Effect of the physicochemical properties of N,N-Disubstituted-2-phenylacetamide derivatives on their retention behavior in RP-TLC
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2007
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The chromatographic behavior of some N,N-disubstituted-2-phenylacetamide derivatives has been studied on the chemically bonded stationary phase RP-C-18 with acetone, acetonitrile, tetrahydrofuran, dioxane, methanol, ethanol, 1-propanol, and 2-propanol as organic modifiers of aqueous mobile phases. The retention observed with different mobile-phase modifiers was correlated. The effects of different physicochemical properties of the compounds on retention behavior when chromatographed with aqueous mobile phases containing protic and aprotic modifiers were also studied. Multiple linear regression analysis was used to correlate chromatographic retention constants of the compounds with physicochemical properties. The chromatographic lipophilicity R-M(0) (determined by linear extrapolation) was correlated with log P values calculated by use of different theoretical methods. Good relationships were obtained for all the systems investigated. Good correlation was obtained between lipophilicity ...measured chromatographically and biological activity predictors.
Ključne reči:
RP-C18 TLC / N,N-Disubstituted-2-phenylacetamides / lipophilicity / correlation analysis / biological activityIzvor:
JPC-Journal of Planar Chromatography-Modern Tlc, 2007, 20, 5, 353-359Izdavač:
- Akademiai Kiado Zrt, Budapest
DOI: 10.1556/JPC.20.2007.5.8
ISSN: 0933-4173
WoS: 000252110600008
Scopus: 2-s2.0-35848935423
Institucija/grupa
Tehnološko-metalurški fakultetTY - JOUR AU - Perišić-Janjić, Nada AU - Vastag, Gyongyi AU - Tomić, Jelena AU - Petrović, Slobodan PY - 2007 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1148 AB - The chromatographic behavior of some N,N-disubstituted-2-phenylacetamide derivatives has been studied on the chemically bonded stationary phase RP-C-18 with acetone, acetonitrile, tetrahydrofuran, dioxane, methanol, ethanol, 1-propanol, and 2-propanol as organic modifiers of aqueous mobile phases. The retention observed with different mobile-phase modifiers was correlated. The effects of different physicochemical properties of the compounds on retention behavior when chromatographed with aqueous mobile phases containing protic and aprotic modifiers were also studied. Multiple linear regression analysis was used to correlate chromatographic retention constants of the compounds with physicochemical properties. The chromatographic lipophilicity R-M(0) (determined by linear extrapolation) was correlated with log P values calculated by use of different theoretical methods. Good relationships were obtained for all the systems investigated. Good correlation was obtained between lipophilicity measured chromatographically and biological activity predictors. PB - Akademiai Kiado Zrt, Budapest T2 - JPC-Journal of Planar Chromatography-Modern Tlc T1 - Effect of the physicochemical properties of N,N-Disubstituted-2-phenylacetamide derivatives on their retention behavior in RP-TLC EP - 359 IS - 5 SP - 353 VL - 20 DO - 10.1556/JPC.20.2007.5.8 ER -
@article{ author = "Perišić-Janjić, Nada and Vastag, Gyongyi and Tomić, Jelena and Petrović, Slobodan", year = "2007", abstract = "The chromatographic behavior of some N,N-disubstituted-2-phenylacetamide derivatives has been studied on the chemically bonded stationary phase RP-C-18 with acetone, acetonitrile, tetrahydrofuran, dioxane, methanol, ethanol, 1-propanol, and 2-propanol as organic modifiers of aqueous mobile phases. The retention observed with different mobile-phase modifiers was correlated. The effects of different physicochemical properties of the compounds on retention behavior when chromatographed with aqueous mobile phases containing protic and aprotic modifiers were also studied. Multiple linear regression analysis was used to correlate chromatographic retention constants of the compounds with physicochemical properties. The chromatographic lipophilicity R-M(0) (determined by linear extrapolation) was correlated with log P values calculated by use of different theoretical methods. Good relationships were obtained for all the systems investigated. Good correlation was obtained between lipophilicity measured chromatographically and biological activity predictors.", publisher = "Akademiai Kiado Zrt, Budapest", journal = "JPC-Journal of Planar Chromatography-Modern Tlc", title = "Effect of the physicochemical properties of N,N-Disubstituted-2-phenylacetamide derivatives on their retention behavior in RP-TLC", pages = "359-353", number = "5", volume = "20", doi = "10.1556/JPC.20.2007.5.8" }
Perišić-Janjić, N., Vastag, G., Tomić, J.,& Petrović, S.. (2007). Effect of the physicochemical properties of N,N-Disubstituted-2-phenylacetamide derivatives on their retention behavior in RP-TLC. in JPC-Journal of Planar Chromatography-Modern Tlc Akademiai Kiado Zrt, Budapest., 20(5), 353-359. https://doi.org/10.1556/JPC.20.2007.5.8
Perišić-Janjić N, Vastag G, Tomić J, Petrović S. Effect of the physicochemical properties of N,N-Disubstituted-2-phenylacetamide derivatives on their retention behavior in RP-TLC. in JPC-Journal of Planar Chromatography-Modern Tlc. 2007;20(5):353-359. doi:10.1556/JPC.20.2007.5.8 .
Perišić-Janjić, Nada, Vastag, Gyongyi, Tomić, Jelena, Petrović, Slobodan, "Effect of the physicochemical properties of N,N-Disubstituted-2-phenylacetamide derivatives on their retention behavior in RP-TLC" in JPC-Journal of Planar Chromatography-Modern Tlc, 20, no. 5 (2007):353-359, https://doi.org/10.1556/JPC.20.2007.5.8 . .