Приказ основних података о документу
Evaluation of alginate hydrogels under in vivo-like bioreactor conditions for cartilage tissue engineering
dc.creator | Stojkovska, Jasmina | |
dc.creator | Bugarski, Branko | |
dc.creator | Obradović, Bojana | |
dc.date.accessioned | 2021-03-10T11:24:40Z | |
dc.date.available | 2021-03-10T11:24:40Z | |
dc.date.issued | 2010 | |
dc.identifier.issn | 0957-4530 | |
dc.identifier.uri | http://TechnoRep.tmf.bg.ac.rs/handle/123456789/1725 | |
dc.description.abstract | Alginate hydrogels in forms of discs and packed beds of microbeads (similar to 800 mu m) were tested in a novel bioreactor at 10% strain using two regimes: at a loading rate of 337.5 mu m/s and at sequential increments of 50 mu m displacement every 30 min. Compressive strength increased with the increase in alginate concentration (1.5 vs. 2% w/w) and the content of guluronic residues (38.5 vs. 67%). Packed beds of microbeads exhibited significantly higher (similar to 1.5-3.4 fold) compression moduli than the respective discs indicating the effects of gel form and entrapped water. Short-term cultivation of microbeads with immobilized bovine calf chondrocytes (1.5% w/w, 33 x 10(6) cells/ml) under biomimetic conditions (dynamic compression: 1 h on/1 h off, 0.42 Hz, 10% strain) resulted in cell proliferation and bed compaction, so that the compression modulus slightly increased. Thus, the novel bioreactor demonstrated advantages in evaluation of biomaterial properties and cell-biomaterial interactions under in vivo-like settings. | en |
dc.publisher | Springer, Dordrecht | |
dc.relation | Swiss National Science Foundation (SNSF)Swiss National Science Foundation (SNSF) [IB73B0-111016/1] | |
dc.relation | info:eu-repo/grantAgreement/MESTD/MPN2006-2010/142075/RS// | |
dc.rights | restrictedAccess | |
dc.source | Journal of Materials Science-Materials in Medicine | |
dc.title | Evaluation of alginate hydrogels under in vivo-like bioreactor conditions for cartilage tissue engineering | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 2879 | |
dc.citation.issue | 10 | |
dc.citation.other | 21(10): 2869-2879 | |
dc.citation.rank | M21 | |
dc.citation.spage | 2869 | |
dc.citation.volume | 21 | |
dc.identifier.doi | 10.1007/s10856-010-4135-0 | |
dc.identifier.pmid | 20717710 | |
dc.identifier.scopus | 2-s2.0-78349307728 | |
dc.identifier.wos | 000283371200017 | |
dc.type.version | publishedVersion |