The role of viscoelasticity in long time cell rearrangement
Само за регистроване кориснике
2022
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Cell rearrangement caused by collective cell migration (CCM) during free expansion of epithelial monolayers has become a landmark in our current understanding of fundamental biological processes such as tissue development, regeneration, wound healing or cancer invasion. Cell spreading causes formation of mechanical waves which has a feedback effect on cell rearrangement and can lead to the cell jamming state. The mechanical waves describe oscillatory changes in cell velocity, as well as, the rheological parameters that affect them. The velocity oscillations, obtained at a time scale of hours, are in the form of forward and backward flows. Collision of forward and backward flows can induce an increase in the cell compressive stress accompanied with cell packing density which have a feedback impact on cell mobility, tissue viscoelasticity and alters the tissue stiffness. The tissue stiffness depends on the cell packing density and the active/passive (i.e. migrating/resting) state of sing...le cells and can be used as an indicator of cell jamming state transition. Since cell stiffness can be measured it may directly show in which state the multicellular system is. In this work a review of existing modeling approaches is given along with assortment of published experimental findings, in order to invite experimentalists to test given theoretical considerations in multicellular systems.
Кључне речи:
Cell packing density / Cell velocity / Collective cell migration / The cell monolayer free expansion / The mechanical waves generation / ViscoelasticityИзвор:
Progress in Biophysics and Molecular Biology, 2022, 173, 60-71Издавач:
- Elsevier Ltd.
Финансирање / пројекти:
- Министарство науке, технолошког развоја и иновација Републике Србије, институционално финансирање - 200135 (Универзитет у Београду, Технолошко-металуршки факултет) (RS-MESTD-inst-2020-200135)
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Pajić-Lijaković, Ivana AU - Milivojević, Milan PY - 2022 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5383 AB - Cell rearrangement caused by collective cell migration (CCM) during free expansion of epithelial monolayers has become a landmark in our current understanding of fundamental biological processes such as tissue development, regeneration, wound healing or cancer invasion. Cell spreading causes formation of mechanical waves which has a feedback effect on cell rearrangement and can lead to the cell jamming state. The mechanical waves describe oscillatory changes in cell velocity, as well as, the rheological parameters that affect them. The velocity oscillations, obtained at a time scale of hours, are in the form of forward and backward flows. Collision of forward and backward flows can induce an increase in the cell compressive stress accompanied with cell packing density which have a feedback impact on cell mobility, tissue viscoelasticity and alters the tissue stiffness. The tissue stiffness depends on the cell packing density and the active/passive (i.e. migrating/resting) state of single cells and can be used as an indicator of cell jamming state transition. Since cell stiffness can be measured it may directly show in which state the multicellular system is. In this work a review of existing modeling approaches is given along with assortment of published experimental findings, in order to invite experimentalists to test given theoretical considerations in multicellular systems. PB - Elsevier Ltd. T2 - Progress in Biophysics and Molecular Biology T1 - The role of viscoelasticity in long time cell rearrangement EP - 71 SP - 60 VL - 173 DO - 10.1016/j.pbiomolbio.2022.05.005 ER -
@article{ author = "Pajić-Lijaković, Ivana and Milivojević, Milan", year = "2022", abstract = "Cell rearrangement caused by collective cell migration (CCM) during free expansion of epithelial monolayers has become a landmark in our current understanding of fundamental biological processes such as tissue development, regeneration, wound healing or cancer invasion. Cell spreading causes formation of mechanical waves which has a feedback effect on cell rearrangement and can lead to the cell jamming state. The mechanical waves describe oscillatory changes in cell velocity, as well as, the rheological parameters that affect them. The velocity oscillations, obtained at a time scale of hours, are in the form of forward and backward flows. Collision of forward and backward flows can induce an increase in the cell compressive stress accompanied with cell packing density which have a feedback impact on cell mobility, tissue viscoelasticity and alters the tissue stiffness. The tissue stiffness depends on the cell packing density and the active/passive (i.e. migrating/resting) state of single cells and can be used as an indicator of cell jamming state transition. Since cell stiffness can be measured it may directly show in which state the multicellular system is. In this work a review of existing modeling approaches is given along with assortment of published experimental findings, in order to invite experimentalists to test given theoretical considerations in multicellular systems.", publisher = "Elsevier Ltd.", journal = "Progress in Biophysics and Molecular Biology", title = "The role of viscoelasticity in long time cell rearrangement", pages = "71-60", volume = "173", doi = "10.1016/j.pbiomolbio.2022.05.005" }
Pajić-Lijaković, I.,& Milivojević, M.. (2022). The role of viscoelasticity in long time cell rearrangement. in Progress in Biophysics and Molecular Biology Elsevier Ltd.., 173, 60-71. https://doi.org/10.1016/j.pbiomolbio.2022.05.005
Pajić-Lijaković I, Milivojević M. The role of viscoelasticity in long time cell rearrangement. in Progress in Biophysics and Molecular Biology. 2022;173:60-71. doi:10.1016/j.pbiomolbio.2022.05.005 .
Pajić-Lijaković, Ivana, Milivojević, Milan, "The role of viscoelasticity in long time cell rearrangement" in Progress in Biophysics and Molecular Biology, 173 (2022):60-71, https://doi.org/10.1016/j.pbiomolbio.2022.05.005 . .