@conference{
author = "Marković, Maja D. and Miladinović, Nina N. and Savić, Sanja I. and Panić, Vesna V. and Pantić, Olga J. and Spasojević, Pavle M. and Pjanović, Rada V.",
year = "2023",
abstract = "Controlled release of drugs is a promising tool for improvement of therapy for many
diseases because drug concentration for long period of time is kept constant, whereas
number of drug doses and side effects are reduced. pH sensitive hydrogels, such as
hydrogels based on poly(methacrylic acid) (PMAA), are extensively employed for
drug delivery. The synthesis of the hydrogel is one of the most important factors
which affect encapsulation of drug and its bioactivity. In present study, we investigate
if the encapsulation of poorly water-soluble active substance (caffeine) during the
synthesis of PMAA hydrogels, and later its controlled release from the PMAA
hydrogels, can be achieved by applying novel ”green” method for the hydrogels
preparation. The PMAA hydrogels with encapsulated caffeine and various amount of
crosslinker are prepared by free radical polymerisation in aqueous solution and
ambient conditions by using novel initiation system based on hydrogen peroxide and
vitamin C. The swelling behaviour of the PMAA hydrogels and controlled release of
caffeine are investigated in two media with pH 1 and pH 6.8 as simulation of human
stomach and intestines, respectively. The SDeq values of the PMAA hydrogels are
eight times higher in the medium with pH 6.8 and as a consequence, three times higher
amount of caffeine is released in that medium. The increase in the crosslinker amount
leads to the decrease of SDeq values of the PMAA hydrogels and amount of released
caffeine. The results show that the PMAA hydrogels have great potential for controlled
release of poorly water-soluble drugs.",
publisher = "Leskovac : Faculty of Technology",
journal = "Book of abstracts / 15th International Symposium "Novel Technologies and Sustainable Development" Leskovac, October, 20-21, 2023",
title = "POLY(METHACRYLIC ACID) HYDROGELS PREPARED BY ”GREEN” METHOD: SWELLING PROPERTIES AND CONTROLLED RELEASE OF CAFFEINE",
pages = "97",
url = "https://hdl.handle.net/21.15107/rcub_technorep_7300"
}