TY  - JOUR
AU  - Boltić, Zorana
AU  - Ružić, Nenad Lj.
AU  - Jovanović, Mica
AU  - Mihajlović, Marina
AU  - Jovanović, Jovan
AU  - Petrović, Slobodan
PY  - 2013
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2519
AB  - The aim of the article is to present a case study related to implementation of cleaner production (CP) process with the concept of minimizing emissions versus the end of pipe (EOP) approach within pharmaceutical industry. The idea is to move beyond simple pollution control by technology improvement and prevention of organic solvents emission into the atmosphere. Furthermore, cost-effectiveness of the suggested approach is evaluated compared to traditional concepts of polluted air treatment, ensuring both environmentally friendly and effective production of film coated tablets. Technological changes to improve the impact on the environment have been applied already in many industries as well as in pharmaceutical manufacturing. However, more effort is to be made in order to further decrease particularly VOCs emission into the atmosphere. An analysis is provided to stimulate a proactive approach in this field towards completely eliminating the use of organic solvents from film-coating systems in the production of the pharmaceutical solid dosage forms. The new way of addressing the costs actually associated with embracing cleaner technologies, which are mostly related to regulatory aspects in pharmaceutical industry, is aimed to promote the change in culture, as well as to be applied in the decision making process for other pharmaceutical facilities still using organic solvents based coatings in the manufacturing of tablets. The significance of the small scale projects is additionally emphasized considering the magnitude of the world generic market.
PB  - Elsevier Sci Ltd, Oxford
T2  - Journal of Cleaner Production
T1  - Cleaner production aspects of tablet coating process in pharmaceutical industry: problem of VOCs emission
EP  - 132
SP  - 123
VL  - 44
DO  - 10.1016/j.jclepro.2013.01.004
ER  - 

@article{
author = "Boltić, Zorana and Ružić, Nenad Lj. and Jovanović, Mica and Mihajlović, Marina and Jovanović, Jovan and Petrović, Slobodan",
year = "2013",
abstract = "The aim of the article is to present a case study related to implementation of cleaner production (CP) process with the concept of minimizing emissions versus the end of pipe (EOP) approach within pharmaceutical industry. The idea is to move beyond simple pollution control by technology improvement and prevention of organic solvents emission into the atmosphere. Furthermore, cost-effectiveness of the suggested approach is evaluated compared to traditional concepts of polluted air treatment, ensuring both environmentally friendly and effective production of film coated tablets. Technological changes to improve the impact on the environment have been applied already in many industries as well as in pharmaceutical manufacturing. However, more effort is to be made in order to further decrease particularly VOCs emission into the atmosphere. An analysis is provided to stimulate a proactive approach in this field towards completely eliminating the use of organic solvents from film-coating systems in the production of the pharmaceutical solid dosage forms. The new way of addressing the costs actually associated with embracing cleaner technologies, which are mostly related to regulatory aspects in pharmaceutical industry, is aimed to promote the change in culture, as well as to be applied in the decision making process for other pharmaceutical facilities still using organic solvents based coatings in the manufacturing of tablets. The significance of the small scale projects is additionally emphasized considering the magnitude of the world generic market.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Journal of Cleaner Production",
title = "Cleaner production aspects of tablet coating process in pharmaceutical industry: problem of VOCs emission",
pages = "132-123",
volume = "44",
doi = "10.1016/j.jclepro.2013.01.004"
}

Boltić, Z., Ružić, N. Lj., Jovanović, M., Mihajlović, M., Jovanović, J.,& Petrović, S.. (2013). Cleaner production aspects of tablet coating process in pharmaceutical industry: problem of VOCs emission. in Journal of Cleaner Production
Elsevier Sci Ltd, Oxford., 44, 123-132.
https://doi.org/10.1016/j.jclepro.2013.01.004

Boltić Z, Ružić NL, Jovanović M, Mihajlović M, Jovanović J, Petrović S. Cleaner production aspects of tablet coating process in pharmaceutical industry: problem of VOCs emission. in Journal of Cleaner Production. 2013;44:123-132.
doi:10.1016/j.jclepro.2013.01.004 .

Boltić, Zorana, Ružić, Nenad Lj., Jovanović, Mica, Mihajlović, Marina, Jovanović, Jovan, Petrović, Slobodan, "Cleaner production aspects of tablet coating process in pharmaceutical industry: problem of VOCs emission" in Journal of Cleaner Production, 44 (2013):123-132,
https://doi.org/10.1016/j.jclepro.2013.01.004 . .