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dc.creatorPjanović, Rada
dc.creatorStojanović, Radoslava
dc.creatorŠajber, Milana
dc.creatorVeljković, Jelena
dc.creatorBošković-Vragolović, Nevenka
dc.creatorPejanović, Srđan
dc.date.accessioned2021-03-10T11:06:51Z
dc.date.available2021-03-10T11:06:51Z
dc.date.issued2009
dc.identifier.issn1451-9372
dc.identifier.urihttp://TechnoRep.tmf.bg.ac.rs/handle/123456789/1454
dc.description.abstractLipid particles, as drug carriers, are of increasing research interest, because a sustained drug release and avoidance of side effects could be achieved by using them. Lidocaine hydrochloride is a very efficient local anesthetic, but it has a short effect. The objective was to prolong the effect of the drug by encapsulating lidocaine hydrochloride in phospholipids microparticles. Two different procedures were used for the preparation of phospholipids microparticles. In both cases, phosphatidylcholine and lysophosphatidylcholine were used for the preparation of microparticles in which 5 % w/w lidocaine hydrochloride solution was encapsulated. The standard Franz diffusion cell was used for the experimental diffusion rate determination. The obtained results show that diffusion rate from microparticles is significantly lower than from the lidocaine hydrochloride solution, which means that this kind of microparticles could be used for the prolonged drug release. There was no much difference in diffusion rates from microparticles obtained by different procedures. That indicates that only the composition of the particles membrane has an influence on the lidocaine hydrochloride release rate.en
dc.publisherAssociation of the Chemical Engineers of Serbia
dc.rightsopenAccess
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.sourceChemical Industry & Chemical Engineering Quarterly
dc.subjectmicroparticlesen
dc.subjectdiffusionen
dc.subjectphospholipidsen
dc.subjectlidocaineen
dc.subjectFranz cellen
dc.titleDiffusion of lidocaine hydrochloride from lipid microparticlesen
dc.typearticle
dc.rights.licenseBY-NC-ND
dc.citation.epage35
dc.citation.issue1
dc.citation.other15(1): 33-35
dc.citation.rankM23
dc.citation.spage33
dc.citation.volume15
dc.identifier.doi10.2298/CICEQ0901033P
dc.identifier.fulltexthttp://TechnoRep.tmf.bg.ac.rs/bitstream/id/8622/1451-93720901033P.pdf
dc.identifier.scopus2-s2.0-74049146367
dc.identifier.wos000263780100009
dc.type.versionpublishedVersion


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