Mathematical Model of Gentamicin Sulfate Release from a Bioactive Textile Material as a Transdermal System Under In Vitro Conditions
Samo za registrovane korisnike
2010
Autori
Simović, LjiljanaŠkundrić, Petar
Pajić-Lijaković, Ivana
Ristić, Katarina
Medović, Adela
Tasić, Goran
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
A mathematical model was developed to estimate the release of gentamicin sulfate from a bioactive textile material as a transdermal system for wound dressing. The gentamicin sulfate released from the antibiotic/chitosan hydrogel complexes was measured in vitro by the Franz diffusion cell technique. The diffusive transport of gentamicin sulfate through three connected compartments, that is, chitosan hydrogel, membrane, and solution, was considered by the formulation of a model based on Fick's second law. Initially, the total amount of gentamicin sulfate was placed within an already swollen chitosan hydrogel. The value of the diffusivity coefficient of the drug through the chitosan hydrogel was calculated for every initial amount of the active substance. For the initial concentration of gentamicin sulfate, which was lower than 2.81 x 10(4) mu g/mL, the diffusion coefficient was approximately constant. A higher amount of gentamicin sulfate in the hydrogel reduced its own transport as a co...nsequence of an increase in the intensity of the interaction field between the molecules of gentamicin sulfate. The model provides the possibility of optimizing the process of drug release by ensuring a compromise between a higher value of the diffusivity coefficient and a desirable amount of gentamicin sulfate and a constant concentration within the solution over 48 h.
Ključne reči:
biomaterials / diffusion / drug delivery systems / hydrogelsIzvor:
Journal of Applied Polymer Science, 2010, 117, 3, 1424-1430Izdavač:
- John Wiley & Sons Inc, Hoboken
Finansiranje / projekti:
DOI: 10.1002/app.31964
ISSN: 0021-8995
WoS: 000278571200020
Scopus: 2-s2.0-77952018754
Institucija/grupa
Tehnološko-metalurški fakultetTY - JOUR AU - Simović, Ljiljana AU - Škundrić, Petar AU - Pajić-Lijaković, Ivana AU - Ristić, Katarina AU - Medović, Adela AU - Tasić, Goran PY - 2010 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1606 AB - A mathematical model was developed to estimate the release of gentamicin sulfate from a bioactive textile material as a transdermal system for wound dressing. The gentamicin sulfate released from the antibiotic/chitosan hydrogel complexes was measured in vitro by the Franz diffusion cell technique. The diffusive transport of gentamicin sulfate through three connected compartments, that is, chitosan hydrogel, membrane, and solution, was considered by the formulation of a model based on Fick's second law. Initially, the total amount of gentamicin sulfate was placed within an already swollen chitosan hydrogel. The value of the diffusivity coefficient of the drug through the chitosan hydrogel was calculated for every initial amount of the active substance. For the initial concentration of gentamicin sulfate, which was lower than 2.81 x 10(4) mu g/mL, the diffusion coefficient was approximately constant. A higher amount of gentamicin sulfate in the hydrogel reduced its own transport as a consequence of an increase in the intensity of the interaction field between the molecules of gentamicin sulfate. The model provides the possibility of optimizing the process of drug release by ensuring a compromise between a higher value of the diffusivity coefficient and a desirable amount of gentamicin sulfate and a constant concentration within the solution over 48 h. PB - John Wiley & Sons Inc, Hoboken T2 - Journal of Applied Polymer Science T1 - Mathematical Model of Gentamicin Sulfate Release from a Bioactive Textile Material as a Transdermal System Under In Vitro Conditions EP - 1430 IS - 3 SP - 1424 VL - 117 DO - 10.1002/app.31964 ER -
@article{ author = "Simović, Ljiljana and Škundrić, Petar and Pajić-Lijaković, Ivana and Ristić, Katarina and Medović, Adela and Tasić, Goran", year = "2010", abstract = "A mathematical model was developed to estimate the release of gentamicin sulfate from a bioactive textile material as a transdermal system for wound dressing. The gentamicin sulfate released from the antibiotic/chitosan hydrogel complexes was measured in vitro by the Franz diffusion cell technique. The diffusive transport of gentamicin sulfate through three connected compartments, that is, chitosan hydrogel, membrane, and solution, was considered by the formulation of a model based on Fick's second law. Initially, the total amount of gentamicin sulfate was placed within an already swollen chitosan hydrogel. The value of the diffusivity coefficient of the drug through the chitosan hydrogel was calculated for every initial amount of the active substance. For the initial concentration of gentamicin sulfate, which was lower than 2.81 x 10(4) mu g/mL, the diffusion coefficient was approximately constant. A higher amount of gentamicin sulfate in the hydrogel reduced its own transport as a consequence of an increase in the intensity of the interaction field between the molecules of gentamicin sulfate. The model provides the possibility of optimizing the process of drug release by ensuring a compromise between a higher value of the diffusivity coefficient and a desirable amount of gentamicin sulfate and a constant concentration within the solution over 48 h.", publisher = "John Wiley & Sons Inc, Hoboken", journal = "Journal of Applied Polymer Science", title = "Mathematical Model of Gentamicin Sulfate Release from a Bioactive Textile Material as a Transdermal System Under In Vitro Conditions", pages = "1430-1424", number = "3", volume = "117", doi = "10.1002/app.31964" }
Simović, L., Škundrić, P., Pajić-Lijaković, I., Ristić, K., Medović, A.,& Tasić, G.. (2010). Mathematical Model of Gentamicin Sulfate Release from a Bioactive Textile Material as a Transdermal System Under In Vitro Conditions. in Journal of Applied Polymer Science John Wiley & Sons Inc, Hoboken., 117(3), 1424-1430. https://doi.org/10.1002/app.31964
Simović L, Škundrić P, Pajić-Lijaković I, Ristić K, Medović A, Tasić G. Mathematical Model of Gentamicin Sulfate Release from a Bioactive Textile Material as a Transdermal System Under In Vitro Conditions. in Journal of Applied Polymer Science. 2010;117(3):1424-1430. doi:10.1002/app.31964 .
Simović, Ljiljana, Škundrić, Petar, Pajić-Lijaković, Ivana, Ristić, Katarina, Medović, Adela, Tasić, Goran, "Mathematical Model of Gentamicin Sulfate Release from a Bioactive Textile Material as a Transdermal System Under In Vitro Conditions" in Journal of Applied Polymer Science, 117, no. 3 (2010):1424-1430, https://doi.org/10.1002/app.31964 . .