Synthesis and characterization of biodegradable aliphatic copolyesters with poly(tetramethylene oxide) soft segments
Abstract
A series of aliphatic poly(ether-ester)s based on flexible poly(tetramethylene oxide) (PTMO) and hard poly (butylene succinate) (PBS) segments were synthesized by the catalyzed two-step transesterification reaction of dimethyl succinate, 1,4-butanediol, and alpha,omega-hydroxy-terminated PTMO (M-n = 1000 g/mol) in the bulk. The content of soft PTMO segments in the polymer chains was varied from 10 to 50 mass %. The effect of the introduction of the soft segments on the structure, thermal, and physical properties, as well as on the biodegradation properties was investigated. The composition and structure of the aliphatic segmented copolyesters were determined by H-1 NMR spectroscopy. The molecular weights of the polyesters were verified by viscometry of dilute solutions and polymer melts. The thermal properties were investigated using DSC. The degree of crystallinity was determined by means of DSC and WAXS. Biodegradation of the synthesized copolyesters, estimated in enzymatic degradati...on tests on polymer films in phosphate buffer solution with Candida rugosa lipase at 37 degrees C, was compared with hydrolytic degradation in the buffer solution. Viscosity measurements confirmed that there was no change in molecular weight of the copolyesters leading to the conclusion that the degradation mechanism of poly(ester-ether)s based on PTMO segments occurs through the surface erosion.
Keywords:
poly(ether-ester)s / poly(tetramethylene oxide) / polycondensation / biodegradable / enzymesSource:
Journal of Applied Polymer Science, 2007, 106, 3, 1777-1786Publisher:
- Wiley, Hoboken
Funding / projects:
- Sinteza i karakterizacija polimera i polimernih (nano)kompozita definisane molekulske i nadmolekulske strukture (RS-MESTD-MPN2006-2010-142023)
DOI: 10.1002/app.26860
ISSN: 0021-8995
WoS: 000249312000042
Scopus: 2-s2.0-34948902000
Institution/Community
Tehnološko-metalurški fakultetTY - JOUR AU - Pepić, Dragana AU - Nikolić, Marija AU - Đonlagić, Jasna PY - 2007 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1174 AB - A series of aliphatic poly(ether-ester)s based on flexible poly(tetramethylene oxide) (PTMO) and hard poly (butylene succinate) (PBS) segments were synthesized by the catalyzed two-step transesterification reaction of dimethyl succinate, 1,4-butanediol, and alpha,omega-hydroxy-terminated PTMO (M-n = 1000 g/mol) in the bulk. The content of soft PTMO segments in the polymer chains was varied from 10 to 50 mass %. The effect of the introduction of the soft segments on the structure, thermal, and physical properties, as well as on the biodegradation properties was investigated. The composition and structure of the aliphatic segmented copolyesters were determined by H-1 NMR spectroscopy. The molecular weights of the polyesters were verified by viscometry of dilute solutions and polymer melts. The thermal properties were investigated using DSC. The degree of crystallinity was determined by means of DSC and WAXS. Biodegradation of the synthesized copolyesters, estimated in enzymatic degradation tests on polymer films in phosphate buffer solution with Candida rugosa lipase at 37 degrees C, was compared with hydrolytic degradation in the buffer solution. Viscosity measurements confirmed that there was no change in molecular weight of the copolyesters leading to the conclusion that the degradation mechanism of poly(ester-ether)s based on PTMO segments occurs through the surface erosion. PB - Wiley, Hoboken T2 - Journal of Applied Polymer Science T1 - Synthesis and characterization of biodegradable aliphatic copolyesters with poly(tetramethylene oxide) soft segments EP - 1786 IS - 3 SP - 1777 VL - 106 DO - 10.1002/app.26860 ER -
@article{ author = "Pepić, Dragana and Nikolić, Marija and Đonlagić, Jasna", year = "2007", abstract = "A series of aliphatic poly(ether-ester)s based on flexible poly(tetramethylene oxide) (PTMO) and hard poly (butylene succinate) (PBS) segments were synthesized by the catalyzed two-step transesterification reaction of dimethyl succinate, 1,4-butanediol, and alpha,omega-hydroxy-terminated PTMO (M-n = 1000 g/mol) in the bulk. The content of soft PTMO segments in the polymer chains was varied from 10 to 50 mass %. The effect of the introduction of the soft segments on the structure, thermal, and physical properties, as well as on the biodegradation properties was investigated. The composition and structure of the aliphatic segmented copolyesters were determined by H-1 NMR spectroscopy. The molecular weights of the polyesters were verified by viscometry of dilute solutions and polymer melts. The thermal properties were investigated using DSC. The degree of crystallinity was determined by means of DSC and WAXS. Biodegradation of the synthesized copolyesters, estimated in enzymatic degradation tests on polymer films in phosphate buffer solution with Candida rugosa lipase at 37 degrees C, was compared with hydrolytic degradation in the buffer solution. Viscosity measurements confirmed that there was no change in molecular weight of the copolyesters leading to the conclusion that the degradation mechanism of poly(ester-ether)s based on PTMO segments occurs through the surface erosion.", publisher = "Wiley, Hoboken", journal = "Journal of Applied Polymer Science", title = "Synthesis and characterization of biodegradable aliphatic copolyesters with poly(tetramethylene oxide) soft segments", pages = "1786-1777", number = "3", volume = "106", doi = "10.1002/app.26860" }
Pepić, D., Nikolić, M.,& Đonlagić, J.. (2007). Synthesis and characterization of biodegradable aliphatic copolyesters with poly(tetramethylene oxide) soft segments. in Journal of Applied Polymer Science Wiley, Hoboken., 106(3), 1777-1786. https://doi.org/10.1002/app.26860
Pepić D, Nikolić M, Đonlagić J. Synthesis and characterization of biodegradable aliphatic copolyesters with poly(tetramethylene oxide) soft segments. in Journal of Applied Polymer Science. 2007;106(3):1777-1786. doi:10.1002/app.26860 .
Pepić, Dragana, Nikolić, Marija, Đonlagić, Jasna, "Synthesis and characterization of biodegradable aliphatic copolyesters with poly(tetramethylene oxide) soft segments" in Journal of Applied Polymer Science, 106, no. 3 (2007):1777-1786, https://doi.org/10.1002/app.26860 . .