Smart poly(2-hydroxyethyl methacrylate/itaconic acid) hydrogels for biomedical application
Abstract
pH- and temperature-sensitive hydrogels, based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) copolymers, were prepared by gamma-irradiation and characterized in order to examine their potential use in biomedical applications. The influence of comonomer ratio in these smart copolymers on their morphology, mechanical and thermal properties, biocompatibility and microbe penetration capability was investigated. The mechanical properties of copolymers were investigated using the dynamic mechanical analysis (DMA), while their thermal properties and morphology were examined by thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). The morphology, mechanical and thermal properties of these hydrogels were found to be suitable for most requirements of biomedical applications. The in vitro study of P(HEMA/IA) biocompatibility showed no evidence of cell toxicity nor any considerable hemolytic activity. Furthermore, the microbe penetration test showed that neither S...taphylococcus aureus nor Escherichia coli passed through the hydogel dressing; thus the P(HEMA/IA) dressing could be considered a good barrier against microbes. All results indicate that stimuli-responsive P(HEMA/IA) hydrogels have great potential for biomedical applications, especially for skin treatment and wound dressings.
Keywords:
gamma-radiation / Smart hydrogels / 2-Hydroxyethyl methacrylate / Itaconic acid / Biocompatibility / Microbe penetrationSource:
Radiation Physics and Chemistry, 2010, 79, 5, 643-649Publisher:
- Pergamon-Elsevier Science Ltd, Oxford
Funding / projects:
- Regeneracija skeletnih tkiva pomognuta biomaterijalima kao tkivnim matricama - in vivo i in vitro studija (RS-145072)
- Modifikacija, sinteza i analiza nanostrukturnih materijala jonskim snopovima, gama zračenjem i vakuumskim deponovanjem (RS-141013)
DOI: 10.1016/j.radphyschem.2009.11.015
ISSN: 0969-806X
WoS: 000275997400014
Scopus: 2-s2.0-76849096607
Institution/Community
Tehnološko-metalurški fakultetTY - JOUR AU - Tomić, Simonida AU - Mićić, Maja M. AU - Dobić, Sava N. AU - Filipović, Jovanka M. AU - Suljovrujić, Edin H. PY - 2010 UR - http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1707 AB - pH- and temperature-sensitive hydrogels, based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) copolymers, were prepared by gamma-irradiation and characterized in order to examine their potential use in biomedical applications. The influence of comonomer ratio in these smart copolymers on their morphology, mechanical and thermal properties, biocompatibility and microbe penetration capability was investigated. The mechanical properties of copolymers were investigated using the dynamic mechanical analysis (DMA), while their thermal properties and morphology were examined by thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). The morphology, mechanical and thermal properties of these hydrogels were found to be suitable for most requirements of biomedical applications. The in vitro study of P(HEMA/IA) biocompatibility showed no evidence of cell toxicity nor any considerable hemolytic activity. Furthermore, the microbe penetration test showed that neither Staphylococcus aureus nor Escherichia coli passed through the hydogel dressing; thus the P(HEMA/IA) dressing could be considered a good barrier against microbes. All results indicate that stimuli-responsive P(HEMA/IA) hydrogels have great potential for biomedical applications, especially for skin treatment and wound dressings. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Radiation Physics and Chemistry T1 - Smart poly(2-hydroxyethyl methacrylate/itaconic acid) hydrogels for biomedical application EP - 649 IS - 5 SP - 643 VL - 79 DO - 10.1016/j.radphyschem.2009.11.015 ER -
@article{ author = "Tomić, Simonida and Mićić, Maja M. and Dobić, Sava N. and Filipović, Jovanka M. and Suljovrujić, Edin H.", year = "2010", abstract = "pH- and temperature-sensitive hydrogels, based on 2-hydroxyethyl methacrylate (HEMA) and itaconic acid (IA) copolymers, were prepared by gamma-irradiation and characterized in order to examine their potential use in biomedical applications. The influence of comonomer ratio in these smart copolymers on their morphology, mechanical and thermal properties, biocompatibility and microbe penetration capability was investigated. The mechanical properties of copolymers were investigated using the dynamic mechanical analysis (DMA), while their thermal properties and morphology were examined by thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). The morphology, mechanical and thermal properties of these hydrogels were found to be suitable for most requirements of biomedical applications. The in vitro study of P(HEMA/IA) biocompatibility showed no evidence of cell toxicity nor any considerable hemolytic activity. Furthermore, the microbe penetration test showed that neither Staphylococcus aureus nor Escherichia coli passed through the hydogel dressing; thus the P(HEMA/IA) dressing could be considered a good barrier against microbes. All results indicate that stimuli-responsive P(HEMA/IA) hydrogels have great potential for biomedical applications, especially for skin treatment and wound dressings.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Radiation Physics and Chemistry", title = "Smart poly(2-hydroxyethyl methacrylate/itaconic acid) hydrogels for biomedical application", pages = "649-643", number = "5", volume = "79", doi = "10.1016/j.radphyschem.2009.11.015" }
Tomić, S., Mićić, M. M., Dobić, S. N., Filipović, J. M.,& Suljovrujić, E. H.. (2010). Smart poly(2-hydroxyethyl methacrylate/itaconic acid) hydrogels for biomedical application. in Radiation Physics and Chemistry Pergamon-Elsevier Science Ltd, Oxford., 79(5), 643-649. https://doi.org/10.1016/j.radphyschem.2009.11.015
Tomić S, Mićić MM, Dobić SN, Filipović JM, Suljovrujić EH. Smart poly(2-hydroxyethyl methacrylate/itaconic acid) hydrogels for biomedical application. in Radiation Physics and Chemistry. 2010;79(5):643-649. doi:10.1016/j.radphyschem.2009.11.015 .
Tomić, Simonida, Mićić, Maja M., Dobić, Sava N., Filipović, Jovanka M., Suljovrujić, Edin H., "Smart poly(2-hydroxyethyl methacrylate/itaconic acid) hydrogels for biomedical application" in Radiation Physics and Chemistry, 79, no. 5 (2010):643-649, https://doi.org/10.1016/j.radphyschem.2009.11.015 . .