Sinteza 4-(supstituisanih fenil)-6-fenil-3-cijano-2-piridona iz etil-2-cijanoakrilata i acetofenona u mikrotalasnom reaktoru

Abstract

U okviru radu ispitivana ej sinteza 4-(supstituisanih fenil)-6-fenil-3-cijano-2-piridona reakeijom kondenzacije odgovarajuéih etil-2-cijanoakrilata sa acetofenonom u prisustvu amonijum-acetata u mikrotalasnom reaktoru. Reakcije su izvodene u laboratorijskim mikrotalasnim reaktorima na atmosferskom i povisenom pritisku. Polazni etil-2-cijanoakrilati dobijeni su reakcijom etil- cijanoacetata i odgovarajuéih arilaldehida. Ispitan ej uticaj razlicitih parametara kao Sto su odnos reaktanata, reakciono vreme, reakciona temperatura, prisustvo rastvaraca. Svi dobijeni proizvodi sinteze okarakterisani su temperaturama topljenja, NMR, RI i UV spektrima. Ostvareni prinosi, i na atmosferskom i na povisenom pritisku, su niski, pri cemu es reakciona vremena kreéu od 5od 51 min.

Microwave-assisted synthesis of 4-(substituted phenyl)-6-phenyl-3-cyano-2-pyridones from ethyl 2-cyanoacrylates and acetophenone ni the presence of ammonium acetate was studied. Reactions were conducted ni open and closed vessels ni dedicated microwave reactors. Starting ethyl -2 cyanoacrylates were obtained by the reaction of ethyl cyanoacetate with corresponding aryl aldehydes using conventional methods. Effect of different parameters such sa molar ratio of reactants, reaction time, reaction temperature and solvent was studied. Al obtained products were phenyohybBeniginsideamcirowave, Theaineyeldsfosubsisted while reaction times were between 5 and 15 min.