TY  - CHAP
AU  - Milivojević, Milan
AU  - Pajić-Lijaković, Ivana
AU  - Dajić, Zora
AU  - Dhara, Amal Kumar
AU  - Nayak, Amit Kumar
AU  - Hasnain, Md Saquib
PY  - 2024
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/7431
AB  - In many cases, conventional therapeutics are not able to cure diseases in a proper and safe manner. Conversely, plants and their derivatives have been successfully used for the treatment of numerous diseases and disorders for centuries and have proven themselves as efficient, inexpensive, environmentally friendly, faster, and less toxic. However, their use is sometimes connected to some issues, mainly due to inefficient systemic delivery and bioavailability, which prevent to translate their promising in vitro and in vivo effects into clinical use. During the past decade, nanotechnology has made big progress in developing different nanocarriers for drug delivery formulations. In the case of phytopharmaceuticals their encapsulation in nanoparticles can help in improving drug solubility, physical and chemical stability, pharmacological activity, reducing its toxicity and side effects, and providing targeted and sustained delivery which all leads to better bioavailability. The current review highlights the main problems connected to the delivery of phytopharmaceuticals, the main properties of different types of plant drugs, and gives a critical review of properties and limitations connected to the application of numerous lipid, polymer, and inorganic nanoparticles as phytodrug carriers. It also provides information about up-to-date investigated combinations of phytopharmaceuticals and nanocarriers.
PB  - Singapore : Springer
T2  - Role of Herbal Medicines
T1  - Nanotechnology in Delivery and Targeting of Phytochemicals for Lifestyle Diseases
EP  - 524
SP  - 497
DO  - 10.1007/978-981-99-7703-1_25
ER  - 

@inbook{
author = "Milivojević, Milan and Pajić-Lijaković, Ivana and Dajić, Zora and Dhara, Amal Kumar and Nayak, Amit Kumar and Hasnain, Md Saquib",
year = "2024",
abstract = "In many cases, conventional therapeutics are not able to cure diseases in a proper and safe manner. Conversely, plants and their derivatives have been successfully used for the treatment of numerous diseases and disorders for centuries and have proven themselves as efficient, inexpensive, environmentally friendly, faster, and less toxic. However, their use is sometimes connected to some issues, mainly due to inefficient systemic delivery and bioavailability, which prevent to translate their promising in vitro and in vivo effects into clinical use. During the past decade, nanotechnology has made big progress in developing different nanocarriers for drug delivery formulations. In the case of phytopharmaceuticals their encapsulation in nanoparticles can help in improving drug solubility, physical and chemical stability, pharmacological activity, reducing its toxicity and side effects, and providing targeted and sustained delivery which all leads to better bioavailability. The current review highlights the main problems connected to the delivery of phytopharmaceuticals, the main properties of different types of plant drugs, and gives a critical review of properties and limitations connected to the application of numerous lipid, polymer, and inorganic nanoparticles as phytodrug carriers. It also provides information about up-to-date investigated combinations of phytopharmaceuticals and nanocarriers.",
publisher = "Singapore : Springer",
journal = "Role of Herbal Medicines",
booktitle = "Nanotechnology in Delivery and Targeting of Phytochemicals for Lifestyle Diseases",
pages = "524-497",
doi = "10.1007/978-981-99-7703-1_25"
}

Milivojević, M., Pajić-Lijaković, I., Dajić, Z., Dhara, A. K., Nayak, A. K.,& Hasnain, M. S.. (2024). Nanotechnology in Delivery and Targeting of Phytochemicals for Lifestyle Diseases. in Role of Herbal Medicines
Singapore : Springer., 497-524.
https://doi.org/10.1007/978-981-99-7703-1_25

Milivojević M, Pajić-Lijaković I, Dajić Z, Dhara AK, Nayak AK, Hasnain MS. Nanotechnology in Delivery and Targeting of Phytochemicals for Lifestyle Diseases. in Role of Herbal Medicines. 2024;:497-524.
doi:10.1007/978-981-99-7703-1_25 .

Milivojević, Milan, Pajić-Lijaković, Ivana, Dajić, Zora, Dhara, Amal Kumar, Nayak, Amit Kumar, Hasnain, Md Saquib, "Nanotechnology in Delivery and Targeting of Phytochemicals for Lifestyle Diseases" in Role of Herbal Medicines (2024):497-524,
https://doi.org/10.1007/978-981-99-7703-1_25 . .

TY  - JOUR
AU  - Milivojević, Milan
AU  - Popović, Aleksandra
AU  - Pajić-Lijaković, Ivana
AU  - Šoštarić, Ivan
AU  - Kolašinac, Stefan
AU  - Dajić Stevanović, Zora
PY  - 2023
UR  - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/6616
AB  - Sodium alginate is one of the most interesting and the most investigated and applied biopolymers due to its advantageous properties. Among them, easy, simple, mild, rapid, non-toxic gelation by divalent cations is the most important. In addition, it is abundant, low-cost, eco-friendly, bio-compatible, bio-adhesive, biodegradable, stable, etc. All those properties were systematically considered within this review. Carotenoids are functional components in the human diet with plenty of health benefits. However, their sensitivity to environmental and process stresses, chemical instability, easy oxidation, low water solubility, and bioavailability limit their food and pharmaceutical applications. Encapsulation may help in overcoming these limitations and within this review, the role of alginate-based encapsulation systems in improving the stability and bioavailability of carotenoids is explored. It may be concluded that all alginate-based systems increase carotenoid stability, but only those of micro- and nano-size, as well as emulsion-based, may improve their low bioaccessibility. In addition, the incorporation of other biopolymers may further improve encapsulation system properties. Furthermore, the main techniques for evaluating the encapsulation are briefly considered. This review critically and profoundly explains the role of alginates in improving the encapsulation process of carotenoids, suggesting the best alternatives for those systems. Moreover, it provides a comprehensive cover of recent advances in this field.
PB  - MDPI
T2  - Gels
T1  - Alginate Gel-Based Carriers for Encapsulation of Carotenoids: On Challenges and Applications
IS  - 8
SP  - 620
VL  - 9
DO  - 10.3390/gels9080620
ER  - 

@article{
author = "Milivojević, Milan and Popović, Aleksandra and Pajić-Lijaković, Ivana and Šoštarić, Ivan and Kolašinac, Stefan and Dajić Stevanović, Zora",
year = "2023",
abstract = "Sodium alginate is one of the most interesting and the most investigated and applied biopolymers due to its advantageous properties. Among them, easy, simple, mild, rapid, non-toxic gelation by divalent cations is the most important. In addition, it is abundant, low-cost, eco-friendly, bio-compatible, bio-adhesive, biodegradable, stable, etc. All those properties were systematically considered within this review. Carotenoids are functional components in the human diet with plenty of health benefits. However, their sensitivity to environmental and process stresses, chemical instability, easy oxidation, low water solubility, and bioavailability limit their food and pharmaceutical applications. Encapsulation may help in overcoming these limitations and within this review, the role of alginate-based encapsulation systems in improving the stability and bioavailability of carotenoids is explored. It may be concluded that all alginate-based systems increase carotenoid stability, but only those of micro- and nano-size, as well as emulsion-based, may improve their low bioaccessibility. In addition, the incorporation of other biopolymers may further improve encapsulation system properties. Furthermore, the main techniques for evaluating the encapsulation are briefly considered. This review critically and profoundly explains the role of alginates in improving the encapsulation process of carotenoids, suggesting the best alternatives for those systems. Moreover, it provides a comprehensive cover of recent advances in this field.",
publisher = "MDPI",
journal = "Gels",
title = "Alginate Gel-Based Carriers for Encapsulation of Carotenoids: On Challenges and Applications",
number = "8",
pages = "620",
volume = "9",
doi = "10.3390/gels9080620"
}

Milivojević, M., Popović, A., Pajić-Lijaković, I., Šoštarić, I., Kolašinac, S.,& Dajić Stevanović, Z.. (2023). Alginate Gel-Based Carriers for Encapsulation of Carotenoids: On Challenges and Applications. in Gels
MDPI., 9(8), 620.
https://doi.org/10.3390/gels9080620

Milivojević M, Popović A, Pajić-Lijaković I, Šoštarić I, Kolašinac S, Dajić Stevanović Z. Alginate Gel-Based Carriers for Encapsulation of Carotenoids: On Challenges and Applications. in Gels. 2023;9(8):620.
doi:10.3390/gels9080620 .

Milivojević, Milan, Popović, Aleksandra, Pajić-Lijaković, Ivana, Šoštarić, Ivan, Kolašinac, Stefan, Dajić Stevanović, Zora, "Alginate Gel-Based Carriers for Encapsulation of Carotenoids: On Challenges and Applications" in Gels, 9, no. 8 (2023):620,
https://doi.org/10.3390/gels9080620 . .