TY  - JOUR
AU  - Babić Radić, Marija M.
AU  - Vukomanović, Marija
AU  - Nikodinović-Runić, Jasmina
AU  - Tomić, Simonida
PY  - 2024
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7410
AB  - This study proposes synthesis and evaluation of gelatin-/alginate-based hydrogel scaffolds reinforced with titanium dioxide (TiO2) nanoparticles which, through their combination with allantoin, quercetin, and caffeic acid, provide multi-target therapy directed on all phases of the wound healing process. These scaffolds provide the simultaneous release of bioactive agents and concurrently support cell/tissue repair through the replicated structure of a native extracellular matrix. The hydrogel scaffolds were synthesized via a crosslinking reaction using EDC as a crosslinker for gelatin. Synthesized hydrogel scaffolds and the effect of TiO2 on their properties were characterized by structural, mechanical, morphological, and swelling properties, and the porosity, wettability, adhesion to skin tissue, and simultaneous release features. The biocompatibility of the scaffolds was tested in vitro on fibroblasts (MRC5 cells) and in vivo (Caenorhabditis elegans) in a survival probe. The scaffolds revealed porous interconnected morphology, porosity of 88.33 to 96.76%, elastic modulus of 1.53 to 4.29 MPa, full hydrophilicity, favorable skin adhesivity, and biocompatibility. The simultaneous release was investigated in vitro indicating dependence on the scaffold’s composition and type of bioactive agents. The novel scaffolds designed as multi-target therapy have significant promise for improved wound healing in a beneficial and non-invasive manner.
PB  - MDPI
T2  - Pharmaceutics
T1  - Gelatin-/Alginate-Based Hydrogel Scaffolds Reinforced with TiO2 Nanoparticles for Simultaneous Release of Allantoin, Caffeic Acid, and Quercetin as Multi-Target Wound Therapy Platform
IS  - 3
SP  - 372
VL  - 16
DO  - 10.3390/pharmaceutics16030372
ER  - 

@article{
author = "Babić Radić, Marija M. and Vukomanović, Marija and Nikodinović-Runić, Jasmina and Tomić, Simonida",
year = "2024",
abstract = "This study proposes synthesis and evaluation of gelatin-/alginate-based hydrogel scaffolds reinforced with titanium dioxide (TiO2) nanoparticles which, through their combination with allantoin, quercetin, and caffeic acid, provide multi-target therapy directed on all phases of the wound healing process. These scaffolds provide the simultaneous release of bioactive agents and concurrently support cell/tissue repair through the replicated structure of a native extracellular matrix. The hydrogel scaffolds were synthesized via a crosslinking reaction using EDC as a crosslinker for gelatin. Synthesized hydrogel scaffolds and the effect of TiO2 on their properties were characterized by structural, mechanical, morphological, and swelling properties, and the porosity, wettability, adhesion to skin tissue, and simultaneous release features. The biocompatibility of the scaffolds was tested in vitro on fibroblasts (MRC5 cells) and in vivo (Caenorhabditis elegans) in a survival probe. The scaffolds revealed porous interconnected morphology, porosity of 88.33 to 96.76%, elastic modulus of 1.53 to 4.29 MPa, full hydrophilicity, favorable skin adhesivity, and biocompatibility. The simultaneous release was investigated in vitro indicating dependence on the scaffold’s composition and type of bioactive agents. The novel scaffolds designed as multi-target therapy have significant promise for improved wound healing in a beneficial and non-invasive manner.",
publisher = "MDPI",
journal = "Pharmaceutics",
title = "Gelatin-/Alginate-Based Hydrogel Scaffolds Reinforced with TiO2 Nanoparticles for Simultaneous Release of Allantoin, Caffeic Acid, and Quercetin as Multi-Target Wound Therapy Platform",
number = "3",
pages = "372",
volume = "16",
doi = "10.3390/pharmaceutics16030372"
}

Babić Radić, M. M., Vukomanović, M., Nikodinović-Runić, J.,& Tomić, S.. (2024). Gelatin-/Alginate-Based Hydrogel Scaffolds Reinforced with TiO2 Nanoparticles for Simultaneous Release of Allantoin, Caffeic Acid, and Quercetin as Multi-Target Wound Therapy Platform. in Pharmaceutics
MDPI., 16(3), 372.
https://doi.org/10.3390/pharmaceutics16030372

Babić Radić MM, Vukomanović M, Nikodinović-Runić J, Tomić S. Gelatin-/Alginate-Based Hydrogel Scaffolds Reinforced with TiO2 Nanoparticles for Simultaneous Release of Allantoin, Caffeic Acid, and Quercetin as Multi-Target Wound Therapy Platform. in Pharmaceutics. 2024;16(3):372.
doi:10.3390/pharmaceutics16030372 .

Babić Radić, Marija M., Vukomanović, Marija, Nikodinović-Runić, Jasmina, Tomić, Simonida, "Gelatin-/Alginate-Based Hydrogel Scaffolds Reinforced with TiO2 Nanoparticles for Simultaneous Release of Allantoin, Caffeic Acid, and Quercetin as Multi-Target Wound Therapy Platform" in Pharmaceutics, 16, no. 3 (2024):372,
https://doi.org/10.3390/pharmaceutics16030372 . .

TY  - JOUR
AU  - Janković, Vukašin
AU  - Marković, Darka
AU  - Nikodinović-Runić, Jasmina
AU  - Radetić, Maja
AU  - Ilić-Tomić, Tatjana
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5276
AB  - Given the environmental burden of textile industry, especially of dyeing processes and the volume of synthetic dyes and surfactants, the intensive development of the greener approaches is under way. Herein, an environmentaly-friendly dyeing of polyamide (PA) and PA/Elastane (PA/EA) knits using live bacterial approach in water environment, completely eliminating usage of textile auxiliaries is described. A total of 12 pigment-producing Streptomyces strains were isolated and purified from soil and rizoshere or bark of smoke tree Cotinus coggygria samples. The antibacterial, antifungal and cytotoxic effects of crude bacterial extracts were tested. Antimicrobial effect was obtained by the majority of extracts but only two streptomycetes extracts, 11–5 and BPS51, showed moderate cytotoxicity against HaCaT human cell line. This was the reason to select 11–5 and BPS51 strains for the dyeing of the textile materials. Excellent properties of dyeing wool, silk and PA are achieved initially using live cultures, and the bioprocess is optimized on commercial PA and PA/EA knits used for stockings production. Satisfactory coloration of both knits is achieved with dynamic conditions (culture shaking at 180 rpm over 5–14 days at 30 ºC) giving the best coloration results, except in the case of the PA sample dyed with a bacterial strain 11–5. The prolongation of dyeing time leads to higher color yields independently of fabric and bacteria strain. Although the color differences between the samples before and after washing are observed, washing fastness after three washing cycles can be considered as satisfactory.
PB  - Springer Science and Business Media
T2  - World Journal of Microbiology and Biotechnology
T1  - Eco‑friendly dyeing of polyamide and polyamide‑elastane knits with living bacterial cultures of two Streptomyces sp. strains
IS  - 1
SP  - 32
VL  - 39
DO  - 10.1007/s11274-022-03473-4
ER  - 

@article{
author = "Janković, Vukašin and Marković, Darka and Nikodinović-Runić, Jasmina and Radetić, Maja and Ilić-Tomić, Tatjana",
year = "2023",
abstract = "Given the environmental burden of textile industry, especially of dyeing processes and the volume of synthetic dyes and surfactants, the intensive development of the greener approaches is under way. Herein, an environmentaly-friendly dyeing of polyamide (PA) and PA/Elastane (PA/EA) knits using live bacterial approach in water environment, completely eliminating usage of textile auxiliaries is described. A total of 12 pigment-producing Streptomyces strains were isolated and purified from soil and rizoshere or bark of smoke tree Cotinus coggygria samples. The antibacterial, antifungal and cytotoxic effects of crude bacterial extracts were tested. Antimicrobial effect was obtained by the majority of extracts but only two streptomycetes extracts, 11–5 and BPS51, showed moderate cytotoxicity against HaCaT human cell line. This was the reason to select 11–5 and BPS51 strains for the dyeing of the textile materials. Excellent properties of dyeing wool, silk and PA are achieved initially using live cultures, and the bioprocess is optimized on commercial PA and PA/EA knits used for stockings production. Satisfactory coloration of both knits is achieved with dynamic conditions (culture shaking at 180 rpm over 5–14 days at 30 ºC) giving the best coloration results, except in the case of the PA sample dyed with a bacterial strain 11–5. The prolongation of dyeing time leads to higher color yields independently of fabric and bacteria strain. Although the color differences between the samples before and after washing are observed, washing fastness after three washing cycles can be considered as satisfactory.",
publisher = "Springer Science and Business Media",
journal = "World Journal of Microbiology and Biotechnology",
title = "Eco‑friendly dyeing of polyamide and polyamide‑elastane knits with living bacterial cultures of two Streptomyces sp. strains",
number = "1",
pages = "32",
volume = "39",
doi = "10.1007/s11274-022-03473-4"
}

Janković, V., Marković, D., Nikodinović-Runić, J., Radetić, M.,& Ilić-Tomić, T.. (2023). Eco‑friendly dyeing of polyamide and polyamide‑elastane knits with living bacterial cultures of two Streptomyces sp. strains. in World Journal of Microbiology and Biotechnology
Springer Science and Business Media., 39(1), 32.
https://doi.org/10.1007/s11274-022-03473-4

Janković V, Marković D, Nikodinović-Runić J, Radetić M, Ilić-Tomić T. Eco‑friendly dyeing of polyamide and polyamide‑elastane knits with living bacterial cultures of two Streptomyces sp. strains. in World Journal of Microbiology and Biotechnology. 2023;39(1):32.
doi:10.1007/s11274-022-03473-4 .

Janković, Vukašin, Marković, Darka, Nikodinović-Runić, Jasmina, Radetić, Maja, Ilić-Tomić, Tatjana, "Eco‑friendly dyeing of polyamide and polyamide‑elastane knits with living bacterial cultures of two Streptomyces sp. strains" in World Journal of Microbiology and Biotechnology, 39, no. 1 (2023):32,
https://doi.org/10.1007/s11274-022-03473-4 . .

TY  - CONF
AU  - Kramar, Ana
AU  - Ilić-Tomić, Tatjana
AU  - Lađarević, Jelena
AU  - Nikodinović-Runić, Jasmina
AU  - Kostić, Mirjana
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6755
AB  - In this work, cellulose (viscose) was functionalized with chitosan and dyed with an extract of Streptomyces sp. NP4 bacterial culture. Cellulose was first converted to dialdehyde cellulose; afterward chitosan was deposited, making fabric susceptible to dyeing. The dyed fabric exhibited pH responsiveness in a broad range of pH, 4-7-10, where colour shade of the fabric, exposed to buffer solutions, was pink, red, and blue, respectively. Response to the pH change was measured in seconds, whereby faster colour shift is from blue to red/pink. The dyed fabrics can withstand 10 cycles of colour change. Due to the broad range of pH activity, the presented cellulose product has the potential to be used as a textile pH sensor, and, more importantly, it is completely made from natural and sustainable resources.
PB  - Sciencentris
C3  - Book of Abstracts / 5th International International Conference on Natural Fibers - Materials of the Future, ICNF2021, 17–19. maj 2021., Portugal
T1  - Functional pH-sensitive cellulose fabric dyed with bacterial extract from Streptomyces sp.
EP  - 29
SP  - 28
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6755
ER  - 

@conference{
author = "Kramar, Ana and Ilić-Tomić, Tatjana and Lađarević, Jelena and Nikodinović-Runić, Jasmina and Kostić, Mirjana",
year = "2021",
abstract = "In this work, cellulose (viscose) was functionalized with chitosan and dyed with an extract of Streptomyces sp. NP4 bacterial culture. Cellulose was first converted to dialdehyde cellulose; afterward chitosan was deposited, making fabric susceptible to dyeing. The dyed fabric exhibited pH responsiveness in a broad range of pH, 4-7-10, where colour shade of the fabric, exposed to buffer solutions, was pink, red, and blue, respectively. Response to the pH change was measured in seconds, whereby faster colour shift is from blue to red/pink. The dyed fabrics can withstand 10 cycles of colour change. Due to the broad range of pH activity, the presented cellulose product has the potential to be used as a textile pH sensor, and, more importantly, it is completely made from natural and sustainable resources.",
publisher = "Sciencentris",
journal = "Book of Abstracts / 5th International International Conference on Natural Fibers - Materials of the Future, ICNF2021, 17–19. maj 2021., Portugal",
title = "Functional pH-sensitive cellulose fabric dyed with bacterial extract from Streptomyces sp.",
pages = "29-28",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6755"
}

Kramar, A., Ilić-Tomić, T., Lađarević, J., Nikodinović-Runić, J.,& Kostić, M.. (2021). Functional pH-sensitive cellulose fabric dyed with bacterial extract from Streptomyces sp.. in Book of Abstracts / 5th International International Conference on Natural Fibers - Materials of the Future, ICNF2021, 17–19. maj 2021., Portugal
Sciencentris., 28-29.
https://hdl.handle.net/21.15107/rcub_technorep_6755

Kramar A, Ilić-Tomić T, Lađarević J, Nikodinović-Runić J, Kostić M. Functional pH-sensitive cellulose fabric dyed with bacterial extract from Streptomyces sp.. in Book of Abstracts / 5th International International Conference on Natural Fibers - Materials of the Future, ICNF2021, 17–19. maj 2021., Portugal. 2021;:28-29.
https://hdl.handle.net/21.15107/rcub_technorep_6755 .

Kramar, Ana, Ilić-Tomić, Tatjana, Lađarević, Jelena, Nikodinović-Runić, Jasmina, Kostić, Mirjana, "Functional pH-sensitive cellulose fabric dyed with bacterial extract from Streptomyces sp." in Book of Abstracts / 5th International International Conference on Natural Fibers - Materials of the Future, ICNF2021, 17–19. maj 2021., Portugal (2021):28-29,
https://hdl.handle.net/21.15107/rcub_technorep_6755 .

TY  - CONF
AU  - Tomšič, Brigita
AU  - Marković, Darka
AU  - Simončić, Barbara
AU  - Janković, Vukašin
AU  - Ilić-Tomić, Tatjana
AU  - Nikodinović-Runić, Jasmina
AU  - Radetić, Maja
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6865
AB  - Nano-finishing of textiles with Cu-based nanoparticles (NPs) is continually gaining scientific attention
due to their extraordinary antimicrobial activity and inexpensive precursor salts. After exploitation,
such textile goods commonly end-up on landfills becoming prone to biodegradation. The aim of this
study is to highlight the influence of in situ synthetized CuO/Cu2O NPs on biodegradation behavior of
cotton (CO) fabrics impregnated with 1,2,3,4-butanetetracarboxylic (BTCA) and succinic (SUC) acids in
soil and compost. Biodegradation of impregnated samples in soil was slower compared to control CO
fabric. The presence of CuO/Cu2O NPs negligibly affected biodegradation process in compost which
ran much faster than in soil.
PB  - Portugal : University of Minho
C3  - Book of abstracts / Unfolding the future, 20th World Textile Conference AUTEX 2021, 5 - 9 September 2021, Guimarães, Portugal
T1  - Biodegradation of cotton fabric modified with polycarboxylic acids and CuO/Cu2O nanoparticles in soil and compost
EP  - 101
SP  - 100
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6865
ER  - 

@conference{
author = "Tomšič, Brigita and Marković, Darka and Simončić, Barbara and Janković, Vukašin and Ilić-Tomić, Tatjana and Nikodinović-Runić, Jasmina and Radetić, Maja",
year = "2021",
abstract = "Nano-finishing of textiles with Cu-based nanoparticles (NPs) is continually gaining scientific attention
due to their extraordinary antimicrobial activity and inexpensive precursor salts. After exploitation,
such textile goods commonly end-up on landfills becoming prone to biodegradation. The aim of this
study is to highlight the influence of in situ synthetized CuO/Cu2O NPs on biodegradation behavior of
cotton (CO) fabrics impregnated with 1,2,3,4-butanetetracarboxylic (BTCA) and succinic (SUC) acids in
soil and compost. Biodegradation of impregnated samples in soil was slower compared to control CO
fabric. The presence of CuO/Cu2O NPs negligibly affected biodegradation process in compost which
ran much faster than in soil.",
publisher = "Portugal : University of Minho",
journal = "Book of abstracts / Unfolding the future, 20th World Textile Conference AUTEX 2021, 5 - 9 September 2021, Guimarães, Portugal",
title = "Biodegradation of cotton fabric modified with polycarboxylic acids and CuO/Cu2O nanoparticles in soil and compost",
pages = "101-100",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6865"
}

Tomšič, B., Marković, D., Simončić, B., Janković, V., Ilić-Tomić, T., Nikodinović-Runić, J.,& Radetić, M.. (2021). Biodegradation of cotton fabric modified with polycarboxylic acids and CuO/Cu2O nanoparticles in soil and compost. in Book of abstracts / Unfolding the future, 20th World Textile Conference AUTEX 2021, 5 - 9 September 2021, Guimarães, Portugal
Portugal : University of Minho., 100-101.
https://hdl.handle.net/21.15107/rcub_technorep_6865

Tomšič B, Marković D, Simončić B, Janković V, Ilić-Tomić T, Nikodinović-Runić J, Radetić M. Biodegradation of cotton fabric modified with polycarboxylic acids and CuO/Cu2O nanoparticles in soil and compost. in Book of abstracts / Unfolding the future, 20th World Textile Conference AUTEX 2021, 5 - 9 September 2021, Guimarães, Portugal. 2021;:100-101.
https://hdl.handle.net/21.15107/rcub_technorep_6865 .

Tomšič, Brigita, Marković, Darka, Simončić, Barbara, Janković, Vukašin, Ilić-Tomić, Tatjana, Nikodinović-Runić, Jasmina, Radetić, Maja, "Biodegradation of cotton fabric modified with polycarboxylic acids and CuO/Cu2O nanoparticles in soil and compost" in Book of abstracts / Unfolding the future, 20th World Textile Conference AUTEX 2021, 5 - 9 September 2021, Guimarães, Portugal (2021):100-101,
https://hdl.handle.net/21.15107/rcub_technorep_6865 .