Hydantoins: Synthesis, properties and anticonvulsant activity
Hidantoini - dobijanje, svojstva i antikonvulzivna aktivnost
Article (Published version)
Metadata
Show full item recordAbstract
Hydantoin is a five-membered cyclic ureide that is present in numerous biologically active compounds including antiarrhytmics, anticonvulsants and antitumor agents. This paper describes different ways of synthesis of hydantoin-derivatives, their physical properties and reactivity. Also, the most widely used hydantoin anticonvulsants and the analysis of structureactivity relationships of anticonvulsant drugs in terms of lipophilicity and hydrogen bonding are presented here.
Hidantoin je petočlani ciklični ureid koji je sadržan u brojnim biološki aktivnim jedinjenjima kao što su antiaritmici, antikonvulzivi i antitumor agensi. U ovom radu su opisani postupci dobijanja derivata hidantoina, njihova fizička svojstva i reaktivnost. Prikazani su najčešće korišćeni antikonvulzivi iz grupe hidantoina, a razmatran je i uticaj strukture na antikovulzivnu aktivnost različitih derivata sa aspekta lipofilnosti i mogućnosti uspostavljanja vodoničnih veza.
Keywords:
hydantoin / properties / reactivity / synthesis / phenytoin / anticonvulsant activity / pharmacofor model / lipophilicity / hydrogen bonding / hidantoin / svojstva / reaktivnost / sinteza / fenitoin / anticonvulzivna aktivnost / farmakoforni model / lipofilnost / vodonične vezeSource:
Hemijska industrija, 2009, 63, 1, 17-31Publisher:
- Association of Chemical Engineers of Serbia
Funding / projects:
- Proučavanje sinteze, strukture i aktivnosti organskih jedinjenja prirodnog i sintetskog porekla (RS-142063)
DOI: 10.2298/HEMIND0901017T
ISSN: 0367-598X
WoS: 000265518900003
Scopus: 2-s2.0-77952925518
Institution/Community
Tehnološko-metalurški fakultetTY - JOUR AU - Trišović, Nemanja AU - Ušćumlić, Gordana AU - Petrović, Slobodan PY - 2009 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1408 AB - Hydantoin is a five-membered cyclic ureide that is present in numerous biologically active compounds including antiarrhytmics, anticonvulsants and antitumor agents. This paper describes different ways of synthesis of hydantoin-derivatives, their physical properties and reactivity. Also, the most widely used hydantoin anticonvulsants and the analysis of structureactivity relationships of anticonvulsant drugs in terms of lipophilicity and hydrogen bonding are presented here. AB - Hidantoin je petočlani ciklični ureid koji je sadržan u brojnim biološki aktivnim jedinjenjima kao što su antiaritmici, antikonvulzivi i antitumor agensi. U ovom radu su opisani postupci dobijanja derivata hidantoina, njihova fizička svojstva i reaktivnost. Prikazani su najčešće korišćeni antikonvulzivi iz grupe hidantoina, a razmatran je i uticaj strukture na antikovulzivnu aktivnost različitih derivata sa aspekta lipofilnosti i mogućnosti uspostavljanja vodoničnih veza. PB - Association of Chemical Engineers of Serbia T2 - Hemijska industrija T1 - Hydantoins: Synthesis, properties and anticonvulsant activity T1 - Hidantoini - dobijanje, svojstva i antikonvulzivna aktivnost EP - 31 IS - 1 SP - 17 VL - 63 DO - 10.2298/HEMIND0901017T ER -
@article{ author = "Trišović, Nemanja and Ušćumlić, Gordana and Petrović, Slobodan", year = "2009", abstract = "Hydantoin is a five-membered cyclic ureide that is present in numerous biologically active compounds including antiarrhytmics, anticonvulsants and antitumor agents. This paper describes different ways of synthesis of hydantoin-derivatives, their physical properties and reactivity. Also, the most widely used hydantoin anticonvulsants and the analysis of structureactivity relationships of anticonvulsant drugs in terms of lipophilicity and hydrogen bonding are presented here., Hidantoin je petočlani ciklični ureid koji je sadržan u brojnim biološki aktivnim jedinjenjima kao što su antiaritmici, antikonvulzivi i antitumor agensi. U ovom radu su opisani postupci dobijanja derivata hidantoina, njihova fizička svojstva i reaktivnost. Prikazani su najčešće korišćeni antikonvulzivi iz grupe hidantoina, a razmatran je i uticaj strukture na antikovulzivnu aktivnost različitih derivata sa aspekta lipofilnosti i mogućnosti uspostavljanja vodoničnih veza.", publisher = "Association of Chemical Engineers of Serbia", journal = "Hemijska industrija", title = "Hydantoins: Synthesis, properties and anticonvulsant activity, Hidantoini - dobijanje, svojstva i antikonvulzivna aktivnost", pages = "31-17", number = "1", volume = "63", doi = "10.2298/HEMIND0901017T" }
Trišović, N., Ušćumlić, G.,& Petrović, S.. (2009). Hydantoins: Synthesis, properties and anticonvulsant activity. in Hemijska industrija Association of Chemical Engineers of Serbia., 63(1), 17-31. https://doi.org/10.2298/HEMIND0901017T
Trišović N, Ušćumlić G, Petrović S. Hydantoins: Synthesis, properties and anticonvulsant activity. in Hemijska industrija. 2009;63(1):17-31. doi:10.2298/HEMIND0901017T .
Trišović, Nemanja, Ušćumlić, Gordana, Petrović, Slobodan, "Hydantoins: Synthesis, properties and anticonvulsant activity" in Hemijska industrija, 63, no. 1 (2009):17-31, https://doi.org/10.2298/HEMIND0901017T . .