dc.creator | Elshaflu, Hana | |
dc.creator | Bjelogrlić, Snežana K. | |
dc.creator | Muller, Christian D. | |
dc.creator | Todorović, Tamara | |
dc.creator | Rodić, Marko | |
dc.creator | Marinković, Aleksandar | |
dc.creator | Filipović, Nenad R. | |
dc.date.accessioned | 2021-03-15T12:12:11Z | |
dc.date.available | 2021-03-15T12:12:11Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 0095-8972 | |
dc.identifier.uri | http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4721 | |
dc.description.abstract | Co(III) complex with a 2-hydrazonylthiazole ligand was synthesized and characterized by single-crystal X-ray diffraction. In the inner sphere of the complex, two monoionic ligands are coordinated tridentately forming octahedral geometry around Co(III). Activity of the complex was investigated on MCF-7 breast cancer cell line, with cisplatin (CDDP) as a reference compound. Results showed that after 24-h incubation, Co(III) complex revealed stronger cytotoxic activity compared to CDDP. Treatment of MCF-7 3-D cell model with the complex at 10M concentration achieved complete suppression of spheroid growth in almost the same extent as at 100M. In combination treatments on MCF-7 spheroids, the complex acted synergistically with CDDP, while additive interaction type was achieved when the complex was applied together with paclitaxel. | |
dc.language | en | |
dc.publisher | Taylor & Francis Ltd, Abingdon | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172055/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172013/RS// | |
dc.relation.isversionof | https://technorep.tmf.bg.ac.rs/handle/123456789/3327 | |
dc.relation.isversionof | https://doi.org/10.1080/00958972.2016.1232404 | |
dc.rights | embargoedAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc/4.0/ | |
dc.source | Journal of Coordination Chemistry | |
dc.subject | Thiazoles | |
dc.subject | Co(III) complex | |
dc.subject | X-ray diffraction | |
dc.subject | Anticancer activity | |
dc.subject | Three drug combination study | |
dc.title | Co(III) complex with (E)-2-(2-(pyridine-2-ylmethylene)hydrazinyl)-4-(4-tolyl)-1,3-thiazole: structure and activity against 2-D and 3-D cancer cell models | |
dc.type | article | en |
dc.rights.license | BY-NC | |
dc.citation.epage | 3366 | |
dc.citation.issue | 22 | |
dc.citation.rank | M22 | |
dc.citation.spage | 3354 | |
dc.citation.volume | 69 | |
dc.description.other | This is the peer-reviewed version of the following article: Elshaflu H Bjelogrlić SK, Muller CD, Todorović T, Rodić M, Marinković A, Filipović NR. Co(III) Complex with (E)-2-(2-(Pyridine-2-Ylmethylene)Hydrazinyl)-4-(4-Tolyl)-1,3-Thiazole: Structure and Activity against 2-D and 3-D Cancer Cell Models. in Journal of Coordination Chemistry. 2016;69(22):3354-3366. [https://doi.org/10.1080/00958972.2016.1232404] | |
dc.description.other | Published version: [https://technorep.tmf.bg.ac.rs/handle/123456789/3327] | |
dc.identifier.doi | 10.1080/00958972.2016.1232404 | |
dc.identifier.fulltext | http://TechnoRep.tmf.bg.ac.rs/bitstream/id/7271/Co(III)_complex_with_acc_2016.pdf | |
dc.identifier.scopus | 2-s2.0-84988615513 | |
dc.identifier.wos | 000386021200005 | |
dc.type.version | acceptedVersion | |