TY  - CONF
AU  - Milovanović, Stoja
AU  - Lukić, Ivana
AU  - Tadić, Vanja
AU  - Frank, Almut
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6893
AB  - Supercritical CO2 impregnation (SCI) process allows incorporation of bioactive components into solid carriers in an environmentally friendly manner. In recent years, SCI was highlighted as a promising method for preparation of added value materials that can protect bioactive components from environment (sun light, air, moisture etc.), stabilise them, and increase their shelf life. SCI process is also suitable for preparation of material with controlled release of bioactive component. Taking into account the above-mentioned, SCI process was employed in this study for incorporation of hemp seed oil (HSO) into biocompatible polymers (starch xerogel, starch aerogel, α-cyclodextrin, β-cyclodextrin, and γ-cyclodextrin). Given that efficiency of SCI depends on process conditions and affinity of bioactive component towards scCO2 and polymer, it is necessary to optimise process for every individual system. Proposed SCI process was performed at pressure of 30 MPa and temperature of 40 °C during 5 h and 18 h. FTIR analysis confirmed that scCO2 did not have effect on polymer composition nor it remained in polymer after process. Additionally, FTIR and UV-Vis analysis showed that HSO is present in all tested polymers after SCI process. It was shown that impregnation of HSO is highly dependent on selection of polymeric carrier (its chemical composition and morphology) and operating time employed, resulting in loadings from 0.5% to 40%. Chemical analysis showed that HSO is rich in unsaturated fatty acids especially linoleic acid (54-60%) and α-linolenic acid (17-20%). These essential fatty acids have well-established health benefits including protection against cardiovascular, neurodegenerative and inflammatory diseases. Proposed SCI process gave guidelines for development of added-value materials that are solvent free and can be used as phytopharmaceuticals.
C3  - Book of Abstracts / 1st GREENERING International Conference, COST Action GREENERING CA 18224 Green Chemical Engineering Network towards upscaling sustainable processes, 15th - 16th February 2021
T1  - Supercritical CO2 impregnation - selection of suitable polymeric carrier for hemp seed oil
SP  - 47
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6893
ER  - 

@conference{
author = "Milovanović, Stoja and Lukić, Ivana and Tadić, Vanja and Frank, Almut",
year = "2021",
abstract = "Supercritical CO2 impregnation (SCI) process allows incorporation of bioactive components into solid carriers in an environmentally friendly manner. In recent years, SCI was highlighted as a promising method for preparation of added value materials that can protect bioactive components from environment (sun light, air, moisture etc.), stabilise them, and increase their shelf life. SCI process is also suitable for preparation of material with controlled release of bioactive component. Taking into account the above-mentioned, SCI process was employed in this study for incorporation of hemp seed oil (HSO) into biocompatible polymers (starch xerogel, starch aerogel, α-cyclodextrin, β-cyclodextrin, and γ-cyclodextrin). Given that efficiency of SCI depends on process conditions and affinity of bioactive component towards scCO2 and polymer, it is necessary to optimise process for every individual system. Proposed SCI process was performed at pressure of 30 MPa and temperature of 40 °C during 5 h and 18 h. FTIR analysis confirmed that scCO2 did not have effect on polymer composition nor it remained in polymer after process. Additionally, FTIR and UV-Vis analysis showed that HSO is present in all tested polymers after SCI process. It was shown that impregnation of HSO is highly dependent on selection of polymeric carrier (its chemical composition and morphology) and operating time employed, resulting in loadings from 0.5% to 40%. Chemical analysis showed that HSO is rich in unsaturated fatty acids especially linoleic acid (54-60%) and α-linolenic acid (17-20%). These essential fatty acids have well-established health benefits including protection against cardiovascular, neurodegenerative and inflammatory diseases. Proposed SCI process gave guidelines for development of added-value materials that are solvent free and can be used as phytopharmaceuticals.",
journal = "Book of Abstracts / 1st GREENERING International Conference, COST Action GREENERING CA 18224 Green Chemical Engineering Network towards upscaling sustainable processes, 15th - 16th February 2021",
title = "Supercritical CO2 impregnation - selection of suitable polymeric carrier for hemp seed oil",
pages = "47",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6893"
}

Milovanović, S., Lukić, I., Tadić, V.,& Frank, A.. (2021). Supercritical CO2 impregnation - selection of suitable polymeric carrier for hemp seed oil. in Book of Abstracts / 1st GREENERING International Conference, COST Action GREENERING CA 18224 Green Chemical Engineering Network towards upscaling sustainable processes, 15th - 16th February 2021, 47.
https://hdl.handle.net/21.15107/rcub_technorep_6893

Milovanović S, Lukić I, Tadić V, Frank A. Supercritical CO2 impregnation - selection of suitable polymeric carrier for hemp seed oil. in Book of Abstracts / 1st GREENERING International Conference, COST Action GREENERING CA 18224 Green Chemical Engineering Network towards upscaling sustainable processes, 15th - 16th February 2021. 2021;:47.
https://hdl.handle.net/21.15107/rcub_technorep_6893 .

Milovanović, Stoja, Lukić, Ivana, Tadić, Vanja, Frank, Almut, "Supercritical CO2 impregnation - selection of suitable polymeric carrier for hemp seed oil" in Book of Abstracts / 1st GREENERING International Conference, COST Action GREENERING CA 18224 Green Chemical Engineering Network towards upscaling sustainable processes, 15th - 16th February 2021 (2021):47,
https://hdl.handle.net/21.15107/rcub_technorep_6893 .

TY  - CONF
AU  - Milovanović, Stoja
AU  - Lukić, Ivana
AU  - Pajnik, Jelena
AU  - Maksimović, Svetolik
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6895
AB  - Starch is an abundant and low-cost polysaccharide obtained from renewable resources. Biocompatibility, biodegradability, and versatility of starch enable its application in several industries including food and pharmaceutical.
In this work, supercritical CO2 drying process was tested for preparation of stable and porous starch-based material. First, a hydrogel was formed from an aqueous solution (cornstarch to water mass ratio 1:10) at 95 °C. Subsequently, water was replaced with acetone during several days to form an acetogel. Finally, acetogels were subjected to supercritical CO2 drying at pressures of 8, 10, 20 MPa and temperatures of 35 and 45 °C up to 3 h to form aerogels. Obtained aerogels were compared with starch xerogels prepared by air drying of acetogels.
The SEM, FTIR, and porosity analysis confirmed significant effect of supercritical CO2 drying process conditions on starch aerogels properties and their suitability to form nanostructured matrices. SEM analysis showed that aerogels were filamentous with filament diameter less than 100 nm. Due to their low density (0.273-0.773 g/cm3) and high porosity (48-82%) obtained starch aerogels present promising candidates as matrices and carriers for bioactive substances.
C3  - 18th European Meeting of Supercritical fluids (EMSF), 3-6 May 2021, Bordeaux, France
T1  - Effect of supercritical CO2 drying process conditions on starch aerogel properties
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6895
ER  - 

@conference{
author = "Milovanović, Stoja and Lukić, Ivana and Pajnik, Jelena and Maksimović, Svetolik",
year = "2021",
abstract = "Starch is an abundant and low-cost polysaccharide obtained from renewable resources. Biocompatibility, biodegradability, and versatility of starch enable its application in several industries including food and pharmaceutical.
In this work, supercritical CO2 drying process was tested for preparation of stable and porous starch-based material. First, a hydrogel was formed from an aqueous solution (cornstarch to water mass ratio 1:10) at 95 °C. Subsequently, water was replaced with acetone during several days to form an acetogel. Finally, acetogels were subjected to supercritical CO2 drying at pressures of 8, 10, 20 MPa and temperatures of 35 and 45 °C up to 3 h to form aerogels. Obtained aerogels were compared with starch xerogels prepared by air drying of acetogels.
The SEM, FTIR, and porosity analysis confirmed significant effect of supercritical CO2 drying process conditions on starch aerogels properties and their suitability to form nanostructured matrices. SEM analysis showed that aerogels were filamentous with filament diameter less than 100 nm. Due to their low density (0.273-0.773 g/cm3) and high porosity (48-82%) obtained starch aerogels present promising candidates as matrices and carriers for bioactive substances.",
journal = "18th European Meeting of Supercritical fluids (EMSF), 3-6 May 2021, Bordeaux, France",
title = "Effect of supercritical CO2 drying process conditions on starch aerogel properties",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6895"
}

Milovanović, S., Lukić, I., Pajnik, J.,& Maksimović, S.. (2021). Effect of supercritical CO2 drying process conditions on starch aerogel properties. in 18th European Meeting of Supercritical fluids (EMSF), 3-6 May 2021, Bordeaux, France.
https://hdl.handle.net/21.15107/rcub_technorep_6895

Milovanović S, Lukić I, Pajnik J, Maksimović S. Effect of supercritical CO2 drying process conditions on starch aerogel properties. in 18th European Meeting of Supercritical fluids (EMSF), 3-6 May 2021, Bordeaux, France. 2021;.
https://hdl.handle.net/21.15107/rcub_technorep_6895 .

Milovanović, Stoja, Lukić, Ivana, Pajnik, Jelena, Maksimović, Svetolik, "Effect of supercritical CO2 drying process conditions on starch aerogel properties" in 18th European Meeting of Supercritical fluids (EMSF), 3-6 May 2021, Bordeaux, France (2021),
https://hdl.handle.net/21.15107/rcub_technorep_6895 .

TY  - CONF
AU  - Maksimović, Svetolik
AU  - Milovanović, Stoja
AU  - Ivanović, Jasna
AU  - Žižović, Irena
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6896
AB  - The coupling of supercritical fluid extraction and supercritical solvent impregnation processes has been proved to be convenient in cases where the active substance, to be incorporated in the solid carrier, is supercritical extract. The integrated process enables minimizing the loss of the extract by directly using the supercritical CO2-extract solution leaving the extractor vessel for the impregnation and avoidance of the intermediate decompression step in the separate processes (decompression after extraction), and consequently leads to energy and time savings.
The objective of this work was to examine the application of the integrated process for impregnation of chitosan/alginate and corn starch xerogels and aerogels with Helichrysum italicum supercritical CO2 extract. For that purpose, first chitosan/alginate and starch hydrogels were prepared by sol-gel method. Thereafter hydrogels were transformed into alcogels by water exchange with ethanol or acetone. Xerogels and aerogels were produced by air and supercritical CO2 drying of the alcogels or acetogels, respectively. Finally, impregnation of the xerogels and aerogels was performed in the laboratory unit for the integrated processes.
Both chitosan/alginate and starch xerogels and aerogels showed significant affinity for the incorporation of active principles from H. italicum which was confirmed by FTIR method. SEM method indicated significant differences in materials’ porosity. One of the reason for this is pore collapse phenomenon associated the formation of the xerogels. Obtained results confirmed that it is possible to impregnate chitosan/alginate and starch xerogels and aerogels with H. italicum extract by the integrated process of supercritical CO2 extraction and impregnation.
C3  - 18th European Meeting of Supercritical fluids (EMSF), 3-6 May 2021, Bordeaux, France
T1  - The integrated process of supercritical CO2 extraction from Helichrysum italicum and supercritical impregnation of biocompatible polymers with the obtained extract
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6896
ER  - 

@conference{
author = "Maksimović, Svetolik and Milovanović, Stoja and Ivanović, Jasna and Žižović, Irena",
year = "2021",
abstract = "The coupling of supercritical fluid extraction and supercritical solvent impregnation processes has been proved to be convenient in cases where the active substance, to be incorporated in the solid carrier, is supercritical extract. The integrated process enables minimizing the loss of the extract by directly using the supercritical CO2-extract solution leaving the extractor vessel for the impregnation and avoidance of the intermediate decompression step in the separate processes (decompression after extraction), and consequently leads to energy and time savings.
The objective of this work was to examine the application of the integrated process for impregnation of chitosan/alginate and corn starch xerogels and aerogels with Helichrysum italicum supercritical CO2 extract. For that purpose, first chitosan/alginate and starch hydrogels were prepared by sol-gel method. Thereafter hydrogels were transformed into alcogels by water exchange with ethanol or acetone. Xerogels and aerogels were produced by air and supercritical CO2 drying of the alcogels or acetogels, respectively. Finally, impregnation of the xerogels and aerogels was performed in the laboratory unit for the integrated processes.
Both chitosan/alginate and starch xerogels and aerogels showed significant affinity for the incorporation of active principles from H. italicum which was confirmed by FTIR method. SEM method indicated significant differences in materials’ porosity. One of the reason for this is pore collapse phenomenon associated the formation of the xerogels. Obtained results confirmed that it is possible to impregnate chitosan/alginate and starch xerogels and aerogels with H. italicum extract by the integrated process of supercritical CO2 extraction and impregnation.",
journal = "18th European Meeting of Supercritical fluids (EMSF), 3-6 May 2021, Bordeaux, France",
title = "The integrated process of supercritical CO2 extraction from Helichrysum italicum and supercritical impregnation of biocompatible polymers with the obtained extract",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6896"
}

Maksimović, S., Milovanović, S., Ivanović, J.,& Žižović, I.. (2021). The integrated process of supercritical CO2 extraction from Helichrysum italicum and supercritical impregnation of biocompatible polymers with the obtained extract. in 18th European Meeting of Supercritical fluids (EMSF), 3-6 May 2021, Bordeaux, France.
https://hdl.handle.net/21.15107/rcub_technorep_6896

Maksimović S, Milovanović S, Ivanović J, Žižović I. The integrated process of supercritical CO2 extraction from Helichrysum italicum and supercritical impregnation of biocompatible polymers with the obtained extract. in 18th European Meeting of Supercritical fluids (EMSF), 3-6 May 2021, Bordeaux, France. 2021;.
https://hdl.handle.net/21.15107/rcub_technorep_6896 .

Maksimović, Svetolik, Milovanović, Stoja, Ivanović, Jasna, Žižović, Irena, "The integrated process of supercritical CO2 extraction from Helichrysum italicum and supercritical impregnation of biocompatible polymers with the obtained extract" in 18th European Meeting of Supercritical fluids (EMSF), 3-6 May 2021, Bordeaux, France (2021),
https://hdl.handle.net/21.15107/rcub_technorep_6896 .