The use of a gold electrode for the determination of amphetamine derivatives and application to their analysis in human urine
Određivanje derivata amfetamina i primena u analizi humanog urina na elektrodi od zlata
Аутори
Nevešćanin, MarinaAvramov-Ivić, Milka
Petrović, Slobodan
Mijin, Dušan
Stević-Banović, Sonja N.
Jovanović, Vladislava M.
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The catalytic abilities of a gold electrode were tested for the quantitative determination of amphetamine (A) and 3,4-methylenedioxy-N-methylamphetamine (MDMA) standards by their oxidation using cyclic voltammetry (CV). The values of the oxidative currents of A and MDMA standards at 0.80 V vs. SCE in 0.05 M NaHCO3 at a scan rate of 50 mV s-1 were linear functions of the concentration in range of 110.9-258.9 μM and 38.7-229.2 μM, respectively. Square wave voltammetry (SWV) revealed a linear increase of current with the concentration of MDMA (range 30.9-91.6 μM), which enabled the quantitative determination of amphetamine derivates. SWV analysis was also successfully performed in spiked urine samples. A and MDMA in the presence of sucrose and as a content in illegally produced tablets were also determined. The voltammetric determinations of A and MDMA derivatives using CV and SWV at gold a electrode are rapid, selective and simple procedures and their accuracy was confirmed with a refere...nce method, high performance liquid chromatography (HPLC). The analysis of spiked urine samples offers an additional possibility for the rapid detection of A and MDMA in human urine.
Katalitička svojstva elektrode od zlata su testirana za kvantitativno određivanje amfetamina (A) i 3,4-metilendioksi-N-metilamfetamina (MDMA) standarda. Elektroksidacija A i MDMA je praćena cikličnom voltametrijom (CV). Vrednost oksidativnog pika A i MDMA standarda je linearna funkcija koncentracija u opsegu 110,9-258,9 μM (A) i 38,7-229,2 μM (MDMA). Voltametrija sa pravougaonim impulsima (SWV) je pokazala linearnu zavisnost struja od koncentracija za MDMA standard (u opsegu: 30,9-91,6 μM) kao i u spajkovanim uzorcima humanog urina. Uspešno je analiziran i sadržaj A i MDMA u ilegalno proizvedenim tabletama. Voltametrijsko određivanje A i MDMA derivata uz pomoć CV i SWV na elektrodi od zlata je brza, selektivna i jednostavna procedura. Analiza spajkovanih uzoraka urina nudi dodatnu mogućnost za brzu detekciju A i MDMA u humanom urinu.
Кључне речи:
amphetamine derivatives / cyclic voltammetry / square wave voltammetry / spiked urine samplesИзвор:
Journal of the Serbian Chemical Society, 2013, 78, 9, 1373-1385Издавач:
- Serbian Chemical Society, Belgrade
Финансирање / пројекти:
- Проучавање синтезе, структуре и активности органских једињења природног и синтетског порекла (RS-172013)
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Nevešćanin, Marina AU - Avramov-Ivić, Milka AU - Petrović, Slobodan AU - Mijin, Dušan AU - Stević-Banović, Sonja N. AU - Jovanović, Vladislava M. PY - 2013 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/2358 AB - The catalytic abilities of a gold electrode were tested for the quantitative determination of amphetamine (A) and 3,4-methylenedioxy-N-methylamphetamine (MDMA) standards by their oxidation using cyclic voltammetry (CV). The values of the oxidative currents of A and MDMA standards at 0.80 V vs. SCE in 0.05 M NaHCO3 at a scan rate of 50 mV s-1 were linear functions of the concentration in range of 110.9-258.9 μM and 38.7-229.2 μM, respectively. Square wave voltammetry (SWV) revealed a linear increase of current with the concentration of MDMA (range 30.9-91.6 μM), which enabled the quantitative determination of amphetamine derivates. SWV analysis was also successfully performed in spiked urine samples. A and MDMA in the presence of sucrose and as a content in illegally produced tablets were also determined. The voltammetric determinations of A and MDMA derivatives using CV and SWV at gold a electrode are rapid, selective and simple procedures and their accuracy was confirmed with a reference method, high performance liquid chromatography (HPLC). The analysis of spiked urine samples offers an additional possibility for the rapid detection of A and MDMA in human urine. AB - Katalitička svojstva elektrode od zlata su testirana za kvantitativno određivanje amfetamina (A) i 3,4-metilendioksi-N-metilamfetamina (MDMA) standarda. Elektroksidacija A i MDMA je praćena cikličnom voltametrijom (CV). Vrednost oksidativnog pika A i MDMA standarda je linearna funkcija koncentracija u opsegu 110,9-258,9 μM (A) i 38,7-229,2 μM (MDMA). Voltametrija sa pravougaonim impulsima (SWV) je pokazala linearnu zavisnost struja od koncentracija za MDMA standard (u opsegu: 30,9-91,6 μM) kao i u spajkovanim uzorcima humanog urina. Uspešno je analiziran i sadržaj A i MDMA u ilegalno proizvedenim tabletama. Voltametrijsko određivanje A i MDMA derivata uz pomoć CV i SWV na elektrodi od zlata je brza, selektivna i jednostavna procedura. Analiza spajkovanih uzoraka urina nudi dodatnu mogućnost za brzu detekciju A i MDMA u humanom urinu. PB - Serbian Chemical Society, Belgrade T2 - Journal of the Serbian Chemical Society T1 - The use of a gold electrode for the determination of amphetamine derivatives and application to their analysis in human urine T1 - Određivanje derivata amfetamina i primena u analizi humanog urina na elektrodi od zlata EP - 1385 IS - 9 SP - 1373 VL - 78 UR - https://hdl.handle.net/21.15107/rcub_technorep_2358 ER -
@article{ author = "Nevešćanin, Marina and Avramov-Ivić, Milka and Petrović, Slobodan and Mijin, Dušan and Stević-Banović, Sonja N. and Jovanović, Vladislava M.", year = "2013", abstract = "The catalytic abilities of a gold electrode were tested for the quantitative determination of amphetamine (A) and 3,4-methylenedioxy-N-methylamphetamine (MDMA) standards by their oxidation using cyclic voltammetry (CV). The values of the oxidative currents of A and MDMA standards at 0.80 V vs. SCE in 0.05 M NaHCO3 at a scan rate of 50 mV s-1 were linear functions of the concentration in range of 110.9-258.9 μM and 38.7-229.2 μM, respectively. Square wave voltammetry (SWV) revealed a linear increase of current with the concentration of MDMA (range 30.9-91.6 μM), which enabled the quantitative determination of amphetamine derivates. SWV analysis was also successfully performed in spiked urine samples. A and MDMA in the presence of sucrose and as a content in illegally produced tablets were also determined. The voltammetric determinations of A and MDMA derivatives using CV and SWV at gold a electrode are rapid, selective and simple procedures and their accuracy was confirmed with a reference method, high performance liquid chromatography (HPLC). The analysis of spiked urine samples offers an additional possibility for the rapid detection of A and MDMA in human urine., Katalitička svojstva elektrode od zlata su testirana za kvantitativno određivanje amfetamina (A) i 3,4-metilendioksi-N-metilamfetamina (MDMA) standarda. Elektroksidacija A i MDMA je praćena cikličnom voltametrijom (CV). Vrednost oksidativnog pika A i MDMA standarda je linearna funkcija koncentracija u opsegu 110,9-258,9 μM (A) i 38,7-229,2 μM (MDMA). Voltametrija sa pravougaonim impulsima (SWV) je pokazala linearnu zavisnost struja od koncentracija za MDMA standard (u opsegu: 30,9-91,6 μM) kao i u spajkovanim uzorcima humanog urina. Uspešno je analiziran i sadržaj A i MDMA u ilegalno proizvedenim tabletama. Voltametrijsko određivanje A i MDMA derivata uz pomoć CV i SWV na elektrodi od zlata je brza, selektivna i jednostavna procedura. Analiza spajkovanih uzoraka urina nudi dodatnu mogućnost za brzu detekciju A i MDMA u humanom urinu.", publisher = "Serbian Chemical Society, Belgrade", journal = "Journal of the Serbian Chemical Society", title = "The use of a gold electrode for the determination of amphetamine derivatives and application to their analysis in human urine, Određivanje derivata amfetamina i primena u analizi humanog urina na elektrodi od zlata", pages = "1385-1373", number = "9", volume = "78", url = "https://hdl.handle.net/21.15107/rcub_technorep_2358" }
Nevešćanin, M., Avramov-Ivić, M., Petrović, S., Mijin, D., Stević-Banović, S. N.,& Jovanović, V. M.. (2013). The use of a gold electrode for the determination of amphetamine derivatives and application to their analysis in human urine. in Journal of the Serbian Chemical Society Serbian Chemical Society, Belgrade., 78(9), 1373-1385. https://hdl.handle.net/21.15107/rcub_technorep_2358
Nevešćanin M, Avramov-Ivić M, Petrović S, Mijin D, Stević-Banović SN, Jovanović VM. The use of a gold electrode for the determination of amphetamine derivatives and application to their analysis in human urine. in Journal of the Serbian Chemical Society. 2013;78(9):1373-1385. https://hdl.handle.net/21.15107/rcub_technorep_2358 .
Nevešćanin, Marina, Avramov-Ivić, Milka, Petrović, Slobodan, Mijin, Dušan, Stević-Banović, Sonja N., Jovanović, Vladislava M., "The use of a gold electrode for the determination of amphetamine derivatives and application to their analysis in human urine" in Journal of the Serbian Chemical Society, 78, no. 9 (2013):1373-1385, https://hdl.handle.net/21.15107/rcub_technorep_2358 .