Synthesis, characterization and controlled release of cephalexin drug from smart poly(2-hydroxyethyl methacrylate/poly(alkylene glycol)(meth)acrylates hydrogels
Само за регистроване кориснике
2010
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
In this work, novel hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and different poly(alkylene glycol)(meth)acrylates (BIS) were prepared by radiation-induced copolymerization. The influence of different BIS types with variation in chain length, based on ethylene glycol (EG) and/or propylene glycol (PG) pendant units, on the nature and inherent properties of P(HEMA/BIS) copolymeric hydrogels was the main idea of this paper. Swelling studies were conducted for all types of P(HEMA/BIS) copolymeric hydrogels in a wide pH and temperature range. Additional characterization of structure, morphology and thermal behaviour of the obtained hydrogels was conducted by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and thermogravimetric (TG) analysis. The modelling of drug release and diffusion characteristics was tested using cephalexin (CEX). The results indicate that P(HEMA/BIS) hydrogels' properties are significantly dependent on the type of BIS. The ...hydrogels with ethylene glycol (EG) pendant chains show a noticeable pH and/or temperature sensitivity and can be considered smart hydrogels. The introduction of propylene glycol (PG) units, pure and mixed with ethylene glycol (EG) pendant chains, can additionally tune the characteristics of such gels. Furthermore, drug release studies indicate that these types of P(HEMA/BIS) copolymeric hydrogels are suitable candidates for controlled drug release systems.
Кључне речи:
Smart hydrogels / Environmental sensitivity / Drug release / 2-Hydroxyethyl methacrylate / Poly(alkylene glycol)(meth)acrylatesИзвор:
Chemical Engineering Journal, 2010, 160, 2, 801-809Издавач:
- Elsevier Science Sa, Lausanne
Финансирање / пројекти:
- Регенерација скелетних ткива помогнута биоматеријалима као ткивним матрицама - ин виво и ин витро студија (RS-145072)
- Модификација, синтеза и анализа наноструктурних материјала јонским сноповима, гама зрачењем и вакуумским депоновањем (RS-141013)
DOI: 10.1016/j.cej.2010.03.089
ISSN: 1385-8947
WoS: 000279137900051
Scopus: 2-s2.0-77954815953
Институција/група
Tehnološko-metalurški fakultetTY - JOUR AU - Tomić, Simonida AU - Mićić, Maja M. AU - Filipović, Jovanka M. AU - Suljovrujić, Edin H. PY - 2010 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1620 AB - In this work, novel hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and different poly(alkylene glycol)(meth)acrylates (BIS) were prepared by radiation-induced copolymerization. The influence of different BIS types with variation in chain length, based on ethylene glycol (EG) and/or propylene glycol (PG) pendant units, on the nature and inherent properties of P(HEMA/BIS) copolymeric hydrogels was the main idea of this paper. Swelling studies were conducted for all types of P(HEMA/BIS) copolymeric hydrogels in a wide pH and temperature range. Additional characterization of structure, morphology and thermal behaviour of the obtained hydrogels was conducted by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and thermogravimetric (TG) analysis. The modelling of drug release and diffusion characteristics was tested using cephalexin (CEX). The results indicate that P(HEMA/BIS) hydrogels' properties are significantly dependent on the type of BIS. The hydrogels with ethylene glycol (EG) pendant chains show a noticeable pH and/or temperature sensitivity and can be considered smart hydrogels. The introduction of propylene glycol (PG) units, pure and mixed with ethylene glycol (EG) pendant chains, can additionally tune the characteristics of such gels. Furthermore, drug release studies indicate that these types of P(HEMA/BIS) copolymeric hydrogels are suitable candidates for controlled drug release systems. PB - Elsevier Science Sa, Lausanne T2 - Chemical Engineering Journal T1 - Synthesis, characterization and controlled release of cephalexin drug from smart poly(2-hydroxyethyl methacrylate/poly(alkylene glycol)(meth)acrylates hydrogels EP - 809 IS - 2 SP - 801 VL - 160 DO - 10.1016/j.cej.2010.03.089 ER -
@article{ author = "Tomić, Simonida and Mićić, Maja M. and Filipović, Jovanka M. and Suljovrujić, Edin H.", year = "2010", abstract = "In this work, novel hydrogels based on 2-hydroxyethyl methacrylate (HEMA) and different poly(alkylene glycol)(meth)acrylates (BIS) were prepared by radiation-induced copolymerization. The influence of different BIS types with variation in chain length, based on ethylene glycol (EG) and/or propylene glycol (PG) pendant units, on the nature and inherent properties of P(HEMA/BIS) copolymeric hydrogels was the main idea of this paper. Swelling studies were conducted for all types of P(HEMA/BIS) copolymeric hydrogels in a wide pH and temperature range. Additional characterization of structure, morphology and thermal behaviour of the obtained hydrogels was conducted by Fourier transform infrared (FTIR) spectroscopy, scanning electron microscopy (SEM), and thermogravimetric (TG) analysis. The modelling of drug release and diffusion characteristics was tested using cephalexin (CEX). The results indicate that P(HEMA/BIS) hydrogels' properties are significantly dependent on the type of BIS. The hydrogels with ethylene glycol (EG) pendant chains show a noticeable pH and/or temperature sensitivity and can be considered smart hydrogels. The introduction of propylene glycol (PG) units, pure and mixed with ethylene glycol (EG) pendant chains, can additionally tune the characteristics of such gels. Furthermore, drug release studies indicate that these types of P(HEMA/BIS) copolymeric hydrogels are suitable candidates for controlled drug release systems.", publisher = "Elsevier Science Sa, Lausanne", journal = "Chemical Engineering Journal", title = "Synthesis, characterization and controlled release of cephalexin drug from smart poly(2-hydroxyethyl methacrylate/poly(alkylene glycol)(meth)acrylates hydrogels", pages = "809-801", number = "2", volume = "160", doi = "10.1016/j.cej.2010.03.089" }
Tomić, S., Mićić, M. M., Filipović, J. M.,& Suljovrujić, E. H.. (2010). Synthesis, characterization and controlled release of cephalexin drug from smart poly(2-hydroxyethyl methacrylate/poly(alkylene glycol)(meth)acrylates hydrogels. in Chemical Engineering Journal Elsevier Science Sa, Lausanne., 160(2), 801-809. https://doi.org/10.1016/j.cej.2010.03.089
Tomić S, Mićić MM, Filipović JM, Suljovrujić EH. Synthesis, characterization and controlled release of cephalexin drug from smart poly(2-hydroxyethyl methacrylate/poly(alkylene glycol)(meth)acrylates hydrogels. in Chemical Engineering Journal. 2010;160(2):801-809. doi:10.1016/j.cej.2010.03.089 .
Tomić, Simonida, Mićić, Maja M., Filipović, Jovanka M., Suljovrujić, Edin H., "Synthesis, characterization and controlled release of cephalexin drug from smart poly(2-hydroxyethyl methacrylate/poly(alkylene glycol)(meth)acrylates hydrogels" in Chemical Engineering Journal, 160, no. 2 (2010):801-809, https://doi.org/10.1016/j.cej.2010.03.089 . .