TY  - JOUR
AU  - Taboun, Abdulrraouf
AU  - Jovanović, Marija
AU  - Petrović, Miloš
AU  - Stajčić, Ivana
AU  - Pešić, Ivan
AU  - Stojanović, Dušica B.
AU  - Radojević, Vesna
PY  - 2024
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7455
AB  - The aim of this study is to investigate the influence of cross-linking and reinforcements in gelatin on the physico-mechanical properties of obtained composites. The gelatin-based composites cross-linked with citric acid (CA) were prepared: gelatin type B (GB) and β-tricalcium phosphate (β-TCP) and novel hybrid composite GB with β-TCP and hydroxyapatite (HAp) particles, and their structure, thermal, and mechanical properties were compared with pure gelatin B samples. FTIR analysis revealed that no chemical interaction between the reinforcements and gelatin matrix was established during the processing of hybrid composites by the solution casting method, proving the particles had no influence on GB cross-linking. The morphological investigation of hybrid composites revealed that cross-linking with CA improved the dispersion of particles, which further led to an increase in mechanical performance. The microindentation test showed that the hardness value was increased by up to 449%, which shows the high potential of β-TCP and HAp particle reinforcement combined with CA as a cross-linking agent. Furthermore, the reduced modulus of elasticity was increased by up to 288%. Results of the MTT assay on L929 cells have revealed that the hybrid composite GB-TCP-HA-CA was not cytotoxic. These results showed that GB cross-linked with CA and reinforced with different calcium phosphates presents a valuable novel material with potential applications in dentistry.
PB  - MDPI
T2  - Polymers
T1  - Citric Acid Cross-Linked Gelatin-Based Composites with Improved Microhardness
IS  - 8
SP  - 1077
VL  - 16
DO  - 10.3390/polym16081077
ER  - 

@article{
author = "Taboun, Abdulrraouf and Jovanović, Marija and Petrović, Miloš and Stajčić, Ivana and Pešić, Ivan and Stojanović, Dušica B. and Radojević, Vesna",
year = "2024",
abstract = "The aim of this study is to investigate the influence of cross-linking and reinforcements in gelatin on the physico-mechanical properties of obtained composites. The gelatin-based composites cross-linked with citric acid (CA) were prepared: gelatin type B (GB) and β-tricalcium phosphate (β-TCP) and novel hybrid composite GB with β-TCP and hydroxyapatite (HAp) particles, and their structure, thermal, and mechanical properties were compared with pure gelatin B samples. FTIR analysis revealed that no chemical interaction between the reinforcements and gelatin matrix was established during the processing of hybrid composites by the solution casting method, proving the particles had no influence on GB cross-linking. The morphological investigation of hybrid composites revealed that cross-linking with CA improved the dispersion of particles, which further led to an increase in mechanical performance. The microindentation test showed that the hardness value was increased by up to 449%, which shows the high potential of β-TCP and HAp particle reinforcement combined with CA as a cross-linking agent. Furthermore, the reduced modulus of elasticity was increased by up to 288%. Results of the MTT assay on L929 cells have revealed that the hybrid composite GB-TCP-HA-CA was not cytotoxic. These results showed that GB cross-linked with CA and reinforced with different calcium phosphates presents a valuable novel material with potential applications in dentistry.",
publisher = "MDPI",
journal = "Polymers",
title = "Citric Acid Cross-Linked Gelatin-Based Composites with Improved Microhardness",
number = "8",
pages = "1077",
volume = "16",
doi = "10.3390/polym16081077"
}

Taboun, A., Jovanović, M., Petrović, M., Stajčić, I., Pešić, I., Stojanović, D. B.,& Radojević, V.. (2024). Citric Acid Cross-Linked Gelatin-Based Composites with Improved Microhardness. in Polymers
MDPI., 16(8), 1077.
https://doi.org/10.3390/polym16081077

Taboun A, Jovanović M, Petrović M, Stajčić I, Pešić I, Stojanović DB, Radojević V. Citric Acid Cross-Linked Gelatin-Based Composites with Improved Microhardness. in Polymers. 2024;16(8):1077.
doi:10.3390/polym16081077 .

Taboun, Abdulrraouf, Jovanović, Marija, Petrović, Miloš, Stajčić, Ivana, Pešić, Ivan, Stojanović, Dušica B., Radojević, Vesna, "Citric Acid Cross-Linked Gelatin-Based Composites with Improved Microhardness" in Polymers, 16, no. 8 (2024):1077,
https://doi.org/10.3390/polym16081077 . .

TY  - CONF
AU  - Jovanović, Marija
AU  - Petrović, Miloš
AU  - Stojanović, Dušica
AU  - Radulović, Nataša
AU  - Pantelić, Danijel
AU  - Radojević, Vesna
AU  - Uskoković, Petar
PY  - 2024
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7441
AB  - The objective of this study was to processand evaluatea suitablescaffold matrix system for drug delivery and tissue regeneration. Abioinspired approachwas applied.Thescaffold based onnatural polymer gelatin,blended  with polyvinylpyrrolidone,and crosslinked  by  genipin,was  3D  printed  by semi-solid  extrusion(SSE).This  3D printing techniquedoes not require high temperature or UV curing, so it allows the use  ofthermo-and UV-sensitive drugs, cells, or other biological components.The influence of genipin, a natural crosslinking agent, and itscontent on the mechanical properties and the cytotoxicity of obtained scaffolds were investigated.
PB  - Savez hemijskih inženjera Srbije
C3  - Hemijska industrija - Supplementary Issue - ExcellMater Conference 2024 Abstracts
T1  - Evaluation of crosslinked gelatin-polyvinylpyrrolidone scaffold for application in drug delivery and tissue engineering
IS  - 1S
SP  - 25
VL  - 78
UR  - https://hdl.handle.net/21.15107/rcub_technorep_7441
ER  - 

@conference{
author = "Jovanović, Marija and Petrović, Miloš and Stojanović, Dušica and Radulović, Nataša and Pantelić, Danijel and Radojević, Vesna and Uskoković, Petar",
year = "2024",
abstract = "The objective of this study was to processand evaluatea suitablescaffold matrix system for drug delivery and tissue regeneration. Abioinspired approachwas applied.Thescaffold based onnatural polymer gelatin,blended  with polyvinylpyrrolidone,and crosslinked  by  genipin,was  3D  printed  by semi-solid  extrusion(SSE).This  3D printing techniquedoes not require high temperature or UV curing, so it allows the use  ofthermo-and UV-sensitive drugs, cells, or other biological components.The influence of genipin, a natural crosslinking agent, and itscontent on the mechanical properties and the cytotoxicity of obtained scaffolds were investigated.",
publisher = "Savez hemijskih inženjera Srbije",
journal = "Hemijska industrija - Supplementary Issue - ExcellMater Conference 2024 Abstracts",
title = "Evaluation of crosslinked gelatin-polyvinylpyrrolidone scaffold for application in drug delivery and tissue engineering",
number = "1S",
pages = "25",
volume = "78",
url = "https://hdl.handle.net/21.15107/rcub_technorep_7441"
}

Jovanović, M., Petrović, M., Stojanović, D., Radulović, N., Pantelić, D., Radojević, V.,& Uskoković, P.. (2024). Evaluation of crosslinked gelatin-polyvinylpyrrolidone scaffold for application in drug delivery and tissue engineering. in Hemijska industrija - Supplementary Issue - ExcellMater Conference 2024 Abstracts
Savez hemijskih inženjera Srbije., 78(1S), 25.
https://hdl.handle.net/21.15107/rcub_technorep_7441

Jovanović M, Petrović M, Stojanović D, Radulović N, Pantelić D, Radojević V, Uskoković P. Evaluation of crosslinked gelatin-polyvinylpyrrolidone scaffold for application in drug delivery and tissue engineering. in Hemijska industrija - Supplementary Issue - ExcellMater Conference 2024 Abstracts. 2024;78(1S):25.
https://hdl.handle.net/21.15107/rcub_technorep_7441 .

Jovanović, Marija, Petrović, Miloš, Stojanović, Dušica, Radulović, Nataša, Pantelić, Danijel, Radojević, Vesna, Uskoković, Petar, "Evaluation of crosslinked gelatin-polyvinylpyrrolidone scaffold for application in drug delivery and tissue engineering" in Hemijska industrija - Supplementary Issue - ExcellMater Conference 2024 Abstracts, 78, no. 1S (2024):25,
https://hdl.handle.net/21.15107/rcub_technorep_7441 .

TY  - JOUR
AU  - Elhmali, Houda Taher
AU  - Stajčić, Ivana
AU  - Stajčić, Aleksandar
AU  - Pešić, Ivan
AU  - Jovanović, Marija
AU  - Petrović, Miloš
AU  - Radojević, Vesna
PY  - 2024
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7157
AB  - While dental poly methyl methacrylate(PMMA) possesses distinctive qualities such as ease of fabrication, cost-effectiveness, and favorable physical and mechanical properties, these attributes alone are inadequate to impart the necessary impact strength and hardness. Consequently, pure PMMA is less suitable for dental applications. This research focused on the incorporation of Strontium titanate (SrTiO3-STO) and hybrid filler STO/Manganese oxide (MnO2) to improve impact resistance and hardness. The potential of STO in reinforcing PMMA is poorly investigated, while hybrid filler STO/MnO2 has not been presented yet. Differential scanning calorimetry is conducted in order to investigate the agglomeration influence on the PMMA glass transition temperature (Tg), as well as the leaching of residual monomer and volatile additives that could pose a threat to human health. It has been determined that agglomeration with 1 wt% loading had no influence on Tg, while the first scan revealed differences in evaporation of small molecules, in favor of composite PMMA-STO/MnO2, which showed the trapping potential of volatiles. Investigations of mechanical properties have revealed the significant influence of hybrid STO/MnO2 filler on microhardness and total absorbed impact energy, which were increased by 89.9% and 145.4%, respectively. Results presented in this study revealed the reinforcing potential of hybrid nanoparticles that could find application in other polymers as well.
PB  - MDPI
T2  - Polymers
T1  - Influence of Novel SrTiO3/MnO2 Hybrid Nanoparticles on Poly(methyl methacrylate) Thermal and Mechanical Behavior
IS  - 2
SP  - 278
VL  - 16
DO  - 10.3390/polym16020278
ER  - 

@article{
author = "Elhmali, Houda Taher and Stajčić, Ivana and Stajčić, Aleksandar and Pešić, Ivan and Jovanović, Marija and Petrović, Miloš and Radojević, Vesna",
year = "2024",
abstract = "While dental poly methyl methacrylate(PMMA) possesses distinctive qualities such as ease of fabrication, cost-effectiveness, and favorable physical and mechanical properties, these attributes alone are inadequate to impart the necessary impact strength and hardness. Consequently, pure PMMA is less suitable for dental applications. This research focused on the incorporation of Strontium titanate (SrTiO3-STO) and hybrid filler STO/Manganese oxide (MnO2) to improve impact resistance and hardness. The potential of STO in reinforcing PMMA is poorly investigated, while hybrid filler STO/MnO2 has not been presented yet. Differential scanning calorimetry is conducted in order to investigate the agglomeration influence on the PMMA glass transition temperature (Tg), as well as the leaching of residual monomer and volatile additives that could pose a threat to human health. It has been determined that agglomeration with 1 wt% loading had no influence on Tg, while the first scan revealed differences in evaporation of small molecules, in favor of composite PMMA-STO/MnO2, which showed the trapping potential of volatiles. Investigations of mechanical properties have revealed the significant influence of hybrid STO/MnO2 filler on microhardness and total absorbed impact energy, which were increased by 89.9% and 145.4%, respectively. Results presented in this study revealed the reinforcing potential of hybrid nanoparticles that could find application in other polymers as well.",
publisher = "MDPI",
journal = "Polymers",
title = "Influence of Novel SrTiO3/MnO2 Hybrid Nanoparticles on Poly(methyl methacrylate) Thermal and Mechanical Behavior",
number = "2",
pages = "278",
volume = "16",
doi = "10.3390/polym16020278"
}

Elhmali, H. T., Stajčić, I., Stajčić, A., Pešić, I., Jovanović, M., Petrović, M.,& Radojević, V.. (2024). Influence of Novel SrTiO3/MnO2 Hybrid Nanoparticles on Poly(methyl methacrylate) Thermal and Mechanical Behavior. in Polymers
MDPI., 16(2), 278.
https://doi.org/10.3390/polym16020278

Elhmali HT, Stajčić I, Stajčić A, Pešić I, Jovanović M, Petrović M, Radojević V. Influence of Novel SrTiO3/MnO2 Hybrid Nanoparticles on Poly(methyl methacrylate) Thermal and Mechanical Behavior. in Polymers. 2024;16(2):278.
doi:10.3390/polym16020278 .

Elhmali, Houda Taher, Stajčić, Ivana, Stajčić, Aleksandar, Pešić, Ivan, Jovanović, Marija, Petrović, Miloš, Radojević, Vesna, "Influence of Novel SrTiO3/MnO2 Hybrid Nanoparticles on Poly(methyl methacrylate) Thermal and Mechanical Behavior" in Polymers, 16, no. 2 (2024):278,
https://doi.org/10.3390/polym16020278 . .

TY  - JOUR
AU  - Jovanović, Marija
AU  - Petrović, Miloš
AU  - Stojanović, Dušica
AU  - Ibrić, Svetlana
AU  - Uskoković, Petar
PY  - 2022
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5961
AB  - In this work, a blend of gelatin A (GA) and polyvinylpyrrolidone (PVP K30) was used for semi-solid 3D printing of bone scaffold for ibuprofen (IBU) delivery. The cross-linking of the obtained scaffold was performed with a 1% glutaraldehyde (GTA) solution, followed by lyophilization. The thermal and mechanical properties, as well as drug release profiles, and drug kinetics of prepared scaffolds were investigated. The cross-linked and lyophilized scaffold has shown good thermal stability, mechanical properties, and prolonged release of IBU following the Fickian diffusion process.
PB  - Savez farmaceutskih udruženja Srbije
T2  - Arhiv za Farmaciju
T1  - Preparation and characterization of 3D printed bone scaffold for ibuprofen delivery
T1  - 3D štampa i karakterizacija nosača za dostavu ibuprofena u koštanom tkivu
EP  - 673
IS  - 6
SP  - 661
VL  - 72
DO  - 10.5937/ARHFARM72-40262
ER  - 

@article{
author = "Jovanović, Marija and Petrović, Miloš and Stojanović, Dušica and Ibrić, Svetlana and Uskoković, Petar",
year = "2022",
abstract = "In this work, a blend of gelatin A (GA) and polyvinylpyrrolidone (PVP K30) was used for semi-solid 3D printing of bone scaffold for ibuprofen (IBU) delivery. The cross-linking of the obtained scaffold was performed with a 1% glutaraldehyde (GTA) solution, followed by lyophilization. The thermal and mechanical properties, as well as drug release profiles, and drug kinetics of prepared scaffolds were investigated. The cross-linked and lyophilized scaffold has shown good thermal stability, mechanical properties, and prolonged release of IBU following the Fickian diffusion process.",
publisher = "Savez farmaceutskih udruženja Srbije",
journal = "Arhiv za Farmaciju",
title = "Preparation and characterization of 3D printed bone scaffold for ibuprofen delivery, 3D štampa i karakterizacija nosača za dostavu ibuprofena u koštanom tkivu",
pages = "673-661",
number = "6",
volume = "72",
doi = "10.5937/ARHFARM72-40262"
}

Jovanović, M., Petrović, M., Stojanović, D., Ibrić, S.,& Uskoković, P.. (2022). Preparation and characterization of 3D printed bone scaffold for ibuprofen delivery. in Arhiv za Farmaciju
Savez farmaceutskih udruženja Srbije., 72(6), 661-673.
https://doi.org/10.5937/ARHFARM72-40262

Jovanović M, Petrović M, Stojanović D, Ibrić S, Uskoković P. Preparation and characterization of 3D printed bone scaffold for ibuprofen delivery. in Arhiv za Farmaciju. 2022;72(6):661-673.
doi:10.5937/ARHFARM72-40262 .

Jovanović, Marija, Petrović, Miloš, Stojanović, Dušica, Ibrić, Svetlana, Uskoković, Petar, "Preparation and characterization of 3D printed bone scaffold for ibuprofen delivery" in Arhiv za Farmaciju, 72, no. 6 (2022):661-673,
https://doi.org/10.5937/ARHFARM72-40262 . .

TY  - CONF
AU  - Jovanović, Marija N.
AU  - Radisavljević, Anđela N.
AU  - Petrović, Miloš M.
AU  - Stojanović, Dušica B.
AU  - Ibrić, Svetlana R.
AU  - Uskoković, Petar S.
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6078
AB  - The oral mucoadhesive film is a novel and attractive formulation for local and/or systemic drug
delivery through the mucosal membrane of the oral cavity. Certain active pharmaceutical ingredients (API) in conventional formulations (tablets, capsules, syrups) are absorbed in the gastrointestinal tract and undergo first-pass metabolism through the liver, thereby reducing their bioavailability. This problem can be overcome by using intraoral formulations, such as mucoadhesive buccal films that disintegrate and dissolve in the oral cavity where the absorption of API occurs. In this work, the mucoadhesive films were prepared by 3D paste printing and the influence of processing parameters on film properties and the release rate of a drug was investigated. Gelatin (GA) and the blend of gelatin/polyvinylpyrrolidone (GA/PVP) were used because of their biocompatibility. Propranolol hydrochloride (PRH) was used as a model substance because it has high first-pass metabolism and is soluble in water. Film morphology and drug distribution were followed by SEM analysis. Dissolution test in simulated saliva was done to see how PRH was released from films. Mucoadhesion test revealed that the GA/PVP films with PRH have the highest adhesion force. Obtained results introduce GA/PVP as a promising material with good adhesion and rate of drug release.
PB  - Belgrade : Materials Research Society of Serbia
C3  - Twenty-second Annual Conference YUCOMAT 2021, Herceg Novi, Montenegro
T1  - 3D printed mucoadhesive gelatin based buccal films
SP  - 122
UR  - https://hdl.handle.net/21.15107/rcub_technorep_6078
ER  - 

@conference{
author = "Jovanović, Marija N. and Radisavljević, Anđela N. and Petrović, Miloš M. and Stojanović, Dušica B. and Ibrić, Svetlana R. and Uskoković, Petar S.",
year = "2021",
abstract = "The oral mucoadhesive film is a novel and attractive formulation for local and/or systemic drug
delivery through the mucosal membrane of the oral cavity. Certain active pharmaceutical ingredients (API) in conventional formulations (tablets, capsules, syrups) are absorbed in the gastrointestinal tract and undergo first-pass metabolism through the liver, thereby reducing their bioavailability. This problem can be overcome by using intraoral formulations, such as mucoadhesive buccal films that disintegrate and dissolve in the oral cavity where the absorption of API occurs. In this work, the mucoadhesive films were prepared by 3D paste printing and the influence of processing parameters on film properties and the release rate of a drug was investigated. Gelatin (GA) and the blend of gelatin/polyvinylpyrrolidone (GA/PVP) were used because of their biocompatibility. Propranolol hydrochloride (PRH) was used as a model substance because it has high first-pass metabolism and is soluble in water. Film morphology and drug distribution were followed by SEM analysis. Dissolution test in simulated saliva was done to see how PRH was released from films. Mucoadhesion test revealed that the GA/PVP films with PRH have the highest adhesion force. Obtained results introduce GA/PVP as a promising material with good adhesion and rate of drug release.",
publisher = "Belgrade : Materials Research Society of Serbia",
journal = "Twenty-second Annual Conference YUCOMAT 2021, Herceg Novi, Montenegro",
title = "3D printed mucoadhesive gelatin based buccal films",
pages = "122",
url = "https://hdl.handle.net/21.15107/rcub_technorep_6078"
}

Jovanović, M. N., Radisavljević, A. N., Petrović, M. M., Stojanović, D. B., Ibrić, S. R.,& Uskoković, P. S.. (2021). 3D printed mucoadhesive gelatin based buccal films. in Twenty-second Annual Conference YUCOMAT 2021, Herceg Novi, Montenegro
Belgrade : Materials Research Society of Serbia., 122.
https://hdl.handle.net/21.15107/rcub_technorep_6078

Jovanović MN, Radisavljević AN, Petrović MM, Stojanović DB, Ibrić SR, Uskoković PS. 3D printed mucoadhesive gelatin based buccal films. in Twenty-second Annual Conference YUCOMAT 2021, Herceg Novi, Montenegro. 2021;:122.
https://hdl.handle.net/21.15107/rcub_technorep_6078 .

Jovanović, Marija N., Radisavljević, Anđela N., Petrović, Miloš M., Stojanović, Dušica B., Ibrić, Svetlana R., Uskoković, Petar S., "3D printed mucoadhesive gelatin based buccal films" in Twenty-second Annual Conference YUCOMAT 2021, Herceg Novi, Montenegro (2021):122,
https://hdl.handle.net/21.15107/rcub_technorep_6078 .

TY  - JOUR
AU  - Jovanović, Marija
AU  - Petrović, Miloš
AU  - Cvijic, Sandra
AU  - Tomić, Nataša
AU  - Stojanović, Dušica
AU  - Ibric, Svetlana
AU  - Uskoković, Petar
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4778
AB  - Gelatin-polyvinylpyrrolidone (PVP) and gelatin-poly(vinyl alcohol) (PVA) mucoadhesive buccal films loaded with propranolol hydrochloride (PRH) were prepared by semi-solid extrusion 3D printing. The aim of this study was to evaluate the effects of the synthetic polymers PVP and PVA on thermal and mechanical properties and drug release profiles of gelatin-based films. The Fourier-transform infrared spectroscopy showed that hydrogen bonding between gelatin and PVP formed during printing. In the other blend, neither the esterification of PVA nor gelatin occurred. Differential scanning calorimetry revealed the presence of partial helical structures. In line with these results, the mechanical properties and drug release profiles were different for each blend. Formulation with gelatin-PVP and PRH showed higher tensile strength, hardness, and adhesive strength but slower drug release than formulation with gelatin-PVA and PRH. The in silico population simulations indicated increased drug bioavailability and decreased inter-individual variations in the resulting pharmacokinetic profiles compared to immediate-release tablets. Moreover, the simulation results suggested that reduced PRH daily dosing can be achieved with prolonged-release buccal films, which improves patient compliance.
T2  - Pharmaceutics
T1  - 3D Printed Buccal Films for Prolonged-Release of Propranolol Hydrochloride: Development, Characterization and Bioavailability Prediction
IS  - 12
VL  - 13
DO  - 10.3390/pharmaceutics13122143
ER  - 

@article{
author = "Jovanović, Marija and Petrović, Miloš and Cvijic, Sandra and Tomić, Nataša and Stojanović, Dušica and Ibric, Svetlana and Uskoković, Petar",
year = "2021",
abstract = "Gelatin-polyvinylpyrrolidone (PVP) and gelatin-poly(vinyl alcohol) (PVA) mucoadhesive buccal films loaded with propranolol hydrochloride (PRH) were prepared by semi-solid extrusion 3D printing. The aim of this study was to evaluate the effects of the synthetic polymers PVP and PVA on thermal and mechanical properties and drug release profiles of gelatin-based films. The Fourier-transform infrared spectroscopy showed that hydrogen bonding between gelatin and PVP formed during printing. In the other blend, neither the esterification of PVA nor gelatin occurred. Differential scanning calorimetry revealed the presence of partial helical structures. In line with these results, the mechanical properties and drug release profiles were different for each blend. Formulation with gelatin-PVP and PRH showed higher tensile strength, hardness, and adhesive strength but slower drug release than formulation with gelatin-PVA and PRH. The in silico population simulations indicated increased drug bioavailability and decreased inter-individual variations in the resulting pharmacokinetic profiles compared to immediate-release tablets. Moreover, the simulation results suggested that reduced PRH daily dosing can be achieved with prolonged-release buccal films, which improves patient compliance.",
journal = "Pharmaceutics",
title = "3D Printed Buccal Films for Prolonged-Release of Propranolol Hydrochloride: Development, Characterization and Bioavailability Prediction",
number = "12",
volume = "13",
doi = "10.3390/pharmaceutics13122143"
}

Jovanović, M., Petrović, M., Cvijic, S., Tomić, N., Stojanović, D., Ibric, S.,& Uskoković, P.. (2021). 3D Printed Buccal Films for Prolonged-Release of Propranolol Hydrochloride: Development, Characterization and Bioavailability Prediction. in Pharmaceutics, 13(12).
https://doi.org/10.3390/pharmaceutics13122143

Jovanović M, Petrović M, Cvijic S, Tomić N, Stojanović D, Ibric S, Uskoković P. 3D Printed Buccal Films for Prolonged-Release of Propranolol Hydrochloride: Development, Characterization and Bioavailability Prediction. in Pharmaceutics. 2021;13(12).
doi:10.3390/pharmaceutics13122143 .

Jovanović, Marija, Petrović, Miloš, Cvijic, Sandra, Tomić, Nataša, Stojanović, Dušica, Ibric, Svetlana, Uskoković, Petar, "3D Printed Buccal Films for Prolonged-Release of Propranolol Hydrochloride: Development, Characterization and Bioavailability Prediction" in Pharmaceutics, 13, no. 12 (2021),
https://doi.org/10.3390/pharmaceutics13122143 . .

TY  - JOUR
AU  - Jovanović, Marija
AU  - Tomić, Nataša
AU  - Cvijic, Sandra
AU  - Stojanović, Dušica
AU  - Ibric, Svetlana
AU  - Uskoković, Petar
PY  - 2021
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4909
AB  - This study processes and characterizes propranolol hydrochloride/gelatin mucoadhesive buccal films. Two types of gelatin are used: Gelatin from porcine skin, type A (GA), and gelatin from bovine skin (GB). The influence of gelatin type on mechanical, mucoadhesive, and biopharmaceutical characteristics of buccal films is evaluated. Fourier-Transfer infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) analysis show that GA with propranolol hydrochloride (PRH) in the film (GAP) formed a physical mixture, whereas GB with PRH (GBP) form a compound-complex. Results of mechanical testing (tensile test, hardness) revealed that GAP films exhibit higher elastic modulus, tensile strength, and hardness. A mucoahesion test shows that GBP has higher adhesion strength, while GAP shows higher work of adhesion. Both in vitro release study and in silico simulation indicated that processed films can provide effective drug transport through the buccal mucosa. In silico simulation shows improved bioavailability from buccal films, in comparison to the immediate-release tablets-indicating that the therapeutic drug dose can be markedly reduced.
T2  - Pharmaceutics
T1  - Mucoadhesive Gelatin Buccal Films with Propranolol Hydrochloride: Evaluation of Mechanical, Mucoadhesive, and Biopharmaceutical Properties
IS  - 2
VL  - 13
DO  - 10.3390/pharmaceutics13020273
ER  - 

@article{
author = "Jovanović, Marija and Tomić, Nataša and Cvijic, Sandra and Stojanović, Dušica and Ibric, Svetlana and Uskoković, Petar",
year = "2021",
abstract = "This study processes and characterizes propranolol hydrochloride/gelatin mucoadhesive buccal films. Two types of gelatin are used: Gelatin from porcine skin, type A (GA), and gelatin from bovine skin (GB). The influence of gelatin type on mechanical, mucoadhesive, and biopharmaceutical characteristics of buccal films is evaluated. Fourier-Transfer infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) analysis show that GA with propranolol hydrochloride (PRH) in the film (GAP) formed a physical mixture, whereas GB with PRH (GBP) form a compound-complex. Results of mechanical testing (tensile test, hardness) revealed that GAP films exhibit higher elastic modulus, tensile strength, and hardness. A mucoahesion test shows that GBP has higher adhesion strength, while GAP shows higher work of adhesion. Both in vitro release study and in silico simulation indicated that processed films can provide effective drug transport through the buccal mucosa. In silico simulation shows improved bioavailability from buccal films, in comparison to the immediate-release tablets-indicating that the therapeutic drug dose can be markedly reduced.",
journal = "Pharmaceutics",
title = "Mucoadhesive Gelatin Buccal Films with Propranolol Hydrochloride: Evaluation of Mechanical, Mucoadhesive, and Biopharmaceutical Properties",
number = "2",
volume = "13",
doi = "10.3390/pharmaceutics13020273"
}

Jovanović, M., Tomić, N., Cvijic, S., Stojanović, D., Ibric, S.,& Uskoković, P.. (2021). Mucoadhesive Gelatin Buccal Films with Propranolol Hydrochloride: Evaluation of Mechanical, Mucoadhesive, and Biopharmaceutical Properties. in Pharmaceutics, 13(2).
https://doi.org/10.3390/pharmaceutics13020273

Jovanović M, Tomić N, Cvijic S, Stojanović D, Ibric S, Uskoković P. Mucoadhesive Gelatin Buccal Films with Propranolol Hydrochloride: Evaluation of Mechanical, Mucoadhesive, and Biopharmaceutical Properties. in Pharmaceutics. 2021;13(2).
doi:10.3390/pharmaceutics13020273 .

Jovanović, Marija, Tomić, Nataša, Cvijic, Sandra, Stojanović, Dušica, Ibric, Svetlana, Uskoković, Petar, "Mucoadhesive Gelatin Buccal Films with Propranolol Hydrochloride: Evaluation of Mechanical, Mucoadhesive, and Biopharmaceutical Properties" in Pharmaceutics, 13, no. 2 (2021),
https://doi.org/10.3390/pharmaceutics13020273 . .

TY  - JOUR
AU  - Krstić, Marko
AU  - Radojević, Marija
AU  - Stojanović, Dušica
AU  - Radojević, Vesna
AU  - Uskoković, Petar
AU  - Ibrić, Svetlana
PY  - 2017
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3749
AB  - The preparation and characterization of films and nanofibers with carvedilol as a poorly water-soluble drug in poly (ethylene oxide) (PEO) polymer were investigated. Films are prepared by solution casting method, and nanofibers by electrospinning from a polymer solution. Water and mixture of ethanol and water were used as solvents. FT-IR analysis of the samples showed that there was no interaction between the polymer and the drug substance. DSC analysis revealed that carvedilol was dissolved in the polymer and influenced the degree of crystallinity of PEO. Carvedilol release rate for all of the formulations was increased in comparison with pure carvedilol. Significant differences in the rate of release of carvedilol from the films and nanofibers were observed. Field Emission Scanning Electron Microscope (FESEM) images of the obtained fiber was revealed the dependence of the fiber diameter of formulation and electrospinning process parameters, and consequently influence the amount and distribution of carvedilol in the encapsulated fibers.
PB  - Elsevier Science Bv, Amsterdam
T2  - European Journal of Pharmaceutical Sciences
T1  - Formulation and characterization of nanofibers and films with carvedilol prepared by electrospinning and solution casting method
EP  - 166
SP  - 160
VL  - 101
DO  - 10.1016/j.ejps.2017.02.006
ER  - 

@article{
author = "Krstić, Marko and Radojević, Marija and Stojanović, Dušica and Radojević, Vesna and Uskoković, Petar and Ibrić, Svetlana",
year = "2017",
abstract = "The preparation and characterization of films and nanofibers with carvedilol as a poorly water-soluble drug in poly (ethylene oxide) (PEO) polymer were investigated. Films are prepared by solution casting method, and nanofibers by electrospinning from a polymer solution. Water and mixture of ethanol and water were used as solvents. FT-IR analysis of the samples showed that there was no interaction between the polymer and the drug substance. DSC analysis revealed that carvedilol was dissolved in the polymer and influenced the degree of crystallinity of PEO. Carvedilol release rate for all of the formulations was increased in comparison with pure carvedilol. Significant differences in the rate of release of carvedilol from the films and nanofibers were observed. Field Emission Scanning Electron Microscope (FESEM) images of the obtained fiber was revealed the dependence of the fiber diameter of formulation and electrospinning process parameters, and consequently influence the amount and distribution of carvedilol in the encapsulated fibers.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "European Journal of Pharmaceutical Sciences",
title = "Formulation and characterization of nanofibers and films with carvedilol prepared by electrospinning and solution casting method",
pages = "166-160",
volume = "101",
doi = "10.1016/j.ejps.2017.02.006"
}

Krstić, M., Radojević, M., Stojanović, D., Radojević, V., Uskoković, P.,& Ibrić, S.. (2017). Formulation and characterization of nanofibers and films with carvedilol prepared by electrospinning and solution casting method. in European Journal of Pharmaceutical Sciences
Elsevier Science Bv, Amsterdam., 101, 160-166.
https://doi.org/10.1016/j.ejps.2017.02.006

Krstić M, Radojević M, Stojanović D, Radojević V, Uskoković P, Ibrić S. Formulation and characterization of nanofibers and films with carvedilol prepared by electrospinning and solution casting method. in European Journal of Pharmaceutical Sciences. 2017;101:160-166.
doi:10.1016/j.ejps.2017.02.006 .

Krstić, Marko, Radojević, Marija, Stojanović, Dušica, Radojević, Vesna, Uskoković, Petar, Ibrić, Svetlana, "Formulation and characterization of nanofibers and films with carvedilol prepared by electrospinning and solution casting method" in European Journal of Pharmaceutical Sciences, 101 (2017):160-166,
https://doi.org/10.1016/j.ejps.2017.02.006 . .