Electrochemical degradation of esomeprasole on different electrodes in a sense of environment protection

Abstract

Esomeprazole has been shown to be the most effective oral PPI for controlling intragastric pH. The persistence of esomeprasole in environmental systems could be solved by different types of its degradation. In this work electrocatalytic degradation of esomeprasole has been investigated in the presence of sodium sulfate and sodium chloride using IrOx electrode and was monitored using UV-Vis spectrophotometer at 303 nm. Also the electro degradation process was examined and on Au electrode. NanoScope III A (Veeco, USA) microscope was used to study the morphology of Esomeprazole on the gold surface by atomic force microscopy. By optical microscopy the morphology of Esomeprazole dissolved in human serum on the gold surface was studied as well.

Ezomeprazol je poznat kao najefikasniji lek , tj. inhibitor protonske pumpe u kontroli intragastricne vrednosti pH. Njegovo prisustvo u vodenim tokovima i zemljištu se resava osmišljavanjem novih postupaka degradacije. U ovom radu elektrokatalitiþka degradacija ezomeprazola je prouþavana u natrijum sulfatu i natrijum hloridu na IrOx elektrodi. Reakcija je praüena korišüenjem UV-Vis spektrofotometra na 303 nm. Takoÿe je prouþavana degradacija ezomeprazola na elektrodi od zlata. NanoScope III A (Veeco, USA) mikroskop je korišüen u prouþavanju morfologije ezomeprazola na površini eelektrode od zlata mikroskopijom mneÿuatomskih sila. Optiþkom mikroskopijom je ispitivana morfologija ezomeprazola na površini eelektrode od zlata u prisustvu humanog seruma.