TY  - JOUR
AU  - Filipović, Nenad R.
AU  - Bjelogrlić, Snežana K.
AU  - Marinković, Aleksandar
AU  - Verbić, Tatjana
AU  - Cvijetić, Ilija
AU  - Senćanski, Milan V.
AU  - Rodić, Marko
AU  - Vujčić, Miroslava T.
AU  - Sladić, Dušan M.
AU  - Striković, Zlatko
AU  - Todorović, Tamara
AU  - Muller, Christian D.
PY  - 2015
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3058
AB  - A new Zn(II)-based potential chemotherapeutic agent was synthesized from the ligand 2-quinolinecarboxaldehyde selenosemicarbazone (Hqasesc). Single crystal X-ray diffraction analysis showed that the Zn(II) complex consists of a cation [Zn(Hqasesc)(2)](2+), two perchlorate anions and one ethanol solvent molecule. The interaction of calf thymus (CT) DNA and human serum albumin (HSA) with the Zn(II) complex was explored using absorption and emission spectral methods, and also has been supported by molecular docking studies. The complex has more affinity to minor DNA groove than major, with no significant intercalation. The HSA interaction studies of the complex revealed the quenching of the intrinsic fluorescence of the HSA through a static quenching mechanism. The antitumor activity of the ligand and the complex against pancreatic adenocarcinoma cell line (AsPC-1) and acute monocytic leukemia (THP-1) cells was evaluated. Both compounds are strong concentration-dependent apoptosis inducers in THP-1 cells. While Hqasesc in AsPC-1 cells induces apoptosis only at the highest concentration, treatment with the Zn complex shows a concentration-dependent apoptotic response, where the treated cells are arrested in the G1-to-S phase accompanied with extensive activation of caspase-8 and -9. These results indicate that the ligand and Zn(II) complex display cell phenotype specific activity.
PB  - Royal Society of Chemistry
T2  - RSC Advances
T1  - Zn(II) complex with 2-quinolinecarboxaldehyde selenosemicarbazone: synthesis, structure, interaction studies with DNA/HSA, molecular docking and caspase-8 and-9 independent apoptose induction
EP  - 95211
IS  - 115
SP  - 95191
VL  - 5
DO  - 10.1039/c5ra19849f
ER  - 

@article{
author = "Filipović, Nenad R. and Bjelogrlić, Snežana K. and Marinković, Aleksandar and Verbić, Tatjana and Cvijetić, Ilija and Senćanski, Milan V. and Rodić, Marko and Vujčić, Miroslava T. and Sladić, Dušan M. and Striković, Zlatko and Todorović, Tamara and Muller, Christian D.",
year = "2015",
abstract = "A new Zn(II)-based potential chemotherapeutic agent was synthesized from the ligand 2-quinolinecarboxaldehyde selenosemicarbazone (Hqasesc). Single crystal X-ray diffraction analysis showed that the Zn(II) complex consists of a cation [Zn(Hqasesc)(2)](2+), two perchlorate anions and one ethanol solvent molecule. The interaction of calf thymus (CT) DNA and human serum albumin (HSA) with the Zn(II) complex was explored using absorption and emission spectral methods, and also has been supported by molecular docking studies. The complex has more affinity to minor DNA groove than major, with no significant intercalation. The HSA interaction studies of the complex revealed the quenching of the intrinsic fluorescence of the HSA through a static quenching mechanism. The antitumor activity of the ligand and the complex against pancreatic adenocarcinoma cell line (AsPC-1) and acute monocytic leukemia (THP-1) cells was evaluated. Both compounds are strong concentration-dependent apoptosis inducers in THP-1 cells. While Hqasesc in AsPC-1 cells induces apoptosis only at the highest concentration, treatment with the Zn complex shows a concentration-dependent apoptotic response, where the treated cells are arrested in the G1-to-S phase accompanied with extensive activation of caspase-8 and -9. These results indicate that the ligand and Zn(II) complex display cell phenotype specific activity.",
publisher = "Royal Society of Chemistry",
journal = "RSC Advances",
title = "Zn(II) complex with 2-quinolinecarboxaldehyde selenosemicarbazone: synthesis, structure, interaction studies with DNA/HSA, molecular docking and caspase-8 and-9 independent apoptose induction",
pages = "95211-95191",
number = "115",
volume = "5",
doi = "10.1039/c5ra19849f"
}

Filipović, N. R., Bjelogrlić, S. K., Marinković, A., Verbić, T., Cvijetić, I., Senćanski, M. V., Rodić, M., Vujčić, M. T., Sladić, D. M., Striković, Z., Todorović, T.,& Muller, C. D.. (2015). Zn(II) complex with 2-quinolinecarboxaldehyde selenosemicarbazone: synthesis, structure, interaction studies with DNA/HSA, molecular docking and caspase-8 and-9 independent apoptose induction. in RSC Advances
Royal Society of Chemistry., 5(115), 95191-95211.
https://doi.org/10.1039/c5ra19849f

Filipović NR, Bjelogrlić SK, Marinković A, Verbić T, Cvijetić I, Senćanski MV, Rodić M, Vujčić MT, Sladić DM, Striković Z, Todorović T, Muller CD. Zn(II) complex with 2-quinolinecarboxaldehyde selenosemicarbazone: synthesis, structure, interaction studies with DNA/HSA, molecular docking and caspase-8 and-9 independent apoptose induction. in RSC Advances. 2015;5(115):95191-95211.
doi:10.1039/c5ra19849f .

Filipović, Nenad R., Bjelogrlić, Snežana K., Marinković, Aleksandar, Verbić, Tatjana, Cvijetić, Ilija, Senćanski, Milan V., Rodić, Marko, Vujčić, Miroslava T., Sladić, Dušan M., Striković, Zlatko, Todorović, Tamara, Muller, Christian D., "Zn(II) complex with 2-quinolinecarboxaldehyde selenosemicarbazone: synthesis, structure, interaction studies with DNA/HSA, molecular docking and caspase-8 and-9 independent apoptose induction" in RSC Advances, 5, no. 115 (2015):95191-95211,
https://doi.org/10.1039/c5ra19849f . .

TY  - JOUR
AU  - Dukanović, Zoran
AU  - Glišić, Sandra
AU  - Jancić-Cobanin, Vesna
AU  - Niciforović, Miroslav
AU  - Georgiou, Constantinos A.
AU  - Orlović, Aleksandar
PY  - 2013
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2486
AB  - In order to expand diesel fuel processing capacity an option to co-hydrotreat straight run gas oil blended with fraction containing FCC naphtha and light cycle oil was investigated. Industrial test run was performed under pressure of 40 bar in the catalytic reactor with two layers of conventional Co-Mo/gamma-Al2O3 catalyst, by increasing volume content of FCC naphtha and light cycle oil fraction in the reactor inlet to 20%vol. Reactor inlet temperature was also increased during the test run from 327 to 334 degrees C. Liquid hourly space velocities between 1.05 and 1.32 h(-1) have been used with H-2/oil ratios of 908-1135 Nm(3) hydrogen/m(3) oil. Sulphur inlet concentrations of 6500-8200 ppm were reduced to 36-72 ppm in the hydrotreated oil. GC-MS analysis of the sulphur compound's sub-families has shown that most of the sulphur was present in more reactive classes like alkyl substituted benzothiophenes. High conversion of sulphur was achieved by a combination of the following process parameters: high reaction temperature, low space velocity, presence of FCC naphtha in the feed and distribution of inlet sulphur dominantly concentrated in more reactive benzothiophenes. The activation energy of 33.2 kcal/mol was determined for this type of feedstock using power law kinetic expression.
PB  - Elsevier Science Bv, Amsterdam
T2  - Fuel Processing Technology
T1  - Hydrotreating of straight-run gas oil blended with FCC naphtha and light cycle oil
EP  - 165
SP  - 160
VL  - 106
DO  - 10.1016/j.fuproc.2012.07.018
ER  - 

@article{
author = "Dukanović, Zoran and Glišić, Sandra and Jancić-Cobanin, Vesna and Niciforović, Miroslav and Georgiou, Constantinos A. and Orlović, Aleksandar",
year = "2013",
abstract = "In order to expand diesel fuel processing capacity an option to co-hydrotreat straight run gas oil blended with fraction containing FCC naphtha and light cycle oil was investigated. Industrial test run was performed under pressure of 40 bar in the catalytic reactor with two layers of conventional Co-Mo/gamma-Al2O3 catalyst, by increasing volume content of FCC naphtha and light cycle oil fraction in the reactor inlet to 20%vol. Reactor inlet temperature was also increased during the test run from 327 to 334 degrees C. Liquid hourly space velocities between 1.05 and 1.32 h(-1) have been used with H-2/oil ratios of 908-1135 Nm(3) hydrogen/m(3) oil. Sulphur inlet concentrations of 6500-8200 ppm were reduced to 36-72 ppm in the hydrotreated oil. GC-MS analysis of the sulphur compound's sub-families has shown that most of the sulphur was present in more reactive classes like alkyl substituted benzothiophenes. High conversion of sulphur was achieved by a combination of the following process parameters: high reaction temperature, low space velocity, presence of FCC naphtha in the feed and distribution of inlet sulphur dominantly concentrated in more reactive benzothiophenes. The activation energy of 33.2 kcal/mol was determined for this type of feedstock using power law kinetic expression.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Fuel Processing Technology",
title = "Hydrotreating of straight-run gas oil blended with FCC naphtha and light cycle oil",
pages = "165-160",
volume = "106",
doi = "10.1016/j.fuproc.2012.07.018"
}

Dukanović, Z., Glišić, S., Jancić-Cobanin, V., Niciforović, M., Georgiou, C. A.,& Orlović, A.. (2013). Hydrotreating of straight-run gas oil blended with FCC naphtha and light cycle oil. in Fuel Processing Technology
Elsevier Science Bv, Amsterdam., 106, 160-165.
https://doi.org/10.1016/j.fuproc.2012.07.018

Dukanović Z, Glišić S, Jancić-Cobanin V, Niciforović M, Georgiou CA, Orlović A. Hydrotreating of straight-run gas oil blended with FCC naphtha and light cycle oil. in Fuel Processing Technology. 2013;106:160-165.
doi:10.1016/j.fuproc.2012.07.018 .

Dukanović, Zoran, Glišić, Sandra, Jancić-Cobanin, Vesna, Niciforović, Miroslav, Georgiou, Constantinos A., Orlović, Aleksandar, "Hydrotreating of straight-run gas oil blended with FCC naphtha and light cycle oil" in Fuel Processing Technology, 106 (2013):160-165,
https://doi.org/10.1016/j.fuproc.2012.07.018 . .

TY  - JOUR
AU  - Salcher, Andrea
AU  - Nikolić, Marija
AU  - Casado, Santiago
AU  - Velez, Marisela
AU  - Weller, Horst
AU  - Juarez, Beatriz H.
PY  - 2010
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1687
AB  - In this work, CdSe/CdS semiconductor ligand-exchanged nanoparticles have been immobilized on poly-(N-isopropylacrylamide) (pNIPAM)-based microspheres. The size and the shrinkage capacity of the spheres can be tuned by the ratio of NIPAM/styrene (pNIPAM-PS spheres) or NIPAM/BIS (N-N'-methylene-bis-acrylamide) and MA (maleic acid) (pNIPAM-BIS-MA spheres). A ligand-exchange procedure for the transfer of initially organic compatible nanoparticles into aqueous solution using amine-modified or thiol-modified poly(ethylene oxide)s (PEOs) has been carried out prior to their immobilization. We observed that the interaction of the nanoparticles with the pNIPAM-based system depends on the nature of the ligands and the chemical composition of the microspheres. Nanoparticles capped with amine-or mercapto-poly(ethylene oxide) s ligands interact with pNIPAM-PS beads while only amine-capped ones show a clear tendency to interact with pNIPAM containing acid groups which leads to a high nanoparticle coverage. Dynamic light scattering measurements, atomic force microscopy and optical spectroscopy hint that nanoparticles are placed on the surface of pNIPAM-BIS-MA beads while being partially incorporated into pNIPAM-PS network. Cell culture studies demonstrate that the fluorescent composites show non-specific binding to fibroblasts. These features may be very valuable to develop materials for drug delivery and specific targeting of cells combined with the outstanding optical properties of semiconductor nanoparticles as fluorescent labelers.
PB  - Royal Soc Chemistry, Cambridge
T2  - Journal of Materials Chemistry
T1  - CdSe/CdS nanoparticles immobilized on pNIPAm-based microspheres
EP  - 1374
IS  - 7
SP  - 1367
VL  - 20
DO  - 10.1039/b917022g
ER  - 

@article{
author = "Salcher, Andrea and Nikolić, Marija and Casado, Santiago and Velez, Marisela and Weller, Horst and Juarez, Beatriz H.",
year = "2010",
abstract = "In this work, CdSe/CdS semiconductor ligand-exchanged nanoparticles have been immobilized on poly-(N-isopropylacrylamide) (pNIPAM)-based microspheres. The size and the shrinkage capacity of the spheres can be tuned by the ratio of NIPAM/styrene (pNIPAM-PS spheres) or NIPAM/BIS (N-N'-methylene-bis-acrylamide) and MA (maleic acid) (pNIPAM-BIS-MA spheres). A ligand-exchange procedure for the transfer of initially organic compatible nanoparticles into aqueous solution using amine-modified or thiol-modified poly(ethylene oxide)s (PEOs) has been carried out prior to their immobilization. We observed that the interaction of the nanoparticles with the pNIPAM-based system depends on the nature of the ligands and the chemical composition of the microspheres. Nanoparticles capped with amine-or mercapto-poly(ethylene oxide) s ligands interact with pNIPAM-PS beads while only amine-capped ones show a clear tendency to interact with pNIPAM containing acid groups which leads to a high nanoparticle coverage. Dynamic light scattering measurements, atomic force microscopy and optical spectroscopy hint that nanoparticles are placed on the surface of pNIPAM-BIS-MA beads while being partially incorporated into pNIPAM-PS network. Cell culture studies demonstrate that the fluorescent composites show non-specific binding to fibroblasts. These features may be very valuable to develop materials for drug delivery and specific targeting of cells combined with the outstanding optical properties of semiconductor nanoparticles as fluorescent labelers.",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "Journal of Materials Chemistry",
title = "CdSe/CdS nanoparticles immobilized on pNIPAm-based microspheres",
pages = "1374-1367",
number = "7",
volume = "20",
doi = "10.1039/b917022g"
}

Salcher, A., Nikolić, M., Casado, S., Velez, M., Weller, H.,& Juarez, B. H.. (2010). CdSe/CdS nanoparticles immobilized on pNIPAm-based microspheres. in Journal of Materials Chemistry
Royal Soc Chemistry, Cambridge., 20(7), 1367-1374.
https://doi.org/10.1039/b917022g

Salcher A, Nikolić M, Casado S, Velez M, Weller H, Juarez BH. CdSe/CdS nanoparticles immobilized on pNIPAm-based microspheres. in Journal of Materials Chemistry. 2010;20(7):1367-1374.
doi:10.1039/b917022g .

Salcher, Andrea, Nikolić, Marija, Casado, Santiago, Velez, Marisela, Weller, Horst, Juarez, Beatriz H., "CdSe/CdS nanoparticles immobilized on pNIPAm-based microspheres" in Journal of Materials Chemistry, 20, no. 7 (2010):1367-1374,
https://doi.org/10.1039/b917022g . .