TY  - JOUR
AU  - Roj, Edward
AU  - Tadić, Vanja M.
AU  - Mišić, Dušan
AU  - Žižović, Irena
AU  - Arsić, Ivana
AU  - Dobrzynska-Inger, Agnieszka
AU  - Kostrzewa, Dorota
PY  - 2015
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5797
AB  - Extracts obtained from hops (Humulus lupulus L., Cannabaceae) by supercritical fluid extraction (SFE), SFE followed by isomerization, as well as by conventional technique, were investigated for their chemical composition and antibacterial activity against selected foodborne pathogens and microorganisms capable to cause the food spoilage. The antibacterial activity of the extracts was compared with the antibacterial activity of xanthohumol, compound known for its broad pharmacological properties, isolated from the raw material remained after the SFE. Xanthohumol (XH, 96%) proved to posses the most prominent activity against all the tested strains, with the MIC values ranged between 2.5 and 20 mu g mL(-1). Supercritical hops extract and potassium isomerized supercritical hops extract showed strong antibacterial activity against the tested strains as well. Escherichia coli was not affected by the extracts, meaning that their oral admission would not cause the same problem as antibiotic application in intestinal flora. The chemical composition of the investigated hops extracts was analysed by GC-MS. Contents of a-acids, beta-acids, iso-alpha-acids and xanthohumol in the samples were determined by HPLC.
PB  - De Gruyter Open Ltd, Warsaw
T2  - Open Chemistry
T1  - Supercritical carbon dioxide hops extracts with antimicrobial properties
EP  - 1171
IS  - 1
SP  - 1157
VL  - 13
DO  - 10.1515/chem-2015-0131
ER  - 

@article{
author = "Roj, Edward and Tadić, Vanja M. and Mišić, Dušan and Žižović, Irena and Arsić, Ivana and Dobrzynska-Inger, Agnieszka and Kostrzewa, Dorota",
year = "2015",
abstract = "Extracts obtained from hops (Humulus lupulus L., Cannabaceae) by supercritical fluid extraction (SFE), SFE followed by isomerization, as well as by conventional technique, were investigated for their chemical composition and antibacterial activity against selected foodborne pathogens and microorganisms capable to cause the food spoilage. The antibacterial activity of the extracts was compared with the antibacterial activity of xanthohumol, compound known for its broad pharmacological properties, isolated from the raw material remained after the SFE. Xanthohumol (XH, 96%) proved to posses the most prominent activity against all the tested strains, with the MIC values ranged between 2.5 and 20 mu g mL(-1). Supercritical hops extract and potassium isomerized supercritical hops extract showed strong antibacterial activity against the tested strains as well. Escherichia coli was not affected by the extracts, meaning that their oral admission would not cause the same problem as antibiotic application in intestinal flora. The chemical composition of the investigated hops extracts was analysed by GC-MS. Contents of a-acids, beta-acids, iso-alpha-acids and xanthohumol in the samples were determined by HPLC.",
publisher = "De Gruyter Open Ltd, Warsaw",
journal = "Open Chemistry",
title = "Supercritical carbon dioxide hops extracts with antimicrobial properties",
pages = "1171-1157",
number = "1",
volume = "13",
doi = "10.1515/chem-2015-0131"
}

Roj, E., Tadić, V. M., Mišić, D., Žižović, I., Arsić, I., Dobrzynska-Inger, A.,& Kostrzewa, D.. (2015). Supercritical carbon dioxide hops extracts with antimicrobial properties. in Open Chemistry
De Gruyter Open Ltd, Warsaw., 13(1), 1157-1171.
https://doi.org/10.1515/chem-2015-0131

Roj E, Tadić VM, Mišić D, Žižović I, Arsić I, Dobrzynska-Inger A, Kostrzewa D. Supercritical carbon dioxide hops extracts with antimicrobial properties. in Open Chemistry. 2015;13(1):1157-1171.
doi:10.1515/chem-2015-0131 .

Roj, Edward, Tadić, Vanja M., Mišić, Dušan, Žižović, Irena, Arsić, Ivana, Dobrzynska-Inger, Agnieszka, Kostrzewa, Dorota, "Supercritical carbon dioxide hops extracts with antimicrobial properties" in Open Chemistry, 13, no. 1 (2015):1157-1171,
https://doi.org/10.1515/chem-2015-0131 . .