Supercritical CO2 sorption kinetics and thymol impregnation of PCL and PCL-HA
Само за регистроване кориснике
2016
Аутори
Ivanović, JasnaKnauer, Sandra
Fanovich, Alejandra
Milovanović, Stoja
Stamenić, Marko
Jaeger, Philip
Žižović, Irena
Eggers, Rudolf
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The potential of supercritical carbon dioxide (scCO(2)) processing of polycaprolactone (Pa) and polycaprolactone-hydroxyapatite (PCL-HA) composites for obtaining functional porous scaffolds at moderate temperatures (35-40 degrees C) was analyzed and quantified. The effect of scCO(2) sorption kinetics on the swelling, foam morphology and thermal behavior of the PCL and PCL-HA composites was studied. Sorption isotherms were determined using magnetic suspension balance at 10-30 MPa and 35-40 degrees C. Influence of the pressure, HA amount (10-20%) and procedure for HA powder preparation on the sorption kinetics was discussed. Supercritical solvent impregnation (SSI) of PCL and PCL-HA with thymol was investigated as environmentally friendly way to produce functional scaffolds with controlled microstructure. Moderately high pressures (13-17 MPa) and 10% of HA were proven to be favorable for creation of the PCL scaffolds with satisfying foam microstructure (mean pore size similar to 200-300 ...mu m), filler distribution and thymol impregnation yields (12-18%). This was due to the satisfactory high scCO(2) solubility (0.25-0.30 g/g) and mass transfer rate (similar to 10(-10) m(2)/s) in the polymer phase as well as its great plasticizing effect (-Delta T-m = 26.4-27.4 degrees C). Higher saturation of the polymer phase with scCO(2) (0.30-0.55 g/g), filler amount (20%) and thymol solubility in scCO(2) ( gt 5.5 g/kg) at pressures above 20 MPa resulted in decreased mass transfer rate and SSI efficiency.
Кључне речи:
Polycaprolactone / Polycaprolactone-hydroxyapatite / CO2 sorption kinetics / High-pressure DSC / Melting point depression / Thymol impregnationИзвор:
Journal of Supercritical Fluids, 2016, 107, 486-498Издавач:
- Elsevier, Amsterdam
Финансирање / пројекти:
- Eurotechnica GmbH (Bargteheide,Germany)
- TuTech Innovation GmbH
- Функционални физиолошки активни биљни материјали са додатом вредношћу за примену у фармацеутској и прехрамбеној индустрији (RS-MESTD-Integrated and Interdisciplinary Research (IIR or III)-45017)
- TUHH (Hamburg, Germany)
DOI: 10.1016/j.supflu.2015.07.001
ISSN: 0896-8446
WoS: 000366077100058
Scopus: 2-s2.0-84947487391
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Ivanović, Jasna AU - Knauer, Sandra AU - Fanovich, Alejandra AU - Milovanović, Stoja AU - Stamenić, Marko AU - Jaeger, Philip AU - Žižović, Irena AU - Eggers, Rudolf PY - 2016 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3407 AB - The potential of supercritical carbon dioxide (scCO(2)) processing of polycaprolactone (Pa) and polycaprolactone-hydroxyapatite (PCL-HA) composites for obtaining functional porous scaffolds at moderate temperatures (35-40 degrees C) was analyzed and quantified. The effect of scCO(2) sorption kinetics on the swelling, foam morphology and thermal behavior of the PCL and PCL-HA composites was studied. Sorption isotherms were determined using magnetic suspension balance at 10-30 MPa and 35-40 degrees C. Influence of the pressure, HA amount (10-20%) and procedure for HA powder preparation on the sorption kinetics was discussed. Supercritical solvent impregnation (SSI) of PCL and PCL-HA with thymol was investigated as environmentally friendly way to produce functional scaffolds with controlled microstructure. Moderately high pressures (13-17 MPa) and 10% of HA were proven to be favorable for creation of the PCL scaffolds with satisfying foam microstructure (mean pore size similar to 200-300 mu m), filler distribution and thymol impregnation yields (12-18%). This was due to the satisfactory high scCO(2) solubility (0.25-0.30 g/g) and mass transfer rate (similar to 10(-10) m(2)/s) in the polymer phase as well as its great plasticizing effect (-Delta T-m = 26.4-27.4 degrees C). Higher saturation of the polymer phase with scCO(2) (0.30-0.55 g/g), filler amount (20%) and thymol solubility in scCO(2) ( gt 5.5 g/kg) at pressures above 20 MPa resulted in decreased mass transfer rate and SSI efficiency. PB - Elsevier, Amsterdam T2 - Journal of Supercritical Fluids T1 - Supercritical CO2 sorption kinetics and thymol impregnation of PCL and PCL-HA EP - 498 SP - 486 VL - 107 DO - 10.1016/j.supflu.2015.07.001 ER -
@article{ author = "Ivanović, Jasna and Knauer, Sandra and Fanovich, Alejandra and Milovanović, Stoja and Stamenić, Marko and Jaeger, Philip and Žižović, Irena and Eggers, Rudolf", year = "2016", abstract = "The potential of supercritical carbon dioxide (scCO(2)) processing of polycaprolactone (Pa) and polycaprolactone-hydroxyapatite (PCL-HA) composites for obtaining functional porous scaffolds at moderate temperatures (35-40 degrees C) was analyzed and quantified. The effect of scCO(2) sorption kinetics on the swelling, foam morphology and thermal behavior of the PCL and PCL-HA composites was studied. Sorption isotherms were determined using magnetic suspension balance at 10-30 MPa and 35-40 degrees C. Influence of the pressure, HA amount (10-20%) and procedure for HA powder preparation on the sorption kinetics was discussed. Supercritical solvent impregnation (SSI) of PCL and PCL-HA with thymol was investigated as environmentally friendly way to produce functional scaffolds with controlled microstructure. Moderately high pressures (13-17 MPa) and 10% of HA were proven to be favorable for creation of the PCL scaffolds with satisfying foam microstructure (mean pore size similar to 200-300 mu m), filler distribution and thymol impregnation yields (12-18%). This was due to the satisfactory high scCO(2) solubility (0.25-0.30 g/g) and mass transfer rate (similar to 10(-10) m(2)/s) in the polymer phase as well as its great plasticizing effect (-Delta T-m = 26.4-27.4 degrees C). Higher saturation of the polymer phase with scCO(2) (0.30-0.55 g/g), filler amount (20%) and thymol solubility in scCO(2) ( gt 5.5 g/kg) at pressures above 20 MPa resulted in decreased mass transfer rate and SSI efficiency.", publisher = "Elsevier, Amsterdam", journal = "Journal of Supercritical Fluids", title = "Supercritical CO2 sorption kinetics and thymol impregnation of PCL and PCL-HA", pages = "498-486", volume = "107", doi = "10.1016/j.supflu.2015.07.001" }
Ivanović, J., Knauer, S., Fanovich, A., Milovanović, S., Stamenić, M., Jaeger, P., Žižović, I.,& Eggers, R.. (2016). Supercritical CO2 sorption kinetics and thymol impregnation of PCL and PCL-HA. in Journal of Supercritical Fluids Elsevier, Amsterdam., 107, 486-498. https://doi.org/10.1016/j.supflu.2015.07.001
Ivanović J, Knauer S, Fanovich A, Milovanović S, Stamenić M, Jaeger P, Žižović I, Eggers R. Supercritical CO2 sorption kinetics and thymol impregnation of PCL and PCL-HA. in Journal of Supercritical Fluids. 2016;107:486-498. doi:10.1016/j.supflu.2015.07.001 .
Ivanović, Jasna, Knauer, Sandra, Fanovich, Alejandra, Milovanović, Stoja, Stamenić, Marko, Jaeger, Philip, Žižović, Irena, Eggers, Rudolf, "Supercritical CO2 sorption kinetics and thymol impregnation of PCL and PCL-HA" in Journal of Supercritical Fluids, 107 (2016):486-498, https://doi.org/10.1016/j.supflu.2015.07.001 . .