TY  - JOUR
AU  - Stefanović, Ivan
AU  - Gođevac, Dejan
AU  - Spirkova, Milena
AU  - Jovancic, Petar
AU  - Tešević, Vele
AU  - Milačić, Vesna
AU  - Pergal, Marija
PY  - 2016
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5830
AB  - Segmented thermoplastic polyurethane copolymers (PURs) were synthesized using 4,4'-methylenediphenyl diisocyanate and 1,4-butanediol as the hard segment and alpha,omega-dihydroxy-poly(propylene oxide)-b-poly(dimethylsiloxane)-b-poly(propylene oxide) (PPO-PDMS) as the soft segment. The content of incorporated soft segments in PURs varied in the range from 40 to 90 wt.%. The structure, molecular weights and crystallinity of obtained copolymers were monitored by FTIR, H-1- and 2D-NMR spectroscopy, and GPC and DSC analysis, respectively. Surface free energy analysis indicates the presence of hydrophobic (siloxane) groups on the surface, giving highly hydrophobic nature to the obtained PURs films. Water absorption measurements showed that the increase of the hydrophobic PPO-PDMS segment content led to the decrease of percentage of absorbed water in copolymers. SEM and AFM analysis revealed that copolymers with lower content of PPO-PDMS segments have higher microphase separation between segments. The results obtained in this work indicate that synthesized PURs based on PPO-PDMS demonstrated proper surface and morphological properties with a great potential for variety of applications such as hydrophobic coatings in biomedicine.
PB  - Assoc Chemical Engineers Serbia, Belgrade
T2  - Hemijska industrija
T1  - Impact of the poly(propylene oxide)-b-poly(dimethylsiloxane)-b-poly-(propylene oxide) macrodiols on the surface-related properties of polyurethane copolymers
EP  - 738
IS  - 6
SP  - 725
VL  - 70
DO  - 10.2298/HEMIND151127009S
ER  - 

@article{
author = "Stefanović, Ivan and Gođevac, Dejan and Spirkova, Milena and Jovancic, Petar and Tešević, Vele and Milačić, Vesna and Pergal, Marija",
year = "2016",
abstract = "Segmented thermoplastic polyurethane copolymers (PURs) were synthesized using 4,4'-methylenediphenyl diisocyanate and 1,4-butanediol as the hard segment and alpha,omega-dihydroxy-poly(propylene oxide)-b-poly(dimethylsiloxane)-b-poly(propylene oxide) (PPO-PDMS) as the soft segment. The content of incorporated soft segments in PURs varied in the range from 40 to 90 wt.%. The structure, molecular weights and crystallinity of obtained copolymers were monitored by FTIR, H-1- and 2D-NMR spectroscopy, and GPC and DSC analysis, respectively. Surface free energy analysis indicates the presence of hydrophobic (siloxane) groups on the surface, giving highly hydrophobic nature to the obtained PURs films. Water absorption measurements showed that the increase of the hydrophobic PPO-PDMS segment content led to the decrease of percentage of absorbed water in copolymers. SEM and AFM analysis revealed that copolymers with lower content of PPO-PDMS segments have higher microphase separation between segments. The results obtained in this work indicate that synthesized PURs based on PPO-PDMS demonstrated proper surface and morphological properties with a great potential for variety of applications such as hydrophobic coatings in biomedicine.",
publisher = "Assoc Chemical Engineers Serbia, Belgrade",
journal = "Hemijska industrija",
title = "Impact of the poly(propylene oxide)-b-poly(dimethylsiloxane)-b-poly-(propylene oxide) macrodiols on the surface-related properties of polyurethane copolymers",
pages = "738-725",
number = "6",
volume = "70",
doi = "10.2298/HEMIND151127009S"
}

Stefanović, I., Gođevac, D., Spirkova, M., Jovancic, P., Tešević, V., Milačić, V.,& Pergal, M.. (2016). Impact of the poly(propylene oxide)-b-poly(dimethylsiloxane)-b-poly-(propylene oxide) macrodiols on the surface-related properties of polyurethane copolymers. in Hemijska industrija
Assoc Chemical Engineers Serbia, Belgrade., 70(6), 725-738.
https://doi.org/10.2298/HEMIND151127009S

Stefanović I, Gođevac D, Spirkova M, Jovancic P, Tešević V, Milačić V, Pergal M. Impact of the poly(propylene oxide)-b-poly(dimethylsiloxane)-b-poly-(propylene oxide) macrodiols on the surface-related properties of polyurethane copolymers. in Hemijska industrija. 2016;70(6):725-738.
doi:10.2298/HEMIND151127009S .

Stefanović, Ivan, Gođevac, Dejan, Spirkova, Milena, Jovancic, Petar, Tešević, Vele, Milačić, Vesna, Pergal, Marija, "Impact of the poly(propylene oxide)-b-poly(dimethylsiloxane)-b-poly-(propylene oxide) macrodiols on the surface-related properties of polyurethane copolymers" in Hemijska industrija, 70, no. 6 (2016):725-738,
https://doi.org/10.2298/HEMIND151127009S . .

TY  - JOUR
AU  - Pergal, Marija
AU  - Nestorov, Jelena
AU  - Tovilović, Gordana
AU  - Ostojić, Sanja
AU  - Gođevac, Dejan
AU  - Vasiljević-Radović, Dana
AU  - Đonlagić, Jasna
PY  - 2014
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/5788
AB  - Properties and biocompatibility of a series of thermoplastic poly(urethane-siloxane)s (TPUSs) based on alpha,omega-dihydroxy ethoxy propyl poly(dimethylsiloxane) (PDMS) for potential biomedical application were studied. Thin films of TPUSs with a different PDMS soft segment content were characterized by H-1 NMR, quantitative C-13 NMR, Fourier transform infrared spectroscopy (FTIR), atomic force microscopy (AFM), differential scanning calorimetry (DSC), dynamic mechanical analysis (DMA), contact angle, and water absorption measurements. Different techniques (FTIR, AFM, and DMA) showed that decrease of PDMS content promotes microphase separation in TPUSs. Samples with a higher PDMS content have more hydrophobic surface and better waterproof performances, but lower degree of crystallinity. Biocompatibility of TPUSs was examined after attachment of endothelial cells to the untreated copolymer surface or surface pretreated with multicomponent protein mixture, and by using competitive protein adsorption assay. TPUSs did not exhibit any cytotoxicity toward endothelial cells, as measured by lactate dehydrogenase and 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide assays. The untreated and proteins preadsorbed TPUS samples favored endothelial cells adhesion and growth, indicating good biocompatibility. All TPUSs adsorbed more albumin than fibrinogen in competitive protein adsorption experiment, which is feature regarded as beneficial for biocompatibility. The results indicate that TPUSs have good surface, thermo-mechanical, and biocompatible properties, which can be tailored for biomedical application requirements by adequate selection of the soft/hard segments ratio of the copolymers.
PB  - Wiley-Blackwell, Hoboken
T2  - Journal of Biomedical Materials Research Part A
T1  - Structure and properties of thermoplastic polyurethanes based on poly(dimethylsiloxane): Assessment of biocompatibility
EP  - 3964
IS  - 11
SP  - 3951
VL  - 102
DO  - 10.1002/jbm.a.35071
ER  - 

@article{
author = "Pergal, Marija and Nestorov, Jelena and Tovilović, Gordana and Ostojić, Sanja and Gođevac, Dejan and Vasiljević-Radović, Dana and Đonlagić, Jasna",
year = "2014",
abstract = "Properties and biocompatibility of a series of thermoplastic poly(urethane-siloxane)s (TPUSs) based on alpha,omega-dihydroxy ethoxy propyl poly(dimethylsiloxane) (PDMS) for potential biomedical application were studied. Thin films of TPUSs with a different PDMS soft segment content were characterized by H-1 NMR, quantitative C-13 NMR, Fourier transform infrared spectroscopy (FTIR), atomic force microscopy (AFM), differential scanning calorimetry (DSC), dynamic mechanical analysis (DMA), contact angle, and water absorption measurements. Different techniques (FTIR, AFM, and DMA) showed that decrease of PDMS content promotes microphase separation in TPUSs. Samples with a higher PDMS content have more hydrophobic surface and better waterproof performances, but lower degree of crystallinity. Biocompatibility of TPUSs was examined after attachment of endothelial cells to the untreated copolymer surface or surface pretreated with multicomponent protein mixture, and by using competitive protein adsorption assay. TPUSs did not exhibit any cytotoxicity toward endothelial cells, as measured by lactate dehydrogenase and 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide assays. The untreated and proteins preadsorbed TPUS samples favored endothelial cells adhesion and growth, indicating good biocompatibility. All TPUSs adsorbed more albumin than fibrinogen in competitive protein adsorption experiment, which is feature regarded as beneficial for biocompatibility. The results indicate that TPUSs have good surface, thermo-mechanical, and biocompatible properties, which can be tailored for biomedical application requirements by adequate selection of the soft/hard segments ratio of the copolymers.",
publisher = "Wiley-Blackwell, Hoboken",
journal = "Journal of Biomedical Materials Research Part A",
title = "Structure and properties of thermoplastic polyurethanes based on poly(dimethylsiloxane): Assessment of biocompatibility",
pages = "3964-3951",
number = "11",
volume = "102",
doi = "10.1002/jbm.a.35071"
}

Pergal, M., Nestorov, J., Tovilović, G., Ostojić, S., Gođevac, D., Vasiljević-Radović, D.,& Đonlagić, J.. (2014). Structure and properties of thermoplastic polyurethanes based on poly(dimethylsiloxane): Assessment of biocompatibility. in Journal of Biomedical Materials Research Part A
Wiley-Blackwell, Hoboken., 102(11), 3951-3964.
https://doi.org/10.1002/jbm.a.35071

Pergal M, Nestorov J, Tovilović G, Ostojić S, Gođevac D, Vasiljević-Radović D, Đonlagić J. Structure and properties of thermoplastic polyurethanes based on poly(dimethylsiloxane): Assessment of biocompatibility. in Journal of Biomedical Materials Research Part A. 2014;102(11):3951-3964.
doi:10.1002/jbm.a.35071 .

Pergal, Marija, Nestorov, Jelena, Tovilović, Gordana, Ostojić, Sanja, Gođevac, Dejan, Vasiljević-Radović, Dana, Đonlagić, Jasna, "Structure and properties of thermoplastic polyurethanes based on poly(dimethylsiloxane): Assessment of biocompatibility" in Journal of Biomedical Materials Research Part A, 102, no. 11 (2014):3951-3964,
https://doi.org/10.1002/jbm.a.35071 . .