-cyclodextrin (HP-β-CD) in order to improve the physical and chemical properties of naproxen. The molecular inclusion complexes of naproxen with HP-β-CD were prepared by using the co-precipitation method in the solid state with the molar ratio of 1:1. The structure of the obtained complex was characterized by using FTIR, 1H NMR, UV-Vis and XRD methods. The testing of naproxen photostability by the UV-Vis method indicated the degradation to aromatic ketone, 2-acetyl-6-methoxynaphthalene. FTIR analysis showed that the degradation has started 15 days after the exposure of naproxen to daylight while the inclusion complex of naproxen:2-hydroxypropyl-β-cyclodextrin was photostable for a period of 30 days., Naproksen, (+)-(S)-2-(6-metoksinaftalen-2-il)propionska kiselina, je derivat 2-arilpropionske kiseline (profena) iz grupe nesteroidnih antiinflamatornih lekova koji u terapijskim dozama smanjuje biosintezu prostaglandina i snižava povišenu telesnu temperaturu. Ovaj slabo rastvoran i fotoosetljiv molekul se transformiše pod uticajem svetlosti dajući farmakološki neaktivne proizvode. Cilj ovog rada je priprema inkluzionog kompleksa naproksena sa 2-hidroksipropil-β-ciklodekstrinom (HP-β-CD) u cilju poboljšanja fizičko-hemijskih svojstava naproksena. Molekulski inkluzioni kompleks naproksena i HP-β-CD pripremljen je metodom koprecipitacije u čvrstom stanju u molskom odnosu 1:1. Za strukturnu karakterizaciju kompleksa, kompleksirajućeg agensa, odgovarajuće fizičke smeše i naproksena, korišćene su metode protonske nuklearne magnetne rezonance (1H-NMR), difrakcije rendgenskih zraka (XRD) i infracrvene spektrofotometrije sa Furijeovom transformacijom (FTIR). FTIR i UV-Vis metode korišćene su za analizu fotoosetljivih grupa naproksena u čistom i kompleksiranom obliku radi ispitivanja uticaja na fotostabilnost naproksena. Difraktogram inkluzionog kompleksa naproksen:2-hidroksipropil- β-ciklodekstrin ne sadrži pikove koji su karakteristični za difraktograme naproksena i HP-β-CD. Ovo ukazuje da je naproksen zaklonjen u šupljine domaćina prilikom molekularne inkapsulacije. Odsustvo karakterističnih pikova naproksena u FTIR spektru kompleksa ukazuje na formiranje supramolekularne strukture po tipu inkluzije. Hemijska pomeranja u 1H-NMR spektru nakon inkluzije naproksena u šupljine HP-β-CD, posebno H3, H6 i H9 protona i vodonika iz CH3 u HP-β-CD takođe ukazuju na formiranje molekulskog inkluzionog kompleksa. Ispitivanje fotostabilnosti naproksena, pomoću UV-Vis metode, ukazuje na degradaciju do aromatičnog ketona, 2-acetil-6-metoksinaftalena. FTIR analiza je pokazala da degradacija naproksena počinje nakon 15 dana izlaganja dnevnoj svetlosti i da je molekularnom inkapsulacijom on zaštićen od fotodegradacije za vremenski period od 30 dana.",
publisher = "Association of Chemical Engineers of Serbia",
journal = "Hemijska industrija",
title = "The improved photostability of naproxen in the inclusion complex with 2-hydroxypropyl-β-cyclodextrin, Poboljšana fotostabilnost naproksena u inkluzionom kompleksu sa 2-hidroksipropil-β-ciklodekstrinom",
pages = "370-361",
number = "4",
volume = "69",
doi = "10.2298/HEMIND131128050I"
}
Ilić-Stojanović, S., Nikolić, V. D., Nikolić, L. B., Zdravković, A. S., Kapor, A., Popsavin, M.,& Petrović, S.. (2015). The improved photostability of naproxen in the inclusion complex with 2-hydroxypropyl-β-cyclodextrin. in Hemijska industrija
Association of Chemical Engineers of Serbia., 69(4), 361-370.
https://doi.org/10.2298/HEMIND131128050I
Ilić-Stojanović S, Nikolić VD, Nikolić LB, Zdravković AS, Kapor A, Popsavin M, Petrović S. The improved photostability of naproxen in the inclusion complex with 2-hydroxypropyl-β-cyclodextrin. in Hemijska industrija. 2015;69(4):361-370.
doi:10.2298/HEMIND131128050I .
Ilić-Stojanović, Snežana, Nikolić, Vesna D., Nikolić, Ljubiša B., Zdravković, Aleksandar S., Kapor, Agneš, Popsavin, Mirjana, Petrović, Slobodan, "The improved photostability of naproxen in the inclusion complex with 2-hydroxypropyl-β-cyclodextrin" in Hemijska industrija, 69, no. 4 (2015):361-370,
https://doi.org/10.2298/HEMIND131128050I . .
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13

Inclusion complexes of sulfanilamide with beta-cyclodextrin and 2-hydroxypropyl-beta-cyclodextrin

Tacić, Ana; Savić, Ivan; Nikolić, Vesna; Savić, Ivana; Ilić-Stojanović, Snežana; Ilić, Dušica; Petrović, Slobodan; Popsavin, Mirjana; Kapor, Agneš

(Springer, Dordrecht, 2014)

TY  - JOUR
AU  - Tacić, Ana
AU  - Savić, Ivan
AU  - Nikolić, Vesna
AU  - Savić, Ivana
AU  - Ilić-Stojanović, Snežana
AU  - Ilić, Dušica
AU  - Petrović, Slobodan
AU  - Popsavin, Mirjana
AU  - Kapor, Agneš
PY  - 2014
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2739
AB  - Sulfanilamide belongs to the group of drugs that have a bacteriostatic effect on different pathogenic microorganisms. This activity originates from the competitive antagonism with p-aminobenzoic acid, which is an integral part of folic acid. The safe use of sulfanilamide is limited due to poor solubility in the aqueous medium. Therefore, the aim of this paper is the synthesis of sulfanilamide, as well as preparing and structural characterization of its inclusion complexes with cyclodextrins. The crude sulfanilamide was obtained in the synthesis between acetanilide and chlorosulfonic acid according to the standard procedure. The synthesized sulfanilamide was recrystallized from water in order to obtain the satisfactory purity of the substance. Sufanilamide was complexed with beta-cyclodextrin and 2-hydroxypropyl-beta-cyclodextrin by the co-precipitation method. A molecular encapsulation of sulfanilamide was confirmed by using FTIR, H-1-NMR, XRD and DSC methods. Phase-solubility techniques were used to assess the formation of the inclusion complex between sulfanilamide and cyclodextrins. The photostability of sulfanilamide and its inclusion complexes was estimated by UVB irradiation in a photochemical reactor by applying the UV-Vis method. Based on the UV-Vis analysis, sulfanilamide:2-hydroxypropyl-beta-cyclodextrin complex was presented as more photostable than sulfanilamide:beta-cyclodextrin complex and sulfanilamide. The obtained results enable the potential use of these inclusion complexes for the preparation of oral formulations due to the enhanced solubility of sulfanilamide.
PB  - Springer, Dordrecht
T2  - Journal of Inclusion Phenomena and Macrocyclic Chemistry
T1  - Inclusion complexes of sulfanilamide with beta-cyclodextrin and 2-hydroxypropyl-beta-cyclodextrin
EP  - 124
IS  - 1-2
SP  - 113
VL  - 80
DO  - 10.1007/s10847-014-0410-x
ER  - 
@article{
author = "Tacić, Ana and Savić, Ivan and Nikolić, Vesna and Savić, Ivana and Ilić-Stojanović, Snežana and Ilić, Dušica and Petrović, Slobodan and Popsavin, Mirjana and Kapor, Agneš",
year = "2014",
abstract = "Sulfanilamide belongs to the group of drugs that have a bacteriostatic effect on different pathogenic microorganisms. This activity originates from the competitive antagonism with p-aminobenzoic acid, which is an integral part of folic acid. The safe use of sulfanilamide is limited due to poor solubility in the aqueous medium. Therefore, the aim of this paper is the synthesis of sulfanilamide, as well as preparing and structural characterization of its inclusion complexes with cyclodextrins. The crude sulfanilamide was obtained in the synthesis between acetanilide and chlorosulfonic acid according to the standard procedure. The synthesized sulfanilamide was recrystallized from water in order to obtain the satisfactory purity of the substance. Sufanilamide was complexed with beta-cyclodextrin and 2-hydroxypropyl-beta-cyclodextrin by the co-precipitation method. A molecular encapsulation of sulfanilamide was confirmed by using FTIR, H-1-NMR, XRD and DSC methods. Phase-solubility techniques were used to assess the formation of the inclusion complex between sulfanilamide and cyclodextrins. The photostability of sulfanilamide and its inclusion complexes was estimated by UVB irradiation in a photochemical reactor by applying the UV-Vis method. Based on the UV-Vis analysis, sulfanilamide:2-hydroxypropyl-beta-cyclodextrin complex was presented as more photostable than sulfanilamide:beta-cyclodextrin complex and sulfanilamide. The obtained results enable the potential use of these inclusion complexes for the preparation of oral formulations due to the enhanced solubility of sulfanilamide.",
publisher = "Springer, Dordrecht",
journal = "Journal of Inclusion Phenomena and Macrocyclic Chemistry",
title = "Inclusion complexes of sulfanilamide with beta-cyclodextrin and 2-hydroxypropyl-beta-cyclodextrin",
pages = "124-113",
number = "1-2",
volume = "80",
doi = "10.1007/s10847-014-0410-x"
}
Tacić, A., Savić, I., Nikolić, V., Savić, I., Ilić-Stojanović, S., Ilić, D., Petrović, S., Popsavin, M.,& Kapor, A.. (2014). Inclusion complexes of sulfanilamide with beta-cyclodextrin and 2-hydroxypropyl-beta-cyclodextrin. in Journal of Inclusion Phenomena and Macrocyclic Chemistry
Springer, Dordrecht., 80(1-2), 113-124.
https://doi.org/10.1007/s10847-014-0410-x
Tacić A, Savić I, Nikolić V, Savić I, Ilić-Stojanović S, Ilić D, Petrović S, Popsavin M, Kapor A. Inclusion complexes of sulfanilamide with beta-cyclodextrin and 2-hydroxypropyl-beta-cyclodextrin. in Journal of Inclusion Phenomena and Macrocyclic Chemistry. 2014;80(1-2):113-124.
doi:10.1007/s10847-014-0410-x .
Tacić, Ana, Savić, Ivan, Nikolić, Vesna, Savić, Ivana, Ilić-Stojanović, Snežana, Ilić, Dušica, Petrović, Slobodan, Popsavin, Mirjana, Kapor, Agneš, "Inclusion complexes of sulfanilamide with beta-cyclodextrin and 2-hydroxypropyl-beta-cyclodextrin" in Journal of Inclusion Phenomena and Macrocyclic Chemistry, 80, no. 1-2 (2014):113-124,
https://doi.org/10.1007/s10847-014-0410-x . .
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27

Synthesis, characterization and crystal structure of Cu(II) complex with a diimine-dioxime ligand, [Cu-2(LH)(2)](ClO4)(2). Influence of the weak Cu center dot center dot center dot O(perchlorate) interaction on the structure of the Cu2N2O2 metallocycle

Mirković, Marija D.; Nikolić, Nadežda S.; Mijin, Dušan; Avramov-Ivić, Milka; Kapor, Agneš; Tomić, Zoran D.

(Srpsko hemijsko društvo, Beograd, 2014)

TY  - JOUR
AU  - Mirković, Marija D.
AU  - Nikolić, Nadežda S.
AU  - Mijin, Dušan
AU  - Avramov-Ivić, Milka
AU  - Kapor, Agneš
AU  - Tomić, Zoran D.
PY  - 2014
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2808
AB  - The diimine dioxime ligand, 3,3'-(1,4-butanediyl-dinitrilo)bis-2-pentanone, 2,2'-dioxime (LH2), containing a N-4 donor set was prepared by the Schiff base condensation of 2-hydroxyimino-3-pentanone and 1,4-diaminobutane in two ways: in a protic and in an aprotic solvent. A higher yield of the (LH2) imine was obtained when the synthesis was performed using a protic solvent (C2H5OH) instead of aprotic benzene (78 and 30 %, respectively). The Cu(II) metal complex of diimine dioxime was synthesized in CH3OH from the perchlorate salt of LH2 in a 1:1 mole ratio. The isolated complex was characterized by the elemental analysis, IR spectroscopy and cyclic voltammetry. The structure of [Cu-2(LH)(2)](ClO4)(2) was determined by single-crystal X-ray diffraction analysis. Comparison with structurally related diimine dioxime Cu(II) complexes revealed the influence of a weak Cu center dot center dot center dot O(perchlorate) interaction on the geometry of the metallocycle.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Synthesis, characterization and crystal structure of Cu(II) complex with a diimine-dioxime ligand, [Cu-2(LH)(2)](ClO4)(2). Influence of the weak Cu center dot center dot center dot O(perchlorate) interaction on the structure of the Cu2N2O2 metallocycle
EP  - 556
IS  - 5
SP  - 545
VL  - 79
DO  - 10.2298/JSC130910120M
ER  - 
@article{
author = "Mirković, Marija D. and Nikolić, Nadežda S. and Mijin, Dušan and Avramov-Ivić, Milka and Kapor, Agneš and Tomić, Zoran D.",
year = "2014",
abstract = "The diimine dioxime ligand, 3,3'-(1,4-butanediyl-dinitrilo)bis-2-pentanone, 2,2'-dioxime (LH2), containing a N-4 donor set was prepared by the Schiff base condensation of 2-hydroxyimino-3-pentanone and 1,4-diaminobutane in two ways: in a protic and in an aprotic solvent. A higher yield of the (LH2) imine was obtained when the synthesis was performed using a protic solvent (C2H5OH) instead of aprotic benzene (78 and 30 %, respectively). The Cu(II) metal complex of diimine dioxime was synthesized in CH3OH from the perchlorate salt of LH2 in a 1:1 mole ratio. The isolated complex was characterized by the elemental analysis, IR spectroscopy and cyclic voltammetry. The structure of [Cu-2(LH)(2)](ClO4)(2) was determined by single-crystal X-ray diffraction analysis. Comparison with structurally related diimine dioxime Cu(II) complexes revealed the influence of a weak Cu center dot center dot center dot O(perchlorate) interaction on the geometry of the metallocycle.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Synthesis, characterization and crystal structure of Cu(II) complex with a diimine-dioxime ligand, [Cu-2(LH)(2)](ClO4)(2). Influence of the weak Cu center dot center dot center dot O(perchlorate) interaction on the structure of the Cu2N2O2 metallocycle",
pages = "556-545",
number = "5",
volume = "79",
doi = "10.2298/JSC130910120M"
}
Mirković, M. D., Nikolić, N. S., Mijin, D., Avramov-Ivić, M., Kapor, A.,& Tomić, Z. D.. (2014). Synthesis, characterization and crystal structure of Cu(II) complex with a diimine-dioxime ligand, [Cu-2(LH)(2)](ClO4)(2). Influence of the weak Cu center dot center dot center dot O(perchlorate) interaction on the structure of the Cu2N2O2 metallocycle. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 79(5), 545-556.
https://doi.org/10.2298/JSC130910120M
Mirković MD, Nikolić NS, Mijin D, Avramov-Ivić M, Kapor A, Tomić ZD. Synthesis, characterization and crystal structure of Cu(II) complex with a diimine-dioxime ligand, [Cu-2(LH)(2)](ClO4)(2). Influence of the weak Cu center dot center dot center dot O(perchlorate) interaction on the structure of the Cu2N2O2 metallocycle. in Journal of the Serbian Chemical Society. 2014;79(5):545-556.
doi:10.2298/JSC130910120M .
Mirković, Marija D., Nikolić, Nadežda S., Mijin, Dušan, Avramov-Ivić, Milka, Kapor, Agneš, Tomić, Zoran D., "Synthesis, characterization and crystal structure of Cu(II) complex with a diimine-dioxime ligand, [Cu-2(LH)(2)](ClO4)(2). Influence of the weak Cu center dot center dot center dot O(perchlorate) interaction on the structure of the Cu2N2O2 metallocycle" in Journal of the Serbian Chemical Society, 79, no. 5 (2014):545-556,
https://doi.org/10.2298/JSC130910120M . .
1
1
1

Potential application of thermo-sensitive hydrogels for controlled release of phenacetin

Ilić-Stojanović, Snežana; Nikolić, Ljubiša B.; Nikolić, Vesna D.; Milić, Jela R.; Petrović, Slobodan; Nikolić, Goran M.; Kapor, Agneš

(Association of Chemical Engineers of Serbia, 2012)

TY  - JOUR
AU  - Ilić-Stojanović, Snežana
AU  - Nikolić, Ljubiša B.
AU  - Nikolić, Vesna D.
AU  - Milić, Jela R.
AU  - Petrović, Slobodan
AU  - Nikolić, Goran M.
AU  - Kapor, Agneš
PY  - 2012
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2044
AB  - Over the past years, many scientific research studies have been focused on thermo-sensitive hydrogels containing N-isopropylacrylamide (NIPAM) as a monomer. The NIPAM based hydrogels with 20 mol% 2-hydroxypropyl methacrylate (HPMet) were synthesized using ethylene glycol dimethacrylate as a cross-linker. The characterization of xerogel and phenacetin using Fourier transform infrared (FTIR) spectroscopy and Scanning electron microscopy (SEM)confirm the performed synthesis with satisfactory purity as well as loading of phenacetin into hydrogel. The swelling transport mechanism at simulated physiological conditions (pH 2.20 and 7.40 at 37 °C) is described by the time-independent kinetics. The potential application of synthesized hydrogels for the controlled release of phenacetin as a model drug was investigated at simulated physiological conditions by HPLC method. .
AB  - Brojna naučna istraživanja tokom poslednjih godina usmerena su na hidro- gelove koji sadrže N-izopropilakrilamid (NIPAM) kao monomer. Hidrogelovi na bazi NIPAM-a sa 20 mol% 2-hidroksipropilmetakrilata (HPMet), p(NIPAM-co-HPMet) sintetisani su korišćenjem različitih količina umreživača etilenglikoldimetakrilata (EGDM) i izvršena je njihova karakterizacija. FTIR spektar kserogela ukazuje na izvršenu sintezu iniciranjem pomoću radikala, a FTIR spektar fenacetina potvrđuje da je dobijen proizvod zadovoljavajuće čistoće. FTIR spektar kserogela sa fenacetinom ukazuju na izvršeno uklapanje fenacetina u unutrašnjost gela. SEM mikrografije nabubrelih i liofilizovanih uzoraka hidrogelova pokazuju da je njihova površina porozna, a uzorci sa uklopljenim fenacetinom pokazuju prisustvo fenacetina u porama hidrogela. Rezultati bubrenja pokazuju da termoosetljivi hidrogelovi NA 20 °C ispoljavaju anomaliju u mehanizmu difuzije, bubrenje ne prati Fickov zakon, već je proces bubrenja kontrolisan difuzijom vode i relaksacijom polimernih lanaca. Transportni mehanizam bubrenja na 40 °C može se svrstati u tip III, sa vremenski nezavisnom kinetikom. Slično ponašanje pri bubrenju ovi hidrogelovi pokazuju u simuliranim fiziološkim uslovima (pH 2,20 i 7,40 na 37 °C). Potencijalna primena dobijenih hidrogelova kao nosača lekova sa kontrolisanim oslobađanjem fenacetina, kao model leka, ispitivana je pomoću HPLC metode. Rezultati pokazuju da je u prvih 24 sata otpuštena veća količina fenacetina na 37 °C u rastvoru pH 7,40 (70-90%) u odnosu na količinu otpuštenog fenacetina u rastvoru pH 2,20 (50-65% od apsorbovane količine). Količina otpuštenog fenacetina srazmerno se smanjuje sa povećanjem gustine umreženja gelova. Proces otpuštanja lekovite supstance prati Fikov zakon difuzije za obe pH vrednosti. Dobijeni termoosetljivi hidrogelovi p(NIPAM-co-HPMet) pokazuju dobre mogućnosti za primenu kao 'inteligentni' nosači lekova (npr. fenacetina) sa kontrolisanom oslobađanjem.
PB  - Association of Chemical Engineers of Serbia
T2  - Hemijska industrija
T1  - Potential application of thermo-sensitive hydrogels for controlled release of phenacetin
T1  - Potencijalna primena termoosetljivih hidrogelova za kontrolisano otpuštanje fenacetina
EP  - 839
IS  - 6
SP  - 831
VL  - 66
DO  - 10.2298/HEMIND120222089I
ER  - 
@article{
author = "Ilić-Stojanović, Snežana and Nikolić, Ljubiša B. and Nikolić, Vesna D. and Milić, Jela R. and Petrović, Slobodan and Nikolić, Goran M. and Kapor, Agneš",
year = "2012",
abstract = "Over the past years, many scientific research studies have been focused on thermo-sensitive hydrogels containing N-isopropylacrylamide (NIPAM) as a monomer. The NIPAM based hydrogels with 20 mol% 2-hydroxypropyl methacrylate (HPMet) were synthesized using ethylene glycol dimethacrylate as a cross-linker. The characterization of xerogel and phenacetin using Fourier transform infrared (FTIR) spectroscopy and Scanning electron microscopy (SEM)confirm the performed synthesis with satisfactory purity as well as loading of phenacetin into hydrogel. The swelling transport mechanism at simulated physiological conditions (pH 2.20 and 7.40 at 37 °C) is described by the time-independent kinetics. The potential application of synthesized hydrogels for the controlled release of phenacetin as a model drug was investigated at simulated physiological conditions by HPLC method. ., Brojna naučna istraživanja tokom poslednjih godina usmerena su na hidro- gelove koji sadrže N-izopropilakrilamid (NIPAM) kao monomer. Hidrogelovi na bazi NIPAM-a sa 20 mol% 2-hidroksipropilmetakrilata (HPMet), p(NIPAM-co-HPMet) sintetisani su korišćenjem različitih količina umreživača etilenglikoldimetakrilata (EGDM) i izvršena je njihova karakterizacija. FTIR spektar kserogela ukazuje na izvršenu sintezu iniciranjem pomoću radikala, a FTIR spektar fenacetina potvrđuje da je dobijen proizvod zadovoljavajuće čistoće. FTIR spektar kserogela sa fenacetinom ukazuju na izvršeno uklapanje fenacetina u unutrašnjost gela. SEM mikrografije nabubrelih i liofilizovanih uzoraka hidrogelova pokazuju da je njihova površina porozna, a uzorci sa uklopljenim fenacetinom pokazuju prisustvo fenacetina u porama hidrogela. Rezultati bubrenja pokazuju da termoosetljivi hidrogelovi NA 20 °C ispoljavaju anomaliju u mehanizmu difuzije, bubrenje ne prati Fickov zakon, već je proces bubrenja kontrolisan difuzijom vode i relaksacijom polimernih lanaca. Transportni mehanizam bubrenja na 40 °C može se svrstati u tip III, sa vremenski nezavisnom kinetikom. Slično ponašanje pri bubrenju ovi hidrogelovi pokazuju u simuliranim fiziološkim uslovima (pH 2,20 i 7,40 na 37 °C). Potencijalna primena dobijenih hidrogelova kao nosača lekova sa kontrolisanim oslobađanjem fenacetina, kao model leka, ispitivana je pomoću HPLC metode. Rezultati pokazuju da je u prvih 24 sata otpuštena veća količina fenacetina na 37 °C u rastvoru pH 7,40 (70-90%) u odnosu na količinu otpuštenog fenacetina u rastvoru pH 2,20 (50-65% od apsorbovane količine). Količina otpuštenog fenacetina srazmerno se smanjuje sa povećanjem gustine umreženja gelova. Proces otpuštanja lekovite supstance prati Fikov zakon difuzije za obe pH vrednosti. Dobijeni termoosetljivi hidrogelovi p(NIPAM-co-HPMet) pokazuju dobre mogućnosti za primenu kao 'inteligentni' nosači lekova (npr. fenacetina) sa kontrolisanom oslobađanjem.",
publisher = "Association of Chemical Engineers of Serbia",
journal = "Hemijska industrija",
title = "Potential application of thermo-sensitive hydrogels for controlled release of phenacetin, Potencijalna primena termoosetljivih hidrogelova za kontrolisano otpuštanje fenacetina",
pages = "839-831",
number = "6",
volume = "66",
doi = "10.2298/HEMIND120222089I"
}
Ilić-Stojanović, S., Nikolić, L. B., Nikolić, V. D., Milić, J. R., Petrović, S., Nikolić, G. M.,& Kapor, A.. (2012). Potential application of thermo-sensitive hydrogels for controlled release of phenacetin. in Hemijska industrija
Association of Chemical Engineers of Serbia., 66(6), 831-839.
https://doi.org/10.2298/HEMIND120222089I
Ilić-Stojanović S, Nikolić LB, Nikolić VD, Milić JR, Petrović S, Nikolić GM, Kapor A. Potential application of thermo-sensitive hydrogels for controlled release of phenacetin. in Hemijska industrija. 2012;66(6):831-839.
doi:10.2298/HEMIND120222089I .
Ilić-Stojanović, Snežana, Nikolić, Ljubiša B., Nikolić, Vesna D., Milić, Jela R., Petrović, Slobodan, Nikolić, Goran M., Kapor, Agneš, "Potential application of thermo-sensitive hydrogels for controlled release of phenacetin" in Hemijska industrija, 66, no. 6 (2012):831-839,
https://doi.org/10.2298/HEMIND120222089I . .
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