TY  - JOUR
AU  - Petrusić, Stojanka
AU  - Jovančić, Petar
AU  - Lewandowski, Maryline
AU  - Giraud, Stephane
AU  - Grujić, Svetlana
AU  - Ostojić, Sanja
AU  - Bugarski, Branko
AU  - Koncar, Vladan
PY  - 2013
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2384
AB  - This study highlights the advantages of functionalized poly(N-isopropylacrylamide) (PNIPAAm) microgels over pure PNIPAAm microgels in terms of polymer network properties and drug release profiles. PNIPAAm network was modified by addition of maleic anhydride (MA) as a comonomer and by formation of interpenetrating polymer network in the presence of alginate. The functionalized thermosensitive microgels in the size range from 20 to 80 mu m and with better performance in comparison with pure PNIPAAm microgels were prepared by inverse suspension polymerization. The impact of MA and alginate on the PNIPAAm microgel structure was evaluated through analysis of microgel size, size distribution, volume phase transition temperature (VPTT), equilibrium swelling ratio as well as morphology of the system. It was shown that the controlled modification of PNIPAAm network could result in microgels of considerably improved swelling capacity with unchanged thermosensitivity and maintained open pore morphology. In addition, drug release behavior of microgels could be markedly altered. Release of procaine hydrochloride from the selected microgels was studied using Franz diffusion cell at temperatures below and above VPTT of the microgels. Temperature-controlled drug release pattern was dependent on the type of functionalization of PNIPAAm network. According to drug loading properties and drug release mechanism, PNIPAAm/MA copolymer microgels demonstrated the optimal performances.
PB  - Springer, New York
T2  - Journal of Materials Science
T1  - Properties and drug release profile of poly(N-isopropylacrylamide) microgels functionalized with maleic anhydride and alginate
EP  - 7948
IS  - 22
SP  - 7935
VL  - 48
DO  - 10.1007/s10853-013-7604-2
ER  - 

@article{
author = "Petrusić, Stojanka and Jovančić, Petar and Lewandowski, Maryline and Giraud, Stephane and Grujić, Svetlana and Ostojić, Sanja and Bugarski, Branko and Koncar, Vladan",
year = "2013",
abstract = "This study highlights the advantages of functionalized poly(N-isopropylacrylamide) (PNIPAAm) microgels over pure PNIPAAm microgels in terms of polymer network properties and drug release profiles. PNIPAAm network was modified by addition of maleic anhydride (MA) as a comonomer and by formation of interpenetrating polymer network in the presence of alginate. The functionalized thermosensitive microgels in the size range from 20 to 80 mu m and with better performance in comparison with pure PNIPAAm microgels were prepared by inverse suspension polymerization. The impact of MA and alginate on the PNIPAAm microgel structure was evaluated through analysis of microgel size, size distribution, volume phase transition temperature (VPTT), equilibrium swelling ratio as well as morphology of the system. It was shown that the controlled modification of PNIPAAm network could result in microgels of considerably improved swelling capacity with unchanged thermosensitivity and maintained open pore morphology. In addition, drug release behavior of microgels could be markedly altered. Release of procaine hydrochloride from the selected microgels was studied using Franz diffusion cell at temperatures below and above VPTT of the microgels. Temperature-controlled drug release pattern was dependent on the type of functionalization of PNIPAAm network. According to drug loading properties and drug release mechanism, PNIPAAm/MA copolymer microgels demonstrated the optimal performances.",
publisher = "Springer, New York",
journal = "Journal of Materials Science",
title = "Properties and drug release profile of poly(N-isopropylacrylamide) microgels functionalized with maleic anhydride and alginate",
pages = "7948-7935",
number = "22",
volume = "48",
doi = "10.1007/s10853-013-7604-2"
}

Petrusić, S., Jovančić, P., Lewandowski, M., Giraud, S., Grujić, S., Ostojić, S., Bugarski, B.,& Koncar, V.. (2013). Properties and drug release profile of poly(N-isopropylacrylamide) microgels functionalized with maleic anhydride and alginate. in Journal of Materials Science
Springer, New York., 48(22), 7935-7948.
https://doi.org/10.1007/s10853-013-7604-2

Petrusić S, Jovančić P, Lewandowski M, Giraud S, Grujić S, Ostojić S, Bugarski B, Koncar V. Properties and drug release profile of poly(N-isopropylacrylamide) microgels functionalized with maleic anhydride and alginate. in Journal of Materials Science. 2013;48(22):7935-7948.
doi:10.1007/s10853-013-7604-2 .

Petrusić, Stojanka, Jovančić, Petar, Lewandowski, Maryline, Giraud, Stephane, Grujić, Svetlana, Ostojić, Sanja, Bugarski, Branko, Koncar, Vladan, "Properties and drug release profile of poly(N-isopropylacrylamide) microgels functionalized with maleic anhydride and alginate" in Journal of Materials Science, 48, no. 22 (2013):7935-7948,
https://doi.org/10.1007/s10853-013-7604-2 . .

TY  - JOUR
AU  - Petrusić, Stojanka
AU  - Jovančić, Petar
AU  - Lewandowski, Maryline
AU  - Giraud, Stephane
AU  - Bugarski, Branko
AU  - Đonlagić, Jasna
AU  - Koncar, Vladan
PY  - 2012
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2178
AB  - This study was aimed at optimizing the structure and properties of poly(N-isopropylacrylamide) (PNIPAAm) microgels prepared by inverse suspension polymerization. The influence of the oil-to-water phase ratio, the concentration of emulsifier, and the monomer-to-crosslinker molar ratio on selected properties of the PNIPAAm microgels was examined. Regularity of the microgels shape was estimated by optical microscopy. Laser diffraction technique was used to determine the microgels mean size and size distribution. Equilibrium swelling ratio was studied gravimetrically. Morphology of microgels was followed by SEM. Volume phase transition temperature of PNIPAAm microgels was determined by differential scanning calorimetry. The results obtained imply that the mean diameter of microgels and their equilibrium swelling ratio highly depend on the concentration of emulsifier in oil phase and the crosslinking degree of PNIPAAm. The crosslinking degree of PNIPAAm has no substantial effect on the volume phase transition temperature that is demonstrated to be around 33 degrees C even after complete heating-cooling-heating cycle. In addition, it was confirmed that the swollen microgels have a porous, honeycomb-like structure. Release profiles of procaine hydrochloride from the PNIPAAm microgels confirmed their potential to be considered as efficient matrices in drug release applications.
PB  - Springer, Dordrecht
T2  - Journal of Polymer Research
T1  - Synthesis, characterization and drug release properties of thermosensitive poly(N-isopropylacrylamide) microgels
IS  - 10
VL  - 19
DO  - 10.1007/s10965-012-9979-1
ER  - 

@article{
author = "Petrusić, Stojanka and Jovančić, Petar and Lewandowski, Maryline and Giraud, Stephane and Bugarski, Branko and Đonlagić, Jasna and Koncar, Vladan",
year = "2012",
abstract = "This study was aimed at optimizing the structure and properties of poly(N-isopropylacrylamide) (PNIPAAm) microgels prepared by inverse suspension polymerization. The influence of the oil-to-water phase ratio, the concentration of emulsifier, and the monomer-to-crosslinker molar ratio on selected properties of the PNIPAAm microgels was examined. Regularity of the microgels shape was estimated by optical microscopy. Laser diffraction technique was used to determine the microgels mean size and size distribution. Equilibrium swelling ratio was studied gravimetrically. Morphology of microgels was followed by SEM. Volume phase transition temperature of PNIPAAm microgels was determined by differential scanning calorimetry. The results obtained imply that the mean diameter of microgels and their equilibrium swelling ratio highly depend on the concentration of emulsifier in oil phase and the crosslinking degree of PNIPAAm. The crosslinking degree of PNIPAAm has no substantial effect on the volume phase transition temperature that is demonstrated to be around 33 degrees C even after complete heating-cooling-heating cycle. In addition, it was confirmed that the swollen microgels have a porous, honeycomb-like structure. Release profiles of procaine hydrochloride from the PNIPAAm microgels confirmed their potential to be considered as efficient matrices in drug release applications.",
publisher = "Springer, Dordrecht",
journal = "Journal of Polymer Research",
title = "Synthesis, characterization and drug release properties of thermosensitive poly(N-isopropylacrylamide) microgels",
number = "10",
volume = "19",
doi = "10.1007/s10965-012-9979-1"
}

Petrusić, S., Jovančić, P., Lewandowski, M., Giraud, S., Bugarski, B., Đonlagić, J.,& Koncar, V.. (2012). Synthesis, characterization and drug release properties of thermosensitive poly(N-isopropylacrylamide) microgels. in Journal of Polymer Research
Springer, Dordrecht., 19(10).
https://doi.org/10.1007/s10965-012-9979-1

Petrusić S, Jovančić P, Lewandowski M, Giraud S, Bugarski B, Đonlagić J, Koncar V. Synthesis, characterization and drug release properties of thermosensitive poly(N-isopropylacrylamide) microgels. in Journal of Polymer Research. 2012;19(10).
doi:10.1007/s10965-012-9979-1 .

Petrusić, Stojanka, Jovančić, Petar, Lewandowski, Maryline, Giraud, Stephane, Bugarski, Branko, Đonlagić, Jasna, Koncar, Vladan, "Synthesis, characterization and drug release properties of thermosensitive poly(N-isopropylacrylamide) microgels" in Journal of Polymer Research, 19, no. 10 (2012),
https://doi.org/10.1007/s10965-012-9979-1 . .

TY  - JOUR
AU  - Petrusić, Stojanka
AU  - Lewandowski, Maryline
AU  - Giraud, Stephane
AU  - Jovančić, Petar
AU  - Bugarski, Branko
AU  - Ostojić, Sanja
AU  - Koncar, Vladan
PY  - 2012
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2230
AB  - This work refers to the synthesis and characterization of thermosensitive hydrogels based on interpenetrating polymer networks (IPNs) of poly(N-isopropylacrylamide) (PNIPAAm) and calcium alginate in the form of films. The influence of the crosslinking degree of PNIPAAm and alginate content on thermal, swelling, mechanical, and morphological properties of hydrogels is investigated in detail. Characterization of pure PNIPAAm hydrogels and IPN hydrogels was performed by FTIR, DSC, DMA, and SEM. In addition, the studies of equilibrium swelling behavior as well as swelling, deswelling, and reswelling kinetics are performed. The results obtained imply the benefits of synthesizing IPNs based on PNIPAAm and calcium alginate over pure PNIPAAm hydrogels. The presence of calcium alginate contributes to the improvement of mechanical properties, the deswelling rate of hydrogels, and the network porosity, without altering the thermosensitivity of PNIPAAm significantly.
PB  - Wiley, Hoboken
T2  - Journal of Applied Polymer Science
T1  - Development and characterization of thermosensitive hydrogels based on poly(N-isopropylacrylamide) and calcium alginate
EP  - 903
IS  - 2
SP  - 890
VL  - 124
DO  - 10.1002/app.35122
ER  - 

@article{
author = "Petrusić, Stojanka and Lewandowski, Maryline and Giraud, Stephane and Jovančić, Petar and Bugarski, Branko and Ostojić, Sanja and Koncar, Vladan",
year = "2012",
abstract = "This work refers to the synthesis and characterization of thermosensitive hydrogels based on interpenetrating polymer networks (IPNs) of poly(N-isopropylacrylamide) (PNIPAAm) and calcium alginate in the form of films. The influence of the crosslinking degree of PNIPAAm and alginate content on thermal, swelling, mechanical, and morphological properties of hydrogels is investigated in detail. Characterization of pure PNIPAAm hydrogels and IPN hydrogels was performed by FTIR, DSC, DMA, and SEM. In addition, the studies of equilibrium swelling behavior as well as swelling, deswelling, and reswelling kinetics are performed. The results obtained imply the benefits of synthesizing IPNs based on PNIPAAm and calcium alginate over pure PNIPAAm hydrogels. The presence of calcium alginate contributes to the improvement of mechanical properties, the deswelling rate of hydrogels, and the network porosity, without altering the thermosensitivity of PNIPAAm significantly.",
publisher = "Wiley, Hoboken",
journal = "Journal of Applied Polymer Science",
title = "Development and characterization of thermosensitive hydrogels based on poly(N-isopropylacrylamide) and calcium alginate",
pages = "903-890",
number = "2",
volume = "124",
doi = "10.1002/app.35122"
}

Petrusić, S., Lewandowski, M., Giraud, S., Jovančić, P., Bugarski, B., Ostojić, S.,& Koncar, V.. (2012). Development and characterization of thermosensitive hydrogels based on poly(N-isopropylacrylamide) and calcium alginate. in Journal of Applied Polymer Science
Wiley, Hoboken., 124(2), 890-903.
https://doi.org/10.1002/app.35122

Petrusić S, Lewandowski M, Giraud S, Jovančić P, Bugarski B, Ostojić S, Koncar V. Development and characterization of thermosensitive hydrogels based on poly(N-isopropylacrylamide) and calcium alginate. in Journal of Applied Polymer Science. 2012;124(2):890-903.
doi:10.1002/app.35122 .

Petrusić, Stojanka, Lewandowski, Maryline, Giraud, Stephane, Jovančić, Petar, Bugarski, Branko, Ostojić, Sanja, Koncar, Vladan, "Development and characterization of thermosensitive hydrogels based on poly(N-isopropylacrylamide) and calcium alginate" in Journal of Applied Polymer Science, 124, no. 2 (2012):890-903,
https://doi.org/10.1002/app.35122 . .