pH-sensitive hydrogels based on poly(methacrylic acid), casein and liposomes for targeted delivery of poorly water-soluble active substances
Конференцијски прилог (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Polymeric carriers for targeted delivery of poorly water-soluble active substances (PWSAS)
are facing two challenges. First, encapsulation of PWSAS depends on structure of the carrier. Second
limitation is caused by the phenomenon of burst drug release. Despite the fact that the fast release
of drug in a burst stage is utilized in certain drug administration strategies, the negative effects
brought about by burst can be pharmacologically dangerous and economically inefficient. This study
presents a novel strategy for encapsulation and targeted delivery of PWSAS - caffeine without the
possibility of burst effect. Hydrophilic carrier based on poly(methacylic acid) was modified by amphiphilic substances - casein and centrifuged liposomes to ensure caffeine encapsulation. The caffeine was encapsulated in liposomes which further were incorporated into the carrier networks during the synthesis of the carriers. The release kinetic of caffeine was analyzed with respect to morphology of t...he carriers and interactions that could be established between the components of the
carrier. The swelling of carriers and release of caffeine were further investigated depending on the
neutralization degree of methacrylic acid in two media with different pH simulating the path of the
carrier through the upper and lower human gastrointestinal tract. Synthesized carriers showed significant potential for encapsulation and targeted delivery of PWSAS.
Kod razvoja polimernih nosača za ciljano otpuštanje slabo vodorastvornih aktivnih supstanci
(SVAS) postoje dva ograničenja. Prvo, inkapsulacija SVAS zavisi od strukture nosača. Drugo ograničenje je vezano za naglo oslobađanje leka. Uprkos činjenici da je naglo oslobađanje leka, tzv. burst
efekat poželjno kod nekih sistema, negativni efekti naglog oslobađanja leka u većini slučajeva mogu
biti farmakološki opasni i ekonomski neefikasni. U ovom radu je prikazana nova strategija za inkapsulaciju i ciljano otpuštanje SVAS – kofeina bez burst efekta. Hidrofilni nosač na bazi poli(metakrilne
kiseline) je modifikovan amfifilnim supstancama – kazeinom i centrifugiranim lipozomima kako bi se
postigla inkapsulacija kofeina. Kofein je inkapsuliran u lipozome koji su zatim inkorporirani u mrežu
nosača tokom sinteze nosača. Analiziran je uticaj morfologije nosača i interakcija koje su se uspostavile između njegovih komponenti na kinetiku otpuštanja kofeina. Zatim je analiziran uticaj stepen
n...eutralizacije metakrilne kiseline na bubrenje nosača i otpuštanje kofeina u dve sredine različitih pH
vrednosti koje su simulirale pH sredinu u gastrointestinalnom traktu čoveka. Pokazano je da sintetisani nosači imaju veliki potencijal za inkapsulaciju i ciljano otpuštanje SVAS
Кључне речи:
poly(methacrylic acid) / casein / liposomes / poorly water-soluble active substances / targeted delivery / poli(metakrilna kiselina) / kazein / lipozomi / slabo vodorastvorne aktivne supstance / ciljano otpuštanjeИзвор:
33 RD International Congress On Process Industry, 2020Издавач:
- Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS), Društvo za procesnu tehniku.
Финансирање / пројекти:
Колекције
Институција/група
Inovacioni centarTY - CONF AU - Marković, Maja D. AU - Panić, Vesna V. AU - Seslija, Sanja I. AU - Pjanović, Rada V. PY - 2020 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5072 AB - Polymeric carriers for targeted delivery of poorly water-soluble active substances (PWSAS) are facing two challenges. First, encapsulation of PWSAS depends on structure of the carrier. Second limitation is caused by the phenomenon of burst drug release. Despite the fact that the fast release of drug in a burst stage is utilized in certain drug administration strategies, the negative effects brought about by burst can be pharmacologically dangerous and economically inefficient. This study presents a novel strategy for encapsulation and targeted delivery of PWSAS - caffeine without the possibility of burst effect. Hydrophilic carrier based on poly(methacylic acid) was modified by amphiphilic substances - casein and centrifuged liposomes to ensure caffeine encapsulation. The caffeine was encapsulated in liposomes which further were incorporated into the carrier networks during the synthesis of the carriers. The release kinetic of caffeine was analyzed with respect to morphology of the carriers and interactions that could be established between the components of the carrier. The swelling of carriers and release of caffeine were further investigated depending on the neutralization degree of methacrylic acid in two media with different pH simulating the path of the carrier through the upper and lower human gastrointestinal tract. Synthesized carriers showed significant potential for encapsulation and targeted delivery of PWSAS. AB - Kod razvoja polimernih nosača za ciljano otpuštanje slabo vodorastvornih aktivnih supstanci (SVAS) postoje dva ograničenja. Prvo, inkapsulacija SVAS zavisi od strukture nosača. Drugo ograničenje je vezano za naglo oslobađanje leka. Uprkos činjenici da je naglo oslobađanje leka, tzv. burst efekat poželjno kod nekih sistema, negativni efekti naglog oslobađanja leka u većini slučajeva mogu biti farmakološki opasni i ekonomski neefikasni. U ovom radu je prikazana nova strategija za inkapsulaciju i ciljano otpuštanje SVAS – kofeina bez burst efekta. Hidrofilni nosač na bazi poli(metakrilne kiseline) je modifikovan amfifilnim supstancama – kazeinom i centrifugiranim lipozomima kako bi se postigla inkapsulacija kofeina. Kofein je inkapsuliran u lipozome koji su zatim inkorporirani u mrežu nosača tokom sinteze nosača. Analiziran je uticaj morfologije nosača i interakcija koje su se uspostavile između njegovih komponenti na kinetiku otpuštanja kofeina. Zatim je analiziran uticaj stepen neutralizacije metakrilne kiseline na bubrenje nosača i otpuštanje kofeina u dve sredine različitih pH vrednosti koje su simulirale pH sredinu u gastrointestinalnom traktu čoveka. Pokazano je da sintetisani nosači imaju veliki potencijal za inkapsulaciju i ciljano otpuštanje SVAS PB - Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS), Društvo za procesnu tehniku. C3 - 33 RD International Congress On Process Industry T1 - pH-sensitive hydrogels based on poly(methacrylic acid), casein and liposomes for targeted delivery of poorly water-soluble active substances UR - https://hdl.handle.net/21.15107/rcub_technorep_5072 ER -
@conference{ author = "Marković, Maja D. and Panić, Vesna V. and Seslija, Sanja I. and Pjanović, Rada V.", year = "2020", abstract = "Polymeric carriers for targeted delivery of poorly water-soluble active substances (PWSAS) are facing two challenges. First, encapsulation of PWSAS depends on structure of the carrier. Second limitation is caused by the phenomenon of burst drug release. Despite the fact that the fast release of drug in a burst stage is utilized in certain drug administration strategies, the negative effects brought about by burst can be pharmacologically dangerous and economically inefficient. This study presents a novel strategy for encapsulation and targeted delivery of PWSAS - caffeine without the possibility of burst effect. Hydrophilic carrier based on poly(methacylic acid) was modified by amphiphilic substances - casein and centrifuged liposomes to ensure caffeine encapsulation. The caffeine was encapsulated in liposomes which further were incorporated into the carrier networks during the synthesis of the carriers. The release kinetic of caffeine was analyzed with respect to morphology of the carriers and interactions that could be established between the components of the carrier. The swelling of carriers and release of caffeine were further investigated depending on the neutralization degree of methacrylic acid in two media with different pH simulating the path of the carrier through the upper and lower human gastrointestinal tract. Synthesized carriers showed significant potential for encapsulation and targeted delivery of PWSAS., Kod razvoja polimernih nosača za ciljano otpuštanje slabo vodorastvornih aktivnih supstanci (SVAS) postoje dva ograničenja. Prvo, inkapsulacija SVAS zavisi od strukture nosača. Drugo ograničenje je vezano za naglo oslobađanje leka. Uprkos činjenici da je naglo oslobađanje leka, tzv. burst efekat poželjno kod nekih sistema, negativni efekti naglog oslobađanja leka u većini slučajeva mogu biti farmakološki opasni i ekonomski neefikasni. U ovom radu je prikazana nova strategija za inkapsulaciju i ciljano otpuštanje SVAS – kofeina bez burst efekta. Hidrofilni nosač na bazi poli(metakrilne kiseline) je modifikovan amfifilnim supstancama – kazeinom i centrifugiranim lipozomima kako bi se postigla inkapsulacija kofeina. Kofein je inkapsuliran u lipozome koji su zatim inkorporirani u mrežu nosača tokom sinteze nosača. Analiziran je uticaj morfologije nosača i interakcija koje su se uspostavile između njegovih komponenti na kinetiku otpuštanja kofeina. Zatim je analiziran uticaj stepen neutralizacije metakrilne kiseline na bubrenje nosača i otpuštanje kofeina u dve sredine različitih pH vrednosti koje su simulirale pH sredinu u gastrointestinalnom traktu čoveka. Pokazano je da sintetisani nosači imaju veliki potencijal za inkapsulaciju i ciljano otpuštanje SVAS", publisher = "Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS), Društvo za procesnu tehniku.", journal = "33 RD International Congress On Process Industry", title = "pH-sensitive hydrogels based on poly(methacrylic acid), casein and liposomes for targeted delivery of poorly water-soluble active substances", url = "https://hdl.handle.net/21.15107/rcub_technorep_5072" }
Marković, M. D., Panić, V. V., Seslija, S. I.,& Pjanović, R. V.. (2020). pH-sensitive hydrogels based on poly(methacrylic acid), casein and liposomes for targeted delivery of poorly water-soluble active substances. in 33 RD International Congress On Process Industry Savez mašinskih i elektrotehničkih inženjera i tehničara Srbije (SMEITS), Društvo za procesnu tehniku... https://hdl.handle.net/21.15107/rcub_technorep_5072
Marković MD, Panić VV, Seslija SI, Pjanović RV. pH-sensitive hydrogels based on poly(methacrylic acid), casein and liposomes for targeted delivery of poorly water-soluble active substances. in 33 RD International Congress On Process Industry. 2020;. https://hdl.handle.net/21.15107/rcub_technorep_5072 .
Marković, Maja D., Panić, Vesna V., Seslija, Sanja I., Pjanović, Rada V., "pH-sensitive hydrogels based on poly(methacrylic acid), casein and liposomes for targeted delivery of poorly water-soluble active substances" in 33 RD International Congress On Process Industry (2020), https://hdl.handle.net/21.15107/rcub_technorep_5072 .