TY  - JOUR
AU  - Plavšić, Milenko B.
AU  - Tomić, S
AU  - Sajc, L.
AU  - Bugarski, Branko
AU  - Jovanović, G
PY  - 1998
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/180
AB  - The influence of starting material properties on physical characteristics and drug release kinetics of poly-L-lactide microcapsules was investigated. The density, the distribution of the diameter size of microcapsules, the voidage and the active substance (methylene blue and Sudan III tracers) released concentrations, in paralel with microcapsules structure were studied. It was found that the density, size and structure of the microcapsules influenced in the polymer molar weight. In the case of the voidage, it exist the influence of the tracer and the polymer molar weight. The kinetic studies showed that the release patterns were similar and controllable. It was concluded that PLLA microcapsules showed a great potential for utilization in the active substance administration.
PB  - Trans Tech Publications Ltd, Durnten-Zurich
T2  - Advanced Materials and Processes: Yucomat II
T1  - Structure optimization of polylactide microcapsules for controlled drug release
EP  - 280
SP  - 271
VL  - 282-2
DO  - 10.4028/www.scientific.net/MSF.282-283.271
ER  - 

@article{
author = "Plavšić, Milenko B. and Tomić, S and Sajc, L. and Bugarski, Branko and Jovanović, G",
year = "1998",
abstract = "The influence of starting material properties on physical characteristics and drug release kinetics of poly-L-lactide microcapsules was investigated. The density, the distribution of the diameter size of microcapsules, the voidage and the active substance (methylene blue and Sudan III tracers) released concentrations, in paralel with microcapsules structure were studied. It was found that the density, size and structure of the microcapsules influenced in the polymer molar weight. In the case of the voidage, it exist the influence of the tracer and the polymer molar weight. The kinetic studies showed that the release patterns were similar and controllable. It was concluded that PLLA microcapsules showed a great potential for utilization in the active substance administration.",
publisher = "Trans Tech Publications Ltd, Durnten-Zurich",
journal = "Advanced Materials and Processes: Yucomat II",
title = "Structure optimization of polylactide microcapsules for controlled drug release",
pages = "280-271",
volume = "282-2",
doi = "10.4028/www.scientific.net/MSF.282-283.271"
}

Plavšić, M. B., Tomić, S., Sajc, L., Bugarski, B.,& Jovanović, G.. (1998). Structure optimization of polylactide microcapsules for controlled drug release. in Advanced Materials and Processes: Yucomat II
Trans Tech Publications Ltd, Durnten-Zurich., 282-2, 271-280.
https://doi.org/10.4028/www.scientific.net/MSF.282-283.271

Plavšić MB, Tomić S, Sajc L, Bugarski B, Jovanović G. Structure optimization of polylactide microcapsules for controlled drug release. in Advanced Materials and Processes: Yucomat II. 1998;282-2:271-280.
doi:10.4028/www.scientific.net/MSF.282-283.271 .

Plavšić, Milenko B., Tomić, S, Sajc, L., Bugarski, Branko, Jovanović, G, "Structure optimization of polylactide microcapsules for controlled drug release" in Advanced Materials and Processes: Yucomat II, 282-2 (1998):271-280,
https://doi.org/10.4028/www.scientific.net/MSF.282-283.271 . .

TY  - JOUR
AU  - Ristić, C.
AU  - Plavšić, Milenko B.
AU  - Goosen, M.F.
AU  - Sajc, L.
AU  - Antonović, Dušan
AU  - Bugarski, Branko
PY  - 1996
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/100
AB  - The investigation is based upon recent research in the area of the synthesis of biodegradable poly(L-lactide) (PLLA) for biomedical applications using stannous octoate (SnOct) as an initiator. The objective was to investigate factors that affect the synthesis of poly(L-lactide), such as monomer purification, vacuum required for monomer drying, polymerization reacton time and catalyst concentration. Complete polymer characterization was done by 1H-NMR, IR spectroscopy and light scattering, in order to reveal the polymerization mechanism. An attempt was made to obtain a polymer of high molecular weight and good mechanical properties that could be used for the processing of biodegradable surgical sutures. Experiments showed that the optimum conditions to obtain polymer of high molecular weight (≈ 30 × 104) are: vacuum required for monomer drying (0.2 mmHg), purification of both monomer and polymer by recrystallization/precipitation, monomer/initiator mole ratio ([M]/[I] about 5000 and a polymerization time of approximately 50 h.
PB  - Serbian Chemical Society, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - An investigation of the synthesis of poly(L-lactide) as a biodegradable polymer for orthopaedic applications
EP  - 318
IS  - 4-5
SP  - 311
VL  - 61
UR  - https://hdl.handle.net/21.15107/rcub_technorep_100
ER  - 

@article{
author = "Ristić, C. and Plavšić, Milenko B. and Goosen, M.F. and Sajc, L. and Antonović, Dušan and Bugarski, Branko",
year = "1996",
abstract = "The investigation is based upon recent research in the area of the synthesis of biodegradable poly(L-lactide) (PLLA) for biomedical applications using stannous octoate (SnOct) as an initiator. The objective was to investigate factors that affect the synthesis of poly(L-lactide), such as monomer purification, vacuum required for monomer drying, polymerization reacton time and catalyst concentration. Complete polymer characterization was done by 1H-NMR, IR spectroscopy and light scattering, in order to reveal the polymerization mechanism. An attempt was made to obtain a polymer of high molecular weight and good mechanical properties that could be used for the processing of biodegradable surgical sutures. Experiments showed that the optimum conditions to obtain polymer of high molecular weight (≈ 30 × 104) are: vacuum required for monomer drying (0.2 mmHg), purification of both monomer and polymer by recrystallization/precipitation, monomer/initiator mole ratio ([M]/[I] about 5000 and a polymerization time of approximately 50 h.",
publisher = "Serbian Chemical Society, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "An investigation of the synthesis of poly(L-lactide) as a biodegradable polymer for orthopaedic applications",
pages = "318-311",
number = "4-5",
volume = "61",
url = "https://hdl.handle.net/21.15107/rcub_technorep_100"
}

Ristić, C., Plavšić, M. B., Goosen, M.F., Sajc, L., Antonović, D.,& Bugarski, B.. (1996). An investigation of the synthesis of poly(L-lactide) as a biodegradable polymer for orthopaedic applications. in Journal of the Serbian Chemical Society
Serbian Chemical Society, Belgrade., 61(4-5), 311-318.
https://hdl.handle.net/21.15107/rcub_technorep_100

Ristić C, Plavšić MB, Goosen M, Sajc L, Antonović D, Bugarski B. An investigation of the synthesis of poly(L-lactide) as a biodegradable polymer for orthopaedic applications. in Journal of the Serbian Chemical Society. 1996;61(4-5):311-318.
https://hdl.handle.net/21.15107/rcub_technorep_100 .

Ristić, C., Plavšić, Milenko B., Goosen, M.F., Sajc, L., Antonović, Dušan, Bugarski, Branko, "An investigation of the synthesis of poly(L-lactide) as a biodegradable polymer for orthopaedic applications" in Journal of the Serbian Chemical Society, 61, no. 4-5 (1996):311-318,
https://hdl.handle.net/21.15107/rcub_technorep_100 .

TY  - JOUR
AU  - Sajc, L.
AU  - Jovanović, Z.
AU  - Jovanović, G.
AU  - Bugarski, Branko
AU  - Vunjak-Novaković, Gordana
PY  - 1996
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/98
AB  - The study concerns a phenomenon in which the magnetization of ferromagnetic particles stabilizes the state of uniform fluidization in gas-solid, liquid-solid and gas-liquid-solid fluidized beds. Fluidization regimes and bed structure are functions of the intensity of an external magnetic field and the magnetic propererties of the particles. A fluidized bed of magnetized ferromagnetic particles can be regarded as a ferromagnet, with the permeability proportional to the ferromagnetic material magnetization properties, the intensity of the magnetic field applied by the solenoid, particle diameter and fluidized bed porosity. Stability analysis was performed using mean field theory to determine the magnetic forces acting at the gas-ferromagnet and liquid-ferromagnet surface, a discontinuity boundary, and to predict the mechanism of transition from the unstably fluidized to the stably fluidized sate.
PB  - Serbian Chemical Society, Belgrade
T2  - Journal of the Serbian Chemical Society
T1  - The interfacial stability of magnetically stabilized fluidized beds
EP  - 329
IS  - 4-5
SP  - 319
VL  - 61
UR  - https://hdl.handle.net/21.15107/rcub_technorep_98
ER  - 

@article{
author = "Sajc, L. and Jovanović, Z. and Jovanović, G. and Bugarski, Branko and Vunjak-Novaković, Gordana",
year = "1996",
abstract = "The study concerns a phenomenon in which the magnetization of ferromagnetic particles stabilizes the state of uniform fluidization in gas-solid, liquid-solid and gas-liquid-solid fluidized beds. Fluidization regimes and bed structure are functions of the intensity of an external magnetic field and the magnetic propererties of the particles. A fluidized bed of magnetized ferromagnetic particles can be regarded as a ferromagnet, with the permeability proportional to the ferromagnetic material magnetization properties, the intensity of the magnetic field applied by the solenoid, particle diameter and fluidized bed porosity. Stability analysis was performed using mean field theory to determine the magnetic forces acting at the gas-ferromagnet and liquid-ferromagnet surface, a discontinuity boundary, and to predict the mechanism of transition from the unstably fluidized to the stably fluidized sate.",
publisher = "Serbian Chemical Society, Belgrade",
journal = "Journal of the Serbian Chemical Society",
title = "The interfacial stability of magnetically stabilized fluidized beds",
pages = "329-319",
number = "4-5",
volume = "61",
url = "https://hdl.handle.net/21.15107/rcub_technorep_98"
}

Sajc, L., Jovanović, Z., Jovanović, G., Bugarski, B.,& Vunjak-Novaković, G.. (1996). The interfacial stability of magnetically stabilized fluidized beds. in Journal of the Serbian Chemical Society
Serbian Chemical Society, Belgrade., 61(4-5), 319-329.
https://hdl.handle.net/21.15107/rcub_technorep_98

Sajc L, Jovanović Z, Jovanović G, Bugarski B, Vunjak-Novaković G. The interfacial stability of magnetically stabilized fluidized beds. in Journal of the Serbian Chemical Society. 1996;61(4-5):319-329.
https://hdl.handle.net/21.15107/rcub_technorep_98 .

Sajc, L., Jovanović, Z., Jovanović, G., Bugarski, Branko, Vunjak-Novaković, Gordana, "The interfacial stability of magnetically stabilized fluidized beds" in Journal of the Serbian Chemical Society, 61, no. 4-5 (1996):319-329,
https://hdl.handle.net/21.15107/rcub_technorep_98 .

TY  - JOUR
AU  - Sajc, L.
AU  - Vunjak-Novaković, Gordana
AU  - Grubisić, D.
AU  - Kovačević, N.
AU  - Vuković, Dragan
AU  - Bugarski, Branko
PY  - 1995
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/60
AB  - The production of anthraquinones by Frangula alnus Mill. plant cells was used as a model system to evaluate the performance of a liquid-liquid extractive product-recovery process. The shake flask experiments have shown higher production of anthraquinones in cell suspension and flask cultures of calcium-alginate-immobilized cells when silicone oil was incorporated into the medium, compared to a control without silicone oil. An external-loop air-lift bioreactor, developed and designed for the production and simultaneous extraction of extracellular plant cell products, was regarded as a four-phase system, with dispersed gas, non-aqueous solvent and calcium-alginate-immobilized plant cells in Murashige and Skoog medium. Continuous extraction of anthraquinones by silicone oil and n-hexadecane inside the bioreactor resulted in 10–30 times higher cell productivity, compared to that of immobilized cells in a flask. Based on the mixing pattern, immobilized biocatalyst extraparticle and intraparticle diffusional constraints and the kinetics of growth, substrate consumption and product formation, a mathematical model was developed to describe the time course of a batch plant cell culture.
PB  - Springer, New York
T2  - Applied Microbiology and Biotechnology
T1  - Production of anthraquinones by immobilized Frangula alnus Mill. plant cells in a four-phase air-lift bioreactor
EP  - 423
IS  - 3
SP  - 416
VL  - 43
DO  - 10.1007/BF00218443
ER  - 

@article{
author = "Sajc, L. and Vunjak-Novaković, Gordana and Grubisić, D. and Kovačević, N. and Vuković, Dragan and Bugarski, Branko",
year = "1995",
abstract = "The production of anthraquinones by Frangula alnus Mill. plant cells was used as a model system to evaluate the performance of a liquid-liquid extractive product-recovery process. The shake flask experiments have shown higher production of anthraquinones in cell suspension and flask cultures of calcium-alginate-immobilized cells when silicone oil was incorporated into the medium, compared to a control without silicone oil. An external-loop air-lift bioreactor, developed and designed for the production and simultaneous extraction of extracellular plant cell products, was regarded as a four-phase system, with dispersed gas, non-aqueous solvent and calcium-alginate-immobilized plant cells in Murashige and Skoog medium. Continuous extraction of anthraquinones by silicone oil and n-hexadecane inside the bioreactor resulted in 10–30 times higher cell productivity, compared to that of immobilized cells in a flask. Based on the mixing pattern, immobilized biocatalyst extraparticle and intraparticle diffusional constraints and the kinetics of growth, substrate consumption and product formation, a mathematical model was developed to describe the time course of a batch plant cell culture.",
publisher = "Springer, New York",
journal = "Applied Microbiology and Biotechnology",
title = "Production of anthraquinones by immobilized Frangula alnus Mill. plant cells in a four-phase air-lift bioreactor",
pages = "423-416",
number = "3",
volume = "43",
doi = "10.1007/BF00218443"
}

Sajc, L., Vunjak-Novaković, G., Grubisić, D., Kovačević, N., Vuković, D.,& Bugarski, B.. (1995). Production of anthraquinones by immobilized Frangula alnus Mill. plant cells in a four-phase air-lift bioreactor. in Applied Microbiology and Biotechnology
Springer, New York., 43(3), 416-423.
https://doi.org/10.1007/BF00218443

Sajc L, Vunjak-Novaković G, Grubisić D, Kovačević N, Vuković D, Bugarski B. Production of anthraquinones by immobilized Frangula alnus Mill. plant cells in a four-phase air-lift bioreactor. in Applied Microbiology and Biotechnology. 1995;43(3):416-423.
doi:10.1007/BF00218443 .

Sajc, L., Vunjak-Novaković, Gordana, Grubisić, D., Kovačević, N., Vuković, Dragan, Bugarski, Branko, "Production of anthraquinones by immobilized Frangula alnus Mill. plant cells in a four-phase air-lift bioreactor" in Applied Microbiology and Biotechnology, 43, no. 3 (1995):416-423,
https://doi.org/10.1007/BF00218443 . .

TY  - JOUR
AU  - Sajc, L.
AU  - Obradović, Bojana
AU  - Vuković, Dragan
AU  - Bugarski, Branko
AU  - Grubisić, D.
AU  - Vunjak-Novaković, Gordana
PY  - 1995
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/59
AB  - An external loop air lift reactor (ELALR) was developed and designed for continuous production and extraction of extracellular secondary metabolites by immobilized Frangula alnus Mill. plant cells. This system was considered as a four‐phase system, with dispersed gas, nonaqueous liquid solvent, and calcium alginate particles in water or Murashige and Skoog medium. Analysis of the four‐phase ELALR revealed the influence of gas, solvent, calcium alginate particles and MS medium composition on gas and solvent holdup, liquid circulation velocity, mixing in aqueous liquid phase, and mass transfer coefficients of oxygen and plant cell product. It was shown that the gas holdup appears to be the principal variable determining the properties of the four‐phase system. An unified correlation for the gas holdup, based on drift flux flow in a three‐phase system, has been extended to the four‐phase system. Bubble size and bubble size distribution observed in the bubbly flow regime were the same in water as in the MS medium system (Sauter mean diameter 2.5 mm). Consequently, gas holdup and all related parameters, such as liquid circulation velocity, oxygen mass transfer coefficient, and axial liquid dispersion in MS medium, were similar to those in water for the four‐phase system.
PB  - Wiley, Hoboken
T2  - Biotechnology Progress
T1  - Hydrodynamics and Mass Transfer in a Four‐Phase External Loop Air Lift Bioreactor
EP  - 428
IS  - 4
SP  - 420
VL  - 11
DO  - 10.1021/bp00034a009
ER  - 

@article{
author = "Sajc, L. and Obradović, Bojana and Vuković, Dragan and Bugarski, Branko and Grubisić, D. and Vunjak-Novaković, Gordana",
year = "1995",
abstract = "An external loop air lift reactor (ELALR) was developed and designed for continuous production and extraction of extracellular secondary metabolites by immobilized Frangula alnus Mill. plant cells. This system was considered as a four‐phase system, with dispersed gas, nonaqueous liquid solvent, and calcium alginate particles in water or Murashige and Skoog medium. Analysis of the four‐phase ELALR revealed the influence of gas, solvent, calcium alginate particles and MS medium composition on gas and solvent holdup, liquid circulation velocity, mixing in aqueous liquid phase, and mass transfer coefficients of oxygen and plant cell product. It was shown that the gas holdup appears to be the principal variable determining the properties of the four‐phase system. An unified correlation for the gas holdup, based on drift flux flow in a three‐phase system, has been extended to the four‐phase system. Bubble size and bubble size distribution observed in the bubbly flow regime were the same in water as in the MS medium system (Sauter mean diameter 2.5 mm). Consequently, gas holdup and all related parameters, such as liquid circulation velocity, oxygen mass transfer coefficient, and axial liquid dispersion in MS medium, were similar to those in water for the four‐phase system.",
publisher = "Wiley, Hoboken",
journal = "Biotechnology Progress",
title = "Hydrodynamics and Mass Transfer in a Four‐Phase External Loop Air Lift Bioreactor",
pages = "428-420",
number = "4",
volume = "11",
doi = "10.1021/bp00034a009"
}

Sajc, L., Obradović, B., Vuković, D., Bugarski, B., Grubisić, D.,& Vunjak-Novaković, G.. (1995). Hydrodynamics and Mass Transfer in a Four‐Phase External Loop Air Lift Bioreactor. in Biotechnology Progress
Wiley, Hoboken., 11(4), 420-428.
https://doi.org/10.1021/bp00034a009

Sajc L, Obradović B, Vuković D, Bugarski B, Grubisić D, Vunjak-Novaković G. Hydrodynamics and Mass Transfer in a Four‐Phase External Loop Air Lift Bioreactor. in Biotechnology Progress. 1995;11(4):420-428.
doi:10.1021/bp00034a009 .

Sajc, L., Obradović, Bojana, Vuković, Dragan, Bugarski, Branko, Grubisić, D., Vunjak-Novaković, Gordana, "Hydrodynamics and Mass Transfer in a Four‐Phase External Loop Air Lift Bioreactor" in Biotechnology Progress, 11, no. 4 (1995):420-428,
https://doi.org/10.1021/bp00034a009 . .