TY  - JOUR
AU  - Milosević, Miljan
AU  - Stojanović, Dušica
AU  - Simić, Vladimir
AU  - Grković, Mirjana
AU  - Bjelović, Miloš
AU  - Uskoković, Petar
AU  - Kojić, Miloš
PY  - 2020
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/4388
AB  - The authors present the preparation procedure and a computational model of a three-layered fibrous scaffold for prolonged drug release. The scaffold, produced by emulsion/sequential electrospinning, consists of a poly(d,l-lactic-co-glycolic acid) (PLGA) fiber layer sandwiched between two poly(epsilon -caprolactone) (PCL) layers. Experimental results of drug release rates from the scaffold are compared with the results of the recently introduced computational finite element (FE) models for diffusive drug release from nanofibers to the three-dimensional (3D) surrounding medium. Two different FE models are used: (1) a 3D discretized continuum and fibers represented by a simple radial one-dimensional (1D) finite elements, and (2) a 3D continuum discretized by composite smeared finite elements (CSFEs) containing the fiber smeared and surrounding domains. Both models include the effects of polymer degradation and hydrophobicity (as partitioning) of the drug at the fiber/surrounding interface. The CSFE model includes a volumetric fraction of fibers and diameter distribution, and is additionally enhanced by using correction function to improve the accuracy of the model. The computational results are validated on Rhodamine B (fluorescent drug l) and other hydrophilic drugs. Agreement with experimental results proves that numerical models can serve as efficient tools for drug release to the surrounding porous medium or biological tissue. It is demonstrated that the introduced three-layered scaffold delays the drug release process and can be used for the time-controlled release of drugs in postoperative therapy.
PB  - Nature Publishing Group, London
T2  - Scientific Reports
T1  - Preparation and modeling of three-layered PCL/PLGA/PCL fibrous scaffolds for prolonged drug release
IS  - 1
VL  - 10
DO  - 10.1038/s41598-020-68117-9
ER  - 

@article{
author = "Milosević, Miljan and Stojanović, Dušica and Simić, Vladimir and Grković, Mirjana and Bjelović, Miloš and Uskoković, Petar and Kojić, Miloš",
year = "2020",
abstract = "The authors present the preparation procedure and a computational model of a three-layered fibrous scaffold for prolonged drug release. The scaffold, produced by emulsion/sequential electrospinning, consists of a poly(d,l-lactic-co-glycolic acid) (PLGA) fiber layer sandwiched between two poly(epsilon -caprolactone) (PCL) layers. Experimental results of drug release rates from the scaffold are compared with the results of the recently introduced computational finite element (FE) models for diffusive drug release from nanofibers to the three-dimensional (3D) surrounding medium. Two different FE models are used: (1) a 3D discretized continuum and fibers represented by a simple radial one-dimensional (1D) finite elements, and (2) a 3D continuum discretized by composite smeared finite elements (CSFEs) containing the fiber smeared and surrounding domains. Both models include the effects of polymer degradation and hydrophobicity (as partitioning) of the drug at the fiber/surrounding interface. The CSFE model includes a volumetric fraction of fibers and diameter distribution, and is additionally enhanced by using correction function to improve the accuracy of the model. The computational results are validated on Rhodamine B (fluorescent drug l) and other hydrophilic drugs. Agreement with experimental results proves that numerical models can serve as efficient tools for drug release to the surrounding porous medium or biological tissue. It is demonstrated that the introduced three-layered scaffold delays the drug release process and can be used for the time-controlled release of drugs in postoperative therapy.",
publisher = "Nature Publishing Group, London",
journal = "Scientific Reports",
title = "Preparation and modeling of three-layered PCL/PLGA/PCL fibrous scaffolds for prolonged drug release",
number = "1",
volume = "10",
doi = "10.1038/s41598-020-68117-9"
}

Milosević, M., Stojanović, D., Simić, V., Grković, M., Bjelović, M., Uskoković, P.,& Kojić, M.. (2020). Preparation and modeling of three-layered PCL/PLGA/PCL fibrous scaffolds for prolonged drug release. in Scientific Reports
Nature Publishing Group, London., 10(1).
https://doi.org/10.1038/s41598-020-68117-9

Milosević M, Stojanović D, Simić V, Grković M, Bjelović M, Uskoković P, Kojić M. Preparation and modeling of three-layered PCL/PLGA/PCL fibrous scaffolds for prolonged drug release. in Scientific Reports. 2020;10(1).
doi:10.1038/s41598-020-68117-9 .

Milosević, Miljan, Stojanović, Dušica, Simić, Vladimir, Grković, Mirjana, Bjelović, Miloš, Uskoković, Petar, Kojić, Miloš, "Preparation and modeling of three-layered PCL/PLGA/PCL fibrous scaffolds for prolonged drug release" in Scientific Reports, 10, no. 1 (2020),
https://doi.org/10.1038/s41598-020-68117-9 . .

TY  - JOUR
AU  - Kojić, M.
AU  - Milosević, M.
AU  - Simić, Vladimir
AU  - Stojanović, Dušica
AU  - Uskoković, Petar
PY  - 2017
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/3644
AB  - The aim of this study was to investigate the release performance of an electrospun composite drug loaded nanofiber mat. Electrospun nanofiber mats are promising as drug carriers which offer site-specific delivery of drugs to a target in the human body and may be used for cancer therapy. The authors have formulated a simple radial 1D finite element, which is used to model diffusion within fibers releasing a drug to the surrounding medium discretized by continuum 3D finite elements. The numerical model includes degradation effects and hydrophobicity at the fibers/surroundings interface. For the purpose of experimental investigation, a poly(D, L-lacticco-glycolic acid) (PLGA) implant has been created at the Faculty of Technology and Metallurgy, University of Belgrade. The radial 1D element provides accurate predictions of the diffusion process and serves as an efficient tool for describing transport inside the polymer fiber and surrounding porous medium; which is illustrated through numerical examples.
PB  - Univerzitet u Kragujevcu - Fakultet inženjerskih nauka, Kragujevac
T2  - Journal of the Serbian Society for Computational Mechanics
T1  - A radial 1D Finite Element for Drug Release from Drug Loaded Nanofibers
EP  - 93
IS  - 1
SP  - 82
VL  - 11
DO  - 10.24874/jsscm.2017.11.01.08
ER  - 

@article{
author = "Kojić, M. and Milosević, M. and Simić, Vladimir and Stojanović, Dušica and Uskoković, Petar",
year = "2017",
abstract = "The aim of this study was to investigate the release performance of an electrospun composite drug loaded nanofiber mat. Electrospun nanofiber mats are promising as drug carriers which offer site-specific delivery of drugs to a target in the human body and may be used for cancer therapy. The authors have formulated a simple radial 1D finite element, which is used to model diffusion within fibers releasing a drug to the surrounding medium discretized by continuum 3D finite elements. The numerical model includes degradation effects and hydrophobicity at the fibers/surroundings interface. For the purpose of experimental investigation, a poly(D, L-lacticco-glycolic acid) (PLGA) implant has been created at the Faculty of Technology and Metallurgy, University of Belgrade. The radial 1D element provides accurate predictions of the diffusion process and serves as an efficient tool for describing transport inside the polymer fiber and surrounding porous medium; which is illustrated through numerical examples.",
publisher = "Univerzitet u Kragujevcu - Fakultet inženjerskih nauka, Kragujevac",
journal = "Journal of the Serbian Society for Computational Mechanics",
title = "A radial 1D Finite Element for Drug Release from Drug Loaded Nanofibers",
pages = "93-82",
number = "1",
volume = "11",
doi = "10.24874/jsscm.2017.11.01.08"
}

Kojić, M., Milosević, M., Simić, V., Stojanović, D.,& Uskoković, P.. (2017). A radial 1D Finite Element for Drug Release from Drug Loaded Nanofibers. in Journal of the Serbian Society for Computational Mechanics
Univerzitet u Kragujevcu - Fakultet inženjerskih nauka, Kragujevac., 11(1), 82-93.
https://doi.org/10.24874/jsscm.2017.11.01.08

Kojić M, Milosević M, Simić V, Stojanović D, Uskoković P. A radial 1D Finite Element for Drug Release from Drug Loaded Nanofibers. in Journal of the Serbian Society for Computational Mechanics. 2017;11(1):82-93.
doi:10.24874/jsscm.2017.11.01.08 .

Kojić, M., Milosević, M., Simić, Vladimir, Stojanović, Dušica, Uskoković, Petar, "A radial 1D Finite Element for Drug Release from Drug Loaded Nanofibers" in Journal of the Serbian Society for Computational Mechanics, 11, no. 1 (2017):82-93,
https://doi.org/10.24874/jsscm.2017.11.01.08 . .