Synthesis, characterization and cytotoxicity of surface amino-functionalized water-dispersible multi-walled carbon nanotubes
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2009
Authors
Vuković, Goran D.Marinković, Aleksandar
Obradović, Maja
Radmilović, V.
Čolić, Miodrag
Aleksić, Radoslav
Uskoković, Petar
Article (Published version)
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Show full item recordAbstract
Surface functionalization of multi-walled carbon nanotubes (MWCNTs), with amino groups via chemical modification of carboxyl groups introduced on the nanotube surface, using O-(7-azabenzotriazol-1-yl)-N, N,N',N'-tetramethyluronium hexafluorophosphate (N-HATU) and N,N-diisopropylethylamine (DIEA) is reported. The N-HATU coupling agent provides faster reaction rate and the reaction occurs at lower temperature compared to amidation and acylation-amidation chemistry. The amines, 1,6-hexanediamine (HDA), diethylenetriamine (DETA), triethylenetetramine (TETA) and 1,4-phenylenediamine (PDA) were used. The resulting materials were characterized with different techniques such as FTIR, XRD, elemental analysis, TGA, TEM, UV-vis spectroscopy and cyclic voltammetry. MWCNTs functionalized with PDA posses the best dispersibility and electron transfer properties in comparison to the others amines. Functionalized MWCNTs, at the concentrations between 1 and 50 mu g ml(-1), were not cytotoxic for the fib...roblast L929 cell line. However, the concentrations of MWCNTs higher of 10 mu g ml(-1) reduced cell growth and this effect correlated positively with the degree of their uptake by L929 cells.
Keywords:
Carbon nanotubes / Amino-functionalization / Cyclic voltammetry / CytotoxicitySource:
Applied Surface Science, 2009, 255, 18, 8067-8075Publisher:
- Elsevier Science Bv, Amsterdam
Funding / projects:
- Sinteza funkcionalnih materijala sa kontrolisanom strukturom na molekularnom i nano nivou (RS-142006)
DOI: 10.1016/j.apsusc.2009.05.016
ISSN: 0169-4332
WoS: 000267469500039
Scopus: 2-s2.0-67649097074
Institution/Community
Tehnološko-metalurški fakultetTY - JOUR AU - Vuković, Goran D. AU - Marinković, Aleksandar AU - Obradović, Maja AU - Radmilović, V. AU - Čolić, Miodrag AU - Aleksić, Radoslav AU - Uskoković, Petar PY - 2009 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1512 AB - Surface functionalization of multi-walled carbon nanotubes (MWCNTs), with amino groups via chemical modification of carboxyl groups introduced on the nanotube surface, using O-(7-azabenzotriazol-1-yl)-N, N,N',N'-tetramethyluronium hexafluorophosphate (N-HATU) and N,N-diisopropylethylamine (DIEA) is reported. The N-HATU coupling agent provides faster reaction rate and the reaction occurs at lower temperature compared to amidation and acylation-amidation chemistry. The amines, 1,6-hexanediamine (HDA), diethylenetriamine (DETA), triethylenetetramine (TETA) and 1,4-phenylenediamine (PDA) were used. The resulting materials were characterized with different techniques such as FTIR, XRD, elemental analysis, TGA, TEM, UV-vis spectroscopy and cyclic voltammetry. MWCNTs functionalized with PDA posses the best dispersibility and electron transfer properties in comparison to the others amines. Functionalized MWCNTs, at the concentrations between 1 and 50 mu g ml(-1), were not cytotoxic for the fibroblast L929 cell line. However, the concentrations of MWCNTs higher of 10 mu g ml(-1) reduced cell growth and this effect correlated positively with the degree of their uptake by L929 cells. PB - Elsevier Science Bv, Amsterdam T2 - Applied Surface Science T1 - Synthesis, characterization and cytotoxicity of surface amino-functionalized water-dispersible multi-walled carbon nanotubes EP - 8075 IS - 18 SP - 8067 VL - 255 DO - 10.1016/j.apsusc.2009.05.016 ER -
@article{ author = "Vuković, Goran D. and Marinković, Aleksandar and Obradović, Maja and Radmilović, V. and Čolić, Miodrag and Aleksić, Radoslav and Uskoković, Petar", year = "2009", abstract = "Surface functionalization of multi-walled carbon nanotubes (MWCNTs), with amino groups via chemical modification of carboxyl groups introduced on the nanotube surface, using O-(7-azabenzotriazol-1-yl)-N, N,N',N'-tetramethyluronium hexafluorophosphate (N-HATU) and N,N-diisopropylethylamine (DIEA) is reported. The N-HATU coupling agent provides faster reaction rate and the reaction occurs at lower temperature compared to amidation and acylation-amidation chemistry. The amines, 1,6-hexanediamine (HDA), diethylenetriamine (DETA), triethylenetetramine (TETA) and 1,4-phenylenediamine (PDA) were used. The resulting materials were characterized with different techniques such as FTIR, XRD, elemental analysis, TGA, TEM, UV-vis spectroscopy and cyclic voltammetry. MWCNTs functionalized with PDA posses the best dispersibility and electron transfer properties in comparison to the others amines. Functionalized MWCNTs, at the concentrations between 1 and 50 mu g ml(-1), were not cytotoxic for the fibroblast L929 cell line. However, the concentrations of MWCNTs higher of 10 mu g ml(-1) reduced cell growth and this effect correlated positively with the degree of their uptake by L929 cells.", publisher = "Elsevier Science Bv, Amsterdam", journal = "Applied Surface Science", title = "Synthesis, characterization and cytotoxicity of surface amino-functionalized water-dispersible multi-walled carbon nanotubes", pages = "8075-8067", number = "18", volume = "255", doi = "10.1016/j.apsusc.2009.05.016" }
Vuković, G. D., Marinković, A., Obradović, M., Radmilović, V., Čolić, M., Aleksić, R.,& Uskoković, P.. (2009). Synthesis, characterization and cytotoxicity of surface amino-functionalized water-dispersible multi-walled carbon nanotubes. in Applied Surface Science Elsevier Science Bv, Amsterdam., 255(18), 8067-8075. https://doi.org/10.1016/j.apsusc.2009.05.016
Vuković GD, Marinković A, Obradović M, Radmilović V, Čolić M, Aleksić R, Uskoković P. Synthesis, characterization and cytotoxicity of surface amino-functionalized water-dispersible multi-walled carbon nanotubes. in Applied Surface Science. 2009;255(18):8067-8075. doi:10.1016/j.apsusc.2009.05.016 .
Vuković, Goran D., Marinković, Aleksandar, Obradović, Maja, Radmilović, V., Čolić, Miodrag, Aleksić, Radoslav, Uskoković, Petar, "Synthesis, characterization and cytotoxicity of surface amino-functionalized water-dispersible multi-walled carbon nanotubes" in Applied Surface Science, 255, no. 18 (2009):8067-8075, https://doi.org/10.1016/j.apsusc.2009.05.016 . .