TY  - JOUR
AU  - Lalović, Bojana
AU  - Đurkić, Tatjana
AU  - Vukčević, Marija
AU  - Janković-Častvan, Ivona
AU  - Kalijadis, Ana
AU  - Laušević, Zoran
AU  - Laušević, Mila
PY  - 2017
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3577
AB  - In this paper, pristine and chemically treated multi-walled carbon nanotubes (MWCNTs) were employed as solid-phase extraction sorbents for the isolation and enrichment of multi-class pharmaceuticals from the surface water and groundwater, prior to liquid chromatography-tandem mass spectrometry analysis. Thirteen pharmaceuticals that belong to different therapeutical classes (erythromycin, azithromycin, sulfamethoxazole, diazepam, lorazepam, carbamazepine, metoprolol, bisoprolol, enalapril, cilazapril, simvastatin, clopidogrel, diclofenac) and two metabolites of metamizole (4-acetylaminoantipyrine and 4-formylaminoantipyrine) were selected for this study. The influence of chemical treatment on MWCNT surface characteristics and extraction efficiency was studied, and it was shown that HCl treatment of MWCNT leads to a decrease in the amount of surface oxygen groups and at the same time favorably affects the efficiency toward extraction of selected pharmaceuticals. After the optimization of the SPE procedure, the following conditions were chosen: 50 mg of HCl-treated MCWNT as a sorbent, 100 mL of water sample at pH 6, and 15 mL of the methanol-dichloromethane mixture (1:1, v/v) as eluent. Under optimal conditions, high recoveries (79-119%), as well as low detection (0.2 to 103 ng L-1) and quantitation (0.5-345 ng L-1) limits, were obtained. The optimized method was applied to the analysis of five surface water and two groundwater samples, and three pharmaceuticals were detected, the antiepileptic drug carbamazepine and two metabolites of antipyretic metamizole.
PB  - Springer Heidelberg, Heidelberg
T2  - Environmental Science and Pollution Research
T1  - Solid-phase extraction of multi-class pharmaceuticals from environmental water samples onto modified multi-walled carbon nanotubes followed by LC-MS/MS
EP  - 20793
IS  - 25
SP  - 20784
VL  - 24
DO  - 10.1007/s11356-017-9748-0
ER  - 

@article{
author = "Lalović, Bojana and Đurkić, Tatjana and Vukčević, Marija and Janković-Častvan, Ivona and Kalijadis, Ana and Laušević, Zoran and Laušević, Mila",
year = "2017",
abstract = "In this paper, pristine and chemically treated multi-walled carbon nanotubes (MWCNTs) were employed as solid-phase extraction sorbents for the isolation and enrichment of multi-class pharmaceuticals from the surface water and groundwater, prior to liquid chromatography-tandem mass spectrometry analysis. Thirteen pharmaceuticals that belong to different therapeutical classes (erythromycin, azithromycin, sulfamethoxazole, diazepam, lorazepam, carbamazepine, metoprolol, bisoprolol, enalapril, cilazapril, simvastatin, clopidogrel, diclofenac) and two metabolites of metamizole (4-acetylaminoantipyrine and 4-formylaminoantipyrine) were selected for this study. The influence of chemical treatment on MWCNT surface characteristics and extraction efficiency was studied, and it was shown that HCl treatment of MWCNT leads to a decrease in the amount of surface oxygen groups and at the same time favorably affects the efficiency toward extraction of selected pharmaceuticals. After the optimization of the SPE procedure, the following conditions were chosen: 50 mg of HCl-treated MCWNT as a sorbent, 100 mL of water sample at pH 6, and 15 mL of the methanol-dichloromethane mixture (1:1, v/v) as eluent. Under optimal conditions, high recoveries (79-119%), as well as low detection (0.2 to 103 ng L-1) and quantitation (0.5-345 ng L-1) limits, were obtained. The optimized method was applied to the analysis of five surface water and two groundwater samples, and three pharmaceuticals were detected, the antiepileptic drug carbamazepine and two metabolites of antipyretic metamizole.",
publisher = "Springer Heidelberg, Heidelberg",
journal = "Environmental Science and Pollution Research",
title = "Solid-phase extraction of multi-class pharmaceuticals from environmental water samples onto modified multi-walled carbon nanotubes followed by LC-MS/MS",
pages = "20793-20784",
number = "25",
volume = "24",
doi = "10.1007/s11356-017-9748-0"
}

Lalović, B., Đurkić, T., Vukčević, M., Janković-Častvan, I., Kalijadis, A., Laušević, Z.,& Laušević, M.. (2017). Solid-phase extraction of multi-class pharmaceuticals from environmental water samples onto modified multi-walled carbon nanotubes followed by LC-MS/MS. in Environmental Science and Pollution Research
Springer Heidelberg, Heidelberg., 24(25), 20784-20793.
https://doi.org/10.1007/s11356-017-9748-0

Lalović B, Đurkić T, Vukčević M, Janković-Častvan I, Kalijadis A, Laušević Z, Laušević M. Solid-phase extraction of multi-class pharmaceuticals from environmental water samples onto modified multi-walled carbon nanotubes followed by LC-MS/MS. in Environmental Science and Pollution Research. 2017;24(25):20784-20793.
doi:10.1007/s11356-017-9748-0 .

Lalović, Bojana, Đurkić, Tatjana, Vukčević, Marija, Janković-Častvan, Ivona, Kalijadis, Ana, Laušević, Zoran, Laušević, Mila, "Solid-phase extraction of multi-class pharmaceuticals from environmental water samples onto modified multi-walled carbon nanotubes followed by LC-MS/MS" in Environmental Science and Pollution Research, 24, no. 25 (2017):20784-20793,
https://doi.org/10.1007/s11356-017-9748-0 . .

TY  - CONF
AU  - Vukčević, Marija
AU  - Lalović, Bojana
AU  - Kalijadis, Ana
AU  - Tolić, Ljiljana
AU  - Laušević, Zoran
AU  - Đurkić, Tatjana
AU  - Laušević, Mila
PY  - 2015
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7254
AB  - Predmet ovog rada bio je ispitivanje mogućnosti primene višeslojnih ugljeničnih nanocevi kao sorbenta u metodi ekstrakcije na čvrstoj fazi (eng. solid phase extraction SPE) pri analizi ostataka lekova iz vode. U cilju dobijanja SPE sorbenata različitih karakteristika, izvršeno je hemijsko modifikovanje ugljeničnih nanocevi korišćenjem 4 M KOH, 5 M HNO3 i 1 M HCl. Lekovi odabrani za analizu (metoprolol, sulfametaksazol, azitromicin, bisoprolol, enalapril, eritromicin, karbamazepin, lorazepam, klopidogrel, diklofenak, simvastatin i cilazapril) pripadaju grupama antibiotika, kardiovaskularnih lekova, analgoantipiretika i lekova za lečenje nervnog sistema, a to su istovremeneno najčešće korišćeni lekovi u Republici Srbiji. Pored lekova odabrana su i dva metabolita metamizola (4-AAA i 4-FAA), koji su u prethodnim istraživanjima često detektovani u uzorcima površinskih i podzemnih voda [2]. Za identifikaciju i kvantitativno određivanje analita korišćena je tečna hromatografija visoke performanse u sprezi sa tandem masenom spektrometrijom.
PB  - Beograd : Srpsko hemijsko društvo = Serbian Chemical Society
C3  - Knjiga izvoda = Book of Abstracts / 7. simpozijum Hemija i zaštita životne sredine sa međunarodnim učešćem = 7th Symposium Chemistry and Environmental Protection with International Participation, Palić, Srbija, 09-12. jun 2015
T1  - Ekstrakcija odabranih lekova na višeslojnim ugljeničnim nanocevima
T1  - Extraction of selected pharmaceuticals on multiwalled carbon nanotubes
EP  - 238
SP  - 237
UR  - https://hdl.handle.net/21.15107/rcub_technorep_7254
ER  - 

@conference{
author = "Vukčević, Marija and Lalović, Bojana and Kalijadis, Ana and Tolić, Ljiljana and Laušević, Zoran and Đurkić, Tatjana and Laušević, Mila",
year = "2015",
abstract = "Predmet ovog rada bio je ispitivanje mogućnosti primene višeslojnih ugljeničnih nanocevi kao sorbenta u metodi ekstrakcije na čvrstoj fazi (eng. solid phase extraction SPE) pri analizi ostataka lekova iz vode. U cilju dobijanja SPE sorbenata različitih karakteristika, izvršeno je hemijsko modifikovanje ugljeničnih nanocevi korišćenjem 4 M KOH, 5 M HNO3 i 1 M HCl. Lekovi odabrani za analizu (metoprolol, sulfametaksazol, azitromicin, bisoprolol, enalapril, eritromicin, karbamazepin, lorazepam, klopidogrel, diklofenak, simvastatin i cilazapril) pripadaju grupama antibiotika, kardiovaskularnih lekova, analgoantipiretika i lekova za lečenje nervnog sistema, a to su istovremeneno najčešće korišćeni lekovi u Republici Srbiji. Pored lekova odabrana su i dva metabolita metamizola (4-AAA i 4-FAA), koji su u prethodnim istraživanjima često detektovani u uzorcima površinskih i podzemnih voda [2]. Za identifikaciju i kvantitativno određivanje analita korišćena je tečna hromatografija visoke performanse u sprezi sa tandem masenom spektrometrijom.",
publisher = "Beograd : Srpsko hemijsko društvo = Serbian Chemical Society",
journal = "Knjiga izvoda = Book of Abstracts / 7. simpozijum Hemija i zaštita životne sredine sa međunarodnim učešćem = 7th Symposium Chemistry and Environmental Protection with International Participation, Palić, Srbija, 09-12. jun 2015",
title = "Ekstrakcija odabranih lekova na višeslojnim ugljeničnim nanocevima, Extraction of selected pharmaceuticals on multiwalled carbon nanotubes",
pages = "238-237",
url = "https://hdl.handle.net/21.15107/rcub_technorep_7254"
}

Vukčević, M., Lalović, B., Kalijadis, A., Tolić, L., Laušević, Z., Đurkić, T.,& Laušević, M.. (2015). Ekstrakcija odabranih lekova na višeslojnim ugljeničnim nanocevima. in Knjiga izvoda = Book of Abstracts / 7. simpozijum Hemija i zaštita životne sredine sa međunarodnim učešćem = 7th Symposium Chemistry and Environmental Protection with International Participation, Palić, Srbija, 09-12. jun 2015
Beograd : Srpsko hemijsko društvo = Serbian Chemical Society., 237-238.
https://hdl.handle.net/21.15107/rcub_technorep_7254

Vukčević M, Lalović B, Kalijadis A, Tolić L, Laušević Z, Đurkić T, Laušević M. Ekstrakcija odabranih lekova na višeslojnim ugljeničnim nanocevima. in Knjiga izvoda = Book of Abstracts / 7. simpozijum Hemija i zaštita životne sredine sa međunarodnim učešćem = 7th Symposium Chemistry and Environmental Protection with International Participation, Palić, Srbija, 09-12. jun 2015. 2015;:237-238.
https://hdl.handle.net/21.15107/rcub_technorep_7254 .

Vukčević, Marija, Lalović, Bojana, Kalijadis, Ana, Tolić, Ljiljana, Laušević, Zoran, Đurkić, Tatjana, Laušević, Mila, "Ekstrakcija odabranih lekova na višeslojnim ugljeničnim nanocevima" in Knjiga izvoda = Book of Abstracts / 7. simpozijum Hemija i zaštita životne sredine sa međunarodnim učešćem = 7th Symposium Chemistry and Environmental Protection with International Participation, Palić, Srbija, 09-12. jun 2015 (2015):237-238,
https://hdl.handle.net/21.15107/rcub_technorep_7254 .