Encapsulation of vitamin E and folic acid into liposomes - carrier stability and controlled release

Abstract

In this study liposomes were investigated regarding the ability to encapsulate vitamins, vitamin E and folic acid. Liposomes were prepared using commercial mixture based on the soybean lecithin (Phospholipon 90 G) by the proliposome technique. High entrapment efficiency (85-90%) was achieved for both types of vitamins, while the size was dependent on the vitamin type (350 and 630 nm for vitamin E- and folic acid-containing liposomes). Physical stability expressed via changes of the size, polydispersity and zeta potential during storage was confirmed for the period of one month in case liposomes with folic acid and two months for the liposomes with vitamin E. The release study, done using Franc diffusion cell, under skin conditions (pH=5.5), showed that the release rate was determined by solubility of the vitamins.