TY  - JOUR
AU  - Tomić, Simonida Lj.
AU  - Vuković, Jovana S.
AU  - Babić Radić, Marija M.
AU  - Filipović, Vuk V.
AU  - Živanović, Dubravka P.
AU  - Nikolić, Miloš M.
AU  - Nikodinović-Runić, Jasmina
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5869
AB  - Scaffolding biomaterials are gaining great importance due to their beneficial properties for medical purposes. Targeted biomaterial engineering strategies through the synergy of different material types can be applied to design hybrid scaffolding biomaterials with advantageous properties for biomedical applications. In our research, a novel combination of the bioactive agent Manuka honey (MHo) with 2-hydroxyethyl methacrylate/gelatin (HG) hydrogel scaffolds was created as an efficient bioactive platform for biomedical applications. The effects of Manuka honey content on structural characteristics, porosity, swelling performance, in vitro degradation, and in vitro biocompatibility (fibroblast and keratinocyte cell lines) of hybrid hydrogel scaffolds were studied using Fourier transform infrared spectroscopy, the gravimetric method, and in vitro MTT biocompatibility assays. The engineered hybrid hydrogel scaffolds show advantageous properties, including porosity in the range of 71.25% to 90.09%, specific pH- and temperature-dependent swelling performance, and convenient absorption capacity. In vitro degradation studies showed scaffold degradability ranging from 6.27% to 27.18% for four weeks. In vitro biocompatibility assays on healthy human fibroblast (MRC5 cells) and keratinocyte (HaCaT cells) cell lines by MTT tests showed that cell viability depends on the Manuka honey content loaded in the HG hydrogel scaffolds. A sample containing the highest Manuka honey content (30%) exhibited the best biocompatible properties. The obtained results reveal that the synergy of the bioactive agent, Manuka honey, with 2-hydroxyethyl methacrylate/gelatin as hybrid hydrogel scaffolds has potential for biomedical purposes. By tuning the Manuka honey content in HG hydrogel scaffolds advantageous properties of hybrid scaffolds can be achieved for biomedical applications.
PB  - MDPI
T2  - Polymers
T1  - Manuka Honey/2-Hydroxyethyl Methacrylate/Gelatin Hybrid Hydrogel Scaffolds for Potential Tissue Regeneration
IS  - 3
SP  - 589
VL  - 15
DO  - 10.3390/polym15030589
ER  - 

@article{
author = "Tomić, Simonida Lj. and Vuković, Jovana S. and Babić Radić, Marija M. and Filipović, Vuk V. and Živanović, Dubravka P. and Nikolić, Miloš M. and Nikodinović-Runić, Jasmina",
year = "2023",
abstract = "Scaffolding biomaterials are gaining great importance due to their beneficial properties for medical purposes. Targeted biomaterial engineering strategies through the synergy of different material types can be applied to design hybrid scaffolding biomaterials with advantageous properties for biomedical applications. In our research, a novel combination of the bioactive agent Manuka honey (MHo) with 2-hydroxyethyl methacrylate/gelatin (HG) hydrogel scaffolds was created as an efficient bioactive platform for biomedical applications. The effects of Manuka honey content on structural characteristics, porosity, swelling performance, in vitro degradation, and in vitro biocompatibility (fibroblast and keratinocyte cell lines) of hybrid hydrogel scaffolds were studied using Fourier transform infrared spectroscopy, the gravimetric method, and in vitro MTT biocompatibility assays. The engineered hybrid hydrogel scaffolds show advantageous properties, including porosity in the range of 71.25% to 90.09%, specific pH- and temperature-dependent swelling performance, and convenient absorption capacity. In vitro degradation studies showed scaffold degradability ranging from 6.27% to 27.18% for four weeks. In vitro biocompatibility assays on healthy human fibroblast (MRC5 cells) and keratinocyte (HaCaT cells) cell lines by MTT tests showed that cell viability depends on the Manuka honey content loaded in the HG hydrogel scaffolds. A sample containing the highest Manuka honey content (30%) exhibited the best biocompatible properties. The obtained results reveal that the synergy of the bioactive agent, Manuka honey, with 2-hydroxyethyl methacrylate/gelatin as hybrid hydrogel scaffolds has potential for biomedical purposes. By tuning the Manuka honey content in HG hydrogel scaffolds advantageous properties of hybrid scaffolds can be achieved for biomedical applications.",
publisher = "MDPI",
journal = "Polymers",
title = "Manuka Honey/2-Hydroxyethyl Methacrylate/Gelatin Hybrid Hydrogel Scaffolds for Potential Tissue Regeneration",
number = "3",
pages = "589",
volume = "15",
doi = "10.3390/polym15030589"
}

Tomić, S. Lj., Vuković, J. S., Babić Radić, M. M., Filipović, V. V., Živanović, D. P., Nikolić, M. M.,& Nikodinović-Runić, J.. (2023). Manuka Honey/2-Hydroxyethyl Methacrylate/Gelatin Hybrid Hydrogel Scaffolds for Potential Tissue Regeneration. in Polymers
MDPI., 15(3), 589.
https://doi.org/10.3390/polym15030589

Tomić SL, Vuković JS, Babić Radić MM, Filipović VV, Živanović DP, Nikolić MM, Nikodinović-Runić J. Manuka Honey/2-Hydroxyethyl Methacrylate/Gelatin Hybrid Hydrogel Scaffolds for Potential Tissue Regeneration. in Polymers. 2023;15(3):589.
doi:10.3390/polym15030589 .

Tomić, Simonida Lj., Vuković, Jovana S., Babić Radić, Marija M., Filipović, Vuk V., Živanović, Dubravka P., Nikolić, Miloš M., Nikodinović-Runić, Jasmina, "Manuka Honey/2-Hydroxyethyl Methacrylate/Gelatin Hybrid Hydrogel Scaffolds for Potential Tissue Regeneration" in Polymers, 15, no. 3 (2023):589,
https://doi.org/10.3390/polym15030589 . .

TY  - JOUR
AU  - Filipović, Vuk V.
AU  - Babić Radić, Marija M.
AU  - Vuković, Jovana S.
AU  - Vukomanović, Marija
AU  - Rubert, Marina
AU  - Hofmann, Sandra
AU  - Müller, Ralph
AU  - Tomić, Simonida Lj.
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5018
AB  - New composite 3D scaffolds were developed as a combination of synthetic polymer, poly(2-hydroxyethyl methacrylate) (PHEMA), and a natural polymer, gelatin, with a ceramic component, nanohydroxyapatite (ID nHAp) dopped with metal ions. The combination of a synthetic polymer, to be able to tune the structure and the physicochemical and mechanical properties, and a natural polymer, to ensure the specific biological functions of the scaffold, with inorganic filler was applied. The goal was to make a new material with superior properties for applications in the biomedical field which mimics as closely as possible the native bone extracellular matrix (ECM). Biodegradable PHEMA hydrogel was obtained by crosslinking HEMA by poly(beta-amino esters) (PBAE). The scaffold's physicochemical and mechanical properties, in vitro degradation, and biological activity were assessed so to study the effects of the incorporation of nHAp in the (PHEMA/PBAE/gelatin) hydrogel, as well as the effect of the different pore-forming methods. Cryogels had higher elasticity, swelling, porosity, and percent of mass loss during degradation than the samples obtained by porogenation. The composite scaffolds had a higher mechanical strength, 10.14 MPa for the porogenated samples and 5.87 MPa for the cryogels, but a slightly lower degree of swelling, percent of mass loss, and porosity than the hybrid ones. All the scaffolds were nontoxic and had a high cell adhesion rate, which was 15-20% higher in the composite samples. Cell metabolic activity after 2 and 7 days of culture was higher in the composites, although not statistically different. After 28 days, cell metabolic activity was similar in all scaffolds and the TCP control. No effect of integrating nHAp into the scaffolds on osteogenic cell differentiation could be observed. Synergetic effects occurred which influenced the mechanical behavior, structure, physicochemical properties, and interactions with biological species.
T2  - Polymers
T1  - Biodegradable Hydrogel Scaffolds Based on 2-Hydroxyethyl Methacrylate, Gelatin, Poly(beta-amino esters), and Hydroxyapatite
IS  - 1
SP  - 18
VL  - 14
DO  - 10.3390/polym14010018
ER  - 

@article{
author = "Filipović, Vuk V. and Babić Radić, Marija M. and Vuković, Jovana S. and Vukomanović, Marija and Rubert, Marina and Hofmann, Sandra and Müller, Ralph and Tomić, Simonida Lj.",
year = "2022",
abstract = "New composite 3D scaffolds were developed as a combination of synthetic polymer, poly(2-hydroxyethyl methacrylate) (PHEMA), and a natural polymer, gelatin, with a ceramic component, nanohydroxyapatite (ID nHAp) dopped with metal ions. The combination of a synthetic polymer, to be able to tune the structure and the physicochemical and mechanical properties, and a natural polymer, to ensure the specific biological functions of the scaffold, with inorganic filler was applied. The goal was to make a new material with superior properties for applications in the biomedical field which mimics as closely as possible the native bone extracellular matrix (ECM). Biodegradable PHEMA hydrogel was obtained by crosslinking HEMA by poly(beta-amino esters) (PBAE). The scaffold's physicochemical and mechanical properties, in vitro degradation, and biological activity were assessed so to study the effects of the incorporation of nHAp in the (PHEMA/PBAE/gelatin) hydrogel, as well as the effect of the different pore-forming methods. Cryogels had higher elasticity, swelling, porosity, and percent of mass loss during degradation than the samples obtained by porogenation. The composite scaffolds had a higher mechanical strength, 10.14 MPa for the porogenated samples and 5.87 MPa for the cryogels, but a slightly lower degree of swelling, percent of mass loss, and porosity than the hybrid ones. All the scaffolds were nontoxic and had a high cell adhesion rate, which was 15-20% higher in the composite samples. Cell metabolic activity after 2 and 7 days of culture was higher in the composites, although not statistically different. After 28 days, cell metabolic activity was similar in all scaffolds and the TCP control. No effect of integrating nHAp into the scaffolds on osteogenic cell differentiation could be observed. Synergetic effects occurred which influenced the mechanical behavior, structure, physicochemical properties, and interactions with biological species.",
journal = "Polymers",
title = "Biodegradable Hydrogel Scaffolds Based on 2-Hydroxyethyl Methacrylate, Gelatin, Poly(beta-amino esters), and Hydroxyapatite",
number = "1",
pages = "18",
volume = "14",
doi = "10.3390/polym14010018"
}

Filipović, V. V., Babić Radić, M. M., Vuković, J. S., Vukomanović, M., Rubert, M., Hofmann, S., Müller, R.,& Tomić, S. Lj.. (2022). Biodegradable Hydrogel Scaffolds Based on 2-Hydroxyethyl Methacrylate, Gelatin, Poly(beta-amino esters), and Hydroxyapatite. in Polymers, 14(1), 18.
https://doi.org/10.3390/polym14010018

Filipović VV, Babić Radić MM, Vuković JS, Vukomanović M, Rubert M, Hofmann S, Müller R, Tomić SL. Biodegradable Hydrogel Scaffolds Based on 2-Hydroxyethyl Methacrylate, Gelatin, Poly(beta-amino esters), and Hydroxyapatite. in Polymers. 2022;14(1):18.
doi:10.3390/polym14010018 .

Filipović, Vuk V., Babić Radić, Marija M., Vuković, Jovana S., Vukomanović, Marija, Rubert, Marina, Hofmann, Sandra, Müller, Ralph, Tomić, Simonida Lj., "Biodegradable Hydrogel Scaffolds Based on 2-Hydroxyethyl Methacrylate, Gelatin, Poly(beta-amino esters), and Hydroxyapatite" in Polymers, 14, no. 1 (2022):18,
https://doi.org/10.3390/polym14010018 . .

TY  - JOUR
AU  - Babić Radić, Marija M.
AU  - Filipovic, Vuk V.
AU  - Vukomanovic, Marija
AU  - Nikodinović-Runić, Jasmina
AU  - Tomić, Simonida
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5023
AB  - The design and evaluation of novel 2-hydroxyethyl methacrylate/gelatin/alginate/graphene oxide hydrogels as innovative scaffolding biomaterials, which concurrently are the suitable drug delivery carrier, was proposed. The hydrogels were prepared by the adapted porogen leaching method; this is also the first time this method has been used to incorporate nanocolloidal graphene oxide through the hydrogel and simultaneously form porous structures. The effects of a material's composition on its chemical, morphological, mechanical, and swelling properties, as well as on cell viability and in vitro degradation, were assessed using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), measurements of Young's modulus, gravimetric method and MTT test, respectively. The engineered hydrogels show good swelling capacity, fully hydrophilic surfaces, tunable porosity (from 56 to 76%) and mechanical properties (from 1.69 to 4.78 MPa), curcumin entrapment efficiency above 99% and excellent curcumin release performances. In vitro cytotoxicity on healthy human fibroblast (MRC5 cells) by MTT test reveal that the materials are nontoxic and biocompatible, proposing novel hydrogels for in vivo clinical evaluation to optimize tissue regeneration treatments by coupling the hydrogels with cells and different active agents to create material/biofactor hybrids with new levels of biofunctionality.
T2  - Gels
T1  - Degradable 2-Hydroxyethyl Methacrylate/Gelatin/Alginate Hydrogels Infused by Nanocolloidal Graphene Oxide as Promising Drug Delivery and Scaffolding Biomaterials
IS  - 1
SP  - 22
VL  - 8
DO  - 10.3390/gels8010022
ER  - 

@article{
author = "Babić Radić, Marija M. and Filipovic, Vuk V. and Vukomanovic, Marija and Nikodinović-Runić, Jasmina and Tomić, Simonida",
year = "2022",
abstract = "The design and evaluation of novel 2-hydroxyethyl methacrylate/gelatin/alginate/graphene oxide hydrogels as innovative scaffolding biomaterials, which concurrently are the suitable drug delivery carrier, was proposed. The hydrogels were prepared by the adapted porogen leaching method; this is also the first time this method has been used to incorporate nanocolloidal graphene oxide through the hydrogel and simultaneously form porous structures. The effects of a material's composition on its chemical, morphological, mechanical, and swelling properties, as well as on cell viability and in vitro degradation, were assessed using Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), measurements of Young's modulus, gravimetric method and MTT test, respectively. The engineered hydrogels show good swelling capacity, fully hydrophilic surfaces, tunable porosity (from 56 to 76%) and mechanical properties (from 1.69 to 4.78 MPa), curcumin entrapment efficiency above 99% and excellent curcumin release performances. In vitro cytotoxicity on healthy human fibroblast (MRC5 cells) by MTT test reveal that the materials are nontoxic and biocompatible, proposing novel hydrogels for in vivo clinical evaluation to optimize tissue regeneration treatments by coupling the hydrogels with cells and different active agents to create material/biofactor hybrids with new levels of biofunctionality.",
journal = "Gels",
title = "Degradable 2-Hydroxyethyl Methacrylate/Gelatin/Alginate Hydrogels Infused by Nanocolloidal Graphene Oxide as Promising Drug Delivery and Scaffolding Biomaterials",
number = "1",
pages = "22",
volume = "8",
doi = "10.3390/gels8010022"
}

Babić Radić, M. M., Filipovic, V. V., Vukomanovic, M., Nikodinović-Runić, J.,& Tomić, S.. (2022). Degradable 2-Hydroxyethyl Methacrylate/Gelatin/Alginate Hydrogels Infused by Nanocolloidal Graphene Oxide as Promising Drug Delivery and Scaffolding Biomaterials. in Gels, 8(1), 22.
https://doi.org/10.3390/gels8010022

Babić Radić MM, Filipovic VV, Vukomanovic M, Nikodinović-Runić J, Tomić S. Degradable 2-Hydroxyethyl Methacrylate/Gelatin/Alginate Hydrogels Infused by Nanocolloidal Graphene Oxide as Promising Drug Delivery and Scaffolding Biomaterials. in Gels. 2022;8(1):22.
doi:10.3390/gels8010022 .

Babić Radić, Marija M., Filipovic, Vuk V., Vukomanovic, Marija, Nikodinović-Runić, Jasmina, Tomić, Simonida, "Degradable 2-Hydroxyethyl Methacrylate/Gelatin/Alginate Hydrogels Infused by Nanocolloidal Graphene Oxide as Promising Drug Delivery and Scaffolding Biomaterials" in Gels, 8, no. 1 (2022):22,
https://doi.org/10.3390/gels8010022 . .

TY  - JOUR
AU  - Tomić, Simonida Lj.
AU  - Vuković, Jovana S.
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5065
AB  - The design and use of new potent and specific antimicrobial systems are of crucial importance in the medical field. This will help relieve, fight, and eradicate infections and thus improve
human health. The use of metals in various forms as antimicrobial therapeutics has been known since
ancient times. In this sense, polymeric hydrogel matrices as multifunctional materials and in combination with various metal forms can be a great alternative to conventional treatments for infections.
Hydrogels possess high hydrophilicity, specific three-dimensional networks, fine biocompatibility,
and cell adhesion and are therefore suitable as materials for the loading of active antimicrobial agents
and acting in antimicrobial areas. The biocompatible nature of hydrogels’ matrices makes them a
convenient starting platform to develop biocompatible, selective, active controlled-release antimicrobial materials. Hydrogels based on acrylate and itaconic acid were synthesized and loaded with
silver (Ag+
), copper (Cu2+), and zinc (Zn2+) ions as a controlled release and antimicrobial system to
test release properties and antimicrobial activity in contact with microbes. The metal ions/hydrogel
systems exhibited favorable biocompatibility, release profiles, and antimicrobial activity against
methicillin-sensitive Staphylococcus aureus (MSSA), methicillin-resistant Staphylococcus aureus (MRSA),
Staphylococcus aureus, Escherichia coli, and Candida albicans microbes, and have shown that they have
the capacity to “fight” with the life-threatening infections. Antimicrobial activity depends on types
of metal ions, the composition of polymeric matrices, as well as the types of microbes. Designed
metal ions/poly(acrylate/itaconic acid) antimicrobial systems have shown to have good potential as
antimicrobial therapeutics and suitable biomaterials for medical applications.
PB  - MDPI
T2  - Inorganics
T1  - Antimicrobial Activity of Silver, Copper, and Zinc Ions/Poly(Acrylate/Itaconic Acid) Hydrogel Matrices
IS  - 3
SP  - 38
VL  - 10
DO  - 10.3390/inorganics10030038
ER  - 

@article{
author = "Tomić, Simonida Lj. and Vuković, Jovana S.",
year = "2022",
abstract = "The design and use of new potent and specific antimicrobial systems are of crucial importance in the medical field. This will help relieve, fight, and eradicate infections and thus improve
human health. The use of metals in various forms as antimicrobial therapeutics has been known since
ancient times. In this sense, polymeric hydrogel matrices as multifunctional materials and in combination with various metal forms can be a great alternative to conventional treatments for infections.
Hydrogels possess high hydrophilicity, specific three-dimensional networks, fine biocompatibility,
and cell adhesion and are therefore suitable as materials for the loading of active antimicrobial agents
and acting in antimicrobial areas. The biocompatible nature of hydrogels’ matrices makes them a
convenient starting platform to develop biocompatible, selective, active controlled-release antimicrobial materials. Hydrogels based on acrylate and itaconic acid were synthesized and loaded with
silver (Ag+
), copper (Cu2+), and zinc (Zn2+) ions as a controlled release and antimicrobial system to
test release properties and antimicrobial activity in contact with microbes. The metal ions/hydrogel
systems exhibited favorable biocompatibility, release profiles, and antimicrobial activity against
methicillin-sensitive Staphylococcus aureus (MSSA), methicillin-resistant Staphylococcus aureus (MRSA),
Staphylococcus aureus, Escherichia coli, and Candida albicans microbes, and have shown that they have
the capacity to “fight” with the life-threatening infections. Antimicrobial activity depends on types
of metal ions, the composition of polymeric matrices, as well as the types of microbes. Designed
metal ions/poly(acrylate/itaconic acid) antimicrobial systems have shown to have good potential as
antimicrobial therapeutics and suitable biomaterials for medical applications.",
publisher = "MDPI",
journal = "Inorganics",
title = "Antimicrobial Activity of Silver, Copper, and Zinc Ions/Poly(Acrylate/Itaconic Acid) Hydrogel Matrices",
number = "3",
pages = "38",
volume = "10",
doi = "10.3390/inorganics10030038"
}

Tomić, S. Lj.,& Vuković, J. S.. (2022). Antimicrobial Activity of Silver, Copper, and Zinc Ions/Poly(Acrylate/Itaconic Acid) Hydrogel Matrices. in Inorganics
MDPI., 10(3), 38.
https://doi.org/10.3390/inorganics10030038

Tomić SL, Vuković JS. Antimicrobial Activity of Silver, Copper, and Zinc Ions/Poly(Acrylate/Itaconic Acid) Hydrogel Matrices. in Inorganics. 2022;10(3):38.
doi:10.3390/inorganics10030038 .

Tomić, Simonida Lj., Vuković, Jovana S., "Antimicrobial Activity of Silver, Copper, and Zinc Ions/Poly(Acrylate/Itaconic Acid) Hydrogel Matrices" in Inorganics, 10, no. 3 (2022):38,
https://doi.org/10.3390/inorganics10030038 . .

TY  - JOUR
AU  - Babić Radić, Marija M.
AU  - Filipović, Vuk V.
AU  - Vuković, Jovana S.
AU  - Vukomanović, Marija
AU  - Rubert, Marina
AU  - Hofmann, Sandra
AU  - Müller, Ralph
AU  - Tomić, Simonida Lj.
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5201
AB  - Our goal was to create bioimitated scaffolding materials for biomedical purposes. The guiding idea was that we used an interpenetrating structural hierarchy of natural extracellular matrix as a “pattern” to design hydrogel scaffolds that show favorable properties for tissue regeneration. Polymeric hydrogel scaffolds are made in a simple, environmentally friendly way without additional functionalization. Gelatin and 2-hydroxyethyl methacrylate were selected to prepare interpenetrating polymeric networks and linear alginate chains were added as an interpenetrant to study their influence on the scaffold’s functionalities. Cryogelation and porogenation methods were used to obtain the designed scaffolding biomaterials. The scaffold’s structural, morphological, and mechanical properties, in vitro degradation, and cell viability properties were assessed to study the effects of the preparation method and alginate loading. Apatite as an inorganic agent was incorporated into cryogelated scaffolds to perform an extensive biological assay. Cryogelated scaffolds possess superior functionalities essential for tissue regeneration: fully hydrophilicity, degradability and mechanical features (2.08–9.75 MPa), and an optimal LDH activity. Furthermore, cryogelated scaffolds loaded with apatite showed good cell adhesion capacity, biocompatibility, and non-toxic behavior. All scaffolds performed equally in terms of metabolic activity and osteoconductivity. Cryogelated scaffolds with/without HAp could represent a new advance to promote osteoconductivity and enhance hard tissue repair. The obtained series of scaffolding biomaterials described here can provide a wide range of potential applications in the area of biomedical engineering.
PB  - MDPI
T2  - Polymers
T1  - Bioactive Interpenetrating Hydrogel Networks Based on 2-Hydroxyethyl Methacrylate and Gelatin Intertwined with Alginate and Dopped with Apatite as Scaffolding Biomaterials
IS  - 15
SP  - 3112
VL  - 14
DO  - 10.3390/polym14153112
ER  - 

@article{
author = "Babić Radić, Marija M. and Filipović, Vuk V. and Vuković, Jovana S. and Vukomanović, Marija and Rubert, Marina and Hofmann, Sandra and Müller, Ralph and Tomić, Simonida Lj.",
year = "2022",
abstract = "Our goal was to create bioimitated scaffolding materials for biomedical purposes. The guiding idea was that we used an interpenetrating structural hierarchy of natural extracellular matrix as a “pattern” to design hydrogel scaffolds that show favorable properties for tissue regeneration. Polymeric hydrogel scaffolds are made in a simple, environmentally friendly way without additional functionalization. Gelatin and 2-hydroxyethyl methacrylate were selected to prepare interpenetrating polymeric networks and linear alginate chains were added as an interpenetrant to study their influence on the scaffold’s functionalities. Cryogelation and porogenation methods were used to obtain the designed scaffolding biomaterials. The scaffold’s structural, morphological, and mechanical properties, in vitro degradation, and cell viability properties were assessed to study the effects of the preparation method and alginate loading. Apatite as an inorganic agent was incorporated into cryogelated scaffolds to perform an extensive biological assay. Cryogelated scaffolds possess superior functionalities essential for tissue regeneration: fully hydrophilicity, degradability and mechanical features (2.08–9.75 MPa), and an optimal LDH activity. Furthermore, cryogelated scaffolds loaded with apatite showed good cell adhesion capacity, biocompatibility, and non-toxic behavior. All scaffolds performed equally in terms of metabolic activity and osteoconductivity. Cryogelated scaffolds with/without HAp could represent a new advance to promote osteoconductivity and enhance hard tissue repair. The obtained series of scaffolding biomaterials described here can provide a wide range of potential applications in the area of biomedical engineering.",
publisher = "MDPI",
journal = "Polymers",
title = "Bioactive Interpenetrating Hydrogel Networks Based on 2-Hydroxyethyl Methacrylate and Gelatin Intertwined with Alginate and Dopped with Apatite as Scaffolding Biomaterials",
number = "15",
pages = "3112",
volume = "14",
doi = "10.3390/polym14153112"
}

Babić Radić, M. M., Filipović, V. V., Vuković, J. S., Vukomanović, M., Rubert, M., Hofmann, S., Müller, R.,& Tomić, S. Lj.. (2022). Bioactive Interpenetrating Hydrogel Networks Based on 2-Hydroxyethyl Methacrylate and Gelatin Intertwined with Alginate and Dopped with Apatite as Scaffolding Biomaterials. in Polymers
MDPI., 14(15), 3112.
https://doi.org/10.3390/polym14153112

Babić Radić MM, Filipović VV, Vuković JS, Vukomanović M, Rubert M, Hofmann S, Müller R, Tomić SL. Bioactive Interpenetrating Hydrogel Networks Based on 2-Hydroxyethyl Methacrylate and Gelatin Intertwined with Alginate and Dopped with Apatite as Scaffolding Biomaterials. in Polymers. 2022;14(15):3112.
doi:10.3390/polym14153112 .

Babić Radić, Marija M., Filipović, Vuk V., Vuković, Jovana S., Vukomanović, Marija, Rubert, Marina, Hofmann, Sandra, Müller, Ralph, Tomić, Simonida Lj., "Bioactive Interpenetrating Hydrogel Networks Based on 2-Hydroxyethyl Methacrylate and Gelatin Intertwined with Alginate and Dopped with Apatite as Scaffolding Biomaterials" in Polymers, 14, no. 15 (2022):3112,
https://doi.org/10.3390/polym14153112 . .

TY  - JOUR
AU  - Vuković, Jovana S.
AU  - Filipović, Vuk V.
AU  - Babić Radić, Marija M.
AU  - Vukomanović, Marija
AU  - Milivojević, Dušan
AU  - Ilić-Tomić, Tatjana
AU  - Nikodinović-Runić, Jasmina
AU  - Tomić, Simonida Lj.
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5242
AB  - Scaffold hydrogel biomaterials designed to have advantageous biofunctional properties, which can be applied for controlled bioactive agent release, represent an important concept in biomedical tissue engineering. Our goal was to create scaffolding materials that mimic living tissue for biomedical utilization. In this study, two novel series of interpenetrating hydrogel networks (IPNs) based on 2-hydroxyethyl methacrylate/gelatin and 2-hydroxyethyl methacrylate/alginate were crosslinked using N-ethyl-N′-(3-dimethyl aminopropyl)carbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS). Characterization included examining the effects of crosslinker type and concentration on structure, morphological and mechanical properties, in vitro swelling, hydrophilicity as well as on the in vitro cell viability (fibroblast cells) and in vivo (Caenorhabditis elegans) interactions of novel biomaterials. The engineered IPN hydrogel scaffolds show an interconnected pore morphology and porosity range of 62.36 to 85.20%, favorable in vitro swelling capacity, full hydrophilicity, and Young’s modulus values in the range of 1.40 to 7.50 MPa. In vitro assay on healthy human fibroblast (MRC5 cells) by MTT test and in vivo (Caenorhabditis elegans) survival assays show the advantageous biocompatible properties of novel IPN hydrogel scaffolds. Furthermore, in vitro controlled release study of the therapeutic agent resveratrol showed that these novel scaffolding systems are suitable controlled release platforms. The results revealed that the use of EDC and the combination of EDC/NHS crosslinkers can be applied to prepare and tune the properties of the IPN 2-hydroxyethyl methacrylate/alginate and 2-hydroxyethyl methacrylate/gelatin hydrogel scaffolds series, which have shown great potential for biomedical engineering applications.
PB  - MDPI
T2  - Polymers
T1  - In Vitro and In Vivo Biocompatible and Controlled Resveratrol Release Performances of HEMA/Alginate and HEMA/Gelatin IPN Hydrogel Scaffolds
IS  - 20
SP  - 4459
VL  - 14
DO  - 10.3390/polym14204459
ER  - 

@article{
author = "Vuković, Jovana S. and Filipović, Vuk V. and Babić Radić, Marija M. and Vukomanović, Marija and Milivojević, Dušan and Ilić-Tomić, Tatjana and Nikodinović-Runić, Jasmina and Tomić, Simonida Lj.",
year = "2022",
abstract = "Scaffold hydrogel biomaterials designed to have advantageous biofunctional properties, which can be applied for controlled bioactive agent release, represent an important concept in biomedical tissue engineering. Our goal was to create scaffolding materials that mimic living tissue for biomedical utilization. In this study, two novel series of interpenetrating hydrogel networks (IPNs) based on 2-hydroxyethyl methacrylate/gelatin and 2-hydroxyethyl methacrylate/alginate were crosslinked using N-ethyl-N′-(3-dimethyl aminopropyl)carbodiimide hydrochloride (EDC) and N-hydroxysuccinimide (NHS). Characterization included examining the effects of crosslinker type and concentration on structure, morphological and mechanical properties, in vitro swelling, hydrophilicity as well as on the in vitro cell viability (fibroblast cells) and in vivo (Caenorhabditis elegans) interactions of novel biomaterials. The engineered IPN hydrogel scaffolds show an interconnected pore morphology and porosity range of 62.36 to 85.20%, favorable in vitro swelling capacity, full hydrophilicity, and Young’s modulus values in the range of 1.40 to 7.50 MPa. In vitro assay on healthy human fibroblast (MRC5 cells) by MTT test and in vivo (Caenorhabditis elegans) survival assays show the advantageous biocompatible properties of novel IPN hydrogel scaffolds. Furthermore, in vitro controlled release study of the therapeutic agent resveratrol showed that these novel scaffolding systems are suitable controlled release platforms. The results revealed that the use of EDC and the combination of EDC/NHS crosslinkers can be applied to prepare and tune the properties of the IPN 2-hydroxyethyl methacrylate/alginate and 2-hydroxyethyl methacrylate/gelatin hydrogel scaffolds series, which have shown great potential for biomedical engineering applications.",
publisher = "MDPI",
journal = "Polymers",
title = "In Vitro and In Vivo Biocompatible and Controlled Resveratrol Release Performances of HEMA/Alginate and HEMA/Gelatin IPN Hydrogel Scaffolds",
number = "20",
pages = "4459",
volume = "14",
doi = "10.3390/polym14204459"
}

Vuković, J. S., Filipović, V. V., Babić Radić, M. M., Vukomanović, M., Milivojević, D., Ilić-Tomić, T., Nikodinović-Runić, J.,& Tomić, S. Lj.. (2022). In Vitro and In Vivo Biocompatible and Controlled Resveratrol Release Performances of HEMA/Alginate and HEMA/Gelatin IPN Hydrogel Scaffolds. in Polymers
MDPI., 14(20), 4459.
https://doi.org/10.3390/polym14204459

Vuković JS, Filipović VV, Babić Radić MM, Vukomanović M, Milivojević D, Ilić-Tomić T, Nikodinović-Runić J, Tomić SL. In Vitro and In Vivo Biocompatible and Controlled Resveratrol Release Performances of HEMA/Alginate and HEMA/Gelatin IPN Hydrogel Scaffolds. in Polymers. 2022;14(20):4459.
doi:10.3390/polym14204459 .

Vuković, Jovana S., Filipović, Vuk V., Babić Radić, Marija M., Vukomanović, Marija, Milivojević, Dušan, Ilić-Tomić, Tatjana, Nikodinović-Runić, Jasmina, Tomić, Simonida Lj., "In Vitro and In Vivo Biocompatible and Controlled Resveratrol Release Performances of HEMA/Alginate and HEMA/Gelatin IPN Hydrogel Scaffolds" in Polymers, 14, no. 20 (2022):4459,
https://doi.org/10.3390/polym14204459 . .

TY  - JOUR
AU  - Tomić, Simonida
AU  - Nikodinović-Runić, Jasmina
AU  - Vukomanovic, Marija
AU  - Babić, Marija M.
AU  - Vuković, Jovana
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4926
AB  - Hydrogel scaffolding biomaterials are one of the most attractive polymeric biomaterials for regenerative engineering and can be engineered into tissue mimetic scaffolds to support cell growth due to their similarity to the native extracellular matrix. The novel, versatile hydrogel scaffolds based on alginate, gelatin, 2-hydroxyethyl methacrylate, and inorganic agent hydroxyapatite were prepared by modified cryogelation. The chemical composition, morphology, porosity, mechanical properties, effects on cell viability, in vitro degradation, in vitro and in vivo biocompatibility were tested to correlate the material's composition with the corresponding properties. Scaffolds showed an interconnected porous microstructure, satisfactory mechanical strength, favorable hydrophilicity, degradation, and suitable in vitro and in vivo biocompatible behavior. Materials showed good biocompatibility with healthy human fibroblast in cell culture, as well as in vivo with zebrafish assay, suggesting newly synthesized hydrogel scaffolds as a potential new generation of hydrogel scaffolding biomaterials with tunable properties for versatile biomedical applications and tissue regeneration.
T2  - Polymers
T1  - Novel Hydrogel Scaffolds Based on Alginate, Gelatin, 2-Hydroxyethyl Methacrylate, and Hydroxyapatite
IS  - 6
SP  - 932
VL  - 13
DO  - 10.3390/polym13060932
ER  - 

@article{
author = "Tomić, Simonida and Nikodinović-Runić, Jasmina and Vukomanovic, Marija and Babić, Marija M. and Vuković, Jovana",
year = "2021",
abstract = "Hydrogel scaffolding biomaterials are one of the most attractive polymeric biomaterials for regenerative engineering and can be engineered into tissue mimetic scaffolds to support cell growth due to their similarity to the native extracellular matrix. The novel, versatile hydrogel scaffolds based on alginate, gelatin, 2-hydroxyethyl methacrylate, and inorganic agent hydroxyapatite were prepared by modified cryogelation. The chemical composition, morphology, porosity, mechanical properties, effects on cell viability, in vitro degradation, in vitro and in vivo biocompatibility were tested to correlate the material's composition with the corresponding properties. Scaffolds showed an interconnected porous microstructure, satisfactory mechanical strength, favorable hydrophilicity, degradation, and suitable in vitro and in vivo biocompatible behavior. Materials showed good biocompatibility with healthy human fibroblast in cell culture, as well as in vivo with zebrafish assay, suggesting newly synthesized hydrogel scaffolds as a potential new generation of hydrogel scaffolding biomaterials with tunable properties for versatile biomedical applications and tissue regeneration.",
journal = "Polymers",
title = "Novel Hydrogel Scaffolds Based on Alginate, Gelatin, 2-Hydroxyethyl Methacrylate, and Hydroxyapatite",
number = "6",
pages = "932",
volume = "13",
doi = "10.3390/polym13060932"
}

Tomić, S., Nikodinović-Runić, J., Vukomanovic, M., Babić, M. M.,& Vuković, J.. (2021). Novel Hydrogel Scaffolds Based on Alginate, Gelatin, 2-Hydroxyethyl Methacrylate, and Hydroxyapatite. in Polymers, 13(6), 932.
https://doi.org/10.3390/polym13060932

Tomić S, Nikodinović-Runić J, Vukomanovic M, Babić MM, Vuković J. Novel Hydrogel Scaffolds Based on Alginate, Gelatin, 2-Hydroxyethyl Methacrylate, and Hydroxyapatite. in Polymers. 2021;13(6):932.
doi:10.3390/polym13060932 .

Tomić, Simonida, Nikodinović-Runić, Jasmina, Vukomanovic, Marija, Babić, Marija M., Vuković, Jovana, "Novel Hydrogel Scaffolds Based on Alginate, Gelatin, 2-Hydroxyethyl Methacrylate, and Hydroxyapatite" in Polymers, 13, no. 6 (2021):932,
https://doi.org/10.3390/polym13060932 . .

TY  - JOUR
AU  - Stefanović, Ivan
AU  - Džunuzović, Jasna
AU  - Džunuzović, Enis
AU  - Dapčević, Aleksandra
AU  - Šešlija, Sanja
AU  - Balanč, Bojana
AU  - Dobrzyńska-Mizera, Monika
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4
AB  - This work was focused on the synthesis of polyurethane networks (PUNs) based on polycaprolactone (PCL) as soft segment (SS) and Boltorn (R) aliphatic hyperbranched polyester of the second pseudo generation and 4,4 '-diphenylmethane diisocyanate (MDI) as the parts of the hard segments (HS), by a two-step solution polymerization. In order to find the best ratio between HS and SS to achieve good thermal and mechanical properties, suitable hydrophobicity and morphology of the PUNs, various experimental analyses were conducted. The obtained results revealed that features of the PUNs highly depend on the PCL content. The increase in the PCL content leads to the increase in thermal stability, hydrophobicity and appearance of the microphase separation, but on the other side, it also leads to the decrease in storage modulus in the rubbery plateau, crosslinking density and glass transition temperatures of PUNs. This work shows that features of PUNs can be easily adjusted for a specific application by careful selection of the SS and HS ratio.
PB  - Springer, New York
T2  - Polymer Bulletin
T1  - Composition-property relationship of polyurethane networks based on polycaprolactone diol
EP  - 7128
SP  - 7103
VL  - 78
DO  - 10.1007/s00289-020-03473-0
ER  - 

@article{
author = "Stefanović, Ivan and Džunuzović, Jasna and Džunuzović, Enis and Dapčević, Aleksandra and Šešlija, Sanja and Balanč, Bojana and Dobrzyńska-Mizera, Monika",
year = "2021",
abstract = "This work was focused on the synthesis of polyurethane networks (PUNs) based on polycaprolactone (PCL) as soft segment (SS) and Boltorn (R) aliphatic hyperbranched polyester of the second pseudo generation and 4,4 '-diphenylmethane diisocyanate (MDI) as the parts of the hard segments (HS), by a two-step solution polymerization. In order to find the best ratio between HS and SS to achieve good thermal and mechanical properties, suitable hydrophobicity and morphology of the PUNs, various experimental analyses were conducted. The obtained results revealed that features of the PUNs highly depend on the PCL content. The increase in the PCL content leads to the increase in thermal stability, hydrophobicity and appearance of the microphase separation, but on the other side, it also leads to the decrease in storage modulus in the rubbery plateau, crosslinking density and glass transition temperatures of PUNs. This work shows that features of PUNs can be easily adjusted for a specific application by careful selection of the SS and HS ratio.",
publisher = "Springer, New York",
journal = "Polymer Bulletin",
title = "Composition-property relationship of polyurethane networks based on polycaprolactone diol",
pages = "7128-7103",
volume = "78",
doi = "10.1007/s00289-020-03473-0"
}

Stefanović, I., Džunuzović, J., Džunuzović, E., Dapčević, A., Šešlija, S., Balanč, B.,& Dobrzyńska-Mizera, M.. (2021). Composition-property relationship of polyurethane networks based on polycaprolactone diol. in Polymer Bulletin
Springer, New York., 78, 7103-7128.
https://doi.org/10.1007/s00289-020-03473-0

Stefanović I, Džunuzović J, Džunuzović E, Dapčević A, Šešlija S, Balanč B, Dobrzyńska-Mizera M. Composition-property relationship of polyurethane networks based on polycaprolactone diol. in Polymer Bulletin. 2021;78:7103-7128.
doi:10.1007/s00289-020-03473-0 .

Stefanović, Ivan, Džunuzović, Jasna, Džunuzović, Enis, Dapčević, Aleksandra, Šešlija, Sanja, Balanč, Bojana, Dobrzyńska-Mizera, Monika, "Composition-property relationship of polyurethane networks based on polycaprolactone diol" in Polymer Bulletin, 78 (2021):7103-7128,
https://doi.org/10.1007/s00289-020-03473-0 . .

TY  - JOUR
AU  - Godiya, Chirag B.
AU  - Marcantoni, Enrico
AU  - Dunjić, Branko
AU  - Tomić, Miloš
AU  - Nikolić, Marija
AU  - Maletaškić, Jelena
AU  - Đonlagić, Jasna
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/15
AB  - Poly(methyl methacrylate) (PMMA)/clay nanocomposites (NCs) were prepared by suspension polymerization of methyl methacrylate in the presence of two different organoclays (Cloisite 30B, Cloisite 15A) with clay loading ranged from 0.5 to 5 wt%. Increase in molecular weight of the PMMA matrix with addition of the clay was revealed by gel permeation chromatography (GPC) and intrinsic viscosity measurements. As confirmed by X-ray diffraction (XRD), the NCs had an intercalated structure. The organoclays-MMA/PMMA compatibility was investigated by swelling tests and solubility parameter approach. Rheological behavior of PMMA NCs in molten state was analyzed through construction of master curves of complex viscosity, storage, and loss modulus by applying the time-temperature superposition procedure. Melt rheology, scanning electron microscopy (SEM), and UV/Vis spectroscopy results confirmed higher extent of clay dispersion in the NCs with Cloisite 30B. Compared to pure PMMA, all these NCs show increase of glass transition temperature as measured by DSC and improved thermal stability determined by thermogravimetric analysis (TGA). The results obtained by dynamic mechanical analysis showed that the storage modulus of the NCs was higher by incorporation of clay into the PMMA matrix, increasing as the amount of clay increased and that their mechanical performance was significantly enhanced.
PB  - Springer, New York
T2  - Polymer Bulletin
T1  - Effect of organoclay modifier structure on the viscoelastic and thermal properties of poly(methyl methacrylate)/organoclay nanocomposites
EP  - 2932
IS  - 6
SP  - 2911
VL  - 78
DO  - 10.1007/s00289-020-03248-7
ER  - 

@article{
author = "Godiya, Chirag B. and Marcantoni, Enrico and Dunjić, Branko and Tomić, Miloš and Nikolić, Marija and Maletaškić, Jelena and Đonlagić, Jasna",
year = "2021",
abstract = "Poly(methyl methacrylate) (PMMA)/clay nanocomposites (NCs) were prepared by suspension polymerization of methyl methacrylate in the presence of two different organoclays (Cloisite 30B, Cloisite 15A) with clay loading ranged from 0.5 to 5 wt%. Increase in molecular weight of the PMMA matrix with addition of the clay was revealed by gel permeation chromatography (GPC) and intrinsic viscosity measurements. As confirmed by X-ray diffraction (XRD), the NCs had an intercalated structure. The organoclays-MMA/PMMA compatibility was investigated by swelling tests and solubility parameter approach. Rheological behavior of PMMA NCs in molten state was analyzed through construction of master curves of complex viscosity, storage, and loss modulus by applying the time-temperature superposition procedure. Melt rheology, scanning electron microscopy (SEM), and UV/Vis spectroscopy results confirmed higher extent of clay dispersion in the NCs with Cloisite 30B. Compared to pure PMMA, all these NCs show increase of glass transition temperature as measured by DSC and improved thermal stability determined by thermogravimetric analysis (TGA). The results obtained by dynamic mechanical analysis showed that the storage modulus of the NCs was higher by incorporation of clay into the PMMA matrix, increasing as the amount of clay increased and that their mechanical performance was significantly enhanced.",
publisher = "Springer, New York",
journal = "Polymer Bulletin",
title = "Effect of organoclay modifier structure on the viscoelastic and thermal properties of poly(methyl methacrylate)/organoclay nanocomposites",
pages = "2932-2911",
number = "6",
volume = "78",
doi = "10.1007/s00289-020-03248-7"
}

Godiya, C. B., Marcantoni, E., Dunjić, B., Tomić, M., Nikolić, M., Maletaškić, J.,& Đonlagić, J.. (2021). Effect of organoclay modifier structure on the viscoelastic and thermal properties of poly(methyl methacrylate)/organoclay nanocomposites. in Polymer Bulletin
Springer, New York., 78(6), 2911-2932.
https://doi.org/10.1007/s00289-020-03248-7

Godiya CB, Marcantoni E, Dunjić B, Tomić M, Nikolić M, Maletaškić J, Đonlagić J. Effect of organoclay modifier structure on the viscoelastic and thermal properties of poly(methyl methacrylate)/organoclay nanocomposites. in Polymer Bulletin. 2021;78(6):2911-2932.
doi:10.1007/s00289-020-03248-7 .

Godiya, Chirag B., Marcantoni, Enrico, Dunjić, Branko, Tomić, Miloš, Nikolić, Marija, Maletaškić, Jelena, Đonlagić, Jasna, "Effect of organoclay modifier structure on the viscoelastic and thermal properties of poly(methyl methacrylate)/organoclay nanocomposites" in Polymer Bulletin, 78, no. 6 (2021):2911-2932,
https://doi.org/10.1007/s00289-020-03248-7 . .

TY  - JOUR
AU  - Antić, Katarina
AU  - Onjia, Antonije
AU  - Vasiljevic-Radovic, Dana
AU  - Veličković, Zlate
AU  - Tomić, Simonida
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4784
AB  - The adsorption of Ni2+ ions from water solutions by using hydrogels based on 2-hydroxyethyl acrylate (HEA) and itaconic acid (IA) was studied. Hydrogel synthesis was optimized with response surface methodology (RSM). The hydrogel with the best adsorption capacity towards Ni2+ ions was chosen for further experiments. The hydrogel was characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and atomic force microscopy (AFM) analysis before and after the adsorption of Ni2+ ions. Batch equilibrium experiments were conducted to investigate the influence of solution pH, hydrogel weight, ionic strength, adsorption time, temperature and initial concentration of nickel ions on the adsorption. Time-dependent adsorption fitted the best to the pseudo-second-order kinetic model. A thermodynamic study revealed that the adsorption was an exothermic and non-spontaneous process. Five isotherm models were studied, and the best fit was obtained with the Redlich-Peterson model. Consecutive adsorption/desorption studies indicated that the HEA/IA hydrogel can be efficiently used as a sorbent for the removal of Ni2+ ions from the water solution. This study develops a potential adsorbent for the effective removal of trace nickel ions.
T2  - Gels
T1  - Removal of Nickel Ions from Aqueous Solutions by 2-Hydroxyethyl Acrylate/Itaconic Acid Hydrogels Optimized with Response Surface Methodology
IS  - 4
VL  - 7
DO  - 10.3390/gels7040225
ER  - 

@article{
author = "Antić, Katarina and Onjia, Antonije and Vasiljevic-Radovic, Dana and Veličković, Zlate and Tomić, Simonida",
year = "2021",
abstract = "The adsorption of Ni2+ ions from water solutions by using hydrogels based on 2-hydroxyethyl acrylate (HEA) and itaconic acid (IA) was studied. Hydrogel synthesis was optimized with response surface methodology (RSM). The hydrogel with the best adsorption capacity towards Ni2+ ions was chosen for further experiments. The hydrogel was characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM) and atomic force microscopy (AFM) analysis before and after the adsorption of Ni2+ ions. Batch equilibrium experiments were conducted to investigate the influence of solution pH, hydrogel weight, ionic strength, adsorption time, temperature and initial concentration of nickel ions on the adsorption. Time-dependent adsorption fitted the best to the pseudo-second-order kinetic model. A thermodynamic study revealed that the adsorption was an exothermic and non-spontaneous process. Five isotherm models were studied, and the best fit was obtained with the Redlich-Peterson model. Consecutive adsorption/desorption studies indicated that the HEA/IA hydrogel can be efficiently used as a sorbent for the removal of Ni2+ ions from the water solution. This study develops a potential adsorbent for the effective removal of trace nickel ions.",
journal = "Gels",
title = "Removal of Nickel Ions from Aqueous Solutions by 2-Hydroxyethyl Acrylate/Itaconic Acid Hydrogels Optimized with Response Surface Methodology",
number = "4",
volume = "7",
doi = "10.3390/gels7040225"
}

Antić, K., Onjia, A., Vasiljevic-Radovic, D., Veličković, Z.,& Tomić, S.. (2021). Removal of Nickel Ions from Aqueous Solutions by 2-Hydroxyethyl Acrylate/Itaconic Acid Hydrogels Optimized with Response Surface Methodology. in Gels, 7(4).
https://doi.org/10.3390/gels7040225

Antić K, Onjia A, Vasiljevic-Radovic D, Veličković Z, Tomić S. Removal of Nickel Ions from Aqueous Solutions by 2-Hydroxyethyl Acrylate/Itaconic Acid Hydrogels Optimized with Response Surface Methodology. in Gels. 2021;7(4).
doi:10.3390/gels7040225 .

Antić, Katarina, Onjia, Antonije, Vasiljevic-Radovic, Dana, Veličković, Zlate, Tomić, Simonida, "Removal of Nickel Ions from Aqueous Solutions by 2-Hydroxyethyl Acrylate/Itaconic Acid Hydrogels Optimized with Response Surface Methodology" in Gels, 7, no. 4 (2021),
https://doi.org/10.3390/gels7040225 . .

TY  - THES
AU  - Marković, Maja
PY  - 2020
UR  - http://eteze.bg.ac.rs/application/showtheses?thesesId=8124
UR  - https://fedorabg.bg.ac.rs/fedora/get/o:23643/bdef:Content/download
UR  - http://vbs.rs/scripts/cobiss?command=DISPLAY&base=70036&RID=37501961
UR  - https://nardus.mpn.gov.rs/handle/123456789/18303
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5965
AB  - Hidrogelovi na bazi poli(metakrilne kiseline) - PMAA imaju veliku primenu u sistemimaza ciljano otpuštanje aktivnih supstanci zato što su pH osetljivi, netoksični i biokompatibilni.Ipak zbog izrazite hidrofilnosti ovi hidrogelovi se mogu koristiti samo za kontrolisano otpuštanjehidrofilnih supstanci. U ovoj disertaciji predstavljena je modifikacija PMAA hidrogelovaamfifilnim supstancama: proteinom - kazeinom i fosfolipidnim nanočesticama - lipozomima,kako bi se dobio nosač slabo vodorastvorne aktivne supstance (SVAS). Opisana je sintezanosača, njihova karakterizacija primenom infracrvene spektroskopije sa Furijeovomtransformacijom (FTIR) i skenirajućom elektronskom mikroskopijom (SEM) i karakterizacijalipozoma primenom dinamičkog rasipanja svetlosti (DLS) i metodom elektroforetskog rasipanjasvetlosti (ELS). FTIR spektri su pokazali da su hidrofobne interakcije uspostavljene izmeđuSVAS model leka – kofeina i kazeina omogućile inkapsulaciju kofeina i njegovo kontrolisanooslobađanje, dok su prisutni lipozomi omogućili bolju kontrolu brzine oslobađanja kofeina.Ispitan je i uticaj parametara sinteze (stepen neutralizacije metakrilne kiseline, koncentracijaumreživača i kofeina, prisustvo itakonske kiseline i lipozoma, udeo i oblik lipozomneformulacije) na morfološke karakteristike nosača, njihovo bubrenje i kinetiku oslobađanjakofeina u dve sredine različitih pH vrednosti koje su simulirale uslove prisutne ugastrointestinalnom traktu čoveka. Praćenje oslobađanja kofeina iz nosača u ovim sredinamaizvršeno je primenom ultraljubičaste spektroskopije (UV). Izvedena je detaljna analiza dobijeniheksperimentalnih podataka otpuštanja kofeina u in vitro uslovima, primenom nekolikomatematičkih modela. Najbolja kinetika otpuštanja kofeina postignuta je iz nosača sa potpunoneutralizovanom metakrilnom kiselinom, 1,6mol% umreživača i inkorporiranim lipozomima ukojima je inkapsuliran kofein. Ovaj nosač je odabran za dalje analize - ispitano je njegovoponašanje u uslovima koji su simulirali put nosača kroz gastrointestinalni trakt čoveka. Rezultatisu pokazali da kofein može da se inkapsulira u izabrani nosač u koncentracijama koje su više odnjegove maksimalne rastvorljivosti i da se postigne njihovo ciljano otpuštanje. Inkapsulacijakofeina u koncentracijama ovih vrednosti, postignuta je dodatkom nikotin-amida koji sakofeinom gradi stabilni kompleks. Dobijeni rezultati pokazuju da sintetisani nosači imaju velikipotencijal za ciljanu dostavu slabo vodorastvotnih supstanci.
AB  - Hydrogels based on poly(methacrylic acid) (PMAA) have been extensively used insystems for targeted delivery of active substances because they are pH-sensitive, non-toxic andbiocompatible. However, being highly hydrophilic, these hydrogels are able to deliver onlyhydrophilic active substances. In this dissertation, modification of PMAA hydrogels withamphiphilic substances: protein - casein and phospholipidic nanoparticles - liposomes in order todesign a hydrophilic carrier for a poorly water-soluble substance (PWSS) are presented. Thesynthesis of the carriers and their characterization using the Fourier Transform InfraredSpectroscopy (FTIR) and the Scanning Electron Microscopy (SEM) and the characterization ofthe liposomes using the Dynamic Light Scattering (DLS) and the method of the ElectrophoreticLight Scattering (ELS) are described. The FTIR spectra showed that hydrophobic interactionswere established between PWSS model drug - caffeine and casein and enabled caffeineencapsulation in the carrier and its controlled release, while the presence of the liposomesenabled better control of caffeine release rate. The morphological characteristics of the carriers,their swelling behavior and the caffeine release kinetics were investigated depending on thechanges in the synthesis parameters (neutralization degree of methacrylic acid, crosslinker andcaffeine concentrations, introduction of itaconic acid and liposomes, volume ratio and form ofliposomal formulation) in two media with different pH values that simulated the environment inhuman gastrointestinal tract. Ultraviolet (UV) Spectroscopy was used to monitor caffeine releasefrom these carriers. Data from caffeine in vitro release experiments were analyzed in detail usingseveral mathematical models. The best kinetic of caffeine release was achieved form the carrierin which methacrylic acid was complitely neutralized and which had 1,6mol% of crosslinker andincorporated liposomes with encapsulated caffeine. The behavior of this carrier was furtherinvestigated in the environment which simulated the conditions in the human gastrointestinaltract. Results showed that this carrier could be used for the encapsulation of caffeine inconcentrations which were higher than its solubility and for targeted delivery of theseconcentrations. Encapsulation of caffeine in these values of concentration was achieved byadding nicotinamide, which forms stable complex with caffeine. Presented results showed thatsynthesized carriers have great potential for targeted delivery of poorly water-soluble substances.
PB  - Универзитет у Београду, Технолошко-металуршки факултет
T2  - Универзитет у Београду
T1  - Kinetika oslobađanja slabo vodorastvornih aktivnih supstanci iz nosača na bazi poli(metakrilne kiseline), kazeina i lipozoma
UR  - https://hdl.handle.net/21.15107/rcub_nardus_18303
ER  - 

@phdthesis{
author = "Marković, Maja",
year = "2020",
abstract = "Hidrogelovi na bazi poli(metakrilne kiseline) - PMAA imaju veliku primenu u sistemimaza ciljano otpuštanje aktivnih supstanci zato što su pH osetljivi, netoksični i biokompatibilni.Ipak zbog izrazite hidrofilnosti ovi hidrogelovi se mogu koristiti samo za kontrolisano otpuštanjehidrofilnih supstanci. U ovoj disertaciji predstavljena je modifikacija PMAA hidrogelovaamfifilnim supstancama: proteinom - kazeinom i fosfolipidnim nanočesticama - lipozomima,kako bi se dobio nosač slabo vodorastvorne aktivne supstance (SVAS). Opisana je sintezanosača, njihova karakterizacija primenom infracrvene spektroskopije sa Furijeovomtransformacijom (FTIR) i skenirajućom elektronskom mikroskopijom (SEM) i karakterizacijalipozoma primenom dinamičkog rasipanja svetlosti (DLS) i metodom elektroforetskog rasipanjasvetlosti (ELS). FTIR spektri su pokazali da su hidrofobne interakcije uspostavljene izmeđuSVAS model leka – kofeina i kazeina omogućile inkapsulaciju kofeina i njegovo kontrolisanooslobađanje, dok su prisutni lipozomi omogućili bolju kontrolu brzine oslobađanja kofeina.Ispitan je i uticaj parametara sinteze (stepen neutralizacije metakrilne kiseline, koncentracijaumreživača i kofeina, prisustvo itakonske kiseline i lipozoma, udeo i oblik lipozomneformulacije) na morfološke karakteristike nosača, njihovo bubrenje i kinetiku oslobađanjakofeina u dve sredine različitih pH vrednosti koje su simulirale uslove prisutne ugastrointestinalnom traktu čoveka. Praćenje oslobađanja kofeina iz nosača u ovim sredinamaizvršeno je primenom ultraljubičaste spektroskopije (UV). Izvedena je detaljna analiza dobijeniheksperimentalnih podataka otpuštanja kofeina u in vitro uslovima, primenom nekolikomatematičkih modela. Najbolja kinetika otpuštanja kofeina postignuta je iz nosača sa potpunoneutralizovanom metakrilnom kiselinom, 1,6mol% umreživača i inkorporiranim lipozomima ukojima je inkapsuliran kofein. Ovaj nosač je odabran za dalje analize - ispitano je njegovoponašanje u uslovima koji su simulirali put nosača kroz gastrointestinalni trakt čoveka. Rezultatisu pokazali da kofein može da se inkapsulira u izabrani nosač u koncentracijama koje su više odnjegove maksimalne rastvorljivosti i da se postigne njihovo ciljano otpuštanje. Inkapsulacijakofeina u koncentracijama ovih vrednosti, postignuta je dodatkom nikotin-amida koji sakofeinom gradi stabilni kompleks. Dobijeni rezultati pokazuju da sintetisani nosači imaju velikipotencijal za ciljanu dostavu slabo vodorastvotnih supstanci., Hydrogels based on poly(methacrylic acid) (PMAA) have been extensively used insystems for targeted delivery of active substances because they are pH-sensitive, non-toxic andbiocompatible. However, being highly hydrophilic, these hydrogels are able to deliver onlyhydrophilic active substances. In this dissertation, modification of PMAA hydrogels withamphiphilic substances: protein - casein and phospholipidic nanoparticles - liposomes in order todesign a hydrophilic carrier for a poorly water-soluble substance (PWSS) are presented. Thesynthesis of the carriers and their characterization using the Fourier Transform InfraredSpectroscopy (FTIR) and the Scanning Electron Microscopy (SEM) and the characterization ofthe liposomes using the Dynamic Light Scattering (DLS) and the method of the ElectrophoreticLight Scattering (ELS) are described. The FTIR spectra showed that hydrophobic interactionswere established between PWSS model drug - caffeine and casein and enabled caffeineencapsulation in the carrier and its controlled release, while the presence of the liposomesenabled better control of caffeine release rate. The morphological characteristics of the carriers,their swelling behavior and the caffeine release kinetics were investigated depending on thechanges in the synthesis parameters (neutralization degree of methacrylic acid, crosslinker andcaffeine concentrations, introduction of itaconic acid and liposomes, volume ratio and form ofliposomal formulation) in two media with different pH values that simulated the environment inhuman gastrointestinal tract. Ultraviolet (UV) Spectroscopy was used to monitor caffeine releasefrom these carriers. Data from caffeine in vitro release experiments were analyzed in detail usingseveral mathematical models. The best kinetic of caffeine release was achieved form the carrierin which methacrylic acid was complitely neutralized and which had 1,6mol% of crosslinker andincorporated liposomes with encapsulated caffeine. The behavior of this carrier was furtherinvestigated in the environment which simulated the conditions in the human gastrointestinaltract. Results showed that this carrier could be used for the encapsulation of caffeine inconcentrations which were higher than its solubility and for targeted delivery of theseconcentrations. Encapsulation of caffeine in these values of concentration was achieved byadding nicotinamide, which forms stable complex with caffeine. Presented results showed thatsynthesized carriers have great potential for targeted delivery of poorly water-soluble substances.",
publisher = "Универзитет у Београду, Технолошко-металуршки факултет",
journal = "Универзитет у Београду",
title = "Kinetika oslobađanja slabo vodorastvornih aktivnih supstanci iz nosača na bazi poli(metakrilne kiseline), kazeina i lipozoma",
url = "https://hdl.handle.net/21.15107/rcub_nardus_18303"
}

Marković, M.. (2020). Kinetika oslobađanja slabo vodorastvornih aktivnih supstanci iz nosača na bazi poli(metakrilne kiseline), kazeina i lipozoma. in Универзитет у Београду
Универзитет у Београду, Технолошко-металуршки факултет..
https://hdl.handle.net/21.15107/rcub_nardus_18303

Marković M. Kinetika oslobađanja slabo vodorastvornih aktivnih supstanci iz nosača na bazi poli(metakrilne kiseline), kazeina i lipozoma. in Универзитет у Београду. 2020;.
https://hdl.handle.net/21.15107/rcub_nardus_18303 .

Marković, Maja, "Kinetika oslobađanja slabo vodorastvornih aktivnih supstanci iz nosača na bazi poli(metakrilne kiseline), kazeina i lipozoma" in Универзитет у Београду (2020),
https://hdl.handle.net/21.15107/rcub_nardus_18303 .

TY  - JOUR
AU  - Marković, Maja
AU  - Panić, Vesna
AU  - Šešlija, Sanja
AU  - Spasojević, Pavle
AU  - Ugrinović, Vukašin
AU  - Bošković-Vragolović, Nevenka
AU  - Pjanović, Rada
PY  - 2020
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4382
AB  - pH sensitive, nontoxic, and biocompatible poly(methacrylic) acid (PMAA) based soft networks have been extensively used in the design of systems for targeted drug delivery. Still, their highly hydrophilic nature limits their potential to be used as a carrier of poorly water-soluble substances. With the aim to overcome this limitation, the present study details a new approach for modification of PMAA based carriers using two amphiphilic components: casein and liposomes. The FTIR analysis revealed structural features of each component as well as the synergetic effect that originated from the formation of specific interactions. Namely, hydrophobic interactions between the poorly water-soluble model drug (caffeine) and casein enabled caffeine encapsulation and controlled release, while addition of liposomes ensured better control of the release rate. The morphological properties of the carriers, swelling behavior, and release kinetics of caffeine were investigated depending on the variable synthesis parameters (neutralization degree of methacrylic acid, concentration of caffeine, presence/absence of liposomes) in two different media simulating the pH environment of human intestines and stomach. The data obtained from in vitro caffeine release were correlated and analyzed in detail using several mathematical models, indicating significant potential of investigated carriers for targeted delivery and controlled release of poorly water-soluble substances.
PB  - Wiley, Hoboken
T2  - Polymer Engineering and Science
T1  - Modification of hydrophilic polymer network to design a carrier for a poorly water-soluble substance
EP  - 2510
IS  - 10
SP  - 2496
VL  - 60
DO  - 10.1002/pen.25487
ER  - 

@article{
author = "Marković, Maja and Panić, Vesna and Šešlija, Sanja and Spasojević, Pavle and Ugrinović, Vukašin and Bošković-Vragolović, Nevenka and Pjanović, Rada",
year = "2020",
abstract = "pH sensitive, nontoxic, and biocompatible poly(methacrylic) acid (PMAA) based soft networks have been extensively used in the design of systems for targeted drug delivery. Still, their highly hydrophilic nature limits their potential to be used as a carrier of poorly water-soluble substances. With the aim to overcome this limitation, the present study details a new approach for modification of PMAA based carriers using two amphiphilic components: casein and liposomes. The FTIR analysis revealed structural features of each component as well as the synergetic effect that originated from the formation of specific interactions. Namely, hydrophobic interactions between the poorly water-soluble model drug (caffeine) and casein enabled caffeine encapsulation and controlled release, while addition of liposomes ensured better control of the release rate. The morphological properties of the carriers, swelling behavior, and release kinetics of caffeine were investigated depending on the variable synthesis parameters (neutralization degree of methacrylic acid, concentration of caffeine, presence/absence of liposomes) in two different media simulating the pH environment of human intestines and stomach. The data obtained from in vitro caffeine release were correlated and analyzed in detail using several mathematical models, indicating significant potential of investigated carriers for targeted delivery and controlled release of poorly water-soluble substances.",
publisher = "Wiley, Hoboken",
journal = "Polymer Engineering and Science",
title = "Modification of hydrophilic polymer network to design a carrier for a poorly water-soluble substance",
pages = "2510-2496",
number = "10",
volume = "60",
doi = "10.1002/pen.25487"
}

Marković, M., Panić, V., Šešlija, S., Spasojević, P., Ugrinović, V., Bošković-Vragolović, N.,& Pjanović, R.. (2020). Modification of hydrophilic polymer network to design a carrier for a poorly water-soluble substance. in Polymer Engineering and Science
Wiley, Hoboken., 60(10), 2496-2510.
https://doi.org/10.1002/pen.25487

Marković M, Panić V, Šešlija S, Spasojević P, Ugrinović V, Bošković-Vragolović N, Pjanović R. Modification of hydrophilic polymer network to design a carrier for a poorly water-soluble substance. in Polymer Engineering and Science. 2020;60(10):2496-2510.
doi:10.1002/pen.25487 .

Marković, Maja, Panić, Vesna, Šešlija, Sanja, Spasojević, Pavle, Ugrinović, Vukašin, Bošković-Vragolović, Nevenka, Pjanović, Rada, "Modification of hydrophilic polymer network to design a carrier for a poorly water-soluble substance" in Polymer Engineering and Science, 60, no. 10 (2020):2496-2510,
https://doi.org/10.1002/pen.25487 . .

TY  - JOUR
AU  - Marković, Maja
AU  - Panić, Vesna
AU  - Šešlija, Sanja
AU  - Milivojević, Ana
AU  - Spasojević, Pavle
AU  - Bošković-Vragolović, Nevenka
AU  - Pjanović, Rada
PY  - 2020
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4541
AB  - Carriers for targeted delivery and controlled release of poorly water-soluble active substances (PWSAS) are facing three challenges: (a) the encapsulation issues, (b) limitations of PWSAS water solubility, and
PB  - Wiley, Hoboken
T2  - Polymer Engineering and Science
T1  - Novel strategy for encapsulation and targeted delivery of poorly water-soluble active substances
EP  - 2022
IS  - 8
SP  - 2008
VL  - 60
DO  - 10.1002/pen.25448
ER  - 

@article{
author = "Marković, Maja and Panić, Vesna and Šešlija, Sanja and Milivojević, Ana and Spasojević, Pavle and Bošković-Vragolović, Nevenka and Pjanović, Rada",
year = "2020",
abstract = "Carriers for targeted delivery and controlled release of poorly water-soluble active substances (PWSAS) are facing three challenges: (a) the encapsulation issues, (b) limitations of PWSAS water solubility, and",
publisher = "Wiley, Hoboken",
journal = "Polymer Engineering and Science",
title = "Novel strategy for encapsulation and targeted delivery of poorly water-soluble active substances",
pages = "2022-2008",
number = "8",
volume = "60",
doi = "10.1002/pen.25448"
}

Marković, M., Panić, V., Šešlija, S., Milivojević, A., Spasojević, P., Bošković-Vragolović, N.,& Pjanović, R.. (2020). Novel strategy for encapsulation and targeted delivery of poorly water-soluble active substances. in Polymer Engineering and Science
Wiley, Hoboken., 60(8), 2008-2022.
https://doi.org/10.1002/pen.25448

Marković M, Panić V, Šešlija S, Milivojević A, Spasojević P, Bošković-Vragolović N, Pjanović R. Novel strategy for encapsulation and targeted delivery of poorly water-soluble active substances. in Polymer Engineering and Science. 2020;60(8):2008-2022.
doi:10.1002/pen.25448 .

Marković, Maja, Panić, Vesna, Šešlija, Sanja, Milivojević, Ana, Spasojević, Pavle, Bošković-Vragolović, Nevenka, Pjanović, Rada, "Novel strategy for encapsulation and targeted delivery of poorly water-soluble active substances" in Polymer Engineering and Science, 60, no. 8 (2020):2008-2022,
https://doi.org/10.1002/pen.25448 . .

TY  - JOUR
AU  - Vuković, Jovana
AU  - Perić-Grujić, Aleksandra
AU  - Mitić-Culafić, Dragana S.
AU  - Božić-Nedeljković, Biljana
AU  - Tomić, Simonida
PY  - 2020
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4345
AB  - Since the management of infections becomes prior global healthcare issue, the "post antibiotic era" requires innovative and interdisciplinary approach. As an alternative to widespread and, nowdays mostly uneffective, antibiotic treatment of infections, the series of hydrogels were developed and further investigated as novel antibacterial biomaterials. The hydrogels based on 2-hydroxyethyl acrylate and itaconic acid were synthesized and used for silver(I) ions incorporation. The structural, thermal and swelling characteristics were examined by Fourier transform infrared spectroscopy, differential scanning calorimetry, and swelling study conducted in wide range of pHs at 37 degrees C. Results confirmed the expected structure, while the glass transition temperatures (T-g) of the hydrogels were detected in range of 10-37 degrees C. The in vitro release study revealed suitability of these pH sensitive hydrogels as the systems for topical delivery of silver(I) ions. Performed MTT test and Comet assay proved biocompatibility of the hydrogels, as well as the absence of acute genotoxic effect on human fibroblast cells (MRC-5). The hydrogels exhibited satisfying antibacterial activity against methicillin sensitive Staphylococcus aureus (MSSA) and methicillin resistant Staphylococcus aureus (MRSA), indicating the capacity to treat the life-threatening infections.
PB  - Polymer Soc Korea, Seoul
T2  - Macromolecular Research
T1  - Antibacterial Activity of pH-Sensitive Silver(I)/Poly(2-hydroxyethyl acrylate/itaconic acid) Hydrogels
EP  - 389
IS  - 4
SP  - 382
VL  - 28
DO  - 10.1007/s13233-020-8050-z
ER  - 

@article{
author = "Vuković, Jovana and Perić-Grujić, Aleksandra and Mitić-Culafić, Dragana S. and Božić-Nedeljković, Biljana and Tomić, Simonida",
year = "2020",
abstract = "Since the management of infections becomes prior global healthcare issue, the "post antibiotic era" requires innovative and interdisciplinary approach. As an alternative to widespread and, nowdays mostly uneffective, antibiotic treatment of infections, the series of hydrogels were developed and further investigated as novel antibacterial biomaterials. The hydrogels based on 2-hydroxyethyl acrylate and itaconic acid were synthesized and used for silver(I) ions incorporation. The structural, thermal and swelling characteristics were examined by Fourier transform infrared spectroscopy, differential scanning calorimetry, and swelling study conducted in wide range of pHs at 37 degrees C. Results confirmed the expected structure, while the glass transition temperatures (T-g) of the hydrogels were detected in range of 10-37 degrees C. The in vitro release study revealed suitability of these pH sensitive hydrogels as the systems for topical delivery of silver(I) ions. Performed MTT test and Comet assay proved biocompatibility of the hydrogels, as well as the absence of acute genotoxic effect on human fibroblast cells (MRC-5). The hydrogels exhibited satisfying antibacterial activity against methicillin sensitive Staphylococcus aureus (MSSA) and methicillin resistant Staphylococcus aureus (MRSA), indicating the capacity to treat the life-threatening infections.",
publisher = "Polymer Soc Korea, Seoul",
journal = "Macromolecular Research",
title = "Antibacterial Activity of pH-Sensitive Silver(I)/Poly(2-hydroxyethyl acrylate/itaconic acid) Hydrogels",
pages = "389-382",
number = "4",
volume = "28",
doi = "10.1007/s13233-020-8050-z"
}

Vuković, J., Perić-Grujić, A., Mitić-Culafić, D. S., Božić-Nedeljković, B.,& Tomić, S.. (2020). Antibacterial Activity of pH-Sensitive Silver(I)/Poly(2-hydroxyethyl acrylate/itaconic acid) Hydrogels. in Macromolecular Research
Polymer Soc Korea, Seoul., 28(4), 382-389.
https://doi.org/10.1007/s13233-020-8050-z

Vuković J, Perić-Grujić A, Mitić-Culafić DS, Božić-Nedeljković B, Tomić S. Antibacterial Activity of pH-Sensitive Silver(I)/Poly(2-hydroxyethyl acrylate/itaconic acid) Hydrogels. in Macromolecular Research. 2020;28(4):382-389.
doi:10.1007/s13233-020-8050-z .

Vuković, Jovana, Perić-Grujić, Aleksandra, Mitić-Culafić, Dragana S., Božić-Nedeljković, Biljana, Tomić, Simonida, "Antibacterial Activity of pH-Sensitive Silver(I)/Poly(2-hydroxyethyl acrylate/itaconic acid) Hydrogels" in Macromolecular Research, 28, no. 4 (2020):382-389,
https://doi.org/10.1007/s13233-020-8050-z . .

TY  - JOUR
AU  - Babić, Marija
AU  - Vukomanović, Marija
AU  - Stefanić, Martin
AU  - Nikodinović-Runić, Jasmina
AU  - Tomić, Simonida
PY  - 2020
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4358
AB  - The strategy of combining polymers of natural and synthetic origin with inorganic components to use their unique synergistic effect for the development of the novel, sophisticated, and efficient 3D polymeric biomaterials, whose structure and properties mimic the extracellular matrix and simultaneously represent the suitable hydrogel platform for controlled drug release, is presented. The novel versatile 2-hydroxyethyl methacrylate/gelatin/alginate/iron(III) oxide based hydrogels are prepared by a simple but effective method-modified porogenation. Chemical composition, morphology, swelling capacity, porosity, mechanical properties, effects on cell viability, and in vitro degradation are tested to correlate the material's composition with the corresponding properties. The hydrogels show an interconnected porous microstructure, satisfactory mechanical strength, pH-sensitivity, and favorable curcumin release performances. The materials show good compatibility with healthy human fibroblast in cell culture judged by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, suggesting newly synthesized hydrogels as potentially a new generation of 3D biomaterials with tunable properties for versatile biomedical and pharmaceutical applications.
PB  - Wiley-VCH Verlag Gmbh, Weinheim
T2  - Macromolecular Chemistry and Physics
T1  - Controlled Curcumin Release from Hydrogel Scaffold Platform Based on 2-Hydroxyethyl Methacrylate/Gelatin/Alginate/Iron(III) Oxide
IS  - 20
SP  - 2000186
VL  - 221
DO  - 10.1002/macp.202000186
ER  - 

@article{
author = "Babić, Marija and Vukomanović, Marija and Stefanić, Martin and Nikodinović-Runić, Jasmina and Tomić, Simonida",
year = "2020",
abstract = "The strategy of combining polymers of natural and synthetic origin with inorganic components to use their unique synergistic effect for the development of the novel, sophisticated, and efficient 3D polymeric biomaterials, whose structure and properties mimic the extracellular matrix and simultaneously represent the suitable hydrogel platform for controlled drug release, is presented. The novel versatile 2-hydroxyethyl methacrylate/gelatin/alginate/iron(III) oxide based hydrogels are prepared by a simple but effective method-modified porogenation. Chemical composition, morphology, swelling capacity, porosity, mechanical properties, effects on cell viability, and in vitro degradation are tested to correlate the material's composition with the corresponding properties. The hydrogels show an interconnected porous microstructure, satisfactory mechanical strength, pH-sensitivity, and favorable curcumin release performances. The materials show good compatibility with healthy human fibroblast in cell culture judged by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, suggesting newly synthesized hydrogels as potentially a new generation of 3D biomaterials with tunable properties for versatile biomedical and pharmaceutical applications.",
publisher = "Wiley-VCH Verlag Gmbh, Weinheim",
journal = "Macromolecular Chemistry and Physics",
title = "Controlled Curcumin Release from Hydrogel Scaffold Platform Based on 2-Hydroxyethyl Methacrylate/Gelatin/Alginate/Iron(III) Oxide",
number = "20",
pages = "2000186",
volume = "221",
doi = "10.1002/macp.202000186"
}

Babić, M., Vukomanović, M., Stefanić, M., Nikodinović-Runić, J.,& Tomić, S.. (2020). Controlled Curcumin Release from Hydrogel Scaffold Platform Based on 2-Hydroxyethyl Methacrylate/Gelatin/Alginate/Iron(III) Oxide. in Macromolecular Chemistry and Physics
Wiley-VCH Verlag Gmbh, Weinheim., 221(20), 2000186.
https://doi.org/10.1002/macp.202000186

Babić M, Vukomanović M, Stefanić M, Nikodinović-Runić J, Tomić S. Controlled Curcumin Release from Hydrogel Scaffold Platform Based on 2-Hydroxyethyl Methacrylate/Gelatin/Alginate/Iron(III) Oxide. in Macromolecular Chemistry and Physics. 2020;221(20):2000186.
doi:10.1002/macp.202000186 .

Babić, Marija, Vukomanović, Marija, Stefanić, Martin, Nikodinović-Runić, Jasmina, Tomić, Simonida, "Controlled Curcumin Release from Hydrogel Scaffold Platform Based on 2-Hydroxyethyl Methacrylate/Gelatin/Alginate/Iron(III) Oxide" in Macromolecular Chemistry and Physics, 221, no. 20 (2020):2000186,
https://doi.org/10.1002/macp.202000186 . .

TY  - JOUR
AU  - Tomić, Simonida
AU  - Babić, Marija
AU  - Vuković, Jovana
AU  - Đokić, Lidija
AU  - Pavić, Aleksandar
AU  - Nikodinović-Runić, Jasmina
PY  - 2020
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4379
AB  - We have studied the effect of compositions and methods of preparation on the physico-chemical and biocompatible behavior of the hydrogel matrices. Hydrogel matrices are synthesized by free radical polymerization of 2-hydroxyethyl methacrylate net and with gelatin. Highly porous hydrogel structures were obtained by porogenation, and by cryogenic treatment followed by freeze-drying. All samples were characterized for structural, morphological, absorption, degradation and in vitro (healthy human fibroblast cell line) and in vivo (zebrafishDanio rerio) biocompatible properties. The obtained results show that cryo samples, especially with gelatin show better, favorable absorption, morphological and biocompatible properties in comparison with PHEMA samples, which makes these materials highly attractive for biomedical uses.
PB  - Springer, Dordrecht
T2  - Journal of Polymer Research
T1  - Effect of composition and method of preparation of 2-hydroxyethyl methacrylate/gelatin hydrogels on biological in vitro (cell line) and in vivo (zebrafish) properties
IS  - 10
SP  - 305
VL  - 27
DO  - 10.1007/s10965-020-02219-w
ER  - 

@article{
author = "Tomić, Simonida and Babić, Marija and Vuković, Jovana and Đokić, Lidija and Pavić, Aleksandar and Nikodinović-Runić, Jasmina",
year = "2020",
abstract = "We have studied the effect of compositions and methods of preparation on the physico-chemical and biocompatible behavior of the hydrogel matrices. Hydrogel matrices are synthesized by free radical polymerization of 2-hydroxyethyl methacrylate net and with gelatin. Highly porous hydrogel structures were obtained by porogenation, and by cryogenic treatment followed by freeze-drying. All samples were characterized for structural, morphological, absorption, degradation and in vitro (healthy human fibroblast cell line) and in vivo (zebrafishDanio rerio) biocompatible properties. The obtained results show that cryo samples, especially with gelatin show better, favorable absorption, morphological and biocompatible properties in comparison with PHEMA samples, which makes these materials highly attractive for biomedical uses.",
publisher = "Springer, Dordrecht",
journal = "Journal of Polymer Research",
title = "Effect of composition and method of preparation of 2-hydroxyethyl methacrylate/gelatin hydrogels on biological in vitro (cell line) and in vivo (zebrafish) properties",
number = "10",
pages = "305",
volume = "27",
doi = "10.1007/s10965-020-02219-w"
}

Tomić, S., Babić, M., Vuković, J., Đokić, L., Pavić, A.,& Nikodinović-Runić, J.. (2020). Effect of composition and method of preparation of 2-hydroxyethyl methacrylate/gelatin hydrogels on biological in vitro (cell line) and in vivo (zebrafish) properties. in Journal of Polymer Research
Springer, Dordrecht., 27(10), 305.
https://doi.org/10.1007/s10965-020-02219-w

Tomić S, Babić M, Vuković J, Đokić L, Pavić A, Nikodinović-Runić J. Effect of composition and method of preparation of 2-hydroxyethyl methacrylate/gelatin hydrogels on biological in vitro (cell line) and in vivo (zebrafish) properties. in Journal of Polymer Research. 2020;27(10):305.
doi:10.1007/s10965-020-02219-w .

Tomić, Simonida, Babić, Marija, Vuković, Jovana, Đokić, Lidija, Pavić, Aleksandar, Nikodinović-Runić, Jasmina, "Effect of composition and method of preparation of 2-hydroxyethyl methacrylate/gelatin hydrogels on biological in vitro (cell line) and in vivo (zebrafish) properties" in Journal of Polymer Research, 27, no. 10 (2020):305,
https://doi.org/10.1007/s10965-020-02219-w . .

TY  - JOUR
AU  - Mirković, Ilinka
AU  - Nikolić, Marija
AU  - Ostojić, Sanja
AU  - Maletaškić, Jelena
AU  - Petrović, Zoran
AU  - Đonlagić, Jasna
PY  - 2020
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4365
AB  - Semi-interpenetrating polymer networks (SIPN) based on thermo-responsive poly(N-isopropylacrylamide) (PNIPA) and water-soluble sodium salts of linear hyaluronic acid (Na-HA) were physically cross-linked with synthetic nanoclay (laponite XLG). PNIPA hydrogels with different cross-linking densities and Na-HA concentrations were synthesized by in situ free-radical redox polymerization. The structure and heterogeneity of the semi-IPN hydrogels were examined by SEM and XRD. The content of clay incorporated in the gel was determined by TGA. DSC measurements showed that volume phase transition temperature and its enthalpy varied with the clay and hyaluronic acid content. SIPN hydrogels containing negatively charged polyelectrolyte, Na-HA, exhibited higher Q(e) and faster deswelling rates than the corresponding PNIPA NC hydrogels. The presence of the anionic Na-HA polymer reduced the storage modulus, indicating a weakening of the hydrogel network structure, especially at lower clay contents. The nanocomposite hydrogels exhibited high tan delta values, which increased with increasing Na-HA content.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Thermo-responsive hydrogels based on poly(N-isopropyl- acrylamide) and hyaluronic acid cross-linked with nanoclays
EP  - 1221
IS  - 9
SP  - 1197
VL  - 85
DO  - 10.2298/JSC200109023M
ER  - 

@article{
author = "Mirković, Ilinka and Nikolić, Marija and Ostojić, Sanja and Maletaškić, Jelena and Petrović, Zoran and Đonlagić, Jasna",
year = "2020",
abstract = "Semi-interpenetrating polymer networks (SIPN) based on thermo-responsive poly(N-isopropylacrylamide) (PNIPA) and water-soluble sodium salts of linear hyaluronic acid (Na-HA) were physically cross-linked with synthetic nanoclay (laponite XLG). PNIPA hydrogels with different cross-linking densities and Na-HA concentrations were synthesized by in situ free-radical redox polymerization. The structure and heterogeneity of the semi-IPN hydrogels were examined by SEM and XRD. The content of clay incorporated in the gel was determined by TGA. DSC measurements showed that volume phase transition temperature and its enthalpy varied with the clay and hyaluronic acid content. SIPN hydrogels containing negatively charged polyelectrolyte, Na-HA, exhibited higher Q(e) and faster deswelling rates than the corresponding PNIPA NC hydrogels. The presence of the anionic Na-HA polymer reduced the storage modulus, indicating a weakening of the hydrogel network structure, especially at lower clay contents. The nanocomposite hydrogels exhibited high tan delta values, which increased with increasing Na-HA content.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Thermo-responsive hydrogels based on poly(N-isopropyl- acrylamide) and hyaluronic acid cross-linked with nanoclays",
pages = "1221-1197",
number = "9",
volume = "85",
doi = "10.2298/JSC200109023M"
}

Mirković, I., Nikolić, M., Ostojić, S., Maletaškić, J., Petrović, Z.,& Đonlagić, J.. (2020). Thermo-responsive hydrogels based on poly(N-isopropyl- acrylamide) and hyaluronic acid cross-linked with nanoclays. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 85(9), 1197-1221.
https://doi.org/10.2298/JSC200109023M

Mirković I, Nikolić M, Ostojić S, Maletaškić J, Petrović Z, Đonlagić J. Thermo-responsive hydrogels based on poly(N-isopropyl- acrylamide) and hyaluronic acid cross-linked with nanoclays. in Journal of the Serbian Chemical Society. 2020;85(9):1197-1221.
doi:10.2298/JSC200109023M .

Mirković, Ilinka, Nikolić, Marija, Ostojić, Sanja, Maletaškić, Jelena, Petrović, Zoran, Đonlagić, Jasna, "Thermo-responsive hydrogels based on poly(N-isopropyl- acrylamide) and hyaluronic acid cross-linked with nanoclays" in Journal of the Serbian Chemical Society, 85, no. 9 (2020):1197-1221,
https://doi.org/10.2298/JSC200109023M . .

TY  - CONF
AU  - Marković, Maja D.
AU  - Seslija, Sanja I.
AU  - Panić, Vesna V.
AU  - Pjanović, Rada V.
PY  - 2019
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5074
AB  - Three dimensional polymer networks, hydrogels, have shown a great potential in
controlled release and targeted delivery of active substances. pH sensitive hydrogels
based on poly(methacrylic acid) have attracted significant attention due to their
biocompatibility, non-toxicity and the possession of the huge number of ionogenic
carboxylic groups. On the other hand, the usage of these hydrogels for controlled release
and targeted delivery of poorly water-soluble drugs is limited by their highly hydrophilic
nature. We overcame this limitation by modifying PMAA with amphiphilic substance -
casein. The addition of this natural protein enabled the encapsulation, targeted delivery
and controlled release of poorly water-soluble model drug - caffeine. Three carriers with
different neutralization degree of methacrylic acid were synthesized via free radical
polymerization. The FTIR spectra revealed that two types of interactions were
established between casein and caffeine: hydrophobic interactions and hydrogen bonds.
The SEM micrographs showed that the structure of the carriers depended on the change
of neutralization degree of the methacrylic acid. The swelling of synthesized carriers and
the caffeine in vitro release were monitored in two environments at 37°C: 0.1M HCl
pH=1.2 (simulation of environment in human stomach) and phosphate buffer pH=6.8
(simulation of environment in human intestines). The synthesized carriers had higher
swelling degree and the higher release rate of caffeine in the phosphate buffer pH=6.8
than in 0.1M HCl. The increase in neutralization degree of methacrylic acid caused the
increase in swelling degree of the carriers and the increase in release rate of caffeine.
Presented results showed that synthesized carriers are promising candidates for targeted
delivery of poorly water-soluble drugs.
PB  - Serbian Chemical Society and Serbian Young Chemists Club Karnegijeva 4/III, 11000 Belgrade, Serbia
C3  - Conference of the Young Chemists of Serbia
T1  - Three dimensional polymeric networks based on poly(methacrylic acid) and protein for targeted delivery of poorly water-soluble drugs
SP  - 134
UR  - https://hdl.handle.net/21.15107/rcub_technorep_5074
ER  - 

@conference{
author = "Marković, Maja D. and Seslija, Sanja I. and Panić, Vesna V. and Pjanović, Rada V.",
year = "2019",
abstract = "Three dimensional polymer networks, hydrogels, have shown a great potential in
controlled release and targeted delivery of active substances. pH sensitive hydrogels
based on poly(methacrylic acid) have attracted significant attention due to their
biocompatibility, non-toxicity and the possession of the huge number of ionogenic
carboxylic groups. On the other hand, the usage of these hydrogels for controlled release
and targeted delivery of poorly water-soluble drugs is limited by their highly hydrophilic
nature. We overcame this limitation by modifying PMAA with amphiphilic substance -
casein. The addition of this natural protein enabled the encapsulation, targeted delivery
and controlled release of poorly water-soluble model drug - caffeine. Three carriers with
different neutralization degree of methacrylic acid were synthesized via free radical
polymerization. The FTIR spectra revealed that two types of interactions were
established between casein and caffeine: hydrophobic interactions and hydrogen bonds.
The SEM micrographs showed that the structure of the carriers depended on the change
of neutralization degree of the methacrylic acid. The swelling of synthesized carriers and
the caffeine in vitro release were monitored in two environments at 37°C: 0.1M HCl
pH=1.2 (simulation of environment in human stomach) and phosphate buffer pH=6.8
(simulation of environment in human intestines). The synthesized carriers had higher
swelling degree and the higher release rate of caffeine in the phosphate buffer pH=6.8
than in 0.1M HCl. The increase in neutralization degree of methacrylic acid caused the
increase in swelling degree of the carriers and the increase in release rate of caffeine.
Presented results showed that synthesized carriers are promising candidates for targeted
delivery of poorly water-soluble drugs.",
publisher = "Serbian Chemical Society and Serbian Young Chemists Club Karnegijeva 4/III, 11000 Belgrade, Serbia",
journal = "Conference of the Young Chemists of Serbia",
title = "Three dimensional polymeric networks based on poly(methacrylic acid) and protein for targeted delivery of poorly water-soluble drugs",
pages = "134",
url = "https://hdl.handle.net/21.15107/rcub_technorep_5074"
}

Marković, M. D., Seslija, S. I., Panić, V. V.,& Pjanović, R. V.. (2019). Three dimensional polymeric networks based on poly(methacrylic acid) and protein for targeted delivery of poorly water-soluble drugs. in Conference of the Young Chemists of Serbia
Serbian Chemical Society and Serbian Young Chemists Club Karnegijeva 4/III, 11000 Belgrade, Serbia., 134.
https://hdl.handle.net/21.15107/rcub_technorep_5074

Marković MD, Seslija SI, Panić VV, Pjanović RV. Three dimensional polymeric networks based on poly(methacrylic acid) and protein for targeted delivery of poorly water-soluble drugs. in Conference of the Young Chemists of Serbia. 2019;:134.
https://hdl.handle.net/21.15107/rcub_technorep_5074 .

Marković, Maja D., Seslija, Sanja I., Panić, Vesna V., Pjanović, Rada V., "Three dimensional polymeric networks based on poly(methacrylic acid) and protein for targeted delivery of poorly water-soluble drugs" in Conference of the Young Chemists of Serbia (2019):134,
https://hdl.handle.net/21.15107/rcub_technorep_5074 .

TY  - JOUR
AU  - Džunuzović, Jasna
AU  - Stefanović, Ivan
AU  - Džunuzović, Enis
AU  - Dapčević, Aleksandra
AU  - Šešlija, Sanja
AU  - Balanč, Bojana
AU  - Lamae, Giuseppe C.
PY  - 2019
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4118
AB  - A series of environmentally friendly polyurethane (PU) networks based on polycaprolactone as soft segment (SS) and Boltorn (R) aliphatic hyperbranched polyester of the second pseudo generation as crosslinking agent was prepared by a two-step polymerization in solution. The chemical structure of the PU networks was analyzed by Fourier transform infrared spectroscopy, while XRD analysis revealed that these samples are amorphous. Swelling measurements, water absorption study, dynamic mechanical analysis, differential scanning calorimetry, thermogravimetric analysis, mechanical tests and scanning electron microscope revealed that, swelling behavior, hydrophobicity, thermal and mechanical features and morphology of PU networks show clear dependence on polycaprolactone content. The increase of the SS content induced appearance of the microphase separated morphology, increase of thermal stability, elongation at break, hydrophobicity and swelling ability in tetrahydrofuran and toluene, but at the same time it is responsible for the decrease of crosslinking density, glass transition temperatures, rigidity, tensile strength and Young's modulus of PU networks. Scanning electron microscope images of the fracture surfaces of PU networks show that their surface is rough, irregular, with flake-like structure, where size of flakes increases with increasing SS content. These results indicate that by choosing adequate SS content, PU coatings with diverse features based on polycaprolactone and Boltorn (R) aliphatic hyperbranched polyester can be designed for appropriate and desired application.
PB  - Elsevier Science Sa, Lausanne
T2  - Progress in Organic Coatings
T1  - Polyurethane networks based on polycaprolactone and hyperbranched polyester: Structural, thermal and mechanical investigation
VL  - 137
DO  - 10.1016/j.porgcoat.2019.105305
ER  - 

@article{
author = "Džunuzović, Jasna and Stefanović, Ivan and Džunuzović, Enis and Dapčević, Aleksandra and Šešlija, Sanja and Balanč, Bojana and Lamae, Giuseppe C.",
year = "2019",
abstract = "A series of environmentally friendly polyurethane (PU) networks based on polycaprolactone as soft segment (SS) and Boltorn (R) aliphatic hyperbranched polyester of the second pseudo generation as crosslinking agent was prepared by a two-step polymerization in solution. The chemical structure of the PU networks was analyzed by Fourier transform infrared spectroscopy, while XRD analysis revealed that these samples are amorphous. Swelling measurements, water absorption study, dynamic mechanical analysis, differential scanning calorimetry, thermogravimetric analysis, mechanical tests and scanning electron microscope revealed that, swelling behavior, hydrophobicity, thermal and mechanical features and morphology of PU networks show clear dependence on polycaprolactone content. The increase of the SS content induced appearance of the microphase separated morphology, increase of thermal stability, elongation at break, hydrophobicity and swelling ability in tetrahydrofuran and toluene, but at the same time it is responsible for the decrease of crosslinking density, glass transition temperatures, rigidity, tensile strength and Young's modulus of PU networks. Scanning electron microscope images of the fracture surfaces of PU networks show that their surface is rough, irregular, with flake-like structure, where size of flakes increases with increasing SS content. These results indicate that by choosing adequate SS content, PU coatings with diverse features based on polycaprolactone and Boltorn (R) aliphatic hyperbranched polyester can be designed for appropriate and desired application.",
publisher = "Elsevier Science Sa, Lausanne",
journal = "Progress in Organic Coatings",
title = "Polyurethane networks based on polycaprolactone and hyperbranched polyester: Structural, thermal and mechanical investigation",
volume = "137",
doi = "10.1016/j.porgcoat.2019.105305"
}

Džunuzović, J., Stefanović, I., Džunuzović, E., Dapčević, A., Šešlija, S., Balanč, B.,& Lamae, G. C.. (2019). Polyurethane networks based on polycaprolactone and hyperbranched polyester: Structural, thermal and mechanical investigation. in Progress in Organic Coatings
Elsevier Science Sa, Lausanne., 137.
https://doi.org/10.1016/j.porgcoat.2019.105305

Džunuzović J, Stefanović I, Džunuzović E, Dapčević A, Šešlija S, Balanč B, Lamae GC. Polyurethane networks based on polycaprolactone and hyperbranched polyester: Structural, thermal and mechanical investigation. in Progress in Organic Coatings. 2019;137.
doi:10.1016/j.porgcoat.2019.105305 .

Džunuzović, Jasna, Stefanović, Ivan, Džunuzović, Enis, Dapčević, Aleksandra, Šešlija, Sanja, Balanč, Bojana, Lamae, Giuseppe C., "Polyurethane networks based on polycaprolactone and hyperbranched polyester: Structural, thermal and mechanical investigation" in Progress in Organic Coatings, 137 (2019),
https://doi.org/10.1016/j.porgcoat.2019.105305 . .

TY  - CONF
AU  - Marković, Maja
AU  - Panić, Vesna
AU  - Šešlija, Sanja
AU  - Spasojević, Pavle
AU  - Ugrinović, Vukašin
AU  - Bošković-Vragolović, Nevenka
AU  - Pjanović, Rada
PY  - 2019
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5075
AB  - Soft polymeric networks based on poly(methacrylic
acid) (PMAA) are attractive candidates for targeted and
controlled drug release due to their non-toxicity,
biocompatibility and pH-sensitivity. The highly hydrophilic
nature of PMAA networks enables transport of hydrophilic
drugs only. This limitation has been overcome in present work
by a PMAA modification with casein and liposomes. Casein is a
natural amphiphilic protein which enabled the encapsulation
and targeted and controlled release of the model drug- caffeine.
The FTIR spectra showed that the hydrophobic interactions and
hydrogen bonds were established between the casein and
caffeine. The caffeine in vitro release was monitored in two media
at 37C: phosphate buffer pH=6.8, which simulated the pH
environment in the human intestines and 0.1M HCl pH=1.2,
which simulated the pH environment in the human stomach. The
presence of liposomes with the encapsulated caffeine in the
carriers caused the decrease in the speed of caffeine release.
Introduction of itaconic acid (IA) as a hydrophilic and pHsensitive substance with two carboxylic groups resulted in a nonregular structure of the carriers with large voids which caused
an increase in swelling rate of the carriers and an increase in
speed of caffeine release. All obtained results showed that the
targeted and controlled release of a poorly water-soluble
substance was achieved.
PB  - ETRAN Society, Belgrade, Academic Mind, Belgrade
C3  - 6th International Conference on Electrical, Electronic and Computing Engineering, IcETRAN 2019
T1  - Soft polymeric networks based on poly(methacrylic acid), itaconic acid, casein and liposomes for targeted delivery and controlled release of poorly water soluble active substance
EP  - 670
SP  - 665
UR  - https://hdl.handle.net/21.15107/rcub_technorep_5075
ER  - 

@conference{
author = "Marković, Maja and Panić, Vesna and Šešlija, Sanja and Spasojević, Pavle and Ugrinović, Vukašin and Bošković-Vragolović, Nevenka and Pjanović, Rada",
year = "2019",
abstract = "Soft polymeric networks based on poly(methacrylic
acid) (PMAA) are attractive candidates for targeted and
controlled drug release due to their non-toxicity,
biocompatibility and pH-sensitivity. The highly hydrophilic
nature of PMAA networks enables transport of hydrophilic
drugs only. This limitation has been overcome in present work
by a PMAA modification with casein and liposomes. Casein is a
natural amphiphilic protein which enabled the encapsulation
and targeted and controlled release of the model drug- caffeine.
The FTIR spectra showed that the hydrophobic interactions and
hydrogen bonds were established between the casein and
caffeine. The caffeine in vitro release was monitored in two media
at 37C: phosphate buffer pH=6.8, which simulated the pH
environment in the human intestines and 0.1M HCl pH=1.2,
which simulated the pH environment in the human stomach. The
presence of liposomes with the encapsulated caffeine in the
carriers caused the decrease in the speed of caffeine release.
Introduction of itaconic acid (IA) as a hydrophilic and pHsensitive substance with two carboxylic groups resulted in a nonregular structure of the carriers with large voids which caused
an increase in swelling rate of the carriers and an increase in
speed of caffeine release. All obtained results showed that the
targeted and controlled release of a poorly water-soluble
substance was achieved.",
publisher = "ETRAN Society, Belgrade, Academic Mind, Belgrade",
journal = "6th International Conference on Electrical, Electronic and Computing Engineering, IcETRAN 2019",
title = "Soft polymeric networks based on poly(methacrylic acid), itaconic acid, casein and liposomes for targeted delivery and controlled release of poorly water soluble active substance",
pages = "670-665",
url = "https://hdl.handle.net/21.15107/rcub_technorep_5075"
}

Marković, M., Panić, V., Šešlija, S., Spasojević, P., Ugrinović, V., Bošković-Vragolović, N.,& Pjanović, R.. (2019). Soft polymeric networks based on poly(methacrylic acid), itaconic acid, casein and liposomes for targeted delivery and controlled release of poorly water soluble active substance. in 6th International Conference on Electrical, Electronic and Computing Engineering, IcETRAN 2019
ETRAN Society, Belgrade, Academic Mind, Belgrade., 665-670.
https://hdl.handle.net/21.15107/rcub_technorep_5075

Marković M, Panić V, Šešlija S, Spasojević P, Ugrinović V, Bošković-Vragolović N, Pjanović R. Soft polymeric networks based on poly(methacrylic acid), itaconic acid, casein and liposomes for targeted delivery and controlled release of poorly water soluble active substance. in 6th International Conference on Electrical, Electronic and Computing Engineering, IcETRAN 2019. 2019;:665-670.
https://hdl.handle.net/21.15107/rcub_technorep_5075 .

Marković, Maja, Panić, Vesna, Šešlija, Sanja, Spasojević, Pavle, Ugrinović, Vukašin, Bošković-Vragolović, Nevenka, Pjanović, Rada, "Soft polymeric networks based on poly(methacrylic acid), itaconic acid, casein and liposomes for targeted delivery and controlled release of poorly water soluble active substance" in 6th International Conference on Electrical, Electronic and Computing Engineering, IcETRAN 2019 (2019):665-670,
https://hdl.handle.net/21.15107/rcub_technorep_5075 .

TY  - JOUR
AU  - Jevremović, Nenad
AU  - Kalagasidis Krušić, Melina
AU  - Antanasijević, Davor
AU  - Popović, Ivanka
PY  - 2019
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4093
AB  - Nowadays, the extensive use of pesticides in crops production puts a significant challenge to minimize its side effects along with safe production, storage, and after-use treatment. This paper reports results related to the emission of certain pesticide formulations through the PET containers, as well as, their mitigation to the PET containers during their storage. The influence of storage time on cypermethrin migration to and through the PET was studied in short-term Collaborative International Pesticides Analytical Council test lasting up to 30 days. The PET containers were filled with pure xylene and pesticide formulations, where the amount of active substance, cypermethrin (CY), varied from 5 to 20 wt%, while the amount of emulsifier was kept constant. The results indicate that pesticide formulations diffuse to PET containers with an average increase of its initial mass up to 1.5%. The most intensive diffusion is in the first 24 months of storage, after its rate significantly decreases. It should be noted that the diffusion studied pesticide formulations are also very dependent on CY concentration. Besides the migration to the PET containers, it was also found that pesticide formulation was emitted through the PET containers in the first 17 to 24 months of storage depending on CY concentration. Emission rates were also dependent on CY concentration and were in the range of 15.3 to 38.0 mg/month center dot container. The emission through the PETcontainers was successfully predicted using artificial neural networks with R-2 = 0.94 and the mean absolute percentage error (MAPE) of only 6.2% on testing.
PB  - Springer Verlag
T2  - Environmental Science and Pollution Research
T1  - Migration of cypermethrin to and through the PET containers and artificial neural network-based estimation of its emission
EP  - 28939
IS  - 28
SP  - 28933
VL  - 26
DO  - 10.1007/s11356-019-06108-8
ER  - 

@article{
author = "Jevremović, Nenad and Kalagasidis Krušić, Melina and Antanasijević, Davor and Popović, Ivanka",
year = "2019",
abstract = "Nowadays, the extensive use of pesticides in crops production puts a significant challenge to minimize its side effects along with safe production, storage, and after-use treatment. This paper reports results related to the emission of certain pesticide formulations through the PET containers, as well as, their mitigation to the PET containers during their storage. The influence of storage time on cypermethrin migration to and through the PET was studied in short-term Collaborative International Pesticides Analytical Council test lasting up to 30 days. The PET containers were filled with pure xylene and pesticide formulations, where the amount of active substance, cypermethrin (CY), varied from 5 to 20 wt%, while the amount of emulsifier was kept constant. The results indicate that pesticide formulations diffuse to PET containers with an average increase of its initial mass up to 1.5%. The most intensive diffusion is in the first 24 months of storage, after its rate significantly decreases. It should be noted that the diffusion studied pesticide formulations are also very dependent on CY concentration. Besides the migration to the PET containers, it was also found that pesticide formulation was emitted through the PET containers in the first 17 to 24 months of storage depending on CY concentration. Emission rates were also dependent on CY concentration and were in the range of 15.3 to 38.0 mg/month center dot container. The emission through the PETcontainers was successfully predicted using artificial neural networks with R-2 = 0.94 and the mean absolute percentage error (MAPE) of only 6.2% on testing.",
publisher = "Springer Verlag",
journal = "Environmental Science and Pollution Research",
title = "Migration of cypermethrin to and through the PET containers and artificial neural network-based estimation of its emission",
pages = "28939-28933",
number = "28",
volume = "26",
doi = "10.1007/s11356-019-06108-8"
}

Jevremović, N., Kalagasidis Krušić, M., Antanasijević, D.,& Popović, I.. (2019). Migration of cypermethrin to and through the PET containers and artificial neural network-based estimation of its emission. in Environmental Science and Pollution Research
Springer Verlag., 26(28), 28933-28939.
https://doi.org/10.1007/s11356-019-06108-8

Jevremović N, Kalagasidis Krušić M, Antanasijević D, Popović I. Migration of cypermethrin to and through the PET containers and artificial neural network-based estimation of its emission. in Environmental Science and Pollution Research. 2019;26(28):28933-28939.
doi:10.1007/s11356-019-06108-8 .

Jevremović, Nenad, Kalagasidis Krušić, Melina, Antanasijević, Davor, Popović, Ivanka, "Migration of cypermethrin to and through the PET containers and artificial neural network-based estimation of its emission" in Environmental Science and Pollution Research, 26, no. 28 (2019):28933-28939,
https://doi.org/10.1007/s11356-019-06108-8 . .

TY  - JOUR
AU  - Marković, Maja
AU  - Spasojević, Pavle
AU  - Šešlija, Sanja
AU  - Popović, Ivanka
AU  - Veljović, Đorđe
AU  - Pjanović, Rada
AU  - Panić, Vesna
PY  - 2019
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4245
AB  - The design of complex polymeric materials with predefined task-specific properties meets challenging issues: to establish synthesis-structure-properties relationship, as well as to understand the arrangement and interactions of the involved components. Hybrid networks of protein (casein) and polyelectrolyte (poly(methacrylic acid)) were synthesized and their swelling, dynamic-mechanical and morphological properties were investigated as functions of the neutralization degree of methacrylic acid and the concentrations of caseinate and crosslinker. The domination of different interactions between components led to diverse forms of casein macromolecules-from micelles to unfold chains. That resulted in very different structures and thereby properties of derived hybrid networks: from porous unswellable to highly swellable and reinforced ones. A great opportunity to easily modulate the final characteristics of the reported hybrid system to fit the need of specific application just through the change of one synthesis parameter was thereby demonstrated.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - European Polymer Journal
T1  - Casein-poly(methacrylic acid) hybrid soft networks with easy tunable properties
EP  - 288
SP  - 276
VL  - 113
DO  - 10.1016/j.eurpolymj.2019.01.065
ER  - 

@article{
author = "Marković, Maja and Spasojević, Pavle and Šešlija, Sanja and Popović, Ivanka and Veljović, Đorđe and Pjanović, Rada and Panić, Vesna",
year = "2019",
abstract = "The design of complex polymeric materials with predefined task-specific properties meets challenging issues: to establish synthesis-structure-properties relationship, as well as to understand the arrangement and interactions of the involved components. Hybrid networks of protein (casein) and polyelectrolyte (poly(methacrylic acid)) were synthesized and their swelling, dynamic-mechanical and morphological properties were investigated as functions of the neutralization degree of methacrylic acid and the concentrations of caseinate and crosslinker. The domination of different interactions between components led to diverse forms of casein macromolecules-from micelles to unfold chains. That resulted in very different structures and thereby properties of derived hybrid networks: from porous unswellable to highly swellable and reinforced ones. A great opportunity to easily modulate the final characteristics of the reported hybrid system to fit the need of specific application just through the change of one synthesis parameter was thereby demonstrated.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "European Polymer Journal",
title = "Casein-poly(methacrylic acid) hybrid soft networks with easy tunable properties",
pages = "288-276",
volume = "113",
doi = "10.1016/j.eurpolymj.2019.01.065"
}

Marković, M., Spasojević, P., Šešlija, S., Popović, I., Veljović, Đ., Pjanović, R.,& Panić, V.. (2019). Casein-poly(methacrylic acid) hybrid soft networks with easy tunable properties. in European Polymer Journal
Pergamon-Elsevier Science Ltd, Oxford., 113, 276-288.
https://doi.org/10.1016/j.eurpolymj.2019.01.065

Marković M, Spasojević P, Šešlija S, Popović I, Veljović Đ, Pjanović R, Panić V. Casein-poly(methacrylic acid) hybrid soft networks with easy tunable properties. in European Polymer Journal. 2019;113:276-288.
doi:10.1016/j.eurpolymj.2019.01.065 .

Marković, Maja, Spasojević, Pavle, Šešlija, Sanja, Popović, Ivanka, Veljović, Đorđe, Pjanović, Rada, Panić, Vesna, "Casein-poly(methacrylic acid) hybrid soft networks with easy tunable properties" in European Polymer Journal, 113 (2019):276-288,
https://doi.org/10.1016/j.eurpolymj.2019.01.065 . .

TY  - JOUR
AU  - Tomić, Miloš
AU  - Dunjić, Branko
AU  - Nikolić, Marija
AU  - Trifković, Kata T.
AU  - Stanković, Nadežda
AU  - Pavlović, Vladimir B.
AU  - Bajat, Jelena
AU  - Đonlagić, Jasna
PY  - 2019
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4262
AB  - In the present study the commercial multifunctional fatty acid polyamidoamine (PAA) was for the first time simultaneously applied as a curing agent and clay modifier for epoxy/clay nanocomposites (NC) based on diglycidyl ether of bisphenol A. The montmorillonite (Cloisite (R) Na+) was modified with different quantities of partially and fully protonated polyamidoamine. The NCs with 0.5 wt% novel organoclay were prepared by solution intercalation method. The major aims of this paper are investigations of the effects of the composition of PAA modified clays on structure, mechanical, barrier properties and corrosion stability on steel substrates of NCs were studied. The thermogravimetric, flame photometry and X-ray diffraction analyses confirmed the efficient modification of clay surface with polyamidoamine, predominantly located within layers. The NCs exhibited an intercalated/exfoliated morphology and the presence of free amino groups and increased content of modifier facilitated dispersion of clay particles within the polymer matrix, as shown by electron microscopy techniques (SEM, TEM). Under an optimized loading of PAA (molar quantity of total amino groups per clay cation exchange capacity of 1.75), the layers in stacks were separated by 5.0 nm and high number of individual layers was present in NC. Clay modified by PAA with free amino groups showed increased storage modulus in the rubbery state, glass transition temperature of NCs, while dumping factor was decreased. The tensile test confirmed that introduction of flexible modifier on the epoxy/clay interface lead to increase in the ultimate tensile strenght and elongation at break by 31% and toughness up to 83%. The electrochemical impedance spectroscopy and permeability tests proved the pronounced barrier effect of clay particles against corrosive species and water vapor when high dispersion degree of clay in NC was achieved.
PB  - Elsevier Science Sa, Lausanne
T2  - Progress in Organic Coatings
T1  - Polyamidoamine as a clay modifier and curing agent in preparation of epoxy nanocomposites
EP  - 321
SP  - 311
VL  - 131
DO  - 10.1016/j.porgcoat.2019.02.037
ER  - 

@article{
author = "Tomić, Miloš and Dunjić, Branko and Nikolić, Marija and Trifković, Kata T. and Stanković, Nadežda and Pavlović, Vladimir B. and Bajat, Jelena and Đonlagić, Jasna",
year = "2019",
abstract = "In the present study the commercial multifunctional fatty acid polyamidoamine (PAA) was for the first time simultaneously applied as a curing agent and clay modifier for epoxy/clay nanocomposites (NC) based on diglycidyl ether of bisphenol A. The montmorillonite (Cloisite (R) Na+) was modified with different quantities of partially and fully protonated polyamidoamine. The NCs with 0.5 wt% novel organoclay were prepared by solution intercalation method. The major aims of this paper are investigations of the effects of the composition of PAA modified clays on structure, mechanical, barrier properties and corrosion stability on steel substrates of NCs were studied. The thermogravimetric, flame photometry and X-ray diffraction analyses confirmed the efficient modification of clay surface with polyamidoamine, predominantly located within layers. The NCs exhibited an intercalated/exfoliated morphology and the presence of free amino groups and increased content of modifier facilitated dispersion of clay particles within the polymer matrix, as shown by electron microscopy techniques (SEM, TEM). Under an optimized loading of PAA (molar quantity of total amino groups per clay cation exchange capacity of 1.75), the layers in stacks were separated by 5.0 nm and high number of individual layers was present in NC. Clay modified by PAA with free amino groups showed increased storage modulus in the rubbery state, glass transition temperature of NCs, while dumping factor was decreased. The tensile test confirmed that introduction of flexible modifier on the epoxy/clay interface lead to increase in the ultimate tensile strenght and elongation at break by 31% and toughness up to 83%. The electrochemical impedance spectroscopy and permeability tests proved the pronounced barrier effect of clay particles against corrosive species and water vapor when high dispersion degree of clay in NC was achieved.",
publisher = "Elsevier Science Sa, Lausanne",
journal = "Progress in Organic Coatings",
title = "Polyamidoamine as a clay modifier and curing agent in preparation of epoxy nanocomposites",
pages = "321-311",
volume = "131",
doi = "10.1016/j.porgcoat.2019.02.037"
}

Tomić, M., Dunjić, B., Nikolić, M., Trifković, K. T., Stanković, N., Pavlović, V. B., Bajat, J.,& Đonlagić, J.. (2019). Polyamidoamine as a clay modifier and curing agent in preparation of epoxy nanocomposites. in Progress in Organic Coatings
Elsevier Science Sa, Lausanne., 131, 311-321.
https://doi.org/10.1016/j.porgcoat.2019.02.037

Tomić M, Dunjić B, Nikolić M, Trifković KT, Stanković N, Pavlović VB, Bajat J, Đonlagić J. Polyamidoamine as a clay modifier and curing agent in preparation of epoxy nanocomposites. in Progress in Organic Coatings. 2019;131:311-321.
doi:10.1016/j.porgcoat.2019.02.037 .

Tomić, Miloš, Dunjić, Branko, Nikolić, Marija, Trifković, Kata T., Stanković, Nadežda, Pavlović, Vladimir B., Bajat, Jelena, Đonlagić, Jasna, "Polyamidoamine as a clay modifier and curing agent in preparation of epoxy nanocomposites" in Progress in Organic Coatings, 131 (2019):311-321,
https://doi.org/10.1016/j.porgcoat.2019.02.037 . .

TY  - JOUR
AU  - Lazouzi, Gamal
AU  - Vuksanović, Marija M.
AU  - Tomić, Nataša
AU  - Petrović, Miloš
AU  - Spasojević, Pavle
AU  - Radojević, Vesna
AU  - Jančić-Heinemann, Radmila
PY  - 2019
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4241
AB  - PMMA poly(methyl methacrylate) has a large spectrum of uses as bone cements, in dentistry as denture base materials and other industrial applications. One of the main drawbacks of these materials is the residual monomer that is proven allergen and irritant. It was shown that addition of dimethyl itaconate (DMI) to the PMMA denture base systems decrease the quantity of residual monomer but, also deteriorate mechanical properties. The addition of alumina fillers in the PMMA/DMI produced composite materials results in improved mechanical properties compared with pure PMMA and additionally reduces the level of residual monomer in the composition. POLYM. COMPOS., 40:1691-1701, 2019.
PB  - Wiley, Hoboken
T2  - Polymer Composites
T1  - Dimethyl Itaconate Modified PMMA - Alumina Fillers Composites With Improved Mechanical Properties
EP  - 1701
IS  - 5
SP  - 1691
VL  - 40
DO  - 10.1002/pc.24952
ER  - 

@article{
author = "Lazouzi, Gamal and Vuksanović, Marija M. and Tomić, Nataša and Petrović, Miloš and Spasojević, Pavle and Radojević, Vesna and Jančić-Heinemann, Radmila",
year = "2019",
abstract = "PMMA poly(methyl methacrylate) has a large spectrum of uses as bone cements, in dentistry as denture base materials and other industrial applications. One of the main drawbacks of these materials is the residual monomer that is proven allergen and irritant. It was shown that addition of dimethyl itaconate (DMI) to the PMMA denture base systems decrease the quantity of residual monomer but, also deteriorate mechanical properties. The addition of alumina fillers in the PMMA/DMI produced composite materials results in improved mechanical properties compared with pure PMMA and additionally reduces the level of residual monomer in the composition. POLYM. COMPOS., 40:1691-1701, 2019.",
publisher = "Wiley, Hoboken",
journal = "Polymer Composites",
title = "Dimethyl Itaconate Modified PMMA - Alumina Fillers Composites With Improved Mechanical Properties",
pages = "1701-1691",
number = "5",
volume = "40",
doi = "10.1002/pc.24952"
}

Lazouzi, G., Vuksanović, M. M., Tomić, N., Petrović, M., Spasojević, P., Radojević, V.,& Jančić-Heinemann, R.. (2019). Dimethyl Itaconate Modified PMMA - Alumina Fillers Composites With Improved Mechanical Properties. in Polymer Composites
Wiley, Hoboken., 40(5), 1691-1701.
https://doi.org/10.1002/pc.24952

Lazouzi G, Vuksanović MM, Tomić N, Petrović M, Spasojević P, Radojević V, Jančić-Heinemann R. Dimethyl Itaconate Modified PMMA - Alumina Fillers Composites With Improved Mechanical Properties. in Polymer Composites. 2019;40(5):1691-1701.
doi:10.1002/pc.24952 .

Lazouzi, Gamal, Vuksanović, Marija M., Tomić, Nataša, Petrović, Miloš, Spasojević, Pavle, Radojević, Vesna, Jančić-Heinemann, Radmila, "Dimethyl Itaconate Modified PMMA - Alumina Fillers Composites With Improved Mechanical Properties" in Polymer Composites, 40, no. 5 (2019):1691-1701,
https://doi.org/10.1002/pc.24952 . .

TY  - JOUR
AU  - Filipović, Vuk
AU  - Babić, Marija
AU  - Gođevac, Dejan
AU  - Pavić, Aleksandar
AU  - Nikodinović-Runić, Jasmina
AU  - Tomić, Simonida
PY  - 2019
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4076
AB  - New (beta-aminoester) hydrogels (PBAE) based on di(ethylene glycol)diacrylate and glycine are successfully synthesized and characterized for the first time in this work. PBAE macromers are obtained using Michael addition. By changing the diacrylate/amine stoichiometric ratio, but maintaining it  gt 1, samples with different chemical structure containing acrylate end-groups are obtained. The hydrogels are synthesized from macromers utilizing free radical polymerization. Chemical structure of macromers and hydrogels is confirmed by proton nuclear magnetic resonance, and Fourier transform infra-red spectroscopy. Swelling and degradation rates in physiological pH range change notably with pH and monomer molar ratio, validating pH sensitivity and zwitterionic behavior, which can be finely tuned by changing any of these parameters. In vitro cytotoxicity and in vivo acute embryotoxicity in zebrafish (Danio rerio) performed to assess the biocompatibility of the novel hydrogel materials and their degradation products reveal that materials are nontoxic and biocompatible. The Cephalexin in vitro drug release study, at pH values 2.20, 5.50, and 7.40, demonstrates pH-sensitive delivery with the release profiles effectively controlled by pH and the hydrogel composition. PBAE hydrogels exhibit great potential for a variety of biomedical applications, including tissue regeneration and intelligent drug delivery systems.
PB  - Wiley-VCH Verlag Gmbh, Weinheim
T2  - Macromolecular Chemistry and Physics
T1  - In Vitro and In Vivo Biocompatibility of Novel Zwitterionic Poly(Beta Amino)Ester Hydrogels Based on Diacrylate and Glycine for Site-Specific Controlled Drug Release
IS  - 17
SP  - 1900188
VL  - 220
DO  - 10.1002/macp.201900188
ER  - 

@article{
author = "Filipović, Vuk and Babić, Marija and Gođevac, Dejan and Pavić, Aleksandar and Nikodinović-Runić, Jasmina and Tomić, Simonida",
year = "2019",
abstract = "New (beta-aminoester) hydrogels (PBAE) based on di(ethylene glycol)diacrylate and glycine are successfully synthesized and characterized for the first time in this work. PBAE macromers are obtained using Michael addition. By changing the diacrylate/amine stoichiometric ratio, but maintaining it  gt 1, samples with different chemical structure containing acrylate end-groups are obtained. The hydrogels are synthesized from macromers utilizing free radical polymerization. Chemical structure of macromers and hydrogels is confirmed by proton nuclear magnetic resonance, and Fourier transform infra-red spectroscopy. Swelling and degradation rates in physiological pH range change notably with pH and monomer molar ratio, validating pH sensitivity and zwitterionic behavior, which can be finely tuned by changing any of these parameters. In vitro cytotoxicity and in vivo acute embryotoxicity in zebrafish (Danio rerio) performed to assess the biocompatibility of the novel hydrogel materials and their degradation products reveal that materials are nontoxic and biocompatible. The Cephalexin in vitro drug release study, at pH values 2.20, 5.50, and 7.40, demonstrates pH-sensitive delivery with the release profiles effectively controlled by pH and the hydrogel composition. PBAE hydrogels exhibit great potential for a variety of biomedical applications, including tissue regeneration and intelligent drug delivery systems.",
publisher = "Wiley-VCH Verlag Gmbh, Weinheim",
journal = "Macromolecular Chemistry and Physics",
title = "In Vitro and In Vivo Biocompatibility of Novel Zwitterionic Poly(Beta Amino)Ester Hydrogels Based on Diacrylate and Glycine for Site-Specific Controlled Drug Release",
number = "17",
pages = "1900188",
volume = "220",
doi = "10.1002/macp.201900188"
}

Filipović, V., Babić, M., Gođevac, D., Pavić, A., Nikodinović-Runić, J.,& Tomić, S.. (2019). In Vitro and In Vivo Biocompatibility of Novel Zwitterionic Poly(Beta Amino)Ester Hydrogels Based on Diacrylate and Glycine for Site-Specific Controlled Drug Release. in Macromolecular Chemistry and Physics
Wiley-VCH Verlag Gmbh, Weinheim., 220(17), 1900188.
https://doi.org/10.1002/macp.201900188

Filipović V, Babić M, Gođevac D, Pavić A, Nikodinović-Runić J, Tomić S. In Vitro and In Vivo Biocompatibility of Novel Zwitterionic Poly(Beta Amino)Ester Hydrogels Based on Diacrylate and Glycine for Site-Specific Controlled Drug Release. in Macromolecular Chemistry and Physics. 2019;220(17):1900188.
doi:10.1002/macp.201900188 .

Filipović, Vuk, Babić, Marija, Gođevac, Dejan, Pavić, Aleksandar, Nikodinović-Runić, Jasmina, Tomić, Simonida, "In Vitro and In Vivo Biocompatibility of Novel Zwitterionic Poly(Beta Amino)Ester Hydrogels Based on Diacrylate and Glycine for Site-Specific Controlled Drug Release" in Macromolecular Chemistry and Physics, 220, no. 17 (2019):1900188,
https://doi.org/10.1002/macp.201900188 . .