TY  - JOUR
AU  - Petrusić, Stojanka
AU  - Jovančić, Petar
AU  - Lewandowski, Maryline
AU  - Giraud, Stephane
AU  - Grujić, Svetlana
AU  - Ostojić, Sanja
AU  - Bugarski, Branko
AU  - Koncar, Vladan
PY  - 2013
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2384
AB  - This study highlights the advantages of functionalized poly(N-isopropylacrylamide) (PNIPAAm) microgels over pure PNIPAAm microgels in terms of polymer network properties and drug release profiles. PNIPAAm network was modified by addition of maleic anhydride (MA) as a comonomer and by formation of interpenetrating polymer network in the presence of alginate. The functionalized thermosensitive microgels in the size range from 20 to 80 mu m and with better performance in comparison with pure PNIPAAm microgels were prepared by inverse suspension polymerization. The impact of MA and alginate on the PNIPAAm microgel structure was evaluated through analysis of microgel size, size distribution, volume phase transition temperature (VPTT), equilibrium swelling ratio as well as morphology of the system. It was shown that the controlled modification of PNIPAAm network could result in microgels of considerably improved swelling capacity with unchanged thermosensitivity and maintained open pore morphology. In addition, drug release behavior of microgels could be markedly altered. Release of procaine hydrochloride from the selected microgels was studied using Franz diffusion cell at temperatures below and above VPTT of the microgels. Temperature-controlled drug release pattern was dependent on the type of functionalization of PNIPAAm network. According to drug loading properties and drug release mechanism, PNIPAAm/MA copolymer microgels demonstrated the optimal performances.
PB  - Springer, New York
T2  - Journal of Materials Science
T1  - Properties and drug release profile of poly(N-isopropylacrylamide) microgels functionalized with maleic anhydride and alginate
EP  - 7948
IS  - 22
SP  - 7935
VL  - 48
DO  - 10.1007/s10853-013-7604-2
ER  - 

@article{
author = "Petrusić, Stojanka and Jovančić, Petar and Lewandowski, Maryline and Giraud, Stephane and Grujić, Svetlana and Ostojić, Sanja and Bugarski, Branko and Koncar, Vladan",
year = "2013",
abstract = "This study highlights the advantages of functionalized poly(N-isopropylacrylamide) (PNIPAAm) microgels over pure PNIPAAm microgels in terms of polymer network properties and drug release profiles. PNIPAAm network was modified by addition of maleic anhydride (MA) as a comonomer and by formation of interpenetrating polymer network in the presence of alginate. The functionalized thermosensitive microgels in the size range from 20 to 80 mu m and with better performance in comparison with pure PNIPAAm microgels were prepared by inverse suspension polymerization. The impact of MA and alginate on the PNIPAAm microgel structure was evaluated through analysis of microgel size, size distribution, volume phase transition temperature (VPTT), equilibrium swelling ratio as well as morphology of the system. It was shown that the controlled modification of PNIPAAm network could result in microgels of considerably improved swelling capacity with unchanged thermosensitivity and maintained open pore morphology. In addition, drug release behavior of microgels could be markedly altered. Release of procaine hydrochloride from the selected microgels was studied using Franz diffusion cell at temperatures below and above VPTT of the microgels. Temperature-controlled drug release pattern was dependent on the type of functionalization of PNIPAAm network. According to drug loading properties and drug release mechanism, PNIPAAm/MA copolymer microgels demonstrated the optimal performances.",
publisher = "Springer, New York",
journal = "Journal of Materials Science",
title = "Properties and drug release profile of poly(N-isopropylacrylamide) microgels functionalized with maleic anhydride and alginate",
pages = "7948-7935",
number = "22",
volume = "48",
doi = "10.1007/s10853-013-7604-2"
}

Petrusić, S., Jovančić, P., Lewandowski, M., Giraud, S., Grujić, S., Ostojić, S., Bugarski, B.,& Koncar, V.. (2013). Properties and drug release profile of poly(N-isopropylacrylamide) microgels functionalized with maleic anhydride and alginate. in Journal of Materials Science
Springer, New York., 48(22), 7935-7948.
https://doi.org/10.1007/s10853-013-7604-2

Petrusić S, Jovančić P, Lewandowski M, Giraud S, Grujić S, Ostojić S, Bugarski B, Koncar V. Properties and drug release profile of poly(N-isopropylacrylamide) microgels functionalized with maleic anhydride and alginate. in Journal of Materials Science. 2013;48(22):7935-7948.
doi:10.1007/s10853-013-7604-2 .

Petrusić, Stojanka, Jovančić, Petar, Lewandowski, Maryline, Giraud, Stephane, Grujić, Svetlana, Ostojić, Sanja, Bugarski, Branko, Koncar, Vladan, "Properties and drug release profile of poly(N-isopropylacrylamide) microgels functionalized with maleic anhydride and alginate" in Journal of Materials Science, 48, no. 22 (2013):7935-7948,
https://doi.org/10.1007/s10853-013-7604-2 . .