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dc.creatorKajander, Kajsa
dc.creatorMyllyluoma, E.
dc.creatorRajilić-Stojanović, Mirjana
dc.creatorKyronpalo, S.
dc.creatorRasmussen, M.
dc.creatorJarvenpaa, S.
dc.creatorZoetendal, Erwin G.
dc.creatorde Vos, Willem M.
dc.creatorVapaatalo, H.
dc.creatorKorpela, R.
dc.date.accessioned2021-03-10T10:54:46Z
dc.date.available2021-03-10T10:54:46Z
dc.date.issued2008
dc.identifier.issn0269-2813
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/1269
dc.description.abstractBackground Irritable bowel syndrome is the most common diagnosis in gastroenterology. Trials suggest certain probiotics to be beneficial. Aim To investigate the effects of multispecies probiotic supplementation (Lactobacillus rhamnosus GG, L. rhamnosus Lc705, Propionibacterium freudenreichii ssp. shermanii JS and Bifidobacterium animalis ssp. lactis Bb 12) on abdominal symptoms, quality of life, intestinal microbiota and inflammatory markers in irritable bowel syndrome. Methods Eighty-six irritable bowel syndrome patients (Rome 11 criteria) participated in this randomized, placebo-controlled 5-month intervention. Patients were randomized to receive daily either multispecies probiotic supplementation or placebo. Irritable bowel syndrome symptoms, quality of life, microarray-based intestinal microbiota stability (n = 20), serum cytokines and sensitive C-reactive protein were monitored. Results The composite irritable bowel syndrome score had at 5 months decreased 14 points (95% CI: -19 to -9) from baseline with the multispecies probiotic vs. three points (95% CI: -8 to 1) with placebo (P = 0.0083). Especially, distension and abdominal pain were affected. A stabilization of the microbiota was observed, as the microbiota similarity index increased with the probiotic supplementation (1.9 +/- 3.1), while it decreased with placebo (-2.9 +/- 1.7). No differences were seen in C-reactive protein. Conclusions This multispecies probiotic seems to be an effective and safe option to alleviate symptoms of irritable bowel syndrome, and to stabilize the intestinal microbiota.en
dc.publisherWiley, Hoboken
dc.rightsopenAccess
dc.sourceAlimentary Pharmacology & Therapeutics
dc.titleClinical trial: multispecies probiotic supplementation alleviates the symptoms of irritable bowel syndrome and stabilizes intestinal microbiotaen
dc.typearticle
dc.rights.licenseARR
dc.citation.epage57
dc.citation.issue1
dc.citation.other27(1): 48-57
dc.citation.rankM21
dc.citation.spage48
dc.citation.volume27
dc.identifier.doi10.1111/j.1365-2036.2007.03542.x
dc.identifier.fulltexthttp://TechnoRep.tmf.bg.ac.rs/bitstream/id/99/1266.pdf
dc.identifier.pmid17919270
dc.identifier.rcubconv_2969
dc.identifier.scopus2-s2.0-36749082433
dc.identifier.wos000253385300006
dc.type.versionpublishedVersion


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