Kompleksi derivata izatina i njihovo antimikrobno dejstvo

Abstract

Derivati izatina su se u novije vreme pokazali kao jedinjenja korisna u farmakologiji, jer ispoljavaju širok spektar dejstava kao sto su antivirusna, antitumorna, antibakterijska, antituberkulozna, antigljivična, antikonvulzivna. Reč je o jedinjenjima koja nastaju reakcijom izatina i primarnih amina i spadaju u grupu Šifovih (Schiff) baza. Kao deo serije istraživanja koje se bavi derivatima izatina, sintetisani su i njihovi kompleksi sa metalima. Ispitana je njihova antimikrobna aktivnost, pomoću bujon - mikrodilucione metode, na kojoj se može zasnovati i mogućnost njihove primene.

The isatin derivatives have recently shown the potential to be used in pharmaclogy because of their activities such as antiviral, anticancer, antibacterial, antituberculosis, antifungal and anticonvulsive. These compounds belong to the group of Schiff bases and they are synthesized by the reaction of isatin and primary amines. As a part of the series of investigation that deals with the isatin derivatives, their complexes with metals were synthesized. Their antimicrobial activity was examined using the broth micro-dilution method, which could provide the ground for the application of these compounds.