TY  - CONF
AU  - Filipović, Vuk
AU  - Marković, Maja
AU  - Tomić, Simonida
PY  - 2018
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7370
AB  - Hydrogels represent three-dimensional hydrophilic polymer networks, capable of absorbing large quantities of water1. Due to their tissue-like characteristics, hydrogels have been widely used for a variety of biomedical and pharmaceutical applications. The synthesis and characterization of novel semi-degradable, pH and temperature sensitive hydrogels is presented in this work. These new functional hydrogels represent copolymers based on 2-hydroxyethyl methacrylate (HEMA) and 2-hydroxyethyl acrylate (HEA), crosslinked using poly(β-amino ester) (PBAE) degradable macromer. PBAE crosslinker was synthesized by Michael addition reaction of diethylene glycol diacrylate (DEGDA) and piperazine. PBAE chemical structure was confirmed by proton nuclear magnetic resonance (1H NMR) and Fourier transform infrared (FTIR) spectroscopy. HEMA/HEA/PBAE hydrogels were synthesized by free radical copolymerization, by varying the monomer ratio. Structural characterization of hydrogels was carried out using Fourier transform infrared spectroscopy (FTIR). Swelling studies, performed in different pH buffers, ranging from 2.00 to 7.40, and different temperature values, ranging from 20 to 55°C, showed the pH and temperature sensitivity of the hydrogels. From the obtained results it can also be concluded that the swelling and degradation rates of new hydrogels can easily be adjusted by altering the comonomer ratio, making them a class of materials that is particularly suitable for potential drug delivery and tissue engineering applications.
PB  - Beograd : Srpsko hemijsko društvo = Serbian Chemical Society
C3  - Kratki izvodi radova / Šesta konferencija mladih hemičara Srbije, Beograd, 27. oktobar 2018. = Book of Abstracts / Sixth Conference of Young Chemists of Serbia, Belgrade, 27th October 2018
T1  - Synthesis and characterization of novel semi-degradable, pH and temperature sensitive hydrogels based on 2-hydroxyethyl methacrylate and 2-hydroxyethyl acrylate
SP  - 21
UR  - https://hdl.handle.net/21.15107/rcub_technorep_7370
ER  - 

@conference{
author = "Filipović, Vuk and Marković, Maja and Tomić, Simonida",
year = "2018",
abstract = "Hydrogels represent three-dimensional hydrophilic polymer networks, capable of absorbing large quantities of water1. Due to their tissue-like characteristics, hydrogels have been widely used for a variety of biomedical and pharmaceutical applications. The synthesis and characterization of novel semi-degradable, pH and temperature sensitive hydrogels is presented in this work. These new functional hydrogels represent copolymers based on 2-hydroxyethyl methacrylate (HEMA) and 2-hydroxyethyl acrylate (HEA), crosslinked using poly(β-amino ester) (PBAE) degradable macromer. PBAE crosslinker was synthesized by Michael addition reaction of diethylene glycol diacrylate (DEGDA) and piperazine. PBAE chemical structure was confirmed by proton nuclear magnetic resonance (1H NMR) and Fourier transform infrared (FTIR) spectroscopy. HEMA/HEA/PBAE hydrogels were synthesized by free radical copolymerization, by varying the monomer ratio. Structural characterization of hydrogels was carried out using Fourier transform infrared spectroscopy (FTIR). Swelling studies, performed in different pH buffers, ranging from 2.00 to 7.40, and different temperature values, ranging from 20 to 55°C, showed the pH and temperature sensitivity of the hydrogels. From the obtained results it can also be concluded that the swelling and degradation rates of new hydrogels can easily be adjusted by altering the comonomer ratio, making them a class of materials that is particularly suitable for potential drug delivery and tissue engineering applications.",
publisher = "Beograd : Srpsko hemijsko društvo = Serbian Chemical Society",
journal = "Kratki izvodi radova / Šesta konferencija mladih hemičara Srbije, Beograd, 27. oktobar 2018. = Book of Abstracts / Sixth Conference of Young Chemists of Serbia, Belgrade, 27th October 2018",
title = "Synthesis and characterization of novel semi-degradable, pH and temperature sensitive hydrogels based on 2-hydroxyethyl methacrylate and 2-hydroxyethyl acrylate",
pages = "21",
url = "https://hdl.handle.net/21.15107/rcub_technorep_7370"
}

Filipović, V., Marković, M.,& Tomić, S.. (2018). Synthesis and characterization of novel semi-degradable, pH and temperature sensitive hydrogels based on 2-hydroxyethyl methacrylate and 2-hydroxyethyl acrylate. in Kratki izvodi radova / Šesta konferencija mladih hemičara Srbije, Beograd, 27. oktobar 2018. = Book of Abstracts / Sixth Conference of Young Chemists of Serbia, Belgrade, 27th October 2018
Beograd : Srpsko hemijsko društvo = Serbian Chemical Society., 21.
https://hdl.handle.net/21.15107/rcub_technorep_7370

Filipović V, Marković M, Tomić S. Synthesis and characterization of novel semi-degradable, pH and temperature sensitive hydrogels based on 2-hydroxyethyl methacrylate and 2-hydroxyethyl acrylate. in Kratki izvodi radova / Šesta konferencija mladih hemičara Srbije, Beograd, 27. oktobar 2018. = Book of Abstracts / Sixth Conference of Young Chemists of Serbia, Belgrade, 27th October 2018. 2018;:21.
https://hdl.handle.net/21.15107/rcub_technorep_7370 .

Filipović, Vuk, Marković, Maja, Tomić, Simonida, "Synthesis and characterization of novel semi-degradable, pH and temperature sensitive hydrogels based on 2-hydroxyethyl methacrylate and 2-hydroxyethyl acrylate" in Kratki izvodi radova / Šesta konferencija mladih hemičara Srbije, Beograd, 27. oktobar 2018. = Book of Abstracts / Sixth Conference of Young Chemists of Serbia, Belgrade, 27th October 2018 (2018):21,
https://hdl.handle.net/21.15107/rcub_technorep_7370 .