TY  - JOUR
AU  - Milentijevic, Goran
AU  - Marinković, Aleksandar
AU  - Rancic, Milica
AU  - Bogdanović, Aleksandra
AU  - Prlainović, Nevena
AU  - Markovic, Smiljana
AU  - Milosavljevic, Milutin
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4779
AB  - The specific objectives of the presented study were related to the optimization of the production process of N-alkyl-, N,N-dialkyl-, and N-cycloalkyl-O-isobutyl thiocarbamate; trial industrial production of N-ethyl-O-isobutyl thiocarbamate; and the evaluation of flotation efficiency of N-ethyl-O-isobutyl thiocarbamate using a real ore sample. The optimization of thiocarbamate syntheses were performed by varying the molar ratio of isobutyl alcohol, carbon disulfide, potassium hydroxide, reaction time, and reaction temperature. In the first step, one-pot reaction took place to produce alkyl xanthate and was followed with chlorination to give alkyl chloroformate (O-alkyl carbonochloridothioate); finally, thiocarbamates were obtained by the reaction with corresponding amines. N-alkyl-O-ethyl thiocarbamate was synthesized as a comparative flotation agent. The structure of the synthesized compounds was confirmed by IR, H-1 and C-13 NMR, and MS instrumental methods, and the purity was determined by gas chromatographic method and elemental analysis. The optimized methods gave high-purity products in a significant yield that was also confirmed by semi-industrial production of N-ethyl-O-isobutyl thiocarbamate. The optimized thiocarbamate synthesis, without isolation of intermediates, is of great importance from the aspect of green technologies. Flotation efficiency test results, using real copper and zinc ores, showed the highest activity of N-ethyl-O-isobutyl thiocarbamate. The optimal one-pot thiocarbamate synthesis provides a simple procedure with a high conversion degree, and, thus, offers valuable technology applicable at the industrial scale.
T2  - Minerals
T1  - New Facile One-Pot Synthesis of Isobutyl Thiocarbamate in Recycling Solvent Mixture
IS  - 12
VL  - 11
DO  - 10.3390/min11121346
ER  - 

@article{
author = "Milentijevic, Goran and Marinković, Aleksandar and Rancic, Milica and Bogdanović, Aleksandra and Prlainović, Nevena and Markovic, Smiljana and Milosavljevic, Milutin",
year = "2021",
abstract = "The specific objectives of the presented study were related to the optimization of the production process of N-alkyl-, N,N-dialkyl-, and N-cycloalkyl-O-isobutyl thiocarbamate; trial industrial production of N-ethyl-O-isobutyl thiocarbamate; and the evaluation of flotation efficiency of N-ethyl-O-isobutyl thiocarbamate using a real ore sample. The optimization of thiocarbamate syntheses were performed by varying the molar ratio of isobutyl alcohol, carbon disulfide, potassium hydroxide, reaction time, and reaction temperature. In the first step, one-pot reaction took place to produce alkyl xanthate and was followed with chlorination to give alkyl chloroformate (O-alkyl carbonochloridothioate); finally, thiocarbamates were obtained by the reaction with corresponding amines. N-alkyl-O-ethyl thiocarbamate was synthesized as a comparative flotation agent. The structure of the synthesized compounds was confirmed by IR, H-1 and C-13 NMR, and MS instrumental methods, and the purity was determined by gas chromatographic method and elemental analysis. The optimized methods gave high-purity products in a significant yield that was also confirmed by semi-industrial production of N-ethyl-O-isobutyl thiocarbamate. The optimized thiocarbamate synthesis, without isolation of intermediates, is of great importance from the aspect of green technologies. Flotation efficiency test results, using real copper and zinc ores, showed the highest activity of N-ethyl-O-isobutyl thiocarbamate. The optimal one-pot thiocarbamate synthesis provides a simple procedure with a high conversion degree, and, thus, offers valuable technology applicable at the industrial scale.",
journal = "Minerals",
title = "New Facile One-Pot Synthesis of Isobutyl Thiocarbamate in Recycling Solvent Mixture",
number = "12",
volume = "11",
doi = "10.3390/min11121346"
}

Milentijevic, G., Marinković, A., Rancic, M., Bogdanović, A., Prlainović, N., Markovic, S.,& Milosavljevic, M.. (2021). New Facile One-Pot Synthesis of Isobutyl Thiocarbamate in Recycling Solvent Mixture. in Minerals, 11(12).
https://doi.org/10.3390/min11121346

Milentijevic G, Marinković A, Rancic M, Bogdanović A, Prlainović N, Markovic S, Milosavljevic M. New Facile One-Pot Synthesis of Isobutyl Thiocarbamate in Recycling Solvent Mixture. in Minerals. 2021;11(12).
doi:10.3390/min11121346 .

Milentijevic, Goran, Marinković, Aleksandar, Rancic, Milica, Bogdanović, Aleksandra, Prlainović, Nevena, Markovic, Smiljana, Milosavljevic, Milutin, "New Facile One-Pot Synthesis of Isobutyl Thiocarbamate in Recycling Solvent Mixture" in Minerals, 11, no. 12 (2021),
https://doi.org/10.3390/min11121346 . .