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dc.creatorPetrović, Miloš
dc.creatorMitraković, Dragan
dc.creatorBugarski, Branko
dc.creatorVonwil, Daniel
dc.creatorMartin, Ivan
dc.creatorObradović, Bojana
dc.date.accessioned2021-03-10T11:06:47Z
dc.date.available2021-03-10T11:06:47Z
dc.date.issued2009
dc.identifier.issn1451-9372
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/1453
dc.description.abstractThe provision of mechanical stimulation is believed to be necessary for the functional assembly of skeletal tissues, which are normally exposed to a variety of biomechanical signals in vivo. In this paper, we present a development and validation of a novel bioreactor aimed for skeletal tissue engineering that provides dynamic compression and perfusion of cultivated tissues. Dynamic compression can be applied at frequencies up to 67.5 Hz and displacements down to 5 µm thus suitable for the simulation of physiological conditions in a native cartilage tissue (0.1-1 Hz, 5-10 % strain). The bioreactor also includes a load sensor that was calibrated so to measure average loads imposed on tissue samples. Regimes of the mechanical stimulation and acquisition of load sensor outputs are directed by an automatic control system using applications developed within the LabView platform. In addition, perfusion of tissue samples at physiological velocities (10-100 µm/s) provides efficient mass transfer, as well as the possibilities to expose the cells to hydrodynamic shear and simulate the conditions in a native bone tissue. Thus, the novel bioreactor is suited for studies of the effects of different biomechanical signals on in vitro regeneration of skeletal tissues, as well as for the studies of newly formulated biomaterials and cell biomaterial interactions under in vivo-like settings.en
dc.publisherAssociation of the Chemical Engineers of Serbia
dc.relationSwiss National Science FoundationSwiss National Science Foundation (SNSF) [IB73B0-111016/1]
dc.relationinfo:eu-repo/grantAgreement/MESTD/MPN2006-2010/142075/RS//
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceChemical Industry & Chemical Engineering Quarterly
dc.subjectbioreactoren
dc.subjectdynamic compressionen
dc.subjectperfusionen
dc.subjectcartilageen
dc.subjectboneen
dc.subjecttissue engineeringen
dc.titleA novel bioreactor with mechanical stimulation for skeletal tissue engineeringen
dc.typearticle
dc.rights.licenseBY-NC-ND
dc.citation.epage44
dc.citation.issue1
dc.citation.other15(1): 41-44
dc.citation.spage41
dc.citation.volume15
dc.identifier.doi10.2298/CICEQ0901041P
dc.identifier.rcubconv_1662
dc.identifier.scopus2-s2.0-74049103091
dc.identifier.wos000263780100011
dc.type.versionpublishedVersion


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