Sinteza i karakterizacija jedinjenja trifenilkalaja(IV) sa 3-(4-metil-2-oksohinolinil)propanskom kiselinom

Abstract

U poslednjoj deceniji jedinjenja organokalaja(IV) privukla su veliku pažnju istraživača zbog svoje izvanredne citotoksične aktivnosti protiv raznih oblika tumora. Ovde je prikazana sinteza 3-(4-metil-2-oksohinolinil)propanske kiseline i njenog kompleksa trifenilkalaja(IV). Ligand je dobijen u dva koraka. U prvom koraku, u reakciji između 4-metil-hinolin-2-ona i metil-3-bromopropionata sintetisan je odgovarajući metil-estar, čijom hidrolizom, u drugom koraku, je dobijen ligand. U reakciji liganda, koji je deprotonovan LiOH, i ekvimolarne količine Ph3SnCl dobijen je kompleks u obliku belog taloga. Sintetisana jedinjenja su okarakterisana standardnim analitičkim metodama. Naredna istraživanja sintetisanih jedinjenja biće usmerena ka in vitro ispitivanju citotoksične aktivnosti prema raznim ćelijskim linijama karcinoma, kao i na ispitivanje mehanizma njihovog delovanja.

Organotin(IV) compounds have greatly attracted researchers' attention in the last decade for their outstanding cytotoxic activity against different tumor cells. Herein, the synthesis of 3-(4-methyl-2-oxoquinolinyl)propanoic acid and its triphenyltin(IV) complex has been performed. The ligand precursor has been synthesized in two steps. In the first step, reaction between 4-methylquinoline-2-on and methyl 3-bromopropionate afforded corresponding methyl ester, whose hydrolysis, in the second step, produced targeted ligand. In the reaction of ligand precursor, which was deprotonated with LiOH, with equimolar amount of Ph3SnCl, the expected complex was obtained as white solid. The synthesized compounds have been characterized using standard analytical methods. The following research of synthesized compounds will be focused on in vitro cytotoxic activity against various cancer cell lines, as well as investigation of mechanism of their action.