TY  - CONF
AU  - Lazić, Anita
AU  - Gak, Kristina
AU  - Valentić, Nataša
AU  - Rogan, Jelena
AU  - Radovanović, Lidija
AU  - Đukić, Maja
AU  - Matović, Zoran
AU  - Trišović, Nemanja
PY  - 2019
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7405
AB  - U okviru proučavanja uticaja strukture na farmakološku aktivnost derivata hidantoina,
5-(3-metilfenil)-5-metilhidantoin (1) i 5-(4-metoksifenil)-5-metilhidantoin (2) su sintetisani i
potpuno strukturno okarakterisani određivanjem temperature topljenje, FTIR, 1H i 13C NMR
spektroskopskim metodama. Određene su njihove kristalne strukture i izvršena je analiza
kristalnog pakovanja sa aspekta međumolekulskih interakcija i strukturnih motiva. U
kristalnom pakovanju oba jedinjenja uspostavljaju se jake intermolekulske N-H···O vodonične
veze između njihovih R i S izomera. Vezivanje proučavanih jedinjenja za DNK i serum humanog
albumina (HSA) proučavano je merenjem gašenja fluerescencije triptofana. Pokazano je da 2
ima viši afinitet vezivanja i za DNK i HSA od 1. Predstavljeno istraživanje pruža smernice za
dizajniranje novih derivata hidantoina sa poboljšanim farmakološkim svojstvima.
AB  - Within the framework of the investigation of the structure–activity relationship of
hydantoin derivatives, 5-(3-methylphenyl)-5-methylhydantoin (1) and 5-(4-methoxyphe-
nyl)-5-methylhydantoin (2) were synthesized and structurally characterized by determi-
nation of their melting points, FTIR, 1H and 13C spectroscopic techniques. Their crystal
structures were determined and the analysis of the crystal packings in terms of the
contributing intermolecular interactions and structural motifs was performed. In the crystal
packing of both compounds, strong intermolecular N-H···O hydrogen bonds were observed
between their R and S isomers. Binding of the investigated compounds to DNA and to
human serum albumin (HSA) was studied by measuring quenching of the fluorescence of
tryptophan. It was shown that 2 has a higher binding affinity for both DNA and HSA than 1.
The presented investigation provide guidance for design of novel hydantoin derivatives with
improved pharmacological properties.
PB  - Beograd : Srpsko hemijsko društvo = Serbian Chemical Society
C3  - Kratki izvodi radova = Book of Abstracts / 56. savetovanje Srpskog hemijskog društva , Niš 7. i 8. juni 2019. = 56th meeting of the Serbian chemical society, Niš, Serbia, June 7-8, 2019
T1  - Proučavanje kristalne strukture i interakcija 5-(3- i 4-supstituisanih)-5-metilhidantoina sa albuminom humanog seruma i DNK
T1  - Study of the crystal structure and interactions of 5-(3- and 4-substituted)-5-methylhydantoins with human serum albumin and DNA
SP  - 92
UR  - https://hdl.handle.net/21.15107/rcub_technorep_7405
ER  - 

@conference{
author = "Lazić, Anita and Gak, Kristina and Valentić, Nataša and Rogan, Jelena and Radovanović, Lidija and Đukić, Maja and Matović, Zoran and Trišović, Nemanja",
year = "2019",
abstract = "U okviru proučavanja uticaja strukture na farmakološku aktivnost derivata hidantoina,
5-(3-metilfenil)-5-metilhidantoin (1) i 5-(4-metoksifenil)-5-metilhidantoin (2) su sintetisani i
potpuno strukturno okarakterisani određivanjem temperature topljenje, FTIR, 1H i 13C NMR
spektroskopskim metodama. Određene su njihove kristalne strukture i izvršena je analiza
kristalnog pakovanja sa aspekta međumolekulskih interakcija i strukturnih motiva. U
kristalnom pakovanju oba jedinjenja uspostavljaju se jake intermolekulske N-H···O vodonične
veze između njihovih R i S izomera. Vezivanje proučavanih jedinjenja za DNK i serum humanog
albumina (HSA) proučavano je merenjem gašenja fluerescencije triptofana. Pokazano je da 2
ima viši afinitet vezivanja i za DNK i HSA od 1. Predstavljeno istraživanje pruža smernice za
dizajniranje novih derivata hidantoina sa poboljšanim farmakološkim svojstvima., Within the framework of the investigation of the structure–activity relationship of
hydantoin derivatives, 5-(3-methylphenyl)-5-methylhydantoin (1) and 5-(4-methoxyphe-
nyl)-5-methylhydantoin (2) were synthesized and structurally characterized by determi-
nation of their melting points, FTIR, 1H and 13C spectroscopic techniques. Their crystal
structures were determined and the analysis of the crystal packings in terms of the
contributing intermolecular interactions and structural motifs was performed. In the crystal
packing of both compounds, strong intermolecular N-H···O hydrogen bonds were observed
between their R and S isomers. Binding of the investigated compounds to DNA and to
human serum albumin (HSA) was studied by measuring quenching of the fluorescence of
tryptophan. It was shown that 2 has a higher binding affinity for both DNA and HSA than 1.
The presented investigation provide guidance for design of novel hydantoin derivatives with
improved pharmacological properties.",
publisher = "Beograd : Srpsko hemijsko društvo = Serbian Chemical Society",
journal = "Kratki izvodi radova = Book of Abstracts / 56. savetovanje Srpskog hemijskog društva , Niš 7. i 8. juni 2019. = 56th meeting of the Serbian chemical society, Niš, Serbia, June 7-8, 2019",
title = "Proučavanje kristalne strukture i interakcija 5-(3- i 4-supstituisanih)-5-metilhidantoina sa albuminom humanog seruma i DNK, Study of the crystal structure and interactions of 5-(3- and 4-substituted)-5-methylhydantoins with human serum albumin and DNA",
pages = "92",
url = "https://hdl.handle.net/21.15107/rcub_technorep_7405"
}

Lazić, A., Gak, K., Valentić, N., Rogan, J., Radovanović, L., Đukić, M., Matović, Z.,& Trišović, N.. (2019). Proučavanje kristalne strukture i interakcija 5-(3- i 4-supstituisanih)-5-metilhidantoina sa albuminom humanog seruma i DNK. in Kratki izvodi radova = Book of Abstracts / 56. savetovanje Srpskog hemijskog društva , Niš 7. i 8. juni 2019. = 56th meeting of the Serbian chemical society, Niš, Serbia, June 7-8, 2019
Beograd : Srpsko hemijsko društvo = Serbian Chemical Society., 92.
https://hdl.handle.net/21.15107/rcub_technorep_7405

Lazić A, Gak K, Valentić N, Rogan J, Radovanović L, Đukić M, Matović Z, Trišović N. Proučavanje kristalne strukture i interakcija 5-(3- i 4-supstituisanih)-5-metilhidantoina sa albuminom humanog seruma i DNK. in Kratki izvodi radova = Book of Abstracts / 56. savetovanje Srpskog hemijskog društva , Niš 7. i 8. juni 2019. = 56th meeting of the Serbian chemical society, Niš, Serbia, June 7-8, 2019. 2019;:92.
https://hdl.handle.net/21.15107/rcub_technorep_7405 .

Lazić, Anita, Gak, Kristina, Valentić, Nataša, Rogan, Jelena, Radovanović, Lidija, Đukić, Maja, Matović, Zoran, Trišović, Nemanja, "Proučavanje kristalne strukture i interakcija 5-(3- i 4-supstituisanih)-5-metilhidantoina sa albuminom humanog seruma i DNK" in Kratki izvodi radova = Book of Abstracts / 56. savetovanje Srpskog hemijskog društva , Niš 7. i 8. juni 2019. = 56th meeting of the Serbian chemical society, Niš, Serbia, June 7-8, 2019 (2019):92,
https://hdl.handle.net/21.15107/rcub_technorep_7405 .

TY  - JOUR
AU  - Gržetić, Ivan
AU  - Juranić, Ivan
AU  - Damjanović, Ljiljana
AU  - Popović, Ivanka
AU  - Ivančev-Tumbas, Ivana
AU  - Matović, Zoran
AU  - Anđelković, Tatjana
AU  - Diković, Ljubica
AU  - Antonijević, Milan
PY  - 2012
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2074
AB  - One of the results of the work on the TEMPUS project 'Modernisation of Post-Graduate Studies in Chemistry and Chemistry Related Programmes - MCHEM' are benchmark standards for chemistry and chemistry related subjects. The goal of this text was to make these standards available to Serbian community. Obtained text is a result of the consensus among participants of the project coming from educational institutions that are responsible for chemistry and it is based on already existing standards in Europe created by 'The Chemistry Quality Eurolabels®' and adopted by 'European Association for Chemical and Molecular Sciences' since 2003.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Hemijski pregled
T1  - Referentni obrazovni standardi za hemiju i srodne discipline
EP  - 105
IS  - 4
SP  - 100
VL  - 53
UR  - https://hdl.handle.net/21.15107/rcub_technorep_2074
ER  - 

@article{
author = "Gržetić, Ivan and Juranić, Ivan and Damjanović, Ljiljana and Popović, Ivanka and Ivančev-Tumbas, Ivana and Matović, Zoran and Anđelković, Tatjana and Diković, Ljubica and Antonijević, Milan",
year = "2012",
abstract = "One of the results of the work on the TEMPUS project 'Modernisation of Post-Graduate Studies in Chemistry and Chemistry Related Programmes - MCHEM' are benchmark standards for chemistry and chemistry related subjects. The goal of this text was to make these standards available to Serbian community. Obtained text is a result of the consensus among participants of the project coming from educational institutions that are responsible for chemistry and it is based on already existing standards in Europe created by 'The Chemistry Quality Eurolabels®' and adopted by 'European Association for Chemical and Molecular Sciences' since 2003.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Hemijski pregled",
title = "Referentni obrazovni standardi za hemiju i srodne discipline",
pages = "105-100",
number = "4",
volume = "53",
url = "https://hdl.handle.net/21.15107/rcub_technorep_2074"
}

Gržetić, I., Juranić, I., Damjanović, L., Popović, I., Ivančev-Tumbas, I., Matović, Z., Anđelković, T., Diković, L.,& Antonijević, M.. (2012). Referentni obrazovni standardi za hemiju i srodne discipline. in Hemijski pregled
Srpsko hemijsko društvo, Beograd., 53(4), 100-105.
https://hdl.handle.net/21.15107/rcub_technorep_2074

Gržetić I, Juranić I, Damjanović L, Popović I, Ivančev-Tumbas I, Matović Z, Anđelković T, Diković L, Antonijević M. Referentni obrazovni standardi za hemiju i srodne discipline. in Hemijski pregled. 2012;53(4):100-105.
https://hdl.handle.net/21.15107/rcub_technorep_2074 .

Gržetić, Ivan, Juranić, Ivan, Damjanović, Ljiljana, Popović, Ivanka, Ivančev-Tumbas, Ivana, Matović, Zoran, Anđelković, Tatjana, Diković, Ljubica, Antonijević, Milan, "Referentni obrazovni standardi za hemiju i srodne discipline" in Hemijski pregled, 53, no. 4 (2012):100-105,
https://hdl.handle.net/21.15107/rcub_technorep_2074 .