TY  - JOUR
AU  - Zvicer, Jovana
AU  - Medić, Ana
AU  - Veljović, Đorđe
AU  - Jevtić, Sanja
AU  - Novak, Sasa
AU  - Obradović, Bojana
PY  - 2019
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4090
AB  - This study presents production and biomimetic characterization of macroporous composite scaffolds based on gellan gum and nanoparticulate bioactive glass (GG-BAG) under conditions relevant for bone tissue engineering. Formation of hydroxyapatite (HAp) within the scaffolds was investigated in the simulated body fluid (SBF) during 14 days in two biomimetic bioreactors: perfusion bioreactor (1.1 ml/min SBF flowrate) and a bioreactor with coupled dynamic compression and SBF perfusion (5% strain, 0.68 Hz, 1 h on/1 h off, 1.1 ml/min SBF flowrate). HAp formation was evaluated by scanning electron microscopy (FE-SEM), energy dispersive X-ray (EDS) analysis, Fourier transform infrared spectroscopy (FTIR), and X-ray powder diffraction (XRPD). The superficial SBF velocity of 100 mu m/s in perfusion bioreactors induced the formation of abundant cauliflower-like HAp crystals throughout the scaffold interior and flake-like crystals on external surfaces resulting in improved mechanical properties as compared to the initial scaffolds. The obtained results indicate potentials of macro-porous GG-BAG scaffolds in conjunction with perfusion bioreactors for bone tissue engineering demonstrating high bioactivity suited for cultures of osteogenic cells.
PB  - Elsevier Sci Ltd, Oxford
T2  - Polymer Testing
T1  - Biomimetic characterization reveals enhancement of hydroxyapatite formation by fluid flow in gellan gum and bioactive glass composite scaffolds
EP  - 472
SP  - 464
VL  - 76
DO  - 10.1016/j.polymertesting.2019.04.004
ER  - 

@article{
author = "Zvicer, Jovana and Medić, Ana and Veljović, Đorđe and Jevtić, Sanja and Novak, Sasa and Obradović, Bojana",
year = "2019",
abstract = "This study presents production and biomimetic characterization of macroporous composite scaffolds based on gellan gum and nanoparticulate bioactive glass (GG-BAG) under conditions relevant for bone tissue engineering. Formation of hydroxyapatite (HAp) within the scaffolds was investigated in the simulated body fluid (SBF) during 14 days in two biomimetic bioreactors: perfusion bioreactor (1.1 ml/min SBF flowrate) and a bioreactor with coupled dynamic compression and SBF perfusion (5% strain, 0.68 Hz, 1 h on/1 h off, 1.1 ml/min SBF flowrate). HAp formation was evaluated by scanning electron microscopy (FE-SEM), energy dispersive X-ray (EDS) analysis, Fourier transform infrared spectroscopy (FTIR), and X-ray powder diffraction (XRPD). The superficial SBF velocity of 100 mu m/s in perfusion bioreactors induced the formation of abundant cauliflower-like HAp crystals throughout the scaffold interior and flake-like crystals on external surfaces resulting in improved mechanical properties as compared to the initial scaffolds. The obtained results indicate potentials of macro-porous GG-BAG scaffolds in conjunction with perfusion bioreactors for bone tissue engineering demonstrating high bioactivity suited for cultures of osteogenic cells.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Polymer Testing",
title = "Biomimetic characterization reveals enhancement of hydroxyapatite formation by fluid flow in gellan gum and bioactive glass composite scaffolds",
pages = "472-464",
volume = "76",
doi = "10.1016/j.polymertesting.2019.04.004"
}

Zvicer, J., Medić, A., Veljović, Đ., Jevtić, S., Novak, S.,& Obradović, B.. (2019). Biomimetic characterization reveals enhancement of hydroxyapatite formation by fluid flow in gellan gum and bioactive glass composite scaffolds. in Polymer Testing
Elsevier Sci Ltd, Oxford., 76, 464-472.
https://doi.org/10.1016/j.polymertesting.2019.04.004

Zvicer J, Medić A, Veljović Đ, Jevtić S, Novak S, Obradović B. Biomimetic characterization reveals enhancement of hydroxyapatite formation by fluid flow in gellan gum and bioactive glass composite scaffolds. in Polymer Testing. 2019;76:464-472.
doi:10.1016/j.polymertesting.2019.04.004 .

Zvicer, Jovana, Medić, Ana, Veljović, Đorđe, Jevtić, Sanja, Novak, Sasa, Obradović, Bojana, "Biomimetic characterization reveals enhancement of hydroxyapatite formation by fluid flow in gellan gum and bioactive glass composite scaffolds" in Polymer Testing, 76 (2019):464-472,
https://doi.org/10.1016/j.polymertesting.2019.04.004 . .