TY  - JOUR
AU  - Pajnik, Jelena
AU  - Dikić, Jelena
AU  - Milovanović, Stoja
AU  - Milošević, Milena
AU  - Jevtić, Sanja
AU  - Lukić, Ivana
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5085
AB  - Chitosan/gelatin and chitosan/gelatin/zeolite films prepared by solvent casting method were
impregnated with a mixture of thymol and carvacrol using a green solvent, supercritical carbon 
dioxide at 35 °C and 30 MPa, during 18 h. Proposed method enabled preparation of biocompatible 
and biodegradable blends with strong antioxidant and antibacterial activity, whereby amounts of 
loaded thymol/carvacrol mixture were in the range from 3.3-6%. After initial burst release, both 
types of films exhibited gradual release of bioactive compounds, with around 72 and 96% of 
impregnated thymol/carvacrol mixture released in water and PBS (pH 7.4) during tested period of 10 days, respectively. Results of water vapor transmission rate (> 76 gm-2
day-1) confirmed that prepared composites are suitable for wound dressing application. Thermal analysis showed superior properties of prepared thymol/carvacrol loaded films compared to control samples. In addition, mechanical and structural properties, as well as solubility and swelling behavior of the obtained films were investigated in detail.
PB  - Wiley
T2  - Macromolecular Materials and Engineering
T1  - Zeolite/chitosan/gelatin films: preparation, supercritical CO2 processing, characterization and bioactivity
EP  - 13
IS  - 4
SP  - 1
VL  - 307
DO  - 10.1002/mame.202200009
ER  - 

@article{
author = "Pajnik, Jelena and Dikić, Jelena and Milovanović, Stoja and Milošević, Milena and Jevtić, Sanja and Lukić, Ivana",
year = "2022",
abstract = "Chitosan/gelatin and chitosan/gelatin/zeolite films prepared by solvent casting method were
impregnated with a mixture of thymol and carvacrol using a green solvent, supercritical carbon 
dioxide at 35 °C and 30 MPa, during 18 h. Proposed method enabled preparation of biocompatible 
and biodegradable blends with strong antioxidant and antibacterial activity, whereby amounts of 
loaded thymol/carvacrol mixture were in the range from 3.3-6%. After initial burst release, both 
types of films exhibited gradual release of bioactive compounds, with around 72 and 96% of 
impregnated thymol/carvacrol mixture released in water and PBS (pH 7.4) during tested period of 10 days, respectively. Results of water vapor transmission rate (> 76 gm-2
day-1) confirmed that prepared composites are suitable for wound dressing application. Thermal analysis showed superior properties of prepared thymol/carvacrol loaded films compared to control samples. In addition, mechanical and structural properties, as well as solubility and swelling behavior of the obtained films were investigated in detail.",
publisher = "Wiley",
journal = "Macromolecular Materials and Engineering",
title = "Zeolite/chitosan/gelatin films: preparation, supercritical CO2 processing, characterization and bioactivity",
pages = "13-1",
number = "4",
volume = "307",
doi = "10.1002/mame.202200009"
}

Pajnik, J., Dikić, J., Milovanović, S., Milošević, M., Jevtić, S.,& Lukić, I.. (2022). Zeolite/chitosan/gelatin films: preparation, supercritical CO2 processing, characterization and bioactivity. in Macromolecular Materials and Engineering
Wiley., 307(4), 1-13.
https://doi.org/10.1002/mame.202200009

Pajnik J, Dikić J, Milovanović S, Milošević M, Jevtić S, Lukić I. Zeolite/chitosan/gelatin films: preparation, supercritical CO2 processing, characterization and bioactivity. in Macromolecular Materials and Engineering. 2022;307(4):1-13.
doi:10.1002/mame.202200009 .

Pajnik, Jelena, Dikić, Jelena, Milovanović, Stoja, Milošević, Milena, Jevtić, Sanja, Lukić, Ivana, "Zeolite/chitosan/gelatin films: preparation, supercritical CO2 processing, characterization and bioactivity" in Macromolecular Materials and Engineering, 307, no. 4 (2022):1-13,
https://doi.org/10.1002/mame.202200009 . .