TY  - JOUR
AU  - Milivojević, Ana
AU  - Ćorović, Marija
AU  - Simović, Milica
AU  - Banjanac, Katarina
AU  - Blagojević, Stevan N.
AU  - Pjanović, Rada
AU  - Bezbradica, Dejan
PY  - 2019
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4158
AB  - The present work describes application of natural triglycerides for lipase-catalyzed esterification of structurally diverse flavonoids-esculin, naringin, and phloridzin. Ester mixtures with laurate, linolenate, or linoleate as prevailing products were obtained in reactions with coconut, linseed, and sunflower oils, respectively. By using response surface methodology, the influences of key experimental factors-reaction time, substrates, and enzyme concentrations-for transesterification of esculin with linseed oil were investigated. High molar conversion (78.5%), product yield (19.13 mg/mL), and specific yield (2.83 mmol/g(enzyme)) were achieved at optimized conditions. Determined optimums were successfully applied in esculin transesterification with other two oils. Furthermore, esculin ester mixtures were incorporated in gel emulsions, and their effect on transepidermal water loss (TEWL) as well as skin sensitivity was examined. Obtained results have shown significant hydration effect and good dermatological compatibility without irritating effects of all examined preparations containing oil-derived esculin esters, making them very prospective for application in skin care products.
PB  - Amer Chemical Soc, Washington
T2  - Industrial & Engineering Chemistry Research
T1  - Novel Approach for Flavonoid Esters Production: Statistically Optimized Enzymatic Synthesis Using Natural Oils and Application in Cosmetics
EP  - 3649
IS  - 9
SP  - 3640
VL  - 58
DO  - 10.1021/acs.iecr.8b06113
ER  - 

@article{
author = "Milivojević, Ana and Ćorović, Marija and Simović, Milica and Banjanac, Katarina and Blagojević, Stevan N. and Pjanović, Rada and Bezbradica, Dejan",
year = "2019",
abstract = "The present work describes application of natural triglycerides for lipase-catalyzed esterification of structurally diverse flavonoids-esculin, naringin, and phloridzin. Ester mixtures with laurate, linolenate, or linoleate as prevailing products were obtained in reactions with coconut, linseed, and sunflower oils, respectively. By using response surface methodology, the influences of key experimental factors-reaction time, substrates, and enzyme concentrations-for transesterification of esculin with linseed oil were investigated. High molar conversion (78.5%), product yield (19.13 mg/mL), and specific yield (2.83 mmol/g(enzyme)) were achieved at optimized conditions. Determined optimums were successfully applied in esculin transesterification with other two oils. Furthermore, esculin ester mixtures were incorporated in gel emulsions, and their effect on transepidermal water loss (TEWL) as well as skin sensitivity was examined. Obtained results have shown significant hydration effect and good dermatological compatibility without irritating effects of all examined preparations containing oil-derived esculin esters, making them very prospective for application in skin care products.",
publisher = "Amer Chemical Soc, Washington",
journal = "Industrial & Engineering Chemistry Research",
title = "Novel Approach for Flavonoid Esters Production: Statistically Optimized Enzymatic Synthesis Using Natural Oils and Application in Cosmetics",
pages = "3649-3640",
number = "9",
volume = "58",
doi = "10.1021/acs.iecr.8b06113"
}

Milivojević, A., Ćorović, M., Simović, M., Banjanac, K., Blagojević, S. N., Pjanović, R.,& Bezbradica, D.. (2019). Novel Approach for Flavonoid Esters Production: Statistically Optimized Enzymatic Synthesis Using Natural Oils and Application in Cosmetics. in Industrial & Engineering Chemistry Research
Amer Chemical Soc, Washington., 58(9), 3640-3649.
https://doi.org/10.1021/acs.iecr.8b06113

Milivojević A, Ćorović M, Simović M, Banjanac K, Blagojević SN, Pjanović R, Bezbradica D. Novel Approach for Flavonoid Esters Production: Statistically Optimized Enzymatic Synthesis Using Natural Oils and Application in Cosmetics. in Industrial & Engineering Chemistry Research. 2019;58(9):3640-3649.
doi:10.1021/acs.iecr.8b06113 .

Milivojević, Ana, Ćorović, Marija, Simović, Milica, Banjanac, Katarina, Blagojević, Stevan N., Pjanović, Rada, Bezbradica, Dejan, "Novel Approach for Flavonoid Esters Production: Statistically Optimized Enzymatic Synthesis Using Natural Oils and Application in Cosmetics" in Industrial & Engineering Chemistry Research, 58, no. 9 (2019):3640-3649,
https://doi.org/10.1021/acs.iecr.8b06113 . .